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Shintaro Kawano Last modified date:2022.09.20

Associate Professor / Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science
Department of Dental Science
Faculty of Dental Science




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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/shintarou-kawano
 Reseacher Profiling Tool Kyushu University Pure
Phone
092-642-6447
Fax
092-642-6386
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Oral & maxillofacial surgery
Total Priod of education and research career in the foreign country
00years01months
Outline Activities
Research:A study on the mechanism of invasion and metastasis of oral squamous cell carcinoma
A study on development, proliferation, and differentiation of ameloblastoma

Education: Clinical instruction for dental students and residents
Instruction for postgraduate students
Research
Research Interests
  • Identification and characterization of cancer stem cell (CNS) of oral squamous cell carcinoma
    keyword : cancer stem cell (CNS)
    2008.04.
Academic Activities
Reports
1. Toru Chikui, Makoto Obara, Arjan Simonetti, Masahiro Ohga, Shoichi Koga, Shintaro Kawano, Yoshio Matsuo, Takeshi Kamitani, Tomoko Shiraishi, Erina Kitamoto, K. Nakamura and Kazunori Yoshiura , The principal of dynamic contrast enhanced MRI (DCE-MRI), the method of pharmacokinetic analysis and its application in the head and neck region, International Journal of Dentistry, 2012.09.
Papers
1. Naoki Kaneko, Junsei Sameshima, Shintaro Kawano, Toru Chikui, Takeshi Mitsuyasu, Hu Chen, Taiki Sakamoto, Seiji Nakamura, Comparison of computed tomography findings between odontogenic keratocyst and ameloblastoma in the mandible: Criteria for differential diagnosis, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, https://doi.org/10.1016/j.ajoms.2022.07.016, 2022.09.
2. Yukiko Kami, Toru Chikui, Osamu Togai, Shintaro Kawano, Shinsuke Fujii, Masahiro Ooga, Tamotsu Kiyoshima, Kazunori Yoshiura, Usefulness of reconstructed images of Gd-enhanced 3D gradient echo sequences with compressed sensing for mandibular cancer diagnosis: comparison with CT images and histopathological findings, European Radiology, 10.1007/s00330-022-09075-w, 2022.09.
3. Shintaro Kawano, Taichi Hattori, Yurie Mikami, Toru Chikui, Toshiyuki Kawazu, Taiki Sakamoto, Yasuyuki Maruse, Shoichi Tanaka, Eiki Hamada, Megumi Hiwatashi, Yurika Shiraishi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura , Prediction of nodal metastasis based on intraoral sonographic findings of primary lesion in early-stage tongue cancer
, International Journal of Oral and Maxillofacial Surgery, 2020.06.
4. Taichi Hattori, Shintaro Kawano, Shoichi Tanaka, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Yurie Mikami, Masahiko Morioka, Yasuyuki Maruse, Ryoji Kitamura, Eiki Hamada, Megumi Hiwatashi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura, Protease activated receptor 1 in tumor-microenvironment contributes to nodal metastasis poor prognosis of oral squamous cell carcinoma, International Journal of Oral and Maxillofacial Surgery, 10.1016/j.ijom.2020.04.021, 50, 2, 163-170, 2021.02, Protease activated receptor (PAR) 1 is known as thrombin receptor. Recent studies have reported PAR1 expression in the various malignancies, however, the detail role remains unclear in oral squamous cell carcinoma (OSCC). We previously showed that down-regulation of ΔNp63, a homolog of p53, augments PAR1 expression in OSCC. In this study, we retrospectively examined the association of PAR1 expression in OSCC with clinicopathological findings. Expression of PAR1, thrombin, and ΔNp63 was immunohistochemically examined in the OSCC biopsy specimens. The patients were divided into three groups based on the expression pattern of PAR1 at the invasive front as follows: group A; PAR1-negative in both cancer and stromal cells: group B; positive in stromal cells but negative in cancer cells: group C; positive in both cancer and stromal cells. Histologically high-grade tumors were significantly more common in group C. The patients of group C had the highest incidence rate of nodal metastasis and significantly lower survival rate than other groups. At the invasive front, thrombin was expressed but ΔNp63 was faint. These results indicated that increased PAR1 expression in both cancer and stromal cells could be a useful predictive marker of nodal metastasis and ΔNp63 was involved in regulating PAR1 expression..
