Kyushu University [Tsuyoshi OKAMOTO (Associate Professor) Faculty of Arts and Science, Division for Theoretical Natural Science]

[Outline of research]
I conduct the theoretical, computational, analytical, and experimental researches on sensory systems (visual, auditory, olfactory, taste, and thermal sensations), higher brain function (language, memory, learning, emotion, and motivation), environmental comfort, and neurofeedback training to improve brain functions.

[Outline of education]
Foundational education in the Faculty of Arts and Science.
Lectures for basic math on wave analysis, bioinformatics, and neuroscience.
Practical training on MATLAB/Octave programming.

Research

Research Interests

Brain science on bonfire
keyword : Bonfire, EEG
2021.01.
Brain science research on human olfaction.
keyword : olfactory system
2015.04.
Development and verification of neurofeedback training to improve brain functions.
keyword : Neurofeedback, Biofeedback
2018.04.
Enhancing Learning Analytics Platforms by Brain Science
keyword : Brain Science, Learning Analytics
2017.10～2019.03.
How to upgrade or downgrade the brain functions
keyword : Neuroscience, Brain science
2015.04～2018.03.
Evaluation of human comfort using electrophysiological responses in living environments.
keyword : living environment, human comfort, neuroscience experiments
2012.04.
Innovative multidisciplinary research on smell through medicine, agriculture, science, engineering and psychology.
keyword : olfactory system
2012.01～2015.03.
Objective quantitative analyses on neuropathological images
keyword : neuropathology, image analysis
2011.04～2020.03.
Studies on physiological and psychological effects in odors
keyword : odor, olfaction
2008.04～2012.06.
Multivariate analysis of MEG data
keyword : MEG, Multivariate analysis
2007.12～2009.03.
Study on the Deep Brain Stimulation
keyword : Deep Brain Stimulation
2006.04～2020.03.
Gait analysis of patients with Parkinson's disease.
keyword : Parkinson's disease, Gait analysis
2006.04～2012.03.
Research on visual fatigue using a three-dimensional visual presentation device
keyword : visual fatigue, three-dimensional visual presentation device
2006.04～2007.03.
Measurement of gamma characteristics of human visual system and elucidation of information processing mechanism in brain
keyword : neuroaesthetics
2005.12～2010.06.
Mathematical model and simulation of the pathogenic mechanism of Pokemon epilepsy
keyword : photosensitive epilepsy
2004.08～2010.06.
Analysis of optical measurement data in the primary visual cortex
keyword : primary visual cortex
2003.10～2020.12.
Simulation of contextual modulation of primary visual cortex
keyword : Simulation, contextual modulation, primary visual cortex
1999.04～2011.10.
Simulation and theoretical research on statistical mechanics of crystal growth
keyword : crystal growth
1998.09～1999.03Theoretical analysis and computational simulation on crystal growth..

