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Yosuke Taniguchi Last modified date：2022.06.27

Associate Professor / Bioorganic and Synthetic Chemistry
Department of Chemo-Pharmaceutical Sciences
Faculty of Pharmaceutical Sciences


Graduate School
Department of Medicinal Sciences
Graduate School of Pharmaceutical Sciences
Undergraduate School
Department of General Pharmaceutical Sciences
School of Pharmaceutical Sciences


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/yosuke-taniguchi
　Reseacher Profiling Tool　Kyushu University Pure
http://bioorg.phar.kyushu-u.ac.jp/
Phone
092-642-6569
Fax
092-642-6876
Academic Degree
Pharmaceutical Sciences
Country of degree conferring institution (Overseas)
No
Field of Specialization
Bioorganic and Synthetic Chemistry
ORCID(Open Researcher and Contributor ID)
0000-0002-8985-3629
Total Priod of education and research career in the foreign country
12years00months
Research
Research Interests
  • development of nucleoside analogue for the recognition of oxidative nucleoside damage
    keyword : nucleoside damage
    2010.04.
  • Development of the functional oligonucleotide
    keyword : Inhibition of gene expression, repair
    2007.04.
  • Development of the nucleoside analogs having RNA editing effect
    keyword : RNA editing, functional oligonucleotide
    2007.04.
Academic Activities
Reports
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1. Yosuke Taniguchi and Shigeki Sasaki, Development of Triplex Forming Oligonucleotide Including Artificial Nucleoside Analogues for the Antigene Strategy, Springer, Synthesis of Therapeutic Oligonucleotides p253-270, 2018.12.
Papers
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1. Notomi R., Wang L., Osuki T., Okamiura H., Sasaki S.* and Taniguchi Y.*, Synthesis of C-nucleoside analogues based on the pyrimidine skeleton for the formation of anti-parallel-type triplex DNA with a CG mismatch site, Bioorg. Med. Chem., doi.org/10.1016/j.bmc.2020.115782, accepted., 2020.10.
2. Taniguchi Y.*, Wang L., Okamura H. and Sasaki S.*, Synthesis of 2'-deoxy-4-aminopyridinylpseudocytidine derivatives for incorporation into triplex forming oligonucleotides, Current Protocoles in Nucleic Acids Chemistry, DOI: https://doi.org/10.1002/cpnc.80, 77(1), e80 (2019), 2019.03.
3. Taniguchi Y., Miyazaki M., Matsueda N., Wang L., Okamura H. and Sasaki S, Stable and Selective Antiparallel Type Triplex DNA Formation by Targeting a GC base pair with the TFO containing One N2-Phenyl-2'-deoxyguanosine, Chem. Pharm. Bull., https://doi.org/10.1248/cpb.c18-00043, 66(6), 624-631, 2018.05.
4. Okamura H, Taniguchi Y, Sasaki S, Aminopyridinyl-pseudodeoxycytidine derivatives selectively stabilize antiparalleltriplex DNA with multiple CG inversion sites, Angew. Chem. Int. Ed., 128(40), 12633-12637, 2016.08.
5. Yin Y, Sasaki S, Taniguchi Y, Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNApolymerase and cell proliferation, Bioorg. Med. Chem., 24(16), 3856-3861, 2016.08.
6. Koga Y, Taniguchi Y, Kikukawa Y, Sasaki S, Recognition and detection of 8-oxo-rG in RNA using the DNA/OMeRNAchimera probes containing fluorescent adenosine-diazaphenoxazine analogue, Bioorg. Med. Chem., 24(6), 1308-1313, 2016.05.
7. Yin Y, Sasaki S, Taniguchi Y, Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Actibities, ChemBioChem, doi/10.1002/cbic.201500589, 17(7) 566-569, 2016.05.
8. Taniguchi Y, Tomizaki A, Matsueda N, Okamura H, Sasaki S, Enhancement of TFO Triplex Formation by Conjugation withPyrene via Click Chemistry, 63 (11) 920-926., 2015.06.
9. Yin Y, Sasaki S, Taniguchi Y, Recognition and excision properties of 8-halogenated-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguaanosine analogues and FPG and hOGG1 inhibitors, 16(8), 1190-1198 , 2015.05.
10. Taniguchi Y, Kikukawa Y, Shigeki S, Discrimination Between 8-Oxo-2'-Deoxyguanosine and 2'-Deoxyguanosine in DNA by the Single Nucleotide Primer Extension Reaction with Adap Triphosphate, 54(17), 5147-5151., 2015.04.
11. Yin Yizhen, Yosuke Taniguchi, Shigeki Sasaki, Synthesis of 8-halogenated-7-deaza-2'-deoxyguanosine as an8-oxo-2'-deoxyguanosine analogue and evaluation of its base pairing properties, 70(11), 2040-2047 (2014), 2014.06.
12. Yosuke Taniguchi, Keitaro Fukabori, Yoshiya Kikukawa, Yohei Koga, Shigeki Sasaki, 2,6-Diaminopurine nucleoside derivative of 9-ethyloxy-2-oxo-1,3-diazaphenoxazine(2-amino-Adap) for recognition of 8-oxo-dG in DNA, 22(5), 1634-1641 (2014), 2014.05.
13. Yosuke Taniguchi, Yohei Koga, Shigeki Sasaki, Synthesis of 8-oxoguanosine phosphoramidite and its incorporation intooligoribonucleotides, UNIT4.58 56:4.58.1-4.58., 2014.04.
Presentations
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Membership in Academic Society
  • Antisense DNA/RNA Society
  • Japanese Society for Chemical Biology
  • The Society of Synthetic Organic Chemistry, Japan
  • The Pharmaceutical Society of Japan
  • The Chemical Society of Japan


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