Updated on 2025/06/09

Information

 

写真a

 
NAKAMIZO AKIRA
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Associate Professor
Graduate School of Medical Sciences Department of Medical Sciences（Concurrent）
Graduate School of Medical Sciences Department of Medicine（Concurrent）
School of Medicine Department of Medicine（Concurrent）
Title
Associate Professor
Contact information
メールアドレス
Tel
0926425524
Profile
脳神経外科領域の臨床、研究、教育
External link

Degree

  • MD, PhD

Research History

  • 国立病院機構九州医療センター脳神経外科　医師 貝塚病院脳神経外科　医師 九州厚生年金病院脳神経外科　医師 九州大学医学部脳神経外科　医員 佐賀県立病院好生館麻酔科　医師 九州大学医学部麻酔科蘇生科　研修医   

    国立病院機構九州医療センター脳神経外科　医師 貝塚病院脳神経外科　医師 九州厚生年金病院脳神経外科　医師 九州大学医学部脳神経外科　医員 佐賀県立病院好生館麻酔科　医師 九州大学医学部麻酔科蘇生科　研修医

Research Interests・Research Keywords

  • Research theme： Cognitive dysfunction in cerebrovascular disorder

    Keyword： Moyamoya disease, internal carotid artery stenosis, cognitive function, executive function

    Research period： 2022.4

  • Research theme： Inhibition of proliferation and invasion of glioblastoma

    Keyword： Glioblastoma, proliferation, invasion

    Research period： 2022.4

Papers

  • Dural arteriovenous fistulae in a 6-year-old girl with trisomy 21 and congenital heart disease

    Ishikura, T; Sonoda, Y; Kajiwara, K; Chong, PF; Kanemasa, H; Motomura, Y; Kaku, N; Hirata, Y; Nagata, H; Yamamura, K; Arimura, K; Nakamizo, A; Sakai, Y; Ohga, S

    CLINICAL NEUROLOGY AND NEUROSURGERY   246   108540   2024.11   （ ISSN:0303-8467 eISSN:1872-6968 ）

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    Language：English   Publisher：Clinical Neurology and Neurosurgery  

    Dural arteriovenous fistula (DAVF) represents a pathological group of intracranial shunts arising from the dural artery to venous sinus and veins. Childhood-onset DAVF is generally considered to be poor in prognosis, whereas only limited information is available for the onset and long-term outcomes. We herein report a Japanese girl with trisomy 21, large ventricular septal defects, and pulmonary vein stenosis, for which a transcatheter stent had been placed after birth. At age 6 years, she developed bacterial meningitis due to S. pneumoniae, leading to the diagnosis of venous sinus thrombosis and multiple intracranial shunts. Cerebral angiography identified multiple shunts arising from the middle meningeal arteries to the superior sagittal sinus and a concurrent reflux to cortical vein. Endovascular embolization successfully occluded the shunts without neurovascular complications over 24 months. This report first demonstrates the favorable outcome of DAVF in a pediatric patient with trisomy 21 after the catheter intervention. For children at a risk for intracranial thrombosis, preemptive neurovascular evaluation and transcatheter intervention provide a chance of early diagnosis of DAVF to improve their survival and neurologic outcome.

    DOI： 10.1016/j.clineuro.2024.108540

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  • Hemizygous deletion of cyclin-dependent kinase inhibitor 2A/B with p16 immuno-negative and methylthioadenosine phosphorylase retention predicts poor prognosis in IDH-mutant adult glioma

    Otsuji, R; Hata, N; Yamamoto, H; Kuga, D; Hatae, R; Sangatsuda, Y; Fujioka, Y; Noguchi, N; Sako, A; Togao, O; Yoshitake, T; Nakamizo, A; Mizoguchi, M; Yoshimoto, K

    NEURO-ONCOLOGY ADVANCES   6 ( 1 )   vdae069   2024.7   （ eISSN:2632-2498 ）

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    Language：English   Publisher：Neuro-Oncology Advances  

    Background. Homozygous deletion of the tumor suppression genes cyclin‑dependent kinase inhibitor 2A/B (CDKN2A/B) is a strong adverse prognostic factor in IDH‑mutant gliomas, particularly astrocytoma. However, the impact of hemizygous deletion of CDKN2A/B is unknown. Furthermore, the influence of CDKN2A/B status in IDH‑ mutant and 1p/19q‑codeleted oligodendroglioma remains controversial. We examined the impact of CDKN2A/B status classification, including hemizygous deletions, on the prognosis of IDH‑mutant gliomas. Methods. We enrolled 101 adults with IDH‑mutant glioma between December 2002 and November 2021. CDKN2A/B deletion was evaluated with multiplex ligation‑dependent probe amplification (MLPA). Immunohistochemical anal‑ ysis of p16/MTAP and promoter methylation analysis with methylation‑specific MLPA was performed for cases with CDKN2A/B deletion. Kaplan − Meier plots and Cox proportion hazards model analyses were performed to evaluate the impact on overall (OS) and progression‑free survival. Results. Of 101 cases, 12 and 4 were classified as hemizygous and homozygous deletion, respectively. Immunohistochemistry revealed p16‑negative and MTAP retention in cases with hemizygous deletion, whereas homozygous deletions had p16‑negative and MTAP loss. In astrocytoma, OS was shorter in the order of homozy‑ gous deletion, hemizygous deletion, and copy‑neutral groups (median OS: 38.5, 59.5, and 93.1 months, respec‑ tively). Multivariate analysis revealed hazard ratios of 9.30 (P = .0191) and 2.44 (P = .0943) for homozygous and hemizygous deletions, respectively. Conclusions. CDKN2A/B hemizygous deletions exerted a negative impact on OS in astrocytoma. Immunohistochemistry of p16/MTAP can be utilized to validate hemizygous or homozygous deletions in combina‑ tion with conventional molecular diagnosis.

