Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takeshi Yokoyama Last modified date:2021.06.28

Professor / Maxillofacial Diagnostic and Surgical Sciences / Department of Dental Science / Faculty of Dental Science

1. @Masanori Tsukamoto, Shiori Taura, Hitoshi Yamanaka, @Takashi Hitosugi, @Takeshi Yokoyama, Prediction of appropriate formula for nasotracheal tube size in developmental disability children, Clin Oral Investig , PMID: 32804259 DOI: 10.1007/s00784-020-03517-9, 25, 4, 2077-2080, 2021.04, Objectives: Developmental disability children have differences in growth. Therefore, tube size selection is important for nasotracheal intubation. In our previous study for healthy children undergoing dental surgery, height was the most suitable factor to predict nasotracheal tube size. The aim of this study was to find the most suitable formula for selection of nasotracheal tube size for them, retrospectively.
Material and methods: Developmental disability children aged 2 to 10 years were included in this study. They were intubated nasotracheally from April 2012 until May 2017. Their actually intubated tube sizes were checked. The predicted tube sizes were calculated according to the formulas by the backgrounds: the diameter of the trachea at the 6th cervical (C6), 7th cervical (C7), and 2nd thoracic vertebrae (T2) in X-ray. The actually intubated tube sizes were compared with predicted sizes. Data were analyzed using Spearman's regression analysis.
Results: The tube sizes with 5.0, 5.5, and 6.0 mm ID were intubated in 75 patients. The age-based formula was the most suitable; the correlation coefficients (r2) were 0.9027 (vs age), 0.5434 (vs height), 0.3779 (vs weight), 0.0785 (vs C6), 0.2279 (vs C7), and 0.3065 (Th2) (p < 0.01). However, 0.5-mm smaller size tubes were more frequently intubated actually. Their correspondence rate to the predicted size was 48% (5.0 mm), 52% (5.5 mm), and 39% (6.0 mm), respectively.
Conclusion: The age-based formula could be the most suitable for predicting nasotracheal tube size in developmental disability children aged 2 to 10 years. One smaller size by the age formula was most suitable at first trial tube.
Clinical relevance: The present data indicate that the selection of nasotracheal tube using one smaller size by the age formula (ID = 4 + age [years]/4) might be useful for developmental disability children.
Keywords: Developmental disability; Nasotracheal airway; Nasotracheal intubation; Tube size..
2. Takeshi Ifuku, Takashi Hitosugi , Yoshfumi Kawakubo, Tomoyuki Tanaka, Kazuto Doi, and Takeshi Yokoyama, Effective Method Using a Stool in Cardiopulmonary Resuscitation (CPR) on Dialysis Chair, Emergency Medicine International,, Volume 2020,, