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Koyanagi Satoru Last modified date：2023.06.11

Professor / Medico-Pharmaceutical Sciences
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences


Undergraduate School
Department of General Pharmaceutical Sciences
School of Pharmaceutical Sciences
Other Organization
Experimental Station for Medicinal Plant Studies
Research Center for Education in Health Care System
Pharmacy
Other


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/koyanagi-satoru
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http://glocal.phar.kyushu-u.ac.jp
A variety of pathological conditions exhibit profound day-night changes in the symptom intensity with a large portion exacerbating and occurrence of grave events. Recent developments in our understanding of circadian biology and the availability of tools to characterize the molecular clock indicate that the choosing appropriate dosing time have consequences for the efficacy and safety of new and existing therapeutic drugs. Progression of this research field also suggests that many pathological conditions are under the control of the circadian clock. These notions reveal opportunities for new therapeutic strategies. Now novel therapeutic approaches are facilitated by development of chemical probes and synthetic ligands targeted to an increasing number of the key proteins that causing circadian exacerbation of pathological events. .
https://yakuzai.phar.kyushu-u.ac.jp/
Laboratory of Pharmaceutics .
Phone
092-642-6611
Fax
092-642-6614
Academic Degree
Ph.D
Field of Specialization
Pharmaceutics, Chronopharmacotherapy
ORCID(Open Researcher and Contributor ID)
0000-0003-4849-2377
Total Priod of education and research career in the foreign country
04years00months
Outline Activities
Recent developments in our understanding of circadian biology and the availability of tools to characterize this oscillation system indicate that the choosing appropriate dosing time have consequences for the ef cacy and safety of new and existing therapeutic drugs (Chronopharmacotherapy). Progression of this research eld also suggests that many pathological conditions are under the control of the circadian clock. These notions reveal opportunities for new therapeutic strategies. Now novel therapeutic approaches are facilitated by development of chemical probes and synthetic ligands targeted to an increasing number of the key proteins that causing circadian exacerbation of pathological events.
The major objective of our research is to understand the molecular mechanisms for day-night changes in the pathological events and the impact of circadian rhythms on the onset of diseases. Based on these mechanism, we attempt to identify new therapeutic target and to develop novel strategy for treatment of diseases.
Research
Research Interests
  • Investigation of underlying mechanism of circadian variations in the function of pharmacokinetic regulatory factor by RNA editting
    keyword : RNA editting, pharmacokinetic regulatory factor, circadian rhythm
    2018.04～2024.03.
  • Study on the role of circadian clock gene in the oncogenic transformation
    keyword : Clock genes, Cellular oncogenic transformation
    2011.04.
  • Study on the mechanism for circadian regulation of intractable　pain
    keyword : Neuropathic pain , Cancer, Circadian rhythm
    2010.04.
  • Development of chronopharmacotherapy of anti-cancer drug based on molecular circadian clock
    keyword : Biological rhythm, clock gene, cell cycle
    2005.12～2011.03.
  • Evaluation of the mechanism of circadian time-dependent change of drug efficacy and development of chronodrug delivery system
    keyword : target molecule, drug metabolism, transporter
    2005.12.
Academic Activities
Books
 Show All Books >>
1. Koyanagi S, Kusunose N, Matsunaga N, Ohdo S., Biological Clock with reference to suprachiasmatic nucleus, 北海道大学出版会, 2017.11.
2. Soeda S., Koyanagi S., Shimeno H., Angiogenesis; Functional and Medicinal Foods, Marcel Decker N.Y., 2007.04.
Reports
 Show All Reports >>