    DOI： 10.1093/noajnl/vdae069

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  • Advantages of 3D High-Resolution Vessel Wall Imaging in a Patient With Blood Blister-Like Aneurysm: A Case Report and Literature Review

    Otsuka, T; Kikuchi, K; Togao, O; Yamashita, K; Takagishi, S; Arimura, K; Nakamizo, A; Ishigami, K

    CUREUS JOURNAL OF MEDICAL SCIENCE   16 ( 4 )   e58376   2024.4   （ ISSN:2168-8184 eISSN:2168-8184 ）

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  • Intellectual function and memory in children with moyamoya disease: relationship between Wechsler Intelligence Scale and Benton Visual Retention Test scores and regional cerebral blood flow

    Karashima, S; Nakamizo, A; Arimura, K; Yoshimoto, K

    JOURNAL OF NEUROSURGERY-PEDIATRICS   33 ( 4 )   301 - 306   2024.4   （ ISSN:1933-0707 eISSN:1933-0715 ）

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    Publisher：Journal of Neurosurgery: Pediatrics  

    OBJECTIVE Intellectual function declines in about 30% of children with moyamoya disease (MMD). Memory function underpins higher order brain function, but the relationship between intellectual function and memory in pediatric MMD patients has not been well studied. This study aimed to investigate correlations between scores on the Wechsler Intelligence Scale for Children (WISC) and the Benton Visual Retention Test (BVRT), a visual memory test that can be administered to children, in children with MMD. Relationships between intellectual function or memory and regional cerebral blood flow (rCBF) have also not been well clarified in pediatric MMD patients. The authors also investigated associations between WISC or BVRT scores and rCBF in various brain regions. METHODS WISC and BVRT scores and rCBF were assessed in 17 children with ischemic-onset MMD before revascularization. Single-photon emission CT with 123I-iodoamphetamine was used to measure rCBF. Relationships between WISC and BVRT scores were evaluated using Spearman's correlation coefficient and multivariate linear regression analysis. Cutoff values were identified for BVRT scores. Sensitivity and specificity were calculated to predict full-scale intelligence quotient (FSIQ) > 85 or ≤ 85. Associations between rCBF and WISC or BVRT scores were evaluated using linear regression analysis. RESULTS BVRT scores were significantly correlated with FSIQ and scores on the Working Memory Index (WMI), Processing Speed Index, and Verbal Comprehension Index (VCI)/Verbal Intelligence Quotient (VIQ) of WISC. Multivariate linear regression revealed that number correct score and number of errors score of BVRT were associated with FSIQ. As cutoff values, a number correct score of 5 and a number of errors score of 8 offered the most reliable predictors of FSIQ > 85 and ≤ 85, respectively. FSIQ correlated positively with rCBF in the right and left hemispheres, right and left ganglia, right and left thalamus, right and left cerebellum, right middle cerebral artery (MCA) territory, pons, and vermis. WMI score was positively associated with rCBF in the right hemisphere, right anterior cerebral artery territory, right MCA territory, right basal ganglia, right and left thalamus, right and left cerebellum, pons, and vermis. CONCLUSIONS BVRT score correlated well with WISC index scores, suggesting that BVRT may be helpful in screening for intellectual impairments in children with MMD. In the MCA territory, basal ganglia, thalamus, cerebellum, pons, and vermis, rCBF associated well with WISC index scores, suggesting that reduced rCBF in relevant brain regions may influence intellectual function.

    DOI： 10.3171/2023.11.PEDS23317

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  • Brain volume measured by synthetic magnetic resonance imaging in adult moyamoya disease correlates with cerebral blood flow and brain function

    Kikuchi, K; Togao, O; Yamashita, K; Isoda, T; Nishimura, A; Arimura, K; Nakamizo, A; Yoshimoto, K; Ishigami, K

    SCIENTIFIC REPORTS   14 ( 1 )   5468   2024.3   （ ISSN:2045-2322 ）

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    Language：English   Publisher：Scientific Reports  

    Moyamoya disease (MMD) is characterized by progressive arterial occlusion, causing chronic hemodynamic impairment, which can reduce brain volume. A novel quantitative technique, synthetic magnetic resonance imaging (SyMRI), can evaluate brain volume. This study aimed to investigate whether brain volume measured with SyMRI correlated with cerebral blood flow (CBF) and brain function in adult MMD. In this retrospective study, 18 adult patients with MMD were included. CBF was measured using iodine-123-N-isopropyl-p-iodoamphetamine single photon emission computed tomography. Cerebrovascular reactivity (CVR) to acetazolamide challenge was also evaluated. Brain function was measured using the Wechsler Adult Intelligence Scales (WAIS)-III/IV and the WAIS-R tests. Gray matter (GM), white matter, and myelin-correlated volumes were evaluated in six areas. Resting CBF was positively correlated with GM fractions in the right anterior cerebral arterial and right middle cerebral arterial (MCA) territories. CVR was positively correlated with GM fraction in the right posterior cerebral arterial (PCA) territory. Full-Scale Intelligence Quotient and Verbal Comprehension Index scores were marginally positively correlated with GM fractions in the left PCA territory. Processing Speed Index score was marginally positively correlated with GM fraction in the right MCA territory. The SyMRI-measured territorial GM fraction correlated with CBF and brain function in patients with MMD.

    DOI： 10.1038/s41598-024-56210-2

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  • Liquid Biopsy for Glioma Using Cell-Free DNA in Cerebrospinal Fluid

    Otsuji, R; Fujioka, Y; Hata, N; Kuga, D; Hatae, R; Sangatsuda, Y; Nakamizo, A; Mizoguchi, M; Yoshimoto, K

    CANCERS   16 ( 5 )   2024.3   （ ISSN:2072-6694 eISSN:2072-6694 ）

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    Language：English   Publisher：Cancers  

    Glioma is one of the most common primary central nervous system (CNS) tumors, and its molecular diagnosis is crucial. However, surgical resection or biopsy is risky when the tumor is located deep in the brain or brainstem. In such cases, a minimally invasive approach to liquid biopsy is beneficial. Cell-free DNA (cfDNA), which directly reflects tumor-specific genetic changes, has attracted attention as a target for liquid biopsy, and blood-based cfDNA monitoring has been demonstrated for other extra-cranial cancers. However, it is still challenging to fully detect CNS tumors derived from cfDNA in the blood, including gliomas, because of the unique structure of the blood–brain barrier. Alternatively, cerebrospinal fluid (CSF) is an ideal source of cfDNA and is expected to contribute significantly to the liquid biopsy of gliomas. Several successful studies have been conducted to detect tumor-specific genetic alterations in cfDNA from CSF using digital PCR and/or next-generation sequencing. This review summarizes the current status of CSF-based cfDNA-targeted liquid biopsy for gliomas. It highlights how the approaches differ from liquid biopsies of other extra-cranial cancers and discusses the current issues and prospects.