5. Shoichi Tanaka, Shintaro Kawano, Taichi Hattori, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Yurie Mikami, Masahiko Morioka, Yasuyuki Maruse, Ryoji Kitamura, Eiki Hamada, Megumi Hiwatashi, Kazunari Oobu, Tamotsu Kiyoshima, and Seiji Nakamura, Cytokeratin 19 as a marker of highly invasive oral squamous cell carcinoma with metastatic potential, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, in press, 2019.07, Objective:Cytokeratin (CK) 19 is a member of the acidic type I CK family. Recently, CK19 expression has beenfound in various tumor tissues; however, the significance of this remains unknown. The purpose of this study isto clarify the roles of CK19 in the progression of oral squamous cell carcinoma (OSCC).Methods:A total of 100 patients who had been diagnosed with OSCC at our department between January 2011and December 2016 was included. The patients were divided into three groups based on an optimal cut-offpoints (5% and 77%) of the labeling index (LI) as follows: group A; LI < 5%, group B; 5%≤LI < 77%, group C;LI≥77%. Then, clinicopathological features and survival rates were compared among the groups.Results:Histologically high-grade tumors were significantly more common in group C than in groups A and B.Furthermore, the incidence of nodal metastasis was significantly higher in group C than in other groups. IntenseCK19 immunoreactivity was detected in metastatic lymph nodes of groups B and C, but not from group A.Moreover, patients with advanced pN stage and extranodal extension were more common in groups B and C thangroup A. Disease-specific survival curves revealed poorer prognoses in group C.Conclusions:These results suggest that CK19 is involved in OSCC invasion and metastasis and could be a novelbiomarker of highly invasive OSCC with metastatic potential..
6. Takashi Maehara, Yuka Murakami, Shintaro Kawano, Yurie Miami, Tamotsu Kiyoshima, Noriko Kakizoe, Ryusuke Munemura, and Seiji Nakamura, Osteoid osteoma of mandibular bone: Case report and review of the literature
, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, in press, 2019.06.
7. A S M Rafiul Haque, Masafumi Moriyama, Keigo Kubota, Noriko Ishiguro, Mizuki Sakamoto, Akira Chinju, Keita Mochizuki, Taiki Sakamoto, Naoki Knack, Ryusuke Munemura, Akihiko Tanaka, Takashi Maehara, Jun-Nosuke Hayashida, Shintaro Kawano, and Seiji Nakamura, CD206+ tumor-associated macrophages promote oral squamous cell carcinoma cell proliferation and invasion via EGF production, Scientific Reports, in press, 2019.07.
8. Yurie Mikami, Shinsuke Fujii, Ken-ichi Kohashi, Yuichi Yamada, Masafumi Moriyama, Shintaro Kawano, Seiji Nakamura, Yoshinao Oda, and Tamotsu Kiyoshima, A case of low-grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A Case Report, Oncology Letters, 10.3892/ol.2018.9115, 16, 3, 3889-3894, 2018.09.
9. Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Mai Hazekawa, Atsushi Yasukochi,, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironmen, Molecular Carcinogenesis, 10.1002/mc.22744., 57, 2, 295-302, 2018.02.
10. Syarifah NovaAmiza Zam, Takeshi Mitsuyasu, Shiori Kanda, Shintaro Kawano, Seiji Nakamura, Induction of apoptosis by inhibition of sonic hedgehog signalling pathway in ameloblastoma cell line: a pilot study for novel therapeutic approach, International Journal of Oral and Maxillofacial Surgery, https://doi.org/10.1016/j.ijom.2017.02.748, 46, 221, 2017.07.
11. Eiji Mitate, Shintaro Kawano, Yuka Okabe, Oobu, K, Seiji Nakamura, Effect of cepharanthine and Z-100 against complications during preoperative chemoradiotherapy for oral cancer, Journal of Oral and Maxillofacial Surgery, Medicine and Pathology, 2017.08.
12. Yasuyuki Maruse, Shintaro Kawano, Teppei Jinno, Ryota Matsubara, Yuichi Goto, Naoki Kaneko, Taiki Sakamoto, Yuma Hashiguchi, Masafumi Moriyama, Takeshi Toyoshima, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura, Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and poor prognosis in oral squamous cell carcinoma, International Journal of Oral and Maxillofacial Surgery, 10.1016/j.ijom.2018.01.004, 47, 7, 836-845, 2018.07.
