Kyushu University Academic Staff Educational and Research Activities Database
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Yosuke Taniguchi Last modified date:2022.06.27

Associate Professor / Bioorganic and Synthetic Chemistry
Department of Chemo-Pharmaceutical Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Pharmaceutical Sciences
Country of degree conferring institution (Overseas)
Field of Specialization
Bioorganic and Synthetic Chemistry
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • development of nucleoside analogue for the recognition of oxidative nucleoside damage
    keyword : nucleoside damage
  • Development of the functional oligonucleotide
    keyword : Inhibition of gene expression, repair
  • Development of the nucleoside analogs having RNA editing effect
    keyword : RNA editing, functional oligonucleotide
Academic Activities
1. Yosuke Taniguchi and Shigeki Sasaki, Development of Triplex Forming Oligonucleotide Including Artificial Nucleoside Analogues for the Antigene Strategy, Springer, Synthesis of Therapeutic Oligonucleotides p253-270, 2018.12.
1. Notomi R., Wang L., Osuki T., Okamiura H., Sasaki S.* and Taniguchi Y.*, Synthesis of C-nucleoside analogues based on the pyrimidine skeleton for the formation of anti-parallel-type triplex DNA with a CG mismatch site, Bioorg. Med. Chem.,, accepted., 2020.10.
2. Taniguchi Y.*, Wang L., Okamura H. and Sasaki S.*, Synthesis of 2'-deoxy-4-aminopyridinylpseudocytidine derivatives for incorporation into triplex forming oligonucleotides, Current Protocoles in Nucleic Acids Chemistry, DOI:, 77(1), e80 (2019), 2019.03.
3. Taniguchi Y., Miyazaki M., Matsueda N., Wang L., Okamura H. and Sasaki S, Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC base pair with the TFO containing One N2-Phenyl-2'-deoxyguanosine, Chem. Pharm. Bull.,, 66(6), 624-631, 2018.05.
4. Okamura H, Taniguchi Y, Sasaki S, Aminopyridinyl-pseudodeoxycytidine derivatives selectively stabilize antiparalleltriplex DNA with multiple CG inversion sites, Angew. Chem. Int. Ed., 128(40), 12633-12637, 2016.08.
5. Yin Y, Sasaki S, Taniguchi Y, Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNApolymerase and cell proliferation, Bioorg. Med. Chem., 24(16), 3856-3861, 2016.08.
6. Koga Y, Taniguchi Y, Kikukawa Y, Sasaki S, Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNAchimera probes containing fluorescent adenosine-diazaphenoxazine analogue, Bioorg. Med. Chem., 24(6), 1308-1313, 2016.05.
7. Yin Y, Sasaki S, Taniguchi Y, Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Actibities, ChemBioChem, doi/10.1002/cbic.201500589, 17(7) 566-569, 2016.05.
8. Taniguchi Y, Tomizaki A, Matsueda N, Okamura H, Sasaki S, Enhancement of TFO Triplex Formation by Conjugation withPyrene via Click Chemistry, 63 (11) 920-926., 2015.06.
9. Yin Y, Sasaki S, Taniguchi Y, Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues and FPG and hOGG1 inhibitors, 16(8), 1190-1198 , 2015.05.
10. Taniguchi Y, Kikukawa Y, Shigeki S, Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in DNA by the Single Nucleotide Primer Extension Reaction with Adap Triphosphate, 54(17), 5147-5151., 2015.04.
11. Yin Yizhen, Yosuke Taniguchi, Shigeki Sasaki, Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties, 70(11), 2040-2047 (2014), 2014.06.
12. Yosuke Taniguchi, Keitaro Fukabori, Yoshiya Kikukawa, Yohei Koga, Shigeki Sasaki, 2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA, 22(5), 1634-1641 (2014), 2014.05.
13. Yosuke Taniguchi, Yohei Koga, Shigeki Sasaki, Synthesis of 8-oxoguanosine phosphoramidite and its incorporation intooligoribonucleotides, UNIT4.58 56:4.58.1-4.58., 2014.04.
Membership in Academic Society
  • Antisense DNA/RNA Society
  • Japanese Society for Chemical Biology
  • The Society of Synthetic Organic Chemistry, Japan
  • The Pharmaceutical Society of Japan
  • The Chemical Society of Japan