    DOI： 10.3390/cancers16051009

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  • Hemifacial Spasm Caused by Vascular Compression of the Anterior Inferior Cerebellar Artery-Posterior Inferior Cerebellar Artery Common Trunk Anomaly at the Cisternal Portion of the Facial Nerve: A Case Report

    HOKAZONO Mariya, SHIMOGAWA Takafumi, NAKAMIZO Akira, YOSHIMOTO Koji

    NMC Case Report Journal   10 ( 0 )   253 - 257   2023.12   （ ISSN:2188-4226 eISSN:21884226 ）

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    Language：English   Publisher：The Japan Neurosurgical Society  

    <p>W report the first case of hemifacial spasm (HFS) caused by vascular compression of the anterior inferior cerebellar artery (AICA) -posterior inferior cerebellar artery (PICA) common trunk anomaly at the cisternal portion of cranial nerve VII (CN VII). A 71-year-old female with a typical right HFS was admitted to our hospital. As per her magnetic resonance (MR) imaging results, no offending arteries were noted around the CN VII root exit zone (REZ). Computed tomography angiography revealed an AICA-PICA common trunk anomaly with a dominant PICA, with the rostral branch of the AICA-PICA common trunk anomaly compressing the CN VII at the cisternal portion. The patient underwent microvascular decompression (MVD), and the HFS disappeared after surgery. The amplitude of the abnormal muscle responses (AMR) disappeared immediately after complete transposition of the offending artery. However, the patient experienced mild transient facial palsy 3 days after MVD which was eventually resolved with the administration of vitamin B12. No HFS recurrence was observed during the 1-year follow-up period. The AICA-PICA common trunk anomaly has been found to cause HFS as it compressed the CN VII at the cisternal portion, and not at the REZ. AMR monitoring might be helpful for cases where the unusual vessel particularly compresses the CN VII.</p>

    DOI： 10.2176/jns-nmc.2023-0125

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  • Memory, Executive, and Intellectual Functions in Adults with Moyamoya Disease. Reviewed International journal

    Maehara N, Nakamizo A, Arimura K, Yoshimoto K

    World Neurosurg   2023.12

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.wneu.2023.09.092.

  • Memory, Executive, and Intellectual Functions in Adults with Moyamoya Disease

    Maehara, N; Nakamizo, A; Arimura, K; Yoshimoto, K

    WORLD NEUROSURGERY   180   E474 - E483   2023.12   （ ISSN:1878-8750 eISSN:1878-8769 ）

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    Language：English   Publisher：World Neurosurgery  

    Objective: Cognitive function can decline in adults with moyamoya disease (MMD). Memory, which is an essential but complex and multifaceted function, underpins executive and intellectual functions. However, the relationship between memory and executive or intellectual functions in adults with MMD has not been well studied. The relationship between memory and cerebral blood flow has also not been elucidated. This study investigated correlations between memory, executive function, and intellectual function, and associations between cerebral blood flow and memory in adults with MMD. Methods: Memory, executive function, and intellectual function were assessed using the Wechsler Memory Scale-Revised (WMS-R), Frontal Assessment Battery (FAB), and Wechsler Adult Intelligence Scale (WAIS) third or fourth edition, respectively, in 31 adults with MMD. Cerebral blood flow was measured with iodine 123I-iodoamphetamine single-photon emission computed tomography. Results: WMS-R scores correlated significantly with total FAB and WAIS scores before and after revascularization. Cerebral blood flow in the left posterior cerebral artery territory correlated positively with WMS-R and WAIS scores pre- and postoperatively. Postoperative cerebrovascular reserves of the right cerebellum, pons, and vermis were positively associated with visual memory, and postoperative cerebrovascular reserve of the pons was also associated with general memory. Conclusions: Memory function correlates with executive and intellectual functions in adults with MMD. The FAB, which requires about 10 min to administer, might be useful to screen for memory dysfunction. Memory might be vulnerable to hypoperfusion in the posterior cerebral artery territory among adults with MMD. Postoperative cerebrovascular reserve might help predict memory dysfunction in adults with MMD.

    DOI： 10.1016/j.wneu.2023.09.092

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  • 前下小脳動脈-後下小脳動脈共通幹の異常による顔面神経脳槽部での血管圧迫によって片側顔面痙攣が生じた症例　症例報告(Hemifacial Spasm Caused by Vascular Compression of the Anterior Inferior Cerebellar Artery-Posterior Inferior Cerebellar Artery Common Trunk Anomaly at the Cisternal Portion of the Facial Nerve: A Case Report)

    Hokazono Mariya, Shimogawa Takafumi, Nakamizo Akira, Yoshimoto Koji

    NMC Case Report Journal   10 ( 1 )   253 - 257   2023.12

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    Language：English   Publisher：(一社)日本脳神経外科学会  

    症例は71歳女性。8年間にわたり右片側顔面痙攣(HFS)の病歴があり、当院に入院となった。当初、痙攣は右上眼輪筋に限れていたが、次第に右顔面全体にみられるようになった。カルバマゼピン投与は無効であり、ボツリヌス毒素注射の効果も一時的であった。術前のMRIで、第VII脳神経の神経根出口領域(root exit zone)周辺に問題となる動脈は認められなかった。CT血管造影で、前下小脳動脈-後下小脳動脈(AICA-PICA)の共通幹に異常が認められ、AICA-PICA共通幹異常の吻側分枝が第VII脳神経を圧迫していた。微小血管減圧術(MVD)を施行したところ、HFSは消失し、原因動脈の転位後に異常筋反応も消失した。MVDの3日後に軽度の一過性顔面神経麻痺がみられたが、ビタミンB12の投与によって消失した。1年間の追跡期間中、HFSの再発は認められなかった。

  • A cavernous sinus dural arteriovenous fistula treated by direct puncture of the superior ophthalmic vein with craniotomy: illustrative case

    Iwaki K., Arimura K., Fukuda S., Takagishi S., Ido K., Kurogi R., Matsumoto K., Nakamizo A., Yoshimoto K.

    Journal of Neurosurgery: Case Lessons   6 ( 20 )   2023.11

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    Language：English   Publisher：Journal of Neurosurgery: Case Lessons  

    BACKGROUND The authors report a case of symptomatic cavernous sinus (CS) dural arteriovenous fistula (dAVF) that was successfully treated using direct puncture of the superior ophthalmic vein (SOV) with craniotomy. CS dAVF is commonly treated using transvenous embolization (TVE), with the most common access route via the inferior petrosal sinus (IPS). However, this route is sometimes unavailable because of an occluded, hypoplastic, aplastic, or tortuous IPS. The SOV is an alternative, albeit tortuous and long, route to the CS; therefore, direct SOV puncture is occasionally performed. Direct SOV puncture is mostly percutaneous; however, in this case, it was difficult because of subcutaneous SOV narrowing. OBSERVATIONS As the patient experienced increased intraocular pressure, decreased vision, and eye movement disorders, CS embolization was performed via direct puncture with a craniotomy because of other access difficulties. LESSONS Several reports have described CS dAVF in patients receiving endovascular treatment via direct SOV puncture using a transorbital approach. However, to the best of the authors’ knowledge, this is the first reported case of a CS dAVF treated using TVE with craniotomy. This approach is useful when the SOV cannot be reached intravenously and its distance from the epidermis is long.

    DOI： 10.3171/CASE23464

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  • A cavernous sinus dural arteriovenous fistula treated by direct puncture of the superior ophthalmic vein with craniotomy: illustrative case. Reviewed International journal

    Iwaki K, Arimura K, Fukuda S, Takagishi S, Ido K, Kurogi R, Matsumoto K, Nakamizo A, Yoshimoto K

    J Neurosurg Case Lessons   6 ( 20 )   2023.11

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.3171/CASE23464.