13. Yuma Hashiguchi, Shintaro Kawano, Yuichi Goto, Yasuda Kaori, Naoki Kaneko, Taiki Sakamoto, Ryota Matsubara, Teppei Jinno, Yasuyuki Maruse, Hideaki Tanaka, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Tamotsu Kiyoshima, Seiji Nakamura, Tumor-suppressive roles of ΔNp63-miR205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2, Journal of Cellular Physiolosy, 10.1002/jcp.26267, 233, 10, 6565-6577, 2018.10, We previously revealed that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β, a splicing variant of ΔNp63, in oral squamous cell carcinoma (OSCC). Recent studies have highlighted the involvement of microRNA (miRNA) in EMT of cancer cells, though the mechanism remains unclear. To identify miRNAs responsible for ΔNp63β-mediated EMT, miRNA microarray analyses were performed by ΔNp63β-overexpression in OSCC cells; SQUU-B, which lacks ΔNp63 expression and displays EMT phenotypes. miRNAs microarray analyses revealed miR-205 was the most up-regulated following ΔNp63β-overexpression. In OSCC cells, miR-205 expression was positively associated with ΔNp63 and negatively with zinc-finger E-box binding homeobox (ZEB) 1 and ZEB2, potential targets of miR-205. miR-205 overexpression by miR-205 mimic transfection into SQUU-B cells led to decreasing ZEB1, ZEB2, and mesenchymal markers, increasing epithelial markers, and reducing cell motilities, suggesting inhibition of EMT phenotype. Interestingly, the results opposite to this phenomenon were obtained by transfection of miR-205 inhibitor into OSCC cells, which express ΔNp63 and miR-205. Furthermore, target protector analyses revealed direct regulation by miR-205 of ZEB1 and ZEB2 expression. These results showed tumor-suppressive roles of ΔNp63β and miR-205 by inhibiting EMT thorough modulating ZEB1 and ZEB2 expression in OSCC..
14. Naoki Kaneko, Shintaro Kawano, Kaori Yasuda, Yuma Hashiguchi, Taiki Sakamoto, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Masahiko Morioka, Taichi Hattori, Shoichi Tanaka, Hideaki Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura, Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma, Oral Oncology, in press, 2017.04, We previously reported that epithelial-to-mesenchymal transition (EMT) was mediated by ΔNp63β in oral squamous cell carcinoma (OSCC). In this study, DNA microarray analyses were performed using ΔNp63β-overexpressing OSCC cells to identify genes associated with ΔNp63β-mediated EMT. Thereby, we focused on kallikrein-related peptidase (KLK) 6, most up-regulated following ΔNp63β-overexpression, that activates protease-activated receptors (PARs). In RT-PCR analyses, ΔNp63 was positively associated with KLK6 and PAR2 and negatively with PAR1 in OSCC cells. By ΔNp63 knockdown, KLK6 and PAR2 expression was decreased and PAR1 was increased. Furthermore, KLK6 knockdown led to enhancing migration and invasion, and inhibiting proliferation, suggesting EMT-phenotypes. Although, in the KLK6 or PAR2 knockdown cells, phosphorylation of ERK was reduced, it was restored in the KLK6 knockdown OSCC cells treated with recombinant KLK6 proteins. Immunohistochemistry showed ΔNp63, KLK6, and PAR2 were more strongly expressed in the epithelial dysplasia and central region of OSCC than normal oral epithelium, whereas PAR1 expression was undetectable. Interestingly, at the invasive front of OSCC, ΔNp63, KLK6, and PAR2 were reduced, but PAR1 was elevated. In addition, the OSCC patients with decreasing KLK6 expression at the invasive front had more unfavourable prognosis. These results suggested differential roles of KLK6 in malignant transformation and EMT; high ΔNp63β expression up-regulates KLK6-PAR2 and down-regulates PAR1, inducing malignant transformation in oral epithelium with stimulating proliferation through ERK signal activation. Moreover, KLK6-PAR2 expression is down-regulated and PAR1 is up-regulated when ΔNp63β expression is decreased, leading to EMT with enhancing migration and invasion through ERK signal reduction at the invasive front..
15. Keigo Kubota, Masafumi Moriyama, Sachiko Furukawa, A S M Rafiul Haque, Yasuyuki Maruse, Teppei Jinno, Akihiko Tanaka, Miho Ohta, Noriko Ishiguro, Masaki Yamauchi, Mizuki Sakamoto, Shintaro Kawano, Takashi Maehara, Hayashida Jun-Nosuke, Shintaro Kawano, Tamotsu Kiyoshima, Seiji Nakamura, CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma, Scientific Reports, 7, 1755, 2017.03.