1. Koyanagi S, Kusunose N, Yasukochi S, Ohdo S., Basis for diurnal exacerbation of neuropathic pain hypersensitivity and its application for drug development, J Biochem, 10.1093/jb/mvab143, 2021.11.
2. Ohdo S, Koyanagi S, Matsunaga N, Chronopharmacological strategies focused on chrono-drug discovery, 10.1016/j.pharmthera.2019.05.018, 2021.05.
3. Ohdo S, Koyanagi S, Matsunaga N., Chronopharmacological strategies: Intra- and inter-individual variability of molecular clock, Adv Drug Deliv Rev, 2010.06.
Papers
 Show All Papers >>
1. Omata Y, Okawa M, Haraguchi M, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S, RNA editing enzyme ADAR1 controls miR-381-3p-mediated expression of multidrug resistance protein MRP4 via regulation of circRNA in human renal cells, J Biol Chem, 298, 102184, 2022.07.
2. Omata Y, Yamauchi T, Tsuruta A, Matsunaga N, Koyanagi S, Ohdo S, RNA editing enzyme ADAR1 governs the circadian expression of P-glycoprotein in human renal cells by regulating alternative splicing of the ABCB1 gene, J Biol Chem, 10.1016/j.jbc.2021.100601, 298, 100601, 2021.04.
3. Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S, Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia, Nature Commun., 7, 2016.10.
4. Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S, Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation, J Biol Chem, 291, 2016.05.
5. Horiguchi M, Koyanagi S, Hamdan AM, Kakimoto K, Matsunaga N, Yamashita C, Ohdo S., Rhythmic Control of the ARF-MDM2 Pathway by ATF4 Underlies Circadian Accumulation of p53 in Malignant Cells, Cancer Res, 8, 2013.04.
6. Hamdan AM, Koyanagi S, Wada E, Kusunose N, Murakami Y, Matsunaga N, Ohdo S., Intestinal Expression of Mouse Abcg2/Breast Cancer Resistance Protein (BCRP) Gene Is under Control of Circadian Clock-activating Transcription Factor-4 Pathway, J Biol Chem, 21, 17224-17231, 2012.05.
7. Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S., Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors, Cancer Res., 72, 395-401, 2011.11.
8. Koyanagi S, Hamdan AM, Horiguchi M, Kusunose N, Okamoto A, Matsunaga N, Ohdo S., cAMP response element-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene., J Biol Chem., 286, 32416-32423, 2011.07.
9. Murakami Y, Higashi Y, Matsunaga N, Koyanagi S, Ohdo S, Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice, Gastroenterology, 135, 1636-1644, 2008.08.
10. Takiguchi T., Tomita M., Matsunaga N., Nakagawa H., Koyanagi S., and Ohdo S., Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells, Pharmacogenet. Genomics, 17, 1047-1056, 2007.12.
11. Koyanagi S., Kuramoto Y., Nakagawa H., Aramaki H., Ohdo S., Soeda S., Shimeno H., A molecular mechanism regulating circadian expression of vascular endothelial growth factor in tumor cells, Cancer Res., 21, 7277-7283, 2003.11.
12. Ohdo S., Koyanagi S., Suyama H., Higuchi S., Aramaki H., Changing the dosing schedule minimizes the disruptive effects of interferon on clock function., Nature Medicine, 3, 354-360, 2001.03.
Presentations
 Show All Presentations >>
1. Koyanagi S., Circadian clock and Chronopharmacology, Annual Meeting Taiwan Pharmaceutical Society, 2020.11.
2. Satoru Koyanagi, Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of pain hypersensitivity after peripheral nerve injury, Sapporo Symposium on Biological Rhythm in 2016, 2016.11.
3. Koyanagi Satoru, Shigehiro Ohdo, Molecular basis for circadian sensitivity of tumor cells to chemotherapeutic agents, Spring Annual Convention of Pharmaceutical Society of Korea, 2014.04.
4. Molecular machanim for the circadian expression of intestinal transporters.
Membership in Academic Society
  • The Japanese Pharmacological Society
  • The Japanese Society for Alternatives to Animal Experiments
Awards
  • Chrono-pharmaceutical study based on the molecular mechanism of circadian rhythms in
    pathological condition and drug efficacy
  • Chronopharmacokinetic study based on molecular circadian clock
Educational
Other Educational Activities
  • 2022.04.
  • 2022.04.
  • 2021.04.
  • 2021.04.
  • 2020.04.
  • 2019.04.
  • 2018.04.
  • 2017.04.
  • 2016.04.


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