Academic Activities

Reports

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Papers

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1.	Kaori Tamura, Tsuyoshi Okamoto, Odor descriptive ratings can predict some odor-color associations in different color features of hue or lightness., 2023.04.
2.	Hideko Noguchi, BSc, Sachiko Koyama, BSc, Kaoru Yagita, MD, Masahiro Shijo, MD, PhD, Kosuke Matsuzono, MD, PhD, Hideomi Hamasaki, PhD, Takaaki Kanemaru, PhD, Tsuyoshi Okamoto, PhD, Keita Kai, MD, PhD, Shinichi Aishima, MD, PhD, Koji Abe, MD, PhD, Naokazu Sasagasako, MD, Hiroyuki Honda, MD, PhD, Silence of resident microglia in GPI anchorless prion disease and activation of microglia in Gerstmann-Sträussler-Scheinker disease and sporadic Creutzfeldt-Jakob disease., Journal of Neuropathology & Experimental Neurology, 2022.11.
3.	Kaori Tamura, Sayaka Matsumoto, Yu Hsuan Tseng, Takayuki Kobayashi, Jun'ichi Miwa, Ken'ichi Miyazawa, Soichiro Matsumoto, Seiji Hiramatsu, Hiroyuki Otake, Tsuyoshi Okamoto, Physiological comfort evaluation under different airflow directions in a heating environment., Journal of Physiological Anthropology, https://doi.org/10.1186/s40101-022-00289-x, 2022.04.
4.	Akinori Takeda, Emi Yamada, Taira Uehara, Katsuya Ogata, Tsuyoshi Okamoto, Shozo Tobimatsu, Data-point-wise spatiotemporal mapping of human ventral visual areas: Use of spatial frequency/luminance-modulated chromatic faces., NeuroImage, https://doi.org/10.1016/j.neuroimage.2021.118325, 239, 1, 118325, 2021.10, [URL], Visual information involving facial identity and expression is crucial for social communication. Although the influence of facial features such as spatial frequency (SF) and luminance on face processing in visual areas has been studied extensively using grayscale stimuli, the combined effects of other features in this process have not been characterized. To determine the combined effects of different SFs and color, we created chromatic stimuli with low, high or no SF components, which bring distinct SF and color information into the ventral stream simultaneously. To obtain neural activity data with high spatiotemporal resolution we recorded face-selective responses (M170) using magnetoencephalography. We used a permutation test procedure with threshold-free cluster enhancement to assess statistical significance while resolving problems related to multiple comparisons and arbitrariness found in traditional statistical methods. We found that time windows with statistically significant threshold levels were distributed differently among the stimulus conditions. Face stimuli containing any SF components evoked M170 in the fusiform gyrus (FG), whereas a significant emotional effect on M170 was only observed with the original images. Low SF faces elicited larger activation of the FG and the inferior occipital gyrus than the original images, suggesting an interaction between low and high SF information processing. Interestingly, chromatic face stimuli without SF first activated color-selective regions and then the FG, indicating that facial color was processed according to a hierarchy in the ventral stream. These findings suggest complex effects of SFs in the presence of color information, reflected in M170, and unveil the detailed spatiotemporal dynamics of face processing in the human brain..
5.	Yu-Hsuan Tseng, Kaori Tamura, Tsuyoshi Okamoto:, Neurofeedback training improves episodic and semantic long-term memory performance., Scientific Reports, https://doi.org/10.1038/s41598-021-96726-5, 11, Article number: 17274, 2021.08, [URL], Understanding and improving memory are vital to enhance human life. Theta rhythm is associated with memory consolidation and coding, but the trainability and effects on long-term memory of theta rhythm are unknown. This study investigated the ability to improve long-term memory using a neurofeedback (NFB) technique reflecting the theta/low-beta power ratio on an electroencephalogram (EEG). Our study consisted of three stages. First, the long-term memory of participants was measured. In the second stage, the participants in the NFB group received 3 days of theta/low-beta NFB training. In the third stage, the long-term memory was measured again. The NFB group had better episodic and semantic long-term memory than the control group and significant differences in brain activity between episodic and semantic memory during the recall tests were revealed. These findings suggest that it is possible to improve episodic and semantic long-term memory abilities through theta/low-beta NFB training..
6.	Kaori Tamura, Sayaka Matsumoto, Yu Hsuan Tseng, Takayuki Kobayashi, Jun'ichi Miwa, Ken'ichi Miyazawa, Toyotaka Hirao, Soichiro Matsumoto, Seiji Hiramatsu, Hiroyuki Otake, Tsuyoshi Okamoto, Physiological and subjective comfort evaluation under different airflow directions in a cooling environment., PLOS ONE, https://doi.org/10.1371/journal.pone.0249235, 2021.04, 冷房の「風向設定」が、部屋の中に居る人の周囲の温熱環境だけではなく、その人の主観評価、心理応答、生理応答のそれぞれにも同時に影響を与えることを脳科学的に明らかにした。本研究では、温度設定を一定に保ったまま、人の顔付近に風が当たりやすい「直接風」と、風が当たりにくい「間接風」の2種類の風向設定を切り替えて実験した。研究の意図を知らない学生19人に対し2種類の風向設定で実験を行った結果、間接風の方が顔の表面温度が高く（温熱環境）、体感温度・快適感が高く（主観評価）、心理時間が長い＝負の感情を抑制する（心理応答）ことがわかった。さらに、生理応答に関しては、間接風の方が脳波の左前頭部のガンマ波とベータ波の振幅が低く、心電図の交感神経活動の指標が高いことがわかった。本研究では「冷房時に快適さとガンマ波とベータ波の振幅の低下」を初めて明確に関連付けることができた。.
7.	Chun Lum Andy Ho, Robert Zimmermann, Juan Daniel Flórez Weidinger, Mario Prsa, Manuel Schottdorf, Sam Merlin, Tsuyoshi Okamoto, Koji Ikezoe, Fabien Pifferi, Fabienne Aujard, Alessandra Angelucci, Fred Wolf, Daniel Huber, Orientation Preference Maps in Microcebus murinus Reveal Size-Invariant Design Principles in Primate Visual Cortex, CURRENT BIOLOGY, 10.1016/j.cub.2020.11.027, 31, 4, 733-+, 2021.02.
