Kyushu University Academic Staff Educational and Research Activities Database
Researcher information (To researchers) Need Help? How to update
Kawabe Yoshinori Last modified date:2023.01.04

Associate Professor / Molecular and Biochemical Systems Engineering
Department of Chemical Engineering
Faculty of Engineering


Graduate School
Undergraduate School


E-Mail *Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari.
Homepage
https://kyushu-u.pure.elsevier.com/en/persons/kawabe-yoshinori
 Reseacher Profiling Tool Kyushu University Pure
http://www.chem-eng.kyushu-u.ac.jp/lab3/index.html
Phone
092-802-2753
Fax
092-802-2793
Academic Degree
Doctor of Engineering, Nagoya University, Japan
Country of degree conferring institution (Overseas)
No
Field of Specialization
Biochemical Engineering
Total Priod of education and research career in the foreign country
00years02months
Research
Research Interests
  • Development and application of microalgae biotechnology
    keyword : Algae, Microalgae, Chlamydomonas reinhardtii, transgene integration, gene retargeting, recombinant protein production
    2017.04.
  • Mass production sysytem for the biopharmaceutical proteins by transgenic avian bioreactor
    keyword : transgenic avian bioreactor, biopharmaceuticals, recombinant proteins, monoclonal antibody, retroviral vector
    2004.04.
  • development of maintainance and efficient derivation for pluripotential stem cells
    keyword : pluripotential stem cells, genetically manipulated animals, feeder layer, tissue engineering
    2008.04.
Academic Activities
Books
1. Yoshinori Kawabe, Masamichi Kamihira, Production of Antibody by Transgenic Avians. In: Al-Rubeai, M. (eds) Antibody Expression and Production. Cell Engineering, vol 7. Springer, Dordrecht., https://doi.org/10.1007/978-94-007-1257-7_6, pp121-141, 2011.04, [URL].
Papers
1. Yoshinori Kawabe, Masamichi Kamihira, Novel cell lines derived from Chinese hamster kidney tissue, PLoS One, doi: 10.1371/journal.pone.0266061., 17, 3, e0266061, 2022.03, [URL].
2. Guan Huang$, Yoshinori Kawabe$, Kazuki Shirakawa, Tatsuki Akiyama, Masamichi Kamihira ($Co-1st author), Novel transgenic Chlamydomonas reinhardtii strain with retargetable genomic transgene integration using Cre-loxP system  , J Biosci Bioeng, https://doi.org/10.1016/j.jbiosc.2021.07.006, 132, 5, 469-478, 2021.07, [URL].
3. Feiyang Zheng, Yoshinori Kawabe, Mai Murakami, Mamika Takahashi, Kyoka Nishihata, Souichiro Yoshida, Akira Ito, Masamichi Kamihira, LINE-1 vectors mediate recombinant antibody gene transfer by retrotransposition in Chinese hamster ovary cells, Biotechnol J, https://doi.org/10.1002/biot.202000620, 16, 7, e2000620, 2021.07, [URL].
4. Ryusei Iwao, Yoshinori Kawabe, Mai Murakami, Akira Ito, Masamichi Kamihira, Targeted Knock-in of Transgenes into the CHO Cell Genome Using CRISPR-mediated Integration Systems, MATEC Web of Conferences, https://doi.org/10.1051/matecconf/202133307001, 333, 07001, The 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 2021.01, [URL].
5. Feiyang Zheng, Yoshinori Kawabe, Mai Murakami, Mamika Takahashi, Shoichiro Yoshida, Akira Ito, Masamichi Kamihira, Retrotransposon-mediated Gene Transfer for Animal Cells, MATEC Web of Conferences, https://doi.org/10.1051/matecconf/202133307002, 333, 07002, The 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 2021.01, [URL].
6. Kazuki Shirakawa, Yoshinori Kawabe, Guan Huang, Akira Ito, Masamichi Kamihira, Targeted Gene Integration into Nuclear Genome of Microalgae Using Cre/loxP Recombination System, MATEC Web of Conferences, https://doi.org/10.1051/matecconf/202133307003, 333, 07003, The 18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019), 2021.01, [URL].
7. Ming Shi, Yoshinori Kawabe, Akira Ito, Masamichi Kamihira, Targeted knock-in into the OVA locus of chicken cells using CRISPR/Cas9 system with homology-independent targeted integration, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2019.09.011, 129, 3, 363-370, 2020.03, [URL].