  • OUTCOME IMPACT OF THE CDKN2A/B HEMI-ZYGOUS DELETION IN IDH-MUTANT ASTROCYTOMA

    Otsuji, R; Hata, N; Yamamoto, H; Kuga, D; Hatae, R; Sangatsuda, Y; Fujioka, Y; Noguchi, N; Nakamizo, A; Mizoguchi, M; Yoshimoto, K

    NEURO-ONCOLOGY   25   2023.11   （ ISSN:1522-8517 eISSN:1523-5866 ）

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  • Percutaneous transluminal angioplasty for persistent primitive hypoglossal artery stenosis: illustrative case. Reviewed International journal

    Iwaki K, Arimura K, Fukuda S, Takagishi S, Kurogi R, Nakamura K, Nakamizo A, Yoshimoto K

    J Neurosurg Case Lessons   6 ( 17 )   2023.10

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.3171/CASE23427.

  • Percutaneous transluminal angioplasty for persistent primitive hypoglossal artery stenosis: illustrative case

    Iwaki K., Arimura K., Fukuda S., Takagishi S., Kurogi R., Nakamura K., Nakamizo A., Yoshimoto K.

    Journal of Neurosurgery: Case Lessons   6 ( 17 )   2023.10

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    Language：English   Publisher：Journal of Neurosurgery: Case Lessons  

    BACKGROUND We report a case of symptomatic, progressive stenosis of a persistent primitive hypoglossal artery (PPHA), which was successfully treated with percutaneous transluminal angioplasty (PTA) of the origin of the PPHA. The PPHA is a type of carotid-basilar anastomosis with an incidence of 0.02% to 0.10%. It originates from the internal carotid artery (ICA), passes through the hypoglossal canal, and merges with the basilar artery. In many cases, the ipsilateral vertebral artery is hypoplastic; therefore, PPHA stenosis causes cerebral infarction in the posterior circulation territory, as in this case. OBSERVATIONS The patient’s right PPHA had severe and progressive stenosis; therefore, he experienced cerebral infarction despite medical treatment. Therefore, PTA for the stenosis was performed, which ceased the recurrence of cerebral infarction and dizziness by improving blood flow in the posterior circulation. LESSONS Several reports have described ICA stenosis accompanied by PPHA or PPHA stenosis in patients receiving endovascular treatments. Almost all cases were nonprogressive, and the treatment procedure was stenting. However, in our case, the PPHA stenosis was progressive, and we performed PTA because the patient experienced resistance to antiplatelet drugs and had poor collateral flow.

    DOI： 10.3171/CASE23427

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  • Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease

    Shirozu, N; Ohgidani, M; Hata, N; Tanaka, S; Inamine, S; Sagata, N; Kimura, T; Inoue, I; Arimura, K; Nakamizo, A; Nishimura, A; Maehara, N; Takagishi, S; Iwaki, K; Nakao, T; Masuda, K; Sakai, Y; Mizoguchi, M; Yoshimoto, K; Kato, TA

    SCIENTIFIC REPORTS   13 ( 1 )   14842   2023.9   （ ISSN:2045-2322 ）

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    Language：English   Publisher：Scientific Reports  

    Angiogenic factors associated with Moyamoya disease (MMD) are overexpressed in M2 polarized microglia in ischemic stroke, suggesting that microglia may be involved in the pathophysiology of MMD; however, existing approaches are not applicable to explore this hypothesis. Herein we applied blood induced microglial-like (iMG) cells. We recruited 25 adult patients with MMD and 24 healthy volunteers. Patients with MMD were subdivided into progressive (N = 7) or stable (N = 18) group whether novel symptoms or radiographic advancement of Suzuki stage within 1 year was observed or not. We produced 3 types of iMG cells; resting, M1-, and M2-induced cells from monocytes, then RNA sequencing followed by GO and KEGG pathway enrichment analysis and qPCR assay were performed. RNA sequencing of M2-induced iMG cells revealed that 600 genes were significantly upregulated (338) or downregulated (262) in patients with MMD. Inflammation and immune-related factors and angiogenesis-related factors were specifically associated with MMD in GO analysis. qPCR for MMP9, VEGFA, and TGFB1 expression validated these findings. This study is the first to demonstrate that M2 microglia may be involved in the angiogenic process of MMD. The iMG technique provides a promising approach to explore the bioactivity of microglia in cerebrovascular diseases.

    DOI： 10.1038/s41598-023-41456-z

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  • Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease. Reviewed International journal

    Shirozu N, Ohgidani M, Hata N, Tanaka S, Inamine S, Sagata N, Kimura T, Inoue I, Arimura K, Nakamizo A, Nishimura A, Maehara N, Takagishi S, Iwaki K, Nakao T, Masuda K, Sakai Y, Mizoguchi M, Yoshimoto K, Kato TA

    Sci Rep   13 ( 1 )   14842   2023.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-023-41456-z.

  • 急速な自然血栓化をきたし親血管閉塞にいたった右内頸動脈海綿静脈洞部大型動脈瘤の1例

    尾辻 亮介, 天野 敏之, 宮松 雄一郎, 原 健太, 徳永 聡, 中溝 玲

    脳卒中の外科   51 ( 4 )   302 - 306   2023.8   （ ISSN:0914-5508 ）

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    Language：Japanese   Publisher：(一社)日本脳卒中の外科学会  

    脳動脈瘤に血栓化が生じることがあるが,親動脈まで血栓が進展し閉塞にいたることはまれである.右内頸動脈海綿静脈洞部大型動脈瘤で内頸動脈偽閉塞をきたした1例を経験した.症例は55歳女性.原発性アルドステロン症に対し通院治療中であった.無症候であったが,頭部MRIで右内頸動脈海綿静脈洞部に大型脳動脈瘤を指摘された.血管撮影,バルーン閉塞試験(BOT)を含めた精査を行った.初回の血管撮影では動脈瘤内に血栓はなかった.BOT後7日目に突然頭痛,嘔吐,右眼痛,右眼瞼下垂をきたした.画像検査の結果,動脈瘤の血栓化と右内頸動脈の血栓による血流遅延および右中大脳動脈領域の梗塞をきたしていた.本例は側副血行路が発達しており,梗塞は血栓による遠位塞栓と考えた.さらなる血栓化と順行性の血流による塞栓症増悪の危険があると評価した.BOTでは対側比で10%程度の脳血流低下の所見であり,浅側頭動脈-中大脳動脈(STA-M4)bypass併用下で頸部内頸動脈結紮術を施行する方針とした.術後,右眼痛,眼瞼下垂は消失し,神経脱落症状はなく,新規梗塞巣もなかった.大型脳動脈瘤による親血管の閉塞はまれであり,原因は不明である.その一因としてBOTによる一時的な内頸動脈遮断が血行動態に変化を生じ血栓形成に影響した可能性がある.(著者抄録)

  • がん関連血栓症に伴う脳主幹動脈閉塞症に対する血栓回収術の特徴と治療成績

    有村 公一, 徳永 聡, 井戸 啓介, 吉田 英紀, 山口 慎也, 亀田 勝治, 高岸 創, 岩城 克馬, 中溝 玲, 吉本 幸司

    The Mt. Fuji Workshop on CVD   40   110 - 114   2023.7   （ ISSN:0289-8438 ）

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    2013年1月～2020年12月に包括的脳卒中センター6施設における血栓回収術(MT)885例のうち、癌関連血栓症(CAT)に伴う脳主幹動脈閉塞症23例(女性74%:年齢中央値77歳)に対するMTの成績について後方視的検討を行った。非CAT群862例(女性49%:年齢中央値79歳)との比較では、女性の割合が有意に多く、発症前の抗凝固薬内服が高く、t-PA静注療法の施行例が少なく、院内発症率が有意に高かった。CAT群は90日後の機能予後および死亡率が不良であったが死因の多くが癌の増悪であり、再開通率や合併症率は非CAT群と有意差は認めなかった。

  • Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression. Reviewed International journal

    Togao O, Obara M, Yamashita K, Kikuchi K, Arimura K, Nishimura A, Nakamizo A, Wada T, Tokunaga C, Mikayama R, Yamashita Y, Hamano H, Van Cauteren M, Ishigami K, Baba S

    Neuroradiology   65 ( 3 )   529 - 538   2023.3

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    DOI： 10.1007/s00234-022-03095-5.

  • Assessment of cerebral perfusion in moyamoya disease with dynamic pseudo-continuous arterial spin labeling using a variable repetition time scheme with optimized background suppression

    Togao, O; Obara, M; Yamashita, K; Kikuchi, K; Arimura, K; Nishimura, A; Nakamizo, A; Wada, T; Tokunaga, C; Mikayama, R; Yamashita, Y; Hamano, H; Van Cauteren, M; Ishigami, K; Baba, S

    NEURORADIOLOGY   65 ( 3 )   529 - 538   2023.3   （ ISSN:0028-3940 eISSN:1432-1920 ）

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    Purpose: Accurate assessment of cerebral perfusion in moyamoya disease is necessary to determine the indication for treatment. We aimed to investigate the usefulness of dynamic PCASL using a variable TR scheme with optimized background suppression in the evaluation of cerebral perfusion in moyamoya disease. Methods: We retrospectively analyzed the images of 24 patients (6 men and 18 women, mean age 31.4 ± 18.2 years) with moyamoya disease; each of whom was imaged with both dynamic PCASL using the variable-TR scheme and 123IMP SPECT with acetazolamide challenge. ASL dynamic data at 10 phases are acquired by changing the LD and PLD. The background suppression timing was optimized for each phase. CBF and ATT were measured with ASL, and CBF and CVR to an acetazolamide challenge were measured with SPECT. Results: A significant moderate correlation was found between the CBF measured by dynamic PCASL and that by SPECT (r = 0.53, P < 0.001). The CBF measured by dynamic PCASL (52.5 ± 13.3 ml/100 mg/min) was significantly higher than that measured by SPECT (43.0 ± 12.6 ml/100 mg/min, P < 0.001). The ATT measured by dynamic PCASL showed a significant correlation with the CVR measured by SPECT (r = 0.44, P < 0.001). ATT was significantly longer in areas where the CVR was impaired (CVR < 18.4%, ATT = 1812 ± 353 ms) than in areas where it was preserved (CVR > 18.4%, ATT = 1301 ± 437 ms, P < 0.001). The ROC analysis showed a moderate accuracy (AUC = 0.807, sensitivity = 87.7%, specificity = 70.4%) when the cutoff value of ATT was set at 1518 ms. Conclusion: Dynamic PCASL using this scheme was found to be useful for assessing cerebral perfusion in moyamoya disease.

    DOI： 10.1007/s00234-022-03095-5

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  • Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography. Reviewed International journal

    Yamashita K, Sugimori H, Nakamizo A, Amano T, Kuwashiro T, Watanabe T, Kawamata K, Furuya K, Harada S, Kamei R, Maehara J, Okada Y, Noguchi T

    Acta Radiol   65 ( 3 )   529 - 538   2023.2

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    DOI： 10.1177/02841851221092895.

  • Liquid biopsy with multiplex ligation-dependent probe amplification targeting cell-free tumor DNA in cerebrospinal fluid from patients with adult diffuse glioma

    Otsuji, R; Fujioka, Y; Hata, N; Kuga, D; Sangatsuda, Y; Takigawa, K; Funakoshi, Y; Sako, A; Yamamoto, H; Nakamizo, A; Mizoguchi, M; Yoshimoto, K

    NEURO-ONCOLOGY ADVANCES   5 ( 1 )   vdac178   2023.1   （ eISSN:2632-2498 ）

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    Background: Copy number alterations (CNAs) are common in diffuse gliomas and have been shown to have diagnostic significance. While liquid biopsy for diffuse glioma has been widely investigated, techniques for detecting CNAs are currently limited to methods such as next-generation sequencing. Multiplex ligation-dependent probe amplification (MLPA) is an established method for copy number analysis in pre-specified loci. In this study, we investigated whether CNAs could be detected by MLPA using patients' cerebrospinal fluid (CSF). Methods: Twenty-five cases of adult diffuse glioma with CNAs were selected. Cell-free DNA (cfDNA) was extracted from the CSF, and DNA sizes and concentrations were recorded. Twelve samples, which had appropriate DNA sizes and concentrations, were subsequently used for analysis. Results: MLPA could be successfully performed in all 12 cases, and the detected CNAs were concordant with those detected using tumor tissues. Cases with epidermal growth factor receptor (EGFR) amplification, combination of gain of chromosome 7 and loss of chromosome 10, platelet-derived growth factor receptor alpha amplification, cyclin-dependent kinase 4 amplification, and cyclin-dependent kinase inhibitor 2A (CDKN2A) homozygous deletion were clearly distinguished from those with normal copy numbers. Moreover, EGFR variant III was accurately detected based on CNA. Conclusions: Thus, our results demonstrate that copy number analysis can be successfully performed by MLPA of cfDNA extracted from the CSF of patients with diffuse glioma.

    DOI： 10.1093/noajnl/vdac178

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  • Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

    Kurogi A., Onozuka D., Hagihara A., Nishimura K., Kada A., Hasegawa M., Higashi T., Kitazono T., Ohta T., Sakai N., Arai H., Miyamoto S., Sakamoto T., Iihara K., Takigami M., Kamiyama K., Houkin K., Nishi S., Kaneko S., Oka K., Nakagaki Y., Ooyama H., Takizawa K., Tokumitsu N., Suzuki S., Suzuki N., Kimura T., Izumi N., Nitta K., Ohtaki M., Isobe M., Nishiya M., Kaijima M., Mabuchi S., Ogasawara K., Kubo N., Shimizu Y., Saito K., Yamanome T., Yabuta A., Yoshino A., Harashina J., Shimoda M., Jimbo H., Murakami H., Masaoka H., Ohtaka H., Yoshida H., Suzuki I., Kohno M., Arai Y., Isoshima A., Hokari M., Kawai K., Maehara T., Kawamata T., Noguchi M., Hoshino H., Hiyama H., Yoshida K., Fujitsuka M., Takeda Y., Karasudani H., Kobayashi S., Nakamura M., Ono J., Suda S., Hadeishi H., Wakui K., Tanno H., Sato N., Sakai H., Matsumoto T., Koketsu N., Nakahara I., Hasegawa T., Kuwayama N., Mizutani N., Suzaki N., Yasui K., Ikeda A., Takeuchi Y., Wakabayashi T., Tanaka H., Yoshimoto J., Koichiro O., Yokoe T., Murao K., Yamada T., Kato A., Wakayama A., Kataoka H., Iwatsuki K., Nakajima Y., Gi H., Uranishi R., Nakamura Y., Yamanaka K., Matsumoto H.

    Scientific Reports   12 ( 1 )   2022.12

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    To determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records, captured during 2013–2016. We compared the influence of mechanical thrombectomy (MT) use, the CSC score, and the total EMS response time on the modified Rankin Scale score at discharge among patients with acute ischemic stroke transported by ambulance, in phases I (2013–2014, 1461 patients) and II (2015–2016, 3259 patients). We used ordinal logistic regression analyses to analyze outcomes. From phase I to II, MTs increased from 2.7 to 5.5%, and full-time endovascular physicians per hospital decreased. The CSC score and EMS response time remained unchanged. In phase I, higher CSC scores were associated with better outcomes (1-point increase, odds ratio [95% confidence interval]: 0.951 [0.915–0.989]) and longer EMS response time was associated with worse outcomes (1-min increase, 1.007 [1.001–1.013]). In phase II, neither influenced the outcomes. During the transitional shortage of thrombectomy-capable hospitals, increasing hospitals with moderate CSC scores may increase nationwide access to MT, improving outcomes.

    DOI： 10.1038/s41598-022-06074-1

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  • 中硬膜動脈塞栓術に続いて施行した開頭術後に生じた慢性硬膜下血腫　1症例報告(Chronic Subdural Hematoma after Craniotomy with Preoperative Embolization of Middle Meningeal Artery: A Case Report)

    Otsuji Ryosuke, Amano Toshiyuki, Matsuo Satoshi, Miyamatsu Yuichiro, Hara Kenta, Tokunaga So, Nakamizo Akira

    NMC Case Report Journal   9 ( 1 )   151 - 155   2022.12

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    症例は56歳男性で、複視を訴えて受診した。MRIで右蝶形骨縁に3cm径の腫瘍を認め、右中硬膜動脈の選択的血管造影でanterior convexity branchからの腫瘍濃染像を認めた。まずトリスアクリルゼラチンマイクロスフィアおよびプラチナコイルを用いて右中硬膜動脈のanterior convexity branchに塞栓術を施行し、翌日に腫瘍の完全切除を施行した。病理診断はgrade IIの蝶形骨縁髄膜腫であった。2ヵ月後、頭痛と左片麻痺を訴え、CTで15mm厚の慢性硬膜下血腫とmidline shiftを認めた。穿頭洗浄ドレナージ術を行った。その結果、頭痛と左片麻痺は速やかに消失した。3ヵ月経過時点で血腫は認めていない。

  • Liquid biopsy with multiplex ligation-dependent probe amplification targeting cell-free tumor DNA in cerebrospinal fluid from patients with adult diffuse glioma. Reviewed International journal

    Otsuji R, Fujioka Y, Hana N, Kuga D, Sangatsuda Y, Takigawa K, Funakoshi Y, Sako A, Yamamoto H, Nakamizo A, Mizoguchi M, Yoshimoito K

    Neurooncol Adv   5 ( 1 )   2022.11

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    DOI： 10.1093/noajnl/vdac178.

  • Discrepancy in the Ki67 labeling index of brain and orbital metastatic lesions from gastrointestinal neuroendocrine tumors: A case report

    Matsuo, S; Amano, T; Miyamatsu, Y; Hayashi, D; Yamashita, S; Momosaki, S; Kawabe, K; Nakamizo, A

    NEUROCIRUGIA   33 ( 6 )   345 - 349   2022.11   （ ISSN:1130-1473 eISSN:2340-6305 ）

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  • Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma

    Nakamizo, A; Miyamatsu, Y; Hirose, H; Amano, T; Matsuo, S; Fujiwara, M; Shimamura, T; Yoshimoto, K

    SCIENTIFIC REPORTS   12 ( 1 )   16277   2022.9   （ ISSN:2045-2322 ）

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    Glioblastoma is the most common brain tumor with dismal outcomes in adults. Metabolic remodeling is now widely acknowledged as a hallmark of cancer cells, but glioblastoma-specific metabolic pathways remain unclear. Here we show, using a large-scale targeted proteomics platform and integrated molecular pathway-level analysis tool, that the de novo pyrimidine synthesis pathway and serine synthesis pathway (SSP) are the major enriched pathways in vivo for patients with glioblastoma. Among the enzymes associated with nucleotide synthesis, RRM1 and NME1 are significantly upregulated in glioblastoma. In the SSP, SHMT2 and PSPH are upregulated but the upstream enzyme PSAT1 is downregulated in glioblastoma. Kaplan–Meier curves of overall survival for the GSE16011 and The Cancer Genome Atlas datasets revealed that high SSP activity correlated with poor outcome. Enzymes relating to the pyrimidine synthesis pathway and SSP might offer therapeutic targets for new glioblastoma treatments.

    DOI： 10.1038/s41598-022-20613-w

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  • Metabolic remodeling of pyrimidine synthesis pathway and serine synthesis pathway in human glioblastoma Reviewed International journal

    Nakamizo A, Miyamatsu Y, Hirose H, Amano T, Matsuo S, Fujiwara M, Shimamura T, Yoshimoto K

    Scientific Reports   2022.9

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  • Five-year changes in cognitive function and their predictor in adult moyamoya disease Reviewed International journal

    Nakamizo A, Amano T, Matsuo S, Miyamatsu Y, Kuwashiro T, Yasaka M, Okada Y, Mizoguchi M, Yoshimoto K

    World Neurosurgery   2022.9

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  • Five-Year Changes in Cognitive Function and Their Predictor in Adult Moyamoya Disease

    Nakamizo, A; Amano, T; Matsuo, S; Miyamatsu, Y; Kuwashiro, T; Yasaka, M; Okada, Y; Mizoguchi, M; Yoshimoto, K