16. Sachiko Furukawa, Kazunari Oobu, Masafumi Moriyama, Shintaro Kawano, Hayashida Jun-Nosuke, Ryota Matsubara, Ken-ichi Ogata, Tamotsu Kiyoshima, Seiji Nakamura, Methotrexate-related lymphoproliferative disorder associated with severe osteonecrosis of the jaw: A case report and literature review, Internal Medicine, in press, 2017.03.
17. Taiki Sakamoto, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Naoki Kaneko, Yuma Hashiguchi, Taichi Hattori, Shoichi Tanaka, Ryoji Kitamura, Tamotsu Kiyoshima, Seiji Nakamura, Critical roles of Wnt5a-Ror2 signaling in aggressiveness of oral squamous cell carcinoma and production of matrix metalloproteinase-2 via ΔNp63β-mediated epithelial-mesenchymal transition, Oral Oncology, 69, 15-25, in press, 2017.01, OBJECTIVES:
We previously showed that ΔNp63β, a splicing variant of ΔNp63, mediated EMT and affected cell motility. DNA microarray was thus performed to elucidate the mechanism that ΔNp63β affects cell motility. As the results, Wnt5a was significantly down-regulated by ΔNp63β overexpression in tongue SCC cell line (SQUU-B) with EMT phenotype.
MATERIALS AND METHODS:
Seven OSCC cell lines were used. Expression of ΔNp63, Wnt5a, its receptor Ror2, and matrix metalloproteinases (MMPs) were analyzed by RT-PCR, real-time PCR, and western blotting, and gelatin zymography. Furthermore, we examined the effects of siRNA for Wnt5a or Ror2 and recombinant human Wnt5a (rhWnt5a) on motility of tongue SCC cells. Biopsy specimens from tongue SCC patients were used for immunohistochemical staining of Wnt5a and Ror2.
RESULTS:
Wnt5a and Ror2 were expressed only in SQUU-B cells without ΔNp63 expression, and negatively associated with ΔNp63 expression in other cells. ΔNp63β overexpression in SQUU-B cells decreased Wnt5a and Ror2 expression. By Wnt5a or Ror2 knockdown, cell motility was remarkably inhibited, but EMT markers expression was unaffected. MMP-2 expression and the activities inversely correlated with ΔNp63 expression, and were inhibited by Wnt5a or Ror2 knockdown. Cell motility and MMP-2 activities were recovered by adding rhWnt5a in the cells with Wnt5a knockdown, but not in those with Ror2 knockdown. Moreover, immunohistochemical analyses in tongue SCC specimens found that high expression of Wnt5a or Ror2 was associated with poorer prognosis..
18. Yurie Mikami, Fujii Shinsuke, Kengo Nagata, Hiroko Wada, Kana Hasegawa, Misaki Abe, ReikoYoshimoto, Shintaro Kawano, Seiji Nakamura, Tamotsu Kiyoshima, GLI-KRT17 axis promotes tumorigenesis through the anti-apoptotic function in oral squamous cell carcinomas, Journal of Cancer Research and Clinical Oncology, 143, 8, 1381-1393, 2017.08.
19. Masahiko Morioka, Tomoyo Kawakubo-Yasukochi, Yoshikazu Hayashi, Mai Hazekawa, Nishinakagawa Takuya, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination, Journal of Oral Biosciences, 58, 180-184, 2016.07.
20. Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Teppei Jinno, Yasuyuki Maruse, Taiki Sakamoto, Yuma Hashiguchi, Masakazu Iida, Seiji Nakamura, Tongue squamous cell carcinoma producing both parathyroid hormone-related protein and granulocyte-colony-stimulating factor: a case report and literature review, World Journal of Surgical Oncology, 14, 161, 2016.06.
21. Sitti Fadhillah Oemar Mattalitti, Toshiyuki Kawazu, Shintaro Kawano, Tatsuya Ikari, Hiroko Wada, Kazunori Yoshiura, Estimation of prognosis of tongue cancer using tumor depth and margin shape obtained from ultrasonography, Oral Radiology, 33, 101-107, 2016.06.
22. Masafumi Moriyama, Miho Ohta, Sachiko Furukawa, Yurie Mikami, Akihiko Tanaka, Takashi Maehara, Masaki Yamauchi, Norriko Ishiguro, Jun-Nosuke Hayashida, Shintaro Kawano, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura, The diagnostic utility of labial salivary gland biopsy in IgG4-related disease, Modern Rheumatology, 26, 725-729, 2016.01.
23. Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima, The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes, Journal of Oral Biosciences, 58, 11, 33-38, 2016.02.
