Kyushu University Academic Staff Educational and Research Activities Database
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Yoji Hirano Last modified date:2020.11.14

Lecturer / Neuropsychiatry
Kyushu University Hospital

Graduate School

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Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
Field of Specialization
Psychiatry, Clinical Neurophysiology, EEG, MEG, MRI, PET, Schizophrenia, Metacognitive Training
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
My main focus is to study oscillatory brain dynamics and neuroimaging abnormalities in patients with Schizophrenia and Bipolar disorder.
I'm also a member of ICD-11 field study and a core member of the ICD-11 SCI-11 team.
Research Interests
  • Assessment of AMPA Receptor Density in Psychiatric Disorders: a Cross-sectional [11C]K-2 PET Study
    keyword : AMPA receptor, PET study, Schizophrenia, Bipolar Disorder, Depression, ARMS (At Risk Mental State)
  • Rhythm in the Brain for Speech Comprehension
    keyword : Rhythm in the Brain, Speech Comprehension, Schizophrenia
  • Machine learning using neuroimaging dataset around the onset of schizophrenia and the proposal for the optimal MRI protocol: An Asian multicenter study
    keyword : First-episode Schizophrenia, ARMS (At Risk Mental State), Asia, MRI, Consortium, Multimodality, Machine learning
  • Neuroticism and Emotion Regulation
    keyword : Neuroticism, Emotion Regulation, Culture, EEG, Emotion
  • Detecting neural oscillation abnormalities during emotion regulation in patients with schizophrenia.
    keyword : Schizophrenia, Gamma oscillation, Neural oscillation, Emotion regulation
  • Comprehensive research on abnormal γ-band activity in first episode schizophrenia and clinical high risk group.
    keyword : First episode schizophrenia, clinical high risk group, γ-band activity
  • Evaluation of brain function on schizophrenia and bipolar disorder.
    keyword : schizophrenia, bipolar disorder, functional nouroimaging, MEG, cognitive function
Current and Past Project
  • Title: Assessment of AMPA Receptor Density in Psychiatric Disorders: a Cross-sectional [11C]K-2 PET Study.
  • Since 2017 an international workgroup consisting of psychologist and psychiatrist researchers and clinicians with expertise in devising diagnostic instruments has been developing a Structured Clinical Interview based on the ICD-11: the SCII–11. The aim of the SCII-11 is to provide Mental Health Professionals worldwide with a validated, reliable, and clinically useful diagnostic measure to standardize and facilitate the process of accurate Psychiatric diagnosis in a broad range of settings.
  • To evaluate the reliability and clinical utility of new ICD-11 draft with WHO members
Academic Activities
1. Shogo Hirano, Kevin M. Spencer, Toshiaki Onitsuka, Yoji Hirano*, Language-Related Neurophysiological Deficits in Schizophrenia, Clinical EEG and Neuroscience, 10.1177/1550059419886686, 2019.01.
1. Shogo Hirano, Kevin M. Spencer, Toshiaki Onitsuka, Yoji Hirano*, Language-Related Neurophysiological Deficits in Schizophrenia, Clinical EEG and Neuroscience, 10.1177/1550059419886686, 2019.01.
2. Yoji Hirano, Naoya Oribe, Toshiaki Onitsuka, Shigenobu Kanba, Paul G. Nestor, Taiga Hosokawa, Margaret Levin, Martha E. Shenton, Robert W. McCarley, Kevin M. Spencer, Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia, Clinical EEG and Neuroscience, 10.1177/1550059420914201, 2020.01.
3. Naoya Oribe, Yoji Hirano, Elisabetta del Re, Larry J. Seidman, Raquelle I. Mesholam-Gately, Kristen A. Woodberry, Joanne D. Wojcik, Takefumi Ueno, Shigenobu Kanba, Toshiaki Onitsuka, Martha E. Shenton, Jill M. Goldstein, Margaret A. Niznikiewicz, Robert W. McCarley, Kevin M. Spencer, Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals, Schizophrenia Research, 10.1016/j.schres.2019.03.025, 208, 145-152, 2019.06.