    WORLD NEUROSURGERY   165   E346 - E351   2022.9   （ ISSN:1878-8750 eISSN:1878-8769 ）

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    Objective: The long-term outcomes of cognitive function in moyamoya disease remain unknown. We aimed to assess 5-year changes in cognitive function in adult moyamoya disease patients and to evaluate the value of the magnetic resonance angiography (MRA) steno-occlusive score to predict cognitive changes. Methods: Participants comprised 20 consecutive patients whose cognitive functions had been evaluated using the Frontal Assessment Battery (FAB) and Neurobehavioral Cognitive Status Examination (Cognistat) at baseline and reassessed 5 years later. Results: The total FAB score and total Cognistat score were lower after 5 years in 9 patients each. The Wilcoxon signed-rank test showed that subscores for conceptualization and comprehension increased, while subscores for mental flexibility, programming, and inhibitory control significantly decreased after 5 years. The right MRA total score and right posterior cerebral artery score were negatively associated with 5-year changes in the total FAB score and total Cognistat score. The right posterior cerebral artery score was significantly associated with changes in subscores for mental flexibility, programming, sensitivity to interference, and construction. Conclusions: Specific cognitive domains can decline over time in patients with adult moyamoya disease. MRA findings might be useful for predicting future declines in cognitive function.

    DOI： 10.1016/j.wneu.2022.06.055

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  • Ankle-Brachial Index and Cardio-Ankle Vascular Index as Predictors of Cognitive Decline Over Time After Carotid Endarterectomy

    Miyamatsu, Y; Nakamizo, A; Amano, T; Matsuo, S; Kuwashiro, T; Yasaka, M; Okada, Y; Mizoguchi, M; Yoshimoto, K

    CUREUS JOURNAL OF MEDICAL SCIENCE   14 ( 7 )   e26534   2022.7   （ ISSN:2168-8184 eISSN:2168-8184 ）

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  • Ankle-brachial index and cardio-ankle vascular index as predictors of cognitive decline over time after carotid endarterectomy Reviewed International journal

    Miyamatsu Y, Nakamizo A, Amano T, Matsuo S, Kuwashiro T, Yasaka M, Okada Y, Mizoguchi M, Yoshimoto K

    Cureus   2022.7

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  • Unusual imaging characteristics of cystic meningioma in cerebellopontine angle Reviewed International journal

    Adachi S, Yamashita K, Nakamizo A, Amano T, Momosaki S, Noguchi T

    Neuroradiol J   2022.5

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  • Validity of the γ-Ray evaluation with iodoamphetamine for cerebral blood flow assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test Reviewed International journal

    Miyazaki Y, Kameyama M, Nakamizo A, Noguchi T, Tabata N

    Annals of Nuclear Medicine 36(3):279-284, 2022.   2022.3

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  • アセタゾラミド負荷試験を含めた脳血流量の定量化におけるγ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment(REICA)の有効性(Validity of the γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment(REICA) method for quantification of cerebral blood flow including acetazolamide challenge test)

    Miyazaki Yoshiaki, Kameyama Masashi, Nakamizo Akira, Noguchi Tomoyuki, Tabata Nobuyuki

    Annals of Nuclear Medicine   36 ( 3 )   279 - 284   2022.3   （ ISSN:0914-7187 ）

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    脳血流量の定量化に、SPECTと123I-N-イソプロピル-p-ヨードアンフェタミン(IMP)を用いた、γ-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment(REICA)法の有効性について検討した。Graph-Plot(GP)法と、reference standardには動脈血試料を用いたAutoradiograph(ARG)法を行い、REICA法の精度を評価した。2018年8月～2019年11月までの期間内に、GP法とARG法が同時に行われた血管疾患患者59例(男性22例、女性37例、平均年齢59.7±17.5歳)を調査対象とし、安静時データの取得では、123I-IMP投与後に血液試料を採取した。また、負荷時データの取得では、123I-IMP投与前にアセタゾラミドを静注し、REIKA法で算出された脳血流量数値とGP法ならびにARG法で解析された数値を比較した。その結果、平均脳血流量においては、REICA法とARG法の相関係数が0.792、GP法とARG法の相関係数は0.636であり、脳血管反応性においては、REICA法とARG法の相関係数は0.660、GP法とARG法の相関係数は0.578であることが確認された。これらの結果から、REICA法が脳血流量の定量化において、GP法よりも精度が高くARG法に近い手法と考えられ、123I-IMPを用いた脳血流量の非侵襲的な定量化に有用と判断された。

  • Preoperative prediction of intracranial meningioma grade using conventional CT and MRI Reviewed International journal

    Amano T, Miyamatsu Y, Otsuji R, Nakamizo A, Murata H, Miyamatsu Y, Mugita F, Yamashita K, Noguchi T, Nagata S

    Cureus   2022.1

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  • Chronic subdural hematoma after craniotomy with preoperative embolization of middle meningeal artery: A case report Reviewed International journal

    Otsuji R, Amano T, Matsuo S, Miyamatsu Y, Hara K, Tokunaga S, Nakamizo A

    NMC Case Rep J   2022.1

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  • Efficacy of endoscopic treatment for chronic subdural hematoma surgery. Reviewed International journal

    Amano T, Miyamatsu Y, Otsuji R, Nakamizo A

    Journal of Clinical Neuroscience   92   78 - 84   2021.10

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  • Microsurgical anatomy of the inferior petroclival vein and its relation to surrounding structures: a cadaveric and radiological study. Reviewed International journal

    Matsuo S, Komune N, Amano T, Nakamizo A

    Oper Neurosurg (Hagerstown)   21 ( 2 )   E83 - E88   2021.7

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  • Microsurgical resection of tuberculum sellae meningioma through pterional approach with extradural optic canal unroofing. Reviewed International journal

    Matsuo S, Amano T, Yamashita S, Miyamatsu Y, Nakamizo A

    J Neurol Surg B Skull Base   ( 83 (Suppl 3) )   e635 - e636   2021.5

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    DOI： 10.1055/s-0041-1727148.