24. Keiji Masuda, Shintaro Kawano, Haruyoshi Yamaza, Taiki Sakamoto, Tamotsu Kiyoshima, Seiji Nakamura, Kazuaki Nonaka, Complete resolution of a calcifying cystic odontogenic tumor with physiological eruption of a dislocated permanent tooth after marsupialization in a child with a mixed dentition: A case report, World Journal of Surgical Oncology, 13, 277, 2015.09.
25. Yoshikazu Hayashi, Masafumi Moriyama, Takashi Maehara, Yuichi Goto, Shintaro Kawano, Miho Ohta, Akihiko Tanaka, Sachiko Furukawa, Jun-Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Toru Chikui, Seiji Nakamura, A case of mantle cell lymphoma presenting as IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease, World Journal of Surgical Oncology, 13, 225, 2015.06.
26. Toru Chikui, Erina Kitamoto, Yukiko Nishioka Kami, Shintaro Kawano, Kouji Kobayashi, Takeshi Kamitani, Makoto Obara, Kazunori Yoshiura, Dynamic contrast-enhanced MRI of oral squamous cell carcinoma: A preliminary study of the correlations between quantitative parameters and the clinical stage, British Journal of Radiology, 88, 20140814, 2015.01.
27. Takashi Maehara, Masafumi Moriyama, Shintaro Kawano, Jun-Nosuke Hayashida, Sachiko Furukawa, Miho Ohta, Akihiko Tanaka, Masaki Yamauchi, Yukiko Ohyama, Tamotsu Kiyoshima, Seiji Nakamura, Cytokine Profiles Contribute to Understanding the Pathogenic Difference between Good Syndrome and Oral Lichen Planus: Two Case Report and Literature Review, Medicine, 94, 14, e704, 2015.04.
28. Yasuyuki Maruse, Shintaro Kawano, Tamotsu Kiyoshima, Yuichi Goto, Ryota Matsubara, Toru Chikui, Daigo Yoshiga, Seiji Nakamura, A case of mucoepidermoid carcinoma of the sublingual gland accompanied with extensive dystrophic calcification and intratumoral bone formation, Head and Neck, 37, 11, 161-164, 2015.11.
29. Teppei Jinno, Shintaro Kawano, Yasuyuki Maruse, Ryota Matsubara, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Naoki Kaneko, Hideaki Tanaka, Ryoji Kitamura, Toyoshima Takeshi, Akiko Jinno, Masafumi Moriyama, Kazunari Oobu, Tamotsu Kiyoshima, Seiji Nakamura, Increased expression of interleukin-6 predicts poor response to chemoradiotherapy and unfavorable prognosis in oral squamous cell carcinoma, Oncology Reports, 10.3892/or.2015.3838, 33, 5, 2161-2168, 2015.03.
30. Miho Ohta, Masafumi Moriyama, Yuichi Goto, Shintaro Kawano, Akihiko Tanaka, Takashi Maehara, Sachiko Furukawa, Jun-Nosuke Hayashida, Tamotsu Kiyoshima, Mayumi Shimizu, Yojiro Arinobu, Seiji Nakamura, A case of marginal zone B-cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis, World Journal of Surgical Oncology, 13, 67, in press, 2015.02.
31. Shintaro Kawano, Yanqun Zheng, Kazunari Oobu, Ryota Matsubara, Yuichi Goto, Toru Chikui, Tadamasa Yoshitake, Tamotsu Kiyoshima, Teppei Jinno, Yasuyuki Maruse, Eiji Mitate, Ryoji Kitamura, Hideaki Tanaka, Toyoshima Takeshi, Tsuyoshi Sugiura, Seiji Nakamura, Clinicopathological evaluation of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma, Oncology Letters, 11, 5, 3369-3376, 2016.05.
32. Erina Kitamoto, Toru Chikui, Shintaro Kawano, Masahiro Oga, Kouji Kobayashi, Yoshio Matsuo, Takashi Yoshiura, Makoto Obara, Hiroshi Honda, Kazunori Yoshiura, The application of dynamic contrast-enhanced MRI and diffusion-weighted MRI in patients with maxillofacial tumors, Academic Radiology, 10.1016/j.acra.2014.08.016, 22, 2, 210-216, 2014.02.
33. Masafumi Moriyama, Sachiko Furukawa, Shintaro Kawano, Yuichi Goto, Tamotsu Kiyoshima, Akihiko Tanaka, Takashi Maehara, Jun-Nosuke Hayashida, Seiji Nakamura, The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz’s disease, International Journal of Oral and Maxillofacial Surgery, 43, 10, 1276-1281, 2014.10.