8.	Minkai Sun, Taisuke Nakashima, Yuri Yoshimura, Akiyoshi Honden, Toshinori Nakagawa, Hiromi Saijo, Yuichiro Watanabe, Tsuyoshi Ajimi, Shinji Yasunari, Yuki Yamada, Jun Nagano, Tsuyoshi Okamoto, Hiroya Ishikawa, Koichiro Ohnuki, Noboru Fujimoto, Kuniyoshi Shimizu, Odor mixture perception: can molecular complexity be a factor determining elemental or configural perception?, Journal of Wood Science, 2020.09.
9.	Masayuki Hamakawa, Hiroya Ishikawa, Yumika Kikuchi, Kaori Tamura, Tsuyoshi Okamoto, Odor mixture perception: can molecular complexity be a factor determining elemental or configural perception?, BioRxiv, 2020.05.
10.	Maki Shigyo, Kaori Tamura, Tsuyoshi Okamoto, Expandability differences in learning transfer between computerized and non-computerized games., BioRxiv, 2020.05.
11.	Chosei Sha, Kaori Tamura, Tsuyoshi Okamoto, Enhancement of motor performance by a novel training method combining motor imagery and neurofeedback., BioRxiv, 2020.04.
12.	Kaori Tamura, Masayuki Hamakawa, Tsuyoshi Okamoto, Olfactory modulation of colour working memory How does citrus-like smell influence the memory of orange colour?, PloS one, 10.1371/journal.pone.0203876, 13, 9, 2018.09, Olfactory modulation of vision is not well understood whereas visual modulation of olfaction has been more fully investigated. This study aimed to reveal in a simple manner whether there is olfactory modulation of colour working memory using an odour that induces a citrus-like smell and is associated with orange colours. We assumed that the odour would have modulatory effects on the colour information stored in working memory. To clarify whether these effects are supportive or disruptive, during the colour working memory task we measured an event-related potential component, P3, which is involved in attentional processes of working memory. The results indicated that odour presentation mediated a decline in the rate of correct guesses for orange colours. Furthermore, the odour suppressed P3 during reddish-colour retrieval, including orange. These results suggest that colour working memory in orange can be disrupted via olfactory modulation with citrus-like odours..
13.	Masayuki Hamakawa, Tsuyoshi Okamoto, The effect of different emotional states on olfactory perception: A preliminary study., Flavour and Fragrance Journal, 10.1002/ffj.3469, 33, 420-427, Article ID: FFJ3469, 2018.08, [URL].
14.	Tsuyoshi Okamoto, Kaori Tamura, Naoyuki Miyamoto, Shogo Tanaka, Takaharu Futaeda, Physiological activity in calm thermal indoor environments, SCIENTIFIC REPORTS, 10.1038/s41598-017-11755-3, 7, 2017.09, [URL], Indoor environmental comfort has previously been quantified based on the subjective assessment of thermal physical parameters, such as temperature, humidity, and airflow velocity. However, the relationship of these parameters to brain activity remains poorly understood. The objective of this study was to determine the effect of airflow on brain activity using electroencephalograms (EEG) of participants in a living environment under different airflow conditions. Before the recording, the room was set to a standardised air temperature and humidity. During the recording, each participant was required to perform a simple time-perception task that involved pressing buttons after estimating a 10-second interval. Cooling and heating experiments were conducted in summer and winter, respectively. A frequency analysis of the EEGs revealed that gamma and beta activities showed lower amplitudes under conditions without airflow than with airflow, regardless of the season (i.e., cooling or heating). Our results reveal new neurophysiological markers of the response to airflow sensation. Further, based on the literature linking gamma and beta waves to less anxious states in calm environments, we suggest that airflow may alter the feelings of the participants..
15.	Yoshikazu Kikuchi, Tsuyoshi Okamoto, Katsuya Ogata, Koichi Hagiwara, Toshiro Umezaki, Masamutsu Kenjo, Takashi Nakagawa, Shozo Tobimatsu, Abnormal auditory synchronization in stuttering: A magnetoencephalographic study., Hearing Research, 2016.11, [URL].
16.	Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi O Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwaki, Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study, J Alzheimers Dis., 2016.10.
17.	Kaori TAMURA, Takaaki MIZUBA, Tsuyoshi OKAMOTO, Mayumi MATSUFUJI, Sachio TAKASHIMA, Keiji IRAMINA, Evaluation of cognitive function when hearing one’s own name in patients with brain injuries in early developmental stages., Journal of Clinical Neurophysiology, 2016.10, [URL].
18.	Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, et al., Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities, CLINICAL NEUROPHYSIOLOGY, 10.1016/j.clinph.2013.10.005, 125, 5, 1021-1029, 2014.05.
19.	Taira Uehara, Takao Yamasaki, Tsuyoshi Okamoto, Takahiko Koike, Shigeyuki Kan, Satoru Miyauchi, Jun-ichi Kira, Shozo Tobimatsu, Efficiency of a “small-world” brain network depends on consciousness level: a resting-state fMRI study., Cerebral Cortex (in press), 2013.01.
20.	Shizuka Horie, Takao Yamasaki, Tsuyoshi Okamoto, Shigeyuki Kan, Katsuya Ogata, Satoru Miyauchi, Shozo Tobimatsu, Distinct role of spatial frequency in dissociative reading of ideograms and phonograms: An fMRI study, NEUROIMAGE, 10.1016/j.neuroimage.2012.03.046, 63, 2, 979-988, 2012.11.
21.	Kazuhiro Samura, Yasushi Miyagi, Tsuyoshi Okamoto, Takehito Hayami, Mitsuo Katano, Kazufumi Kamikaseda, Short circuit in deep brain stimulation Clinical article., JOURNAL OF NEUROSURGERY, 10.3171/2012.8.JNS112073, 117, 5, 955-961, 2012.11.
22.	Hiroshi Honda, Tsuyoshi Okamoto, Y.Hamamoto, H.Hamasaki, Satoshi O Suzuki, T.Iwaki, Computational morphological analyses of abnormal tau deposits in human brains. , Neuroscience 2012, the 42nd Annual Meeting of the Society for Neuroscience, Abst.,151.05 　Session Number: 151, 2012.10.