4. Yoji Hirano, Naoya Oribe, Shigenobu Kanba, Toshiaki Onitsuka, Paul G Nestor, Kevin M Spencer, Spontaneous Gamma Activity in Schizophrenia, JAMA Psychiatry, 10.1001/jamapsychiatry.2014.2642., 72, 8, 813-821, 2015.08, [URL], We found increased spontaneous gamma activity during auditory steady-state stimulation in schizophrenia (SZ), reflecting a disruption in the normal balance of excitation and inhibition. This phenomenon interacts with evoked oscillations, possibly contributing to the gamma ASSR deficit found in SZ. The similarity of increased spontaneous gamma power in SZ to the findings of increased spontaneous gamma power in animal models of NMDAR hypofunction suggests that spontaneous gamma power could serve as a biomarker for the integrity of NMDARs on parvalbumin-expressing inhibitory interneurons in humans and in animal models of neuropsychiatric disorders..
5. Shogo Hirano, Yoji Hirano, Toshihiko Maekawa, Choji Obayashi, Naoya Oribe, Toshihide Kuroki, Shigenobu Kanba, Toshiaki Onitsuka, Abnormal neural oscillatory activity to speech sounds in schizophrenia: A magnetoencephalography study, The Journal of Neuroscience, 10.1523/JNEUROSCI.5031-07.2008, 28, 19, 4897-4903, 2008.05, [URL].
6. Yoji Hirano, Shogo Hirano, Choji Obayashi, Naoya Oribe, Akira Monji, Kiyoto Kasai, Shigenobu Kanba, Toshiaki Onitsuka, Auditory gating deficit to human voices in schizophrenia: a MEG study, Schizophr Res, 10.1016/j.schres.2009.09.003., 117, 1, 61-67, 2010.03, [URL].
7. Yoji Hirano, Toshiaki Onitsuka, Toshihide Kuroki, Yuji Matsuki, Shogo Hirano, Toshihiko Maekawa, Shigenobu Kanba, Auditory sensory gating to the human voice: A preliminary MEG study, Psychiatry Research - Neuroimaging, 10.1016/j.pscychresns.2007.07.002, 163, 3, 260-269, 2008.08.
8. Naoya Oribe, Yoji Hirano, Shigenobu Kanba, Del Re E, Seidman L, Mesholam-Gately R, Goldstein JM, Shenton M, Spencer KM, McCarley RW, Niznikiewicz M, Progressive Reduction of Visual P300 Amplitude in Patients With First-Episode Schizophrenia: An ERP Study, Schizophr Bull, 10.1093/schbul/sbu083, 41, 460-470, 2015.03, [URL].
9. Naoya Oribe, Yoji Hirano, Shigenobu Kanba, Elisabetta C. del Re, Larry J. Seidman, Raquelle Mesholam-Gately, Kevin M. Spencer, Robert W. McCarley, Margaret A. Niznikiewicz, Early and late stages of visual processing in individuals in prodromal state and first episode schizophrenia: An ERP study, Schizophrenia Research, 10.1016/j.schres.2013.01.015, 146, 1-3, 95-102, 2013.05.
10. Itta Nakamura, Yoji Hirano, Naotoshi Ohara, Shogo Hirano, Takefumi Ueno, Rikako Tsuchimoto, Shigenobu Kanba, Toshiaki Onitsuka, Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation, Neuropsychobiology, 10.1159/000377680, 71, 4, 187-195, 2015.06, [URL].
1. Yoji Hirano, Naoya Oribe, Robert W McCarley, Kevin M Spencer, Spontaneous and Evoked Auditory Gamma Abnormalities in First-Episode Schizophrenia: A Longitudinal Study, The ACNP Annual Meeting, 2019.12.
2. Yoji Hirano, Spontaneous Gamma Activity in Schizophrenia, 6th Congress of Asian College of Neuropsychopharmacology, 2019.10.