34. Sachiko Furukawa, Masafumi Moriyama, Shintaro Kawano, Takashi Maehara, Jun-Nosuke Hayashida, Yuichi Goto, Tamotsu Kiyoshima, Hideki Shiratsuchi, Yukiko Ohyama, Miho Ohta, Yumi Imabayashi, Seiji Nakamura, Clinical relevance of Küttner tumour and IgG4-related dacryoadenitis and sialoadenitis, Oral Disease, 10.1111/odi.12259, in press, 2014.05.
35. Hideaki Tanaka, Toyoshima Takeshi, Kenzo Sonoda, Ryoji Kitamura, Masaaki Sasaguri, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Seiji Nakamura, Apoptotic function of tumor-associated antigen RCAS1 in oral squamous cell carcinoma , Journal of Translational Medicine, 10.1186/1479-5876-12-112, In press, 2014.05.
36. Toru Chikui, Masahiro Ohga, Erina Kitamoto, Shintaro Kawano, Takashi Yoshiura, Kazunori Yoshiura, Quantification of diffusion and permeability of MRI in the head and neck region, Journal of Radiology & Radiation therapy, 2, 2, 1047, 印刷中, 2014.01.
37. A case of cervical recurrence of the tongue squamous cell carcinoma successfully treated with superselective intra-arterial chemotherapy concurrent with radiotherapy.
38. Yuichi Goto, Shintaro Kawano, Ryota Matsubara, Takahiro Kiyosue, Mitsuhiro Hirano, Teppei Jinno, Yasuyuki Maruse, Toyoshima Takeshi, Ryoji Kitamura, Hideaki Tanaka, Kazunari Oobu, Seiji Nakamura, Possible involvement of ΔNp63 downregulation in the invasion and metastasis of oral squamous cell carcinoma via induction of a mesenchymal phenotype, Clinical & Experimental Metastasis, 214, 289-306, 2014.03.
39. Eiji Mitate, Shintaro Kawano, Tamotsu Kiyoshima, Toshiyuki Kawazu, Toru Chikui, Yuichi Goto, Ryota Matsubara, Seiji Nakamura, Carcinoma ex pleomorphic adenoma of the upper lip: A case of an unusual malignant component of squamous cell carcinoma, World Journal of Surgical Oncology, 10.1186/1477-7819-11-234, in press, 2013.09.
40. Yu Nakao, Takeshi Mitsuyasu, Shintaro Kawano, Norifumi Nakamura, Shiori Kanda, Seiji Nakamura, Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway, International Journal of Oncology, 43, 5, 1377-1384, 2013.11.
41. Shiori Kanda, Takeshi Mitsuyasu, Yu Nakao, Shintaro Kawano, Yuichi Goto, Ryota Matsubara, Seiji Nakamura, Anti-apoptotic role of sonic hedgehog signaling pathway in the proliferation of ameloblastoma, International Journal of Oncology, 43, 3, 695-702, 2013.09.
42. Hiroe Kakehashi, Shintaro Kawano, Tamotsu Kiyoshima, Mayumi Shimizu, Ryota Matsubara, Takahiro Kiyosue, Yuichi Goto, Hideki Shiratsuchi, Seiji Nakamura, Parotid gland myoepithelioma with remarkable cystic formation: A case report
, Journal of Oral and Maxillofacial Surgery, Medicine and Pathology, 25, 183-188, 2013.04.
43. Toru Chikui, Erina Kitamoto, Shintaro Kawano, Tsuyoshi Sugiura, Makoto Obara, Arjan W. Simonetti, Masamitsu Hatakenaka, Yoshio Matsuo, Syoichi Koga, Masahiro Ohga, Katsumasa Nakamura, Yoshiyuki Shioyama, Kazunori Yoshiura, A pharmacokinetic analysis based on dynamic contrast-enhanced MR imaging for evaluating the tumor response to preoperative therapy for oral cancer, Journal of Magnetic Resonance Imaging , 36, 3, 589-597, 2012.09.
44. Eiji Mitate, Shintaro Kawano, Yu Nakao, Yuichi Goto, Ieyoshi Kobayashi, Onozawa K, Takashi Hashimoto, and Seiji Nakamura , Concurrence of autoantibodies to both the γ2 subunit of laminin 332 and laminin γ1 in a patient with rejection response to the transplanted kidney, Acta Dermato-Venereologica, 93, 1, 114-115, 2013.01.