23.	Eri Matsubara, kuniyoshi shimizu, Mio Fukagawa, Yuka Ishizi, Chikako Kakoi, Tomoko Hatayama, Jun NAGANO, Tsuyoshi Okamoto, Koichiro Ohkuni, RYUICHIRO KONDO, Volatiles emitted from the roots of Vetiveria zizanioides suppress the decline in attention during a visual display terminal task., BIOMEDICAL RESEARCH-TOKYO, 33, 5, 299-308, 2012.10.
24.	Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, Taira Uehara, Hiroshi Shigeto, Naruhito Hironaga, Shozo Tobimatsu, Neuromagnetic Changes of the Somatosensory Information Processing in Normal Aging., The 2012 IEEE/ICME International Conference on Complex Medical Engineering (CME 2012), 551-556, 2012.07.
25.	Takashi Yoshiura, Hiwatashi Akio, Satoshi O Suzuki, Tsuyoshi Okamoto, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroshi Honda, In-vivo detection of intracortical myelinated fibers in hippocampal formation: sub-millimeter resolution diffusion tensor imaging compared with histological findings. , International Society for Magnetic Resonance in Medicine (ISMRM) 20th Annual Meeting & Exhibition, 2012.05.
26.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Construction of Brain Simulator System for Computer-aided Diagnosis and Therapy:Progress Overview FY2011., The 3rd International Symposium on Computational Anatomy, 108-109, 2012.03.
27.	Shizuka Horie, Takao Yamasaki, Tsuyoshi Okamoto, Taisuke Nakashima, Katsuya Ogata, Shozo Tobimatsu, Differential roles of spatial frequency on reading processes for ideograms and phonograms: A high-density ERP study., Neuroscience Research, 72, 1, 68-75, 2012.01.
28.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Xian Chen, Takehito Hayami, Three-dimensional Reconstruction of Human Brain Histological Section and the Development of Digital Brain Atlas of the Japanese. , Proceedings of the 3rd International Symposium on Digital Manufacturing (ISDM) 2011, 153-158, 2011.11.
29.	Tsuyoshi Okamoto, Yoshitaka Nakanishi, Katsuya Ogata, Etsuo GENDA, Akifumi Makinouchi, Shozo Tobimatsu, Discrimination analysis of gait in normal aging and Parkinson’s disease., The 2011 International Symposium on Digital Manufacturing (ISDM2011), 179-184, 2011.11.
30.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Kazuyuki Aihara, Ichiro Fujita, Predicted contextual modulation varies with distance from pinwheel centers in the orientation preference map, Scientific Reports, 10.1038/srep00114, Scientific Reports 1, Article number: 114 Received 09 June 2011 Accepted 28 September 2011 Published 12 October 2011, 2011.10, [URL], 医学研究院・先端医療医学部門の岡本剛准教授らの研究グループは、脳活動のイメージングデータを用いたコンピュータ・シミュレーションを行い、物体の形を知覚する際に大脳皮質一次視覚野（V1）で行われている画像細部の線分や縞模様の傾き検出に関する新しい構造の存在を予測しました。このシミュレーションにより、V1では周囲の画像の複雑さ（コンテクスト）に応じて検出特性を変える神経細胞と、コンテクストに関係なく一定の検出特性を保つ神経細胞が、ある規則に基づいて分離配置している可能性を世界で初めて示し、25年にわたり議論が続いてきた問題に1つの答えを出しました。.
31.	Kazuhiro Samura, Tsuyoshi Okamoto, Yasushi Miyagi, Minako Kawaguchi, Development of online questionnaire program about non-motor effect of chronic subthalamic stimulation for advanced Parkinson’s disease, The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
32.	Yasushi Miyagi, Kazuhiro Samura, Tsuyoshi Okamoto, Takehito Hayami, Clinical implication of short circuit in DBS, The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
33.	Yasushi Miyagi, Takaichi Fukuda, KEN'ICHI MOROOKA, Tsuyoshi Okamoto, Kazuhiro Samura, Kenji Sunagawa, Three-dimensional reconstruction of human brain histological section and the development of digital brain atlas of the Japanese., The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
34.	Eri Matsubara, Mio Fukagawa, Tsuyoshi Okamoto, Koichiro Ohkuni, kuniyoshi shimizu, RYUICHIRO KONDO, The essential oil of Abies sibirica (Pinaceae) reduces arousal levels after visual display terminal work, Flavour and Fragrance Journal, 26, 3, 204-210, 2011.04.
35.	Eri Matsubara, Mio Fukagawa, Tsuyoshi Okamoto, Atsuko Fukuda, Chikako Hayashi, Koichiro Ohkuni, kuniyoshi shimizu, RYUICHIRO KONDO, (-)-Bornyl acetate induces autonomic relaxation and reduces arousal level after visual display terminal work without any influences of task performance in low-dose condition, Biomedical Research, 32, 2, 151-157, 2011.04.
36.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi　Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Construction of Brain Simulator System for Computer-aided Diagnosis and Therapy, The 2nd International Symposium on Computational Anatomy, 136-139, 2011.03.
37.	Koichi Hagiwara, Tsuyoshi Okamoto, Taira Uehara, Katsuya Ogata, Hiroshi Shigeto, Yuko Somehara, Shozo Tobimatsu, Age-related plastic changes in the secondary somatosensory cortex, Amerian clinical neurophysiology society, 2011 Annual meeting, 2011.02.
38.	Eri Matsubara, Mio Fukagawa, Tsuyoshi Okamoto, Atsuko Fukuda, Chikako Hayashi, Koichiro Ohkuni, kuniyoshi shimizu, RYUICHIRO KONDO, Volatiles emitted from the leaves of Laurus nobilis L. improve vigilance performance in visual discrimination task, Biomedical Research, 32, 1, 19-28, 2011.02.
39.	Yoshikazu Kikuchi, Katsuya Ogata, Toshiro Umezaki, Takashi Yoshiura, Masamutsu Kenjo, Yoji Hirano, Tsuyoshi Okamoto, Shizuo Komune, Shozo Tobimatsu, Spatiotemporal Signatures of an Abnormal Auditory System in Stuttering, NeuroImage, 55, 3, 891-899, 2011.01.
40.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Kazuyuki Aihara, Detailed Analysis of Orientation Preference Map in Visual Cortex, The 2010 IEEE/ICME International Conference on Complex Medical Engineering, 151-155, Catalog Number: CFP10CME-CDR, 2010.07.
41.	Koichi Hagiwara, Tsuyoshi Okamoto, Hiroshi Shigeto, Katsuya Ogata, Yuko Somehara, Takuya Matsushita, Jun-ichi Kira, Shozo Tobimatsu, Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in Humans., NeuroImage, 51, 1, 412-420, 2010.02.
