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Takeshi Nakahara Last modified date：2023.06.29

Professor / Department of Clinical Medicine
Faculty of Medical Sciences


Graduate School
Department of Medicine
Graduate School of Medical Sciences
Undergraduate School
Department of Medicine
School of Medicine
Other Organization
Dermatology


E-Mail　*Since the e-mail address is not displayed in Internet Explorer, please use another web browser:Google Chrome, safari.
Homepage
https://kyushu-u.pure.elsevier.com/en/persons/takeshi-nakahara
　Reseacher Profiling Tool　Kyushu University Pure
http://www.kyudai-derm.org/
Phone
092-642-5585
Fax
092-642-5600
Academic Degree
PhD in Medicine
Country of degree conferring institution (Overseas)
No
Field of Specialization
Dermatology
ORCID(Open Researcher and Contributor ID)
https://orcid.org/0000-0003-2811-8273
Total Priod of education and research career in the foreign country
02years05months
Research
Research Interests
  • clinical reserch of inflamamtory skin disease
    keyword : clinical reserch
    2015.04.
  • pathogenesis of psoriasis
    keyword : psoriasis
    2014.06.
  • pathogenesis of atopic dermatitis
    keyword : atopic dermatitis
    2013.04.
  • immunotherapy against skin cancer
    keyword : immunotherapy
    2002.04.
  • Biology and functions of dendritic cells
    keyword : Dendritic cells
    2008.04.
  • Immune regulation by Aryl hydrocarbon receptor (AHR)
    keyword : Aryl hydrocarbon receptor (AHR)
    2012.04.
  • prognostic factor of malignant melanoma
    keyword : malignant melanoma
    2008.04.
Academic Activities
Reports
 Show All Reports >>
1. Nakahara T, Kido-Nakahara M, Furue M, Potential Role of Endothelin-1 in Atopic Dermatitis, Current Treatment Options in Allergy 6:156–163, 2019, 2020.10.
2. Nakahara T, Kido-Nakahara M, Tsuji G, Furue M, Basics and recent advances in the pathophysiology of atopic dermatitis., J Dermatol 48(2):130-139, 2021, 2020.12.
3. Furue M, Yamamura K, Kido-Nakahara M, Nakahara T, Fukui Y, Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis., Allergy 73:29-36, 2018, 2018.04.
4. Nakahara T, Morimoto H, Murakami N, Furue M, Mechanistic insights into topical tacrolimus for the treatment of atopic dermatitis., Pediatr Allergy Immunol 29:233-238, 2018. , 2018.04.
5. Nakahara T, Furue M, Nemolizumab and atopic dermatitis: The interaction between interleukin-31 and interleukin-31 , Current Treatment Options in Allergy 5:405–414, 2018, 2018.04.
6. Kido-Nakahara M, Furue M, Ulzii D, Nakahara T, Itch in Atopic Dermatitis.　, Immunol Allergy Clin North Am 37(1):113-122, 2017, 2017.04.
7. Saeki H, Nakahara T, Tanaka A, Kabashima K, Sugaya M, Murota H, Ebihara T, Kataoka Y, Aihara M, Etoh T, Katoh N; Committee for Clinical Practice Guidelines for the　Management of Atopic Dermatitis of Japanese Dermatological Association: , Clinical Practice Guidelines for the Management of Atopic Dermatitis 2016, J Dermatol. 43(10):1117-1145, 2016., 2016.04.
8. Nakahara T, Moroi Y, Uchi H, Furue M. , Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement. , J Dermatol Sci. , 2006.04.
Papers
 Show All Papers >>
1. Kido-Nakahara M, Wang B, Ohno F, Tsuji G, Ulzii D, Takemura M, Furue M, Nakahara T, Inhibition of mite-induced dermatitis, pruritus, and nerve sprouting in mice by the endothelin receptor antagonist bosentan, Allergy 76(1):291-301, 2021, 2021.04.