8. Yoshinori Kawabe, Shinya Komatsu, Shodai Komatsu, Mai Murakami, Akira Ito, Tetsushi Sakuma, Takahiro Nakamura, Takashi Yamamoto, Masamichi Kamihira, Targeted knock-in of an scFv-Fc antibody gene into the hprt locus of Chinese hamster ovary cells using CRISPR/Cas9 and CRIS-PITCh systems, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2017.12.003, 125, 5, 599-605, 2018.05, [URL].
9. Yoshinori Kawabe, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Development of retroviral vectors capable of site-specific gene insertion together with protein delivery, BMC Proceedings, https://doi.org/10.1186/s12919-018-0097-x, 2018, 12(Suppl 1):P-327, 2018.03, [URL].
10. Xue Wang, Yoshinori Kawabe, Takeshi Hada, Akira Ito, Masamichi Kamihira, Cre-mediated transgene integration in Chinese hamster ovary cells using minicircle DNA vectors, Biotechnology Journal, 10.1002/biot.201800063, 13, 7, e1800063, 2018.07, [URL].
11. Xue Wang, Kawabe Yoshinori, Risa Kato, Takeshi Hada, Akira Ito, Yoshimasa Yamana, Masako Kondo, Masamichi Kamihira, Accumulative scFv-Fc antibody gene integration into the hprt chromosomal locus of Chinese hamster ovary cells, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2017.05.017, 124, 5, 583-590, 2017.11, [URL].
12. Kawabe Yoshinori, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Takeshi Omasa, Masamichi Kamihira, Improved recombinant antibody production by CHO cells using a production enhancer DNA element with repeated transgene integration at a predetermined chromosomal site, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2016.10.011, 123, 3, 390-397, 2017.03, [URL].
13. Kawabe Yoshinori, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Targeted transgene insertion into the CHO cell genome using Cre recombinase-incorporating integrase-defective retroviral vectors, Biotechnology and Bioengineering, 10.1002/bit.25923, 113, 7, 1600-1610, 2016.07, [URL].
14. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Akira Ito, Masamichi Kamihira, Cre-mediated cellular modification for establishing producer CHO cells of recombinant scFv-Fc, BMC Proceedings, 10.1186/1753-6561-9-S9-P5, 9(Suppl 9):P5, 2015.12, [URL].
15. Kawabe Yoshinori, Hirokatsu Makitsubo, Yujiro Kameyama, Shuohao Huang, Akira Ito, Masamichi Kamihira, Repeated integration of antibody genes into a pre-selected chromosomal locus of CHO cells using an accumulative site-specific gene integration system, Cytotechnology, 10.1007/s10616-011-9397-y, 64, 3, 267-279, 2012.05, [URL].
16. Hirokazu Obayashi, Kawabe Yoshinori, Hirokatsu Makitsubo, Ryoko Watanabe, Yujiro Kameyama, Shuohao Huang, Yuta Takenouchi, Akira Ito, Masamichi Kamihira, Accumulative gene integration into a pre-determined site using Cre/loxP, Journal of Bioscience and Bioengineering, 10.1016/j.jbiosc.2011.10.027, 113, 3, 381-388, 2012.03, [URL].
17. Kawabe Y, Hayashida Y, Numata K, Harada S, Hayashida Y, Ito A, Kamihira M, Oral immunotherapy for pollen allergy using T-cell epitope-containing egg white derived from genetically manipulated chickens, PLOS ONE, doi:10.1371/journal.pone.0048512, 7, 10, e48512, 2012.10, [URL].
18. Yujiro Kameyama, Kawabe Yoshinori, Akira Ito, Masamichi Kamihira, An accumulative site-specific gene integration system using Cre recombinase-mediated cassette exchange, Biotechnology and Bioengineering, 10.1002/bit.22619, 105, 6, 1106-1114, 2010.04, [URL].
19. Carlos Alberto Penno, Kawabe Yoshinori, Akira Ito, Masamichi Kamihira, Production of recombinant human erythropoietin/Fc fusion protein by genetically manipulated chickens, Transgenic Research, 10.1007/s11248-009-9310-z, 19, 2, 187-195, 2010.04, [URL].