42.	Kentaro Mizuno, Tsuyoshi Okamoto, Takuro Ikeda, Yoshinobu Goto, Changes in visual evoked magnetic fields during mental arithmetic task., The 39th Annual Meeting of the Society for Neuroscience Abst., 652 , 2009.10.
43.	Yasushi　Miyagi, KEN'ICHI MOROOKA, Takaichi　Fukuda, Tsuyoshi Okamoto, Xian Chen, Takehito Hayami, Shozo Tobimatsu, Takashi Yoshiura, Kenji Sunagawa, Three-dimensional reconstruction of human brain histological section: a novel computer graphic technique for the development of digitalized human brain atlas., The 39th Annual Meeting of the Society for Neuroscience Abst., 389.21, 2009.10.
44.	Tsuyoshi Okamoto, Koichi Hagiwara, Yuko Somehara, Hiroshi Shigeto, Jun-ichi Kira, Shozo Tobimatsu, Phase-locking analysis of somatosensory evoked magnetic fields in normal and pathological conditions., The 39th Annual Meeting of the Society for Neuroscience Abst., 363.26, 2009.10.
45.	Yasyshi Miyagi, Tsuyoshi Okamoto, Takato Morioka, Shozo Tobimatsu, Yoshitaka Nakanishi, Kazuyuki Aihara, KIMIAKI HASHIGUCHI, Nobuya Murakami, Fumiaki Yoshida, Kazuhiro Samura, Shinji Nagata, Tomio Sasaki, Spectral analysis of field potential recordings by DBS electrode for localization of subthalamic nucleus in patients with Parkinson's disease., Stereotactic and Functional Neurosurgery, 87, 4, 211-218, in press, 2009.03.
46.	Katsuya Ogata, Tsuyoshi Okamoto, Takao Yamasaki, Hiroshi Shigeto, Shozo Tobimatsu, Premovement Gating of Somatosensory Evoked Potentials by Self-initiated Movements: The Effects of Aging and its Implication., Clinical Neurophysiology, 120, 6, 1143-1148, in press, 2009.03.
47.	Tsuyoshi Okamoto, Koichi Hagiwara, Hiroshi Shigeto, Shozo Tobimatsu, Multivariate analyses for magnetoencephalography data, The 38th Annual Meeting of the Society for Neuroscience, Abst.,397.11, 2008.11.
48.	Yasushi Miyagi, Takaichi Fukuda, KEN'ICHI MOROOKA, Tsuyoshi Okamoto, Xian Chen, Takehito Hayami, Shozo Tobimatsu, Development of the digitalized stereotactic brain tissue atlas for the Japanese:a preliminary study., The 38th Annual Meeting of the Society for Neuroscience, Abst.,495.1, 2008.11.
49.	Katsuya Ogata, Tsuyoshi Okamoto, Takao Yamasaki, Jun-ichi Kira, Shozo Tobimatsu, Altered gating of somatosensory evoked potentials prior to self-paced movement in hand dystonia, The 38th Annual Meeting of the Society for Neuroscience, Abst.,858.10, 2008.11.
50.	Yasushi Miyagi, Tsuyoshi Okamoto, Shozo Tobimatsu, Kazuyuki Aihara, Do local field potentials in subthalamic area work for the electrode implantation surgery in Parkinson disease?, The 37th Annual Meeting of the Society for Neuroscience, Abst., 855.11, 2007.11.
51.	Tsuyoshi Okamoto, Yasushi Miyagi, Shozo Tobimatsu, Kazuyuki　Aihara, A statistical analysis of neuronal firing patterns in the subthalamic nucleus in Parkinson’s disease., The 37th Annual Meeting of the Society for Neuroscience, Abst., 319.8, 2007.11.
52.	Yoshitaka Nakanishi, Hidehiko Higaki, Tatsuki Takashima, T Umeno, Takeshi Shimoto, Tsuyoshi Okamoto, Change in Gait by Footwear, Journal of Biomechanical Science and Engineering, 2, 4, 228-236, Vol.2, No.4, 228-236, 2007.10.
53.	Yoshitaka Nakanishi, Tsuyoshi Okamoto, Tatsuki Takashima, Yasutaka Tashiro, Hidehiko　Higaki, Hiromasa　Murai, Yukihide Iwamoto, Kenji Sunagawa, Dual-mode Lens for 3D Scenography and Endoscopic or Robotic Surgery, Proceedings of the First International Symposium on Information and Computer Elements (ISICE) 2007, 442-445, 2007.09.
54.	岡本剛, 宮城　靖, 合原　一幸, 飛松省三, An analysis of multi-neuronal activities and local field potentials in the subthalamic nucleus in Parkinson's disease., 神経化学, 46, 2-3, 570-570, 2007.08.
55.	p.21.
56.	Yoshitaka Nakanishi, Tatsuki Takashima, Tsuyoshi Okamoto, Hidehiko Higaki, Hiromasa Miura, Yukihide Iwamoto, Dual-Convertible Lens for Accommodative Compensation in 3D Scenography, International Conference on Mechanics in Medicine and Biology (ICMMB-15), pp.382-383, 2006.12.
57.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Ichiro Fujita, Kazuyuki Aihara, Spatial organization of orientation preferences along radial direction from pinwheel centers in monkey striate cortex, The 35th Annual Meeting of the Society for Neuroscience, Abst.　742.2, 2005.11.
58.	Tsuyoshi Okamoto, Masataka Watanabe, Kazuyuki Aihara, Shunsuke Kondo, An Explanation of Contextual Modulation by Short-range Isotropic Connections and Orientation Map Geometry in the Primary Visual Cortex, Biological Cybernetics, 91, 6, 396-407, 91, 396-407, 2004.11.
59.	Shigeru Kubota, Tsuyoshi Okamoto, Kosuke Hamaguchi, Kazuyuki Aihara, A model of visual working memory : Examining effect of intervening stimulus on network dynamics, Mathematical Engineering Technical Reports (MTER), 1-25, 2004-40, 25pp, 2004.08.
60.	Tsuyoshi Okamoto, Koji Ikezoe, Masataka Watanabe, Kazuyuki Aihara, Spatial distribution of orientation preferences in monkey primary visual cortex, International Symposium on Emergent Mechanisms of Communication (IEMC) 2004, 2004.03.
61.	Tsuyoshi Okamoto, Masataka Watanabe, Shunsuke Kondo, Computational prediction about localization of functions in primary visual cortex, The 33rd Annual Meeting of the Society for Neuroscience, Abst.　910.18, 2003.11.
62.	Tsuyoshi Okamoto, Masataka Watanabe, Shunsuke Kondo, Differences in function between pinwheels and linear zones in the primary　visual cortex, The 32nd Annual Meeting of the Society for Neuroscience, Abst.　159.20, 2002.11.
63.	Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, Taira Uehara, Naruhito Hironaga, Hiroshi Shigeto, Jun-ichi Kira, Shozo Tobimatsu, Age-related changes across the primary and secondary somatosensory areas: An analysis of neuromagnetic oscillatory activities., Clinical Neurophysiology(in press).