2. Nakahara T, Kido-Nakahara M, Ulzii D, Miake S, Fujishima K, Sakai S, Chiba T, Tsuji G, Furue M, Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation., Sci Rep. 10(1):9510. doi: 10.1038/s41598-020-66490-z, 2020, 2020.04.
3. Ohno F, Nakahara T, Kido-Nakahara M, Ito T, Nunomura S, Izuhara K, Furue M, Periostin Links Skin Inflammation to Melanoma Progression in Humans and Mice. , Int J Mol Sci 20(1). pii: E169, 2019, 2019.04.
4. Nakahara T, Kido-Nakahara M, Ohno F, Ulzii D, Chiba T, Tsuji G, Furue M, The pruritogenic mediator endothelin-1 shifts the dendritic cell-T-cell response toward Th17/Th1 polarization., Allergy. 73:511-515, 2018, 2018.04.
5. Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, Watanabe M, Kido-Nakahara M, Tsuge I, Furue M, Fukui Y, The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction., Nat Commun. 8:13946, 2017, 2017.04.
6. Itoh E, Nakahara T, Murata M, Ito T, Onozuka D, Furumura M, Hagihara A, Furue M, Chronic spontaneous urticaria: Implications of subcutaneous inflammatory cell infiltration in an intractable clinical course., J Allergy Clin Immunol 139(1):363-366, 2017, 2017.04.
7. Shiratori-Hayashi M, Koga K, Tozaki-Saitoh H, Kohro Y, Toyonaga H, Yamaguchi C, Hasegawa A, Nakahara T, Hachisuka J, Akira S, Okano H, Furue M, Inoue K, Tsuda M, STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch., Nat Med 21(8):927-31, 2015, 2015.01.
8. Oba J, Nakahara T, Hayashida S, Kido M, Xie L, Takahara M, Uchi H, Miyazaki S, Abe T, Hagihara A, Moroi Y, Furue M., Expression of CD10 predicts tumor progression and unfavorable prognosis in malignant melanoma., J Am Acad Dermatol., 65, 6, 1152-60, 2011.12.
9. Oba J, Nakahara T, Abe T, Hagihara A, Moroi Y, Furue M. , Expression of c-Kit, p-ERK and cyclin D1 in malignant melanoma: an immunohistochemical study and analysis of prognostic value., J Dermatol Sci. , 62, 2, 116-23, 2011.03.
10. Nakahara T, Uchi H, Lesokhin AM, Avogadri F, Rizzuto GA, Hirschhorn-Cymerman D, Panageas KS, Merghoub T, Wolchok JD, Houghton AN., Cyclophosphamide enhances immunity by modulating the balance of dendritic cell subsets in lymphoid organs., Blood. 2010 Jun 3;115(22):4384-92., 2010.06.
11. Chen S, Nakahara T, Uchi H, Takeuchi S, Takahara M, Kido M, Dugu L, Tu Y, Moroi Y, Furue M. , Immunohistochemical analysis of the mammalian target of rapamycin signalling pathway in extramammary Paget's disease.
, Br J Dermatol, 2009.08.
12. Nakahara T, Uchi H, Urabe K, Chen Q, Furue M, Moroi Y. , Role of c-Jun N-terminal kinase on lipopolysaccharide induced maturation of human monocyte-derived dendritic cells. Int Immunol. , INTERNATIONAL IMMUNOLOGY, 10.1093/intimm/dxh171, 16, 12, 1701-1709, 16(12):1701-9., 2004.12.
13. Nakahara T, Koga T, Fukagawa S, Uchi H, Furue M, Intermittent　topical corticosteroid/tacrolimus　sequential therapy improves lichenification and chronic papules more efficiently than intermittent topical corticosteroid/emollient sequential therapy in patients with atopic dermatitis., J Dermatol, 31, 7, 524-528, 31(7):524-8., 2004.07.
14. Nakahara T, Urabe K, Fukagawa S, Uchi H, Inaba K, Furue M, Moroi Y., Engagement of human monocyte-derived dendritic cells into interleukin (IL)-12 producers by IL-1beta + interferon (IFN)-gamma., Clin Exp Immunol, 10.1111/j.1365-2249.2005.02709.x, 139, 3, 476-482, 139(3):476-82, 2005.03.
Presentations
 Show All Presentations >>
1. Takeshi Nakahara, Supportive Care -Skin toxicity-, 5th Asia Pasific Lung Cancer Conference, 2012.11.


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