3. Yoji Hirano, Abnormal Cortical Activities in Schizophrenia -Potential Novel Targets for Clinical Applications-, Asia Pacific Society for Biology and Medical Sciences 2019 Annual Meeting, 2019.07.
4. Yoji Hirano, Sensory processing dysfunction and abnormal neural oscillation in schizophrenia, UNSW Sydney Psychiatry Lecture, 2019.03.
5. , [URL].
6. Yoji Hirano, Abnormal Neural Oscillation and Auditory Hallucination in Schizophrenia, The International Consortium on Hallucination Research 2018 KYOTO, 2018.09, [URL].
7. Yoji Hirano, Kevin Spencer, Abnormal cortical activities in psychosis: toward translational research, 生物学的精神医学会, 2018.09, [URL].
8. Yoji Hirano, Progressive spontaneous and synchrony gamma-band oscillation deficits in first episode schizophrenia., The 2018 Congress of The Schizophrenia International Research Society, 2018.04.
9. Yoji Hirano, Toshiaki Onitsuka, Kevin M Spencer, Abnormal cortical activities in psychosis: toward translational research, The 21st International Conference on Biomagnetism, 2018.08, [URL].
10. Yoji Hirano, Altered Gamma Oscillation Patterns During Name Recognition in Schizophrenia, 16th International Congress on Schizophrenia Research, 2016.03.
11. Yoji Hirano, Kevin Spencer, Reduced auditory evoked oscillations and underlying structural abnormality in Schizophrenia, Organization for Human Brain Mapping 2015, 2016.06.
Membership in Academic Society
  • Japanese Pharmaco-EEG Society
  • Schizophrenia International Research Society
  • Society for Neuroscience
  • Societies of Biological Psychiatry
  • Society for Psychophysiological Research
  • Japanese Societies of Biological Psychiatry
  • World Federation of Societies of Biological Psychiatry
  • JSBP Young Investigator Program Award
  • ICOSR Young Investigator Award
  • Fund Award for Brain Science
  • TSSR Award
  • SIRS Travel Award
  • SIRS Research Fund Award
  • The Grand Prize Young Investigator Program Award
  • First Place Young Investigator Program Awards: Japanese Society of Biological Psychiatry
    "Visualizing Mental Phenomena: Investigation of the pathogenesis and treatment of schizophrenia based on gamma oscillation"
  • 60th Research Grant Award: UBE Industries Foundation
    "Clarifying the underlying mechanisms of schizophrenia focusing on the abnormalities of neuronal activities and immune responses."
  • The SIRS Research Fund Award:
    This proposal entitled “Detecting Neural Dynamics During Emotion Regulation in Patients with Schizophrenia” was selected for the award from 98 proposals by the SIRS Research Fund Award Committee. My aims are to 1)detect abnormal gamma-band oscillation (GBO) during abnormal emotion regulation; 2)evaluate the relationship between abnormal emotional processing and top-down control deficits in Schizophrenia by examining which phases of decision making (sensory encoding, evidence accumulation, and selection) are abnormal in Schizophrenia; 3)test the role of top-down and bottom-up regulation processes during emotion regulation in Schizophrenia, and adapt these findings to neurofeedback treatment by real-time EEG-Based Brain Machine Interface (BMI).
  • APSBMS Outstanding Research Award 2019
  • SIRS Young Investigator Award 2018
  • TSSR Award 2017
  • Fund Award for Brain Science 2015
  • JSBP Young Investigator Program Encouragement Award 2015
  • ICOSR Young Investigator Award 2015
Educational Activities
Clinical training/lecture for medical students and residents and interns.
Research training for graduate students using neuroimaging, electrophysiology and neuropsychological approaches in psychiatric disorders.
Other Educational Activities
  • 2016.05, Society of Biological Psychiatry’s (SOBP) Mentor/Mentee Program: Participated as a mentor to supervise postdoctoral research fellows from NY (USA)..
Professional and Outreach Activities
ICD-11 Field Study & ICD-11 SCI-11 core team member. .