Works, Software and Database

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Presentations

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1.	H. LI, S. LI, K. MATSUO, T. OKAMOTO, Quantitative evaluation of food preference using physiological and psychophysical measurements., The 51st Annual Meeting of the Society for Neuroscience (Neuroscience 2022), 2022.11.
2.	Kaori Tamura, Tsuyoshi Okamoto, Quantitative analysis method of color-odor association using Bayesian estimation., The 50th Annual Meeting of the Society for Neuroscience (Neuroscience 2021), 2021.11.
3.	Kaori Tamura, Sayaka Matsumoto, YuHsuan Tseng, Takayuki Kobayashi, Jun’ichi Miwa, Toyotaka Hirao, Tsuyoshi Okamoto, Physiological activities in response to different airflows in an air-conditioned test room., The 49th Annual Meeting of the Society for Neuroscience (Neuroscience 2019), 2019.11.
4.	YuHsuan Tseng, Kaori Tamura, Tsuyoshi Okamoto, Presence of another person can affect neuronal responses and task performance., The 49th Annual Meeting of the Society for Neuroscience (Neuroscience 2019), 2019.11.
5.	Tsuyoshi Okamoto, Kaori Tamura, Sayaka Matsumoto, YuHsuan Tseng, Haruka Matsuo, Takayuki Kobayashi, Jun'ichi Miwa, Toyotaka Hirao, Seiji Hiramatsu, Neural oscillations in the brain under different airflow conditions., The 13th International Conference on Complex Medical Engineering (CME 2019), 2019.09.
6.	Kaori Tamura, Tsuyoshi Okamoto, Misato Oi, Atsushi Shimada, Kohei Hatano, Masahiro Yamada, Min Lu and Shin'Ichi Konomi, Pilot Study to Estimate “Difficult” Area in e-Learning Material by Physiological Measurements., The 2019 Learning at Scale conference (L@S2019), 2019.06.
7.	Hamasaki H, Honda H, Okamoto T, Suzuki OS, Ninomiya T, Iwaki T, Putaminal Tau Pathology in the Aging Japanese Population: The Hisayama Study., The 19th International Congress of Neuropathology (ICN 2018), 2018.09.
8.	M. HAMAKAWA, K. TAMURA, T. OKAMOTO, Perception of odor mixture is influenced by the molecular complexity of the odor components., The 47th Annual Meeting of the Society for Neuroscience (Neuroscience 2017), 2017.11.
9.	Masayuki Hamakawa, Tsuyoshi Okamoto, Molecular complexity influences olfaction to mixed odorants compared to component odorants., The 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016), 2016.11, [URL].
10.	Kaori Tamura, Tsuyoshi Okamoto, Effect of an olfactory stimulus on color perception., The 46th Annual Meeting of the Society for Neuroscience (Neuroscience 2016) , 2016.11, [URL].
11.	Maki Shigyo, Nao Tsuzuki, Masayuki Hamakawa, Kaori Tamura, Yuki Yamada, Tsuyoshi Okamoto, Hiroya Ishikawa, Ayumi Kimura, Mai Morinaga, Norihiko Matsumune, The emotional and electrophysiological effects of odor masking., The 17th International Symposium on Olfaction and Taste (ISOT2016), 2016.06.
12.	Tsuyoshi Okamoto, N. MIYAMOTO, T. FUTAEDA, Electrophysiological response to the thermal environment in human brain varies with season, Neuroscience 2014, the 44th Annual Meeting of the Society for Neuroscience, 2014.11.
13.	S. MATSUMOTO, Tsuyoshi Okamoto, A. YAMAMOTO, et al., Restorative effect of wooden materials on electrophysiological responses in humans., Society for Neuroscience, 2013.11.
14.	Tsuyoshi Okamoto, S. TANAKA, T. FUTAEDA, Evaluating human comfort using electrophysiological responses in different indoor thermal environments. , Society for Neuroscience, 2013.11.
15.	Hiroshi Honda, Tsuyoshi Okamoto, Yumi Hamamoto, Hideomi Hamasaki, Satoshi O Suzuki, Toru Iwaki, Computational morphological analyses of abnormal tau deposits in human brains. , Neuroscience 2012,　the 42nd Annual Meeting of the Society for Neuroscience, 2012.10.
16.	Koichi Hagiwara, Katsuya Ogata, Tsuyoshi Okamoto, Taira Uehara, Hiroshi Shigeto, Naruhito Hironaga, Shozo Tobimatsu, Neuromagnetic Changes of the Somatosensory Information Processing in Normal Aging., The 2012 IEEE/ICME International Conference on Complex Medical Engineering (CME 2012). , 2012.07.
17.	Takashi Yoshiura, Hiwatashi Akio, Satoshi O Suzuki, Tsuyoshi Okamoto, Osamu Togao, Yamashita Koji, Kazufumi Kikuchi, Hiroshi Honda, In-vivo detection of intracortical myelinated fibers in hippocampal formation: sub-millimeter resolution diffusion tensor imaging compared with histological findings. , International Society for Magnetic Resonance in Medicine (ISMRM) 20th Annual Meeting & Exhibition., 2012.05.
18.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Construction of Brain Simulator System for Computer-aided Diagnosis and Therapy: Progress Overview FY2011. , The 3rd International Symposium on Computational Anatomy., 2012.03.
19.	Tsuyoshi Okamoto, Yoshitaka Nakanishi, Katsuya Ogata, Etsuo GENDA, Akifumi Makinouchi, Shozo Tobimatsu, Discrimination analysis of gait in normal aging and Parkinson's disease. , The 2011 International Symposium on Digital Manufacturing (ISDM2011), 2011.12.