45. Ryoji Kitamura, Takeshi Toyoshima, Hideaki Tanaka, Shintaro Kawano, Kazunari Oobu, Takahiro Kiyosue, Ryota Matsubara, Yuichi Goto, and Seiji Nakamura, Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma, Journal of Cancer Research and Clinical Oncology, 138, 8, 1299-1310, 2012.08.
46. Ryota Matsubara, Shintaro Kawano, Toru Chikui, Takahiro Kiyosue, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinnno, Tetsuji Nagata, Kazunari Oobu, Koichiro Abe, and Seiji Nakamura, Clinical significance of combined assessment of the maximum standardized uptake value of F-18 FDG PET with nodal size in the diagnosis of cervical lymph node metastasis of oral squamous cell carcinoma, Academic Radiology, 19, 6, 708-717, 2012.06.
47. Takahiro Kiyosue, Shintaro Kawano, Ryota Matsubara, Yuichi Goto, Mitsuhiro Hirano, Teppei Jinnno, Takeshi Toyoshima, Ryoji Kitamura, Kazunari Oobu, Seiji Nakamura, Immunohistochemical localization of p75 neurotrophin receptor (p75NTR) in oral leukoplakia and oral squamous cell carcinoma, International Journal of Clinical Oncology, in press, 2011.11.
48. Ryota MATSUBARA, Shintaro KAWANO, Takahiro KIYOSUE, Yuichi GOTO, Mitsuhiro HIRANO, Takeshi TOYOSHIMA, Ryoji KITAMURA, Kazunari OOBU and Seiji NAKAMURA , Increased ΔNp63 expression is predictive of malignant transformation in oral epithelial dysplasia and poor prognosis in oral squamous cell carcinoma, International Journal of Oncology, 39, 6, 1391-1399, 2011.12.
49. Toru Chikui, Shintaro Kawano, Toshiyuki Kawazu, Masamitsu Hatakenaka, Syouzou Koga, Masahiro Ohga,Yoshio Matsuo, Syunya Sunami, Tsuyoshi Sugiura, Yoshiyuki Shioyama, Makoto Obara, Kazunori Yoshiura, Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings, European Radiology, 21, 8, 1699-708, 2011.03.
50. A postoperative case of oral cancer in which widening of esphageal entrance with a balloon catheter enabled oral intake.
51. A clinicostatistical study of 151 patients with salivary gland tumors.
52. Tetsuji Nagata, Kazuhide Matsunaga, Toshiyuki Kawazu, Shintaro Kawano, Kazunari Oobu, Masamichi Ohishi., Patency assessment of the internal jagular vein after neck dissection., International Journal of Oral and Maxillofacial Surgery, 35: 416-420, 2006.03.
53. Harada H, Ichimori Y, Yokohama-Tamaki T, Ohshima H, Kawano S, Katsube K, Wakisaka S, Stratum intermedium lineage diverges from ameloblast lineage via Notch signaling., Biochemical and Biophysical Research Communications, 340:611-616, 2006.01.
Presentations
1. Tanaka Shoichi, Kawano Shintaro, Hattori Taichi, Sakamoto Taiki, Hashiguchi Yuma, Kaneko Naoki, Mikami Yurie, Morioka Masahiko, Maruse Yasuyuki, Kitamura Ryoji, Hamada Eiki, Hiwatashi Megumi, Oobu Kazunari, Kiyoshima Tamotsu, Nakamura Seiji, Involvement of increased cytokeratin 19 expression via down-regulation of ΔNp63 in invasion and metastasis of oral squamous cell carcinoma, International Academy of Oral Oncology (IAOO) 7th World Congress, 2019.09.
2. Hattori Taichi, Kawano Shintaro, Tanaka Shoichi, Sakamoto Taiki, Hashiguchi Yuma, Kaneko Naoki, Mikami Yurie, Morioka Masahiko, Maruse Yasuyuki, Kitamura Ryoji, Hamada Eiki, Hiwatashi Megumi, Oobu Kazunari, Kiyoshima Tamotsu, Nakamura Seiji, Expression of protease-activated receptor 1 as a novel prognostic factor for oral squamous cell carcinoma, International Academy of Oral Oncology (IAOO) 7th World Congress., 2019.06.
3. Naoki Kaneko, Shintaro Kawano, Ryota Matsubara, Teppei JInno, Yasuyuki Maruse, Yuichi Goto, Taiki Sakamoto, Yuma Hashiguchi, Ryoji Kitamura, Hideaki Tanaka, Seiji Nakamura, Expression and function of kallikrein-related peptidase 6 in oral squamous cell carcinoma: the association with epithelial-mesenchymal transition mediated by ΔNp63, The 28th Conference of the Taiwan Association of Oral and Maxillofacial Surgeons, 2017.03.