20. Kawabe Yoshinori, Tsutomu Naka, Hiroyuki Komatsu, Ken Ichi Nishijima, Shinji Iijima, Masamichi Kamihira, Retroviral Gene Transduction into Chicken Embryo Gonads through Blood Circulation, Journal of Bioscience and Bioengineering, 10.1263/jbb.106.598, 106, 6, 598-601, 2008.12, [URL].
21. Kawabe Yoshinori, Tsutomu Naka, Naoko Ando-Noumi, Hiroyuki Matsumoto, Ken ichiro Ono, Ken ichi Nishijima, Masamichi Kamihira, Shinji Iijima, Transport of human immunoglobulin G and Fc-fusion proteins to chicken egg yolk, Journal of Bioscience and Bioengineering, 10.1263/jbb.102.518, 102, 6, 518-523, 2006.12, [URL].
22. Kawabe Yoshinori, Masamichi Kamihira, Ken ichiro Ono, Kenji Kyogoku, Ken ichi Nishijima, Shinji Iijima, Production of scFv-Fc fusion protein using genetically manipulated quails, Journal of Bioscience and Bioengineering, 10.1263/jbb.102.297, 102, 4, 297-303, 2006.10, [URL].
23. Yoshinori Kawabe, Akitsu Hotta, Ken-ichiro Ono, Kazuhisa Esaka, Ken-ichi Nishijima, Masamichi Kamihira, and Shinji Iijima, Production of chimeric antibodies by transgenic chicken bioreactor, Animal Cell Technology: Basic & Applied Aspects, https://doi.org/10.1007/1-4020-4457-7_42, 14, 307-314, 2006.05, [URL].
Presentations
1. Huang Guan, Kawabe Yoshinori, Shirakawa Kazuki, Akiyama Tatsuki, Kamihira Masamichi, [PB212] Targeted integration of transgene into a pre-defined genomic locus of Chlamydomonas reinhardtii , 化学工学会第86年会, 2021.03.
2. Yoshinori Kawabe, Hirotaka Nishina, Ryusei Iwao, Masamichi Kamihira, Generation of a New CHK Cell Line with Inducible Differentiation for Enhanced Expression of Recombinant Antibody, JAACT2020 Fuchu, 2020.11.
3. Yoshinori Kawabe, Shinya Komatsu, Feiyang Zheng, Akira Ito, Masamichi Kamihira, Targeted knock-in into CHO cell genome using genome editing tools, 26th European Society for Animal Cell Technology (ESACT) Meeting, 2019.05.
4. Yoshinori Kawabe, Xue Wang, Takeshi Hada, Akio Kuno, Akira Ito, Masamichi Kamihira, Targeted scFv-Fc antibody gene integration into CHO cell genome using minicircle DNA vectors, JAACT2018 Tsukuba, 2018.11.
5. Yoshinori Kawabe, Takuya Shimomura, Shuohao Huang, Suguru Imanishi, Akira Ito, Masamichi Kamihira, Development of retroviral vectors capable of site-specific gene insertion together with protein delivery, 25th European Society for Animal Cell Technology (ESACT) Meeting , 2017.05.
6. Yoshinori Kawabe, Takanori Inao, Shodai Komatsu, Guan Huang, Akira Ito, Masamichi Kamihira, Improved scFv-Fc productivity in CHO cells with tandem-repeat expression units flanked by a production enhancer element, The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2016 Kobe), 2016.11.
7. Kawabe Yoshinori, Takanori Inao, Shodai Komatsu, Akira Ito, Masamichi Kamihira, Cre-mediated cellular modification for establishing producer CHO cells of recombinant scFv-Fc, ESACT ("European Society for Animal Cell Technology" Meeting) 2015, 2015.06.
8. Yoshinori Kawabe, Yuuki Hayashida, Kensaku Numata, Kenta Okuzono, Reina Obata, Akira Ito, Masamichi Kamihira, Egg-based oral immunotherapy with genetically manipulated chickens producing T-cell epitopes against Japanese cedar pollinosis, YABEC2014, 2014.11.
Membership in Academic Society
  • The Society of Biotechnology, Japan
  • The Society of Chemical Engineers, Japan
  • Japanese Association for Animal Cell Technology
  • The Molecular Biology Society of Japan
Educational
Other Educational Activities
  • 2020.11.
  • 2010.07.