20.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Xian Chen, Takehito Hayami, Three-dimensional Reconstruction of Human Brain Histological Section and the Development of Digital Brain Atlas of the Japanese. , Proceedings of the 3rd International Symposium on Digital Manufacturing (ISDM2011)., 2011.11.
21.	Kazuhiro Samura, Tsuyoshi Okamoto, Yasushi Miyagi, Minako Kawaguchi, “Development of online questionnaire program about non-motor effect of chronic subthalamic stimulation for advanced Parkinson’s disease.” , The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
22.	Yasushi Miyagi, Kazuhiro Samura, Tsuyoshi Okamoto, Takehito Hayami, “Clinical implication of short circuit in DBS.” , The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
23.	Yasushi Miyagi, Takaichi Fukuda, KEN'ICHI MOROOKA, Tsuyoshi Okamoto, Kazuhiro Samura, Kenji Sunagawa, “Three-dimensional reconstruction of human brain histological section and the development of digital brain atlas of the Japanese.” , The 8th Asian Australasian Society of Stereotactic & Functional Neurosurgery Scientific meeting (AASSFN 2011), 2011.06.
24.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Kenji Sunagawa, Construction of Brain Simulator System for Computer-aided Diagnosis and Therapy: Progress Overview FY2010. , The 2nd International Symposium on Computational Anatomy., 2011.03.
25.	Koichi Hagiwara, Tsuyoshi Okamoto, Taira Uehara, Katsuya Ogata, Hiroshi Shigeto, Yuko Somehara, Shozo Tobimatsu, Age-related plastic changes in the secondary somatosensory cortex., Amerian clinical neurophysiology society, 2011 Annual meeting., 2011.02.
26.	Koichi Hagiwara, Tsuyoshi Okamoto, Katsuya Ogata, Hiroshi Shigeto, Yuko Somehara, Shozo Tobimatsu, Differential effects of aging on the primary and secondary somatosensory areas: A magnetoencephalographic study., International Congress of Clinical Neurophysiology, 2010, 2010.10.
27.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Kazuyuki Aihara, Detailed Analysis of Orientation Preference Map in Visual Cortex, The 2010 IEEE/ICME International Conference on Complex Medical Engineering, 2010.07, Mammalian primary visual cortex (V1) contains a functional map of orientation preference. Within the orientation preference map, neurons aggregate in two different local patterns. Neurons with similar orientation preferences gather within orientation domains, whereas neurons with all different orientation preferences converge at the center of pinwheel-like arrangements of orientation domains. The differences in local organization of domains and pinwheels have been the subject of considerable controversy. Here, we focus on the differences in global organizations of domains and pinwheels. We analyzed the spatial distribution of orientation preferences in wide regions around domains and pinwheels in monkey V1. A particular distribution pattern of orientation preferences was found more clearly in the regions around domains than in the regions around pinwheels. This suggests that neuronal responses to large stimuli outside of a neuron’s receptive field can vary between domains and pinwheels..
28.	Tsuyoshi Okamoto, Koichi Hagiwara, Yuko Somehara, Hiroshi Shigeto, Jun-ichi Kira, Shozo Tobimatsu, Phase-locking analysis of somatosensory evoked magnetic fields in normal and pathological conditions., Neuroscience 2009, the 39th Annual Meeting of the Society for Neuroscience, 2009.10.
29.	Yasushi Miyagi, KEN'ICHI MOROOKA, Takaichi Fukuda, Tsuyoshi Okamoto, Xian Chen, Taketo Hayami, Shozo Tobimatsu, Takashi Yoshiura, Kenji Sunagawa, Three-dimensional reconstruction of human brain histological section: a novel computer graphic technique for the development of digitalized human brain atlas., Neuroscience 2009, the 39th Annual Meeting of the Society for Neuroscience, 2009.10.
30.	Kentaro Mizuno, Tsuyoshi Okamoto, Takuro Ikeda, Yoshinobu Goto, Changes in visual evoked magnetic fields during mental arithmetic task., Neuroscience 2009, the 39th Annual Meeting of the Society for Neuroscience, 2009.10.
31.	KEN'ICHI MOROOKA, Yasushi Miyagi, Takaichi Fukuda, Tsuyoshi Okamoto, Taketo Hayami, Xian Chen, Kenji Sunagawa, Shozo Tobimatsu, Takashi Yoshiura, Makoto Hashizume, Digital Brain Atlas for Safe and Accurate Stereotactic Neurosugery., 6th Annual Would Congress for Brain Mapping and Image Guided Therapy, 2009.08.
32.	Tsuyoshi Okamoto, Koichi Hagiwara, Hiroshi Shigeto, Shozo Tobimatsu, Multivariate analyses for magnetoencephalography data, Neuroscience 2008, the 38th Annual Meeting of the Society for Neuroscience, 2008.11.
33.	Yasushi Miyagi, Takaichi Fukuda, KEN'ICHI MOROOKA, Tsuyoshi Okamoto, Xian Chen, Taketo Hayami, Shozo Tobimatsu, Development of the digitalized stereotactic brain tissue atlas for the Japanese: a preliminary study, Neuroscience 2008, the 38th Annual Meeting of the Society for Neuroscience, 2008.11.