4. Masafumi Moriyama, Sachiko Furukawa, Shintaro Kawano, Akihiko Tanaka, Jun-Nosuke Hayashida, Keiko Ohyama, Miho Ohta, Tamotsu Kiyoshima, Mayumi Shimizu, Seiji Nakamura, The diagnostic usability of biopsies from submandibular and labial salivary gland in IgG4-related dacryoadenitis and sialoadenitis, 2nd International Symposium on IgG4-RD & Associated Conditions, 2014.02.
5. Miho Ohta, Akihiko Tanaka, Masafumi Moriyama, Shintaro Kawano, Takashi Maehara, Mayumi Shimizu, Sachiko Furukawa, Jun-Nosuke Hayashida, Seiji Nakamura, A case of malignant lymphoma suspected IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS)., 12th International Symposium on Sjögren's Syndrome, 2013.10.
6. Toru Chikui, Erina Kitamoto, Shintaro Kawano, Masahiro Ohba, Makoto Obara, Yoshio Matsuo, Kazunori Yoshiura, Tumor Response Assessments of oral cancer to pre-operative chemoradiotherapy with permeability and diffusion MRI, 25th Congress and Refresher Course of the European Society of Head and Neck Radiology, 2012.09.
7. Erina Kitamoto, Toru Chikui, Shintaro Kawano, Tsuyoshi Sugiura, Makoto Obara, Takashi Yoshiura, Kazunori Yoshiura, The application of a pharmacokinetic analysis to maxillofacial tumors, 25th Congress and Refresher Course of the European Society of Head and Neck Radiology, 2012.09.
8. A case report of rehabilitation with tongue pressure training for glossectomy patient.
9. A case of intractable stomatitis with HIV infection.
10. A case of Good syndrome with oral lichen planus and candidiasis.
11. Clinical evaluation of FDG-PET for primary site and cervical lymph node metastasis of oral squamous cell carcinoma.
12. Clinical study of bisphosphonate-induced osteonecrosis of jaws.
13. Kawano S, Nakamura N, Mitsuyasu T, Nakao Y, Harada H., Differentiation of ameloblastomas and rat dental epithelium mediated by Notch signaling pathway., 6th Asian congress on oral & maxillofacial Surgery, 2004.01.
14. Suzuki H, Oobu K, Kawano S, Matsunaga K, Kawano S, Ohishi M., A clinicopathological study on management of carcinoma of the mandible and lower gum., 6th Asian congress on oral & maxillofacial Surgery, 2004.01.
15. Sasaguri M, Nakamura N, Suzuki A, Matsunaga K, Kawano S, Ohishi M., Total reconstruction with distraction osteogenesis and free fat tissue graft for the treatment of Goldenhar's syndrome., 6th Asian congress on oral & maxillofacial Surgery, 2004.01.
16. Nakao Y, Mitsuyasu T, Sandra F, Kawano S, Toshitani K, Nakamura N, Nakamura S., FGF7 and FGF10 stimulate cell proliferation in ameloblastoma through MAPK pathway., 43th congress of Korean Association of Maxillofacial plastic and reconstructive Surgeons., 2004.01.
17. Mitsuyasu T, Kawano S, Nakao Y, Tateishi K, Nakamura N., An alternative method for vermilion reconstruction after resection of hemangiomas of the lip., 6th Asian congress on oral & maxillofacial Surgery, 2004.01.
18. Kawano S, Uchida T, Toyono T, Seta Y, Kataoka S, Toyoshima K, Ohshima H, Harada H., Immunohistochemical classification of dental epithelium and characterization of dental epithelial (stem-like) cell line, HAT-7., International symposium on tooth structure and evolution, 2002.09.
19. Harada H, Kawano S, Seta Y, Toyono T, Toyoshima K, Ohshima H., Stratum intermedium cells appear as a ramification of ameloblasts cell lineage and its lateral specification through Notch signaling., International symposium on tooth structure and evolution, 2002.09.
20. Kawano S, Morotomi T, Toyono T, Nakamura N, Uchida T, Ohishi M, Toyoshima K, Harada H., Establishment of dental epithelial cell line (HAT-7) and the cell-differentiation dependent on Notch signaling pathway., 7th international Conference on tooth morphogenesis and differentiation., 2002.06.
Membership in Academic Society
  • Japanese society of oral & maxillocafial surgenos
Educational
Educational Activities
Clinical instruction for dental students and residents
Instruction for postgraduate students