恒常維持機構・再生場の理論
キーワード:恒常性維持, 再生場の理論
2010.01~2022.03.
吉田 寛(よしだ ひろし) | データ更新日:2024.04.08 |
主な研究テーマ
研究業績
主要原著論文
1. | Hiroshi Yoshida, A model for analyzing phenomena in multicellular organisms with multivariable polynomials: Polynomial Life, Int. J. Biomath., 11, 1, 1850007, 2018.01. |
2. | Hiroshi Yoshida, Tetsuya Bando, Taro Mito, Hideyo Ohuchi, Sumihare Noji, An extended steepness model for leg-size determination based on Dachsous/Fat trans-dimer system, Scientific Reports, 10.1038/srep04335, 4, 4335, 2014.03, [URL], What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division, and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.. |
3. | Hiroshi Yoshida, A pattern to regenerate through turnover, Biosystems, 10.1016/j.biosystems.2012.08.001, 110, 43-50, 2012.09, [URL]. |
4. | Hiroshi Yoshida, Yoshihiro Miwa, Masanobu KANEKO, Elliptic curves and Fibonacci numbers arising from Lindenmayer system with Symbolic Computation, Applicable Algebra in Engineering, Communication and Computing, 10.1007/s00200-011-0143-7, 22, 2, 147-164, 2011.04, [URL]. |
主要総説, 論評, 解説, 書評, 報告書等
1. | 吉田寛、古澤力、金子邦彦, 多細胞生物の再帰的増殖と細胞タイプ多様性の両立条件, 生物物理 (中西印刷), Vol. 47, No. 1, pp. 29–35, 2007.02. |
主要学会発表等
学会活動
研究資金
科学研究費補助金の採択状況(文部科学省、日本学術振興会)
2018年度~2021年度, 基盤研究(C), 代表, Polynomial-lifeモデルで探る肢のフィボナッチ比発生とセグメント再生.
2014年度~2016年度, 挑戦的萌芽研究, 代表, 多細胞の多変数多項式モデルの構築で迫る動的恒常維持機構の原理と限界.
2011年度~2012年度, 新学術領域研究, 代表, Dachsous:Fatシグナル系実験に基づく再生方程式の導出.
2009年度~2011年度, 若手研究(B), 代表, 楕円曲線=代数方程式による多細胞起源の理解.
2007年度~2008年度, 若手研究(B), 代表, コンパートメントモデルにおける薬物動態のラプラス空間上での代数方程式による解析.
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九大関連コンテンツ
QIR 九州大学学術情報リポジトリ システム情報科学研究院
数理学研究院
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