34.	Katsuya Ogata, Tsuyoshi Okamoto, Takao Yamasaki, Jun-ichi Kira, Shozo Tobimatsu, Altered gating of somatosensory evoked potentials prior to self-paced movement in hand dystonia, Neuroscience 2008, the 38th Annual Meeting of the Society for Neuroscience, 2008.11.
35.	KEN'ICHI MOROOKA, Takaichi Fukuda, Yasushi Miyagi, Takehito Hayami, Tsuyoshi Okamoto, Xian Chen, 3D Human Brain Modeling for Constructing Japanese Brain Database, Medical Imaging and Augmented Reality 4th International Workshop, 2008.08.
36.	Koichi Hagiwara, Tsuyoshi Okamoto, Yuko Somehara, Hiroshi Shigeto, Yoshinobu Goto, Samu Taulu, Shozo Tobimatsu, Applicability of Signal Space Separation (SSS) Method in Clinical and Experimental MEG Studies., BIOMAG 2008, 2008.08.
37.	Hiroshi Shigeto, Koichi Hagiwara, Yuko Somehara, Tsuyoshi Okamoto, Jun-ichi Kira, Shozo Tobimatsu, Clinical application of automatic detection software for epileptic magnetic activities, BIOMAG 2008, 2008.08.
38.	Koichi Hagiwara, Tsuyoshi Okamoto, Yuko Somehara, Hiroshi Shigeto, Yoshinobu Goto, Samu Taulu, Shozo Tobimatsu, Usefulness of Signal Space Separation (SSS) Method in Clinical and Experimental MEG Studies, BIOMAG 2008, 2008.08.
39.	Intraoperative beta oscillation of local field potentials in subthalamic area of Parkinson's disease.
40.	Yasushi Miyagi, Tsuyoshi Okamoto, Shozo Tobimatsu, Kazuyuki Aihara, Do local field potentials in subthalamic area work for the electrode implantation surgery in Parkinson disease?, Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience, 2007.11.
41.	Tsuyoshi Okamoto, Yasushi Miyagi, Shozo Tobimatsu, Kazuyuki Aihara, A statistical analysis of neuronal firing patterns in the subthalamic nucleus in Parkinson's disease, Neuroscience 2007, the 37th Annual Meeting of the Society for Neuroscience, 2007.11.
42.	Yoshitaka Nakanishi, Tsuyoshi Okamoto, Tatsuki Takashima, Yasutaka Tashiro, Hidehiko Higaki, Hiｒomasa Miura, Yukihide Iwamoto, Kenji Sunagawa, Dual-mode Lens for 3D Scenography and Endoscopic or Robotic Surgery, The First International Symposium on Information and Computer Elements (ISICE) 2007, 2007.09.
43.	Tsuyoshi Okamoto, Yasushi　Miyagi, Kazuyuki Aihara, Shozo Tobimatsu, An analysis of multi-neuronal activities and local field potentials in the subthalamic nucleus in Parkinson's disease, Neuro2007 (第30回日本神経科学大会, 第50回日本神経化学会大会, 第17回日本神経回路学会大会合同大会), 2007.09.
44.	Yoshitaka Nakanishi, Tatsuki Takashima, Tsuyoshi Okamoto, Hidehiko Higaki, Hiromasa Miura, Yukihide Iwamoto, Dual-Convertible Lens for Accommodative Compensation in 3D Scenography, International Conference on Mechanics in Medicine and Biology (ICMMB-15), 2006.12.
45.	Reduction of fatigue by means of the Real 3-D Viewer.
46.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Kazuyuki Aihara, Ichiro Fujita, Estimating the topography of contextual modulation from radial distribution of relative preferred orientation in macaque striate cortex, 2006 Japan-Germany Symposium on Computational Neuroscience, 2006.02.
47.	Tsuyoshi Okamoto, Koji Ikezoe, Hiroshi Tamura, Masataka Watanabe, Ichiro Fujita, Kazuyuki Aihara, Spatial organization of orientation preferences along radial direction from pinwheel centers in monkey striate cortex, Neuroscience 2005, the 35th Annual Meeting of the Society for Neuroscience, 2005.11.
48.	A Neural Network Model of Visual Working Memory.
49.	Tsuyoshi Okamoto, Koji Ikezoe, Masataka Watanabe, Kazuyuki Aihara, Spatial distribution of orientation preferences in monkey primary visual cortex, International Symposium on Emergent Mechanisms of Communication (IEMC) 2004, 2004.03.
50.	Tsuyoshi Okamoto, Masataka Watanabe, Shunsuke Kondo, Computational prediction about localization of functions in primary visual cortex, Neuroscience 2003, 33rd Annual Meeting of the Society for Neuroscience, 2003.11.
51.	Tsuyoshi Okamoto, Masataka Watanabe, Localization of contextual effects in primary visual cortex, International Symposium on Emergent Mechanisms of Communication (IEMC) 2003, 2003.02.
52.	Localization of functions in primary visual cortex.
53.	Tsuyoshi Okamoto, Masataka Watanabe, Shunsuke Kondo, Differences in function between pinwheels and linear zones in the primary visual cortex, Neuroscience 2002, 32nd Annual Meeting of the Society for Neuroscience, 2002.11.

Membership in Academic Society

Society for Neuroscience

Educational

Educational Activities

I have classes of KIKAN education for undergraduate and graduate students in all departments, one class for undergraduate students in School of Interdisciplinary Science and Innovation, classes for graduate students in Graduate School of Systems Life Sciences, and classes for graduate students in Joint Graduate School of Mathematics for Innovation.

Other Educational Activities

2023.04.
2023.04.
2023.04.
2022.04.
2022.04.
2018.12.
2018.11.
2018.10.
2018.04.
2016.04.
2015.11.
2015.10.
2014.01.

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