  • Carotid ultrasonography predicts collateral development following combined direct and indirect revascularization surgery in adult ischemic Moyamoya disease. Reviewed International journal

    Matsuo S, Amano T, Miyamatsu Y, Yamashita S, Yasaka M, Okada Y, Nakamizo A

    Clinical Neurology and Neurosurgery   2021.4

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    DOI： 10.1016/j.clineuro.2021.106590

  • Neuroimaging recommendations in outpatients with dementia: three cases of frontal meningioma demonstrating reversible dementia. Reviewed International journal

    Matsuo S, Amano T, Miyamatsu Y, Fujioka Y, Nakamizo A

    Cureus   13 ( 3 )   e14028   2021.3

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  • Common carotid flow velocity is associated with cognitive function after carotid endarterectomy Reviewed International journal

    Nakamizo A, Amano T, Kuwashiro T, Yasaka M, Okada Y

    Journal of Clinical Neuroscience   76   53 - 57   2020.6

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  • Impact of antithrombotic therapy on surgical treatment in patients with chronic subdural hematoma． Reviewed International journal

    Amano T, Matsuo S, Miyamatsu Y, Yamashita S, Nakamizo A

    Journal of Clinical Neuroscience   74   55 - 60   2020.4

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  • Surgical anatomy of the donor arteries for extracranial-intracranial bypass surgery: an anatomic and radiologic study. Reviewed International journal

    Matsuo S, Komune N, Akiyama O, Amano T, Nakamizo A

    World Neurosurgery   136   e447 - e459   2020.4

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  • Single loop interrupted suture technique for cerebrovascular anastomosis: Technical note Reviewed International journal

    Matsuo S, Amano T, Nakamizo A

    Journal of Clinical Neuroscience   72   434 - 437   2020.2

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  • Three-Piece Orbitozygomatic Craniotomy: Anatomical and Clinical Findings. Reviewed International journal

    Matsuo S, Komune N, Hayashi D, Amano T, Nakamizo A

    World Neurosurgery   128   106 - 113   2019.8

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  • Impact of Coronary Artery Disease on Long-Term Cognitive Outcome after Carotid Endarterectomy. Reviewed International journal

    Nakamizo A, Amano T, Kuwashiro T, Yasaka M, Okada Y

    Journal of Cardiology and Vascular Medicine   5 ( 105 )   1 - 9   2019.7

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  • Predictors of recurrence and postoperative outcomes in patients with non-skull base　meningiomas based on modern neurosurgical standards. Reviewed International journal

    Michiwaki Y, Hata N, Amano T, Suzuki OS, Akagi Y, Kuga D, Onozuka D, Momosaki S, Nakamizo A, Yoshimoto K, Iwaki T, Iihara K

    Interdisciplinary Neurosurgery   15   30 - 37   2019.3

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  • eGFR and deep white matter hyperintensity as predictors of cognitive decline long after carotid endarterectomy. Reviewed International journal

    Nakamizo A, Amano T, Kuwashiro T, Yasaka M, Okada Y

    Scientific Reports   9 ( 1 )   17855   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-019-54459-6

  • Time-of-flight MRA signal intensity predicts the cerebral hemodynamic status after superficial temporal artery to middle cerebral artery anastomosis. Reviewed International journal

    Matsuo S, Nakamizo A, Fujioka Y, Amano T, Yasaka M, Okada Y, Nagata S

    Journal of Clinical Neuroscience   59   124 - 129   2019.1

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Long-Term Neurocognitive Outcomes in Patients with Adult Moyamoya Disease. Reviewed International journal

    Nakamizo A, Amano T, Michiwaki Y, Kawano Y, Kuwashiro T, Yasaka M, Okada Y

    World Neurosurgery   119   e441 - e448   2018.11

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Surgical outcome in elderly patients with intracranial meningioma. Reviewed International journal

    Amano T, Nakamizo A, Michiwaki Y, Matsuo S, Fujioka Y, Nagata S

    Journal of Clinical Neuroscience   56   63 - 66   2018.10

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    Language：English   Publishing type：Research paper (scientific journal)  

  • Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells. Reviewed International journal

    Kurogi R, Nakamizo A, Suzuki OS, Mizoguchi M, Yoshimoto K, Amano T, Amemiya T, Takagishi S, Iihara K

    Journal of Neurosurgery   130 ( 1 )   44 - 55   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

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Presentations

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Professional Memberships

  • The Japan Neurosurgical SocietyJapan

  • The Japanese Congress of Neurological Surgeons

  • The Japan Stroke Society

  • The Japanese Society on Surgery for Cerebral Stroke

  • Japanese Society of Skull Base Surgery

  • Japanese Society for Neuroendoscopy

  • Cardiovascular Stroke Society of Japan

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Committee Memberships

  • 日本心血管脳卒中学会   Councilor   Domestic

    2022.4 - Present   

  • 日本脳神経外科学会   Councilor   Domestic

    2022.4 - Present   

  • 日本脳卒中学会   Councilor   Domestic

    2022.4 - Present   

Research Projects

  • 膠芽腫の増殖抑制を目的にmicroRNA含有ナノ粒子によるセリン合成経路の新規抑制療 法

    Grant number：23K08501  2023 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    中溝 玲, 有村 公一, 村田 正治, 吉本 幸司, 高岸 創

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    Authorship：Principal investigator  Grant type：Scientific research funding

    ナノパーティクルはセリン合成経路を抑制するmiRの有効なdelivery vehicleとなりうるのかを検証する。1)膠芽腫におけるセリン合成経路のkey enzyme であるPSPHとSHMT2を最も効率的に抑制するmiRの同定、2)膠芽腫に対する指向性を付 与したナノパーティクルに当該miRを組み込んだmiR-ナノパーティクルの開発、3)in vivoでの治療効果の判定(間葉系幹細胞との 比較)、4)当該miRが膠芽腫および周囲の正常脳組織の代謝に及ぼす総体的影響の検討でを行う。

    CiNii Research

  • Elucidation of glioma immune microenvironment heterogeneity based on immunogenomics by liquid biopsy

    Grant number：21H03044  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    溝口 昌弘, 藤岡 寛, 秦 暢宏, 空閑 太亮, 三月田 祐平, 加藤 隆弘, 扇谷 昌宏, 中溝 玲

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    Authorship：Coinvestigator(s)  Grant type：Scientific research funding

    がんゲノム医療時代において、グリオーマにおける最大の障壁が腫瘍のゲノム多様性と特有の微小免疫環境にある。グリオーマに対しても免疫療法が導入されつつあるが、脳という特殊な免疫環境下に発生する生物学的特性より他のがん種とは一線を画した独自の研究展開が求められる。本研究では、従来のctDNA、miRNA、エクソソームを含む細胞外小胞を対象としたリキッドバイオプシーに、新たに末梢血より直接誘導したミクログリア様細胞（iMG）の解析を追加することにより、免疫環境の多様性解明を目指す。また、エクソソームの特性に着目し、腫瘍微小環境形成機序の解明と新たな標的治療法開発へと繋げる。

    CiNii Research

Educational Activities

  • 医学部医学科学生の教育：講義、実習、クリニカルクラークシップ
    大学院医学研究院大学院生の教育：脳神経外科学の基礎および臨床研究
    大学病院スタッフへの教育：脳神経外科学および手術

Class subject

  • 系統講義(II)　神経

    2023.10 - 2024.3   Second semester

  • 系統講義(II)　神経

    2022.10 - 2023.3   Second semester

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Neurosurgery

Clinician qualification

  • Specialist

    The Japan Neurosurgical Society（JNS）

  • Specialist

    The Japan Stroke Society

  • 技術指導医

    日本脳卒中の外科学会

Notable Clinical Activities

  • 脳血管障害全般の直達手術 良性脳腫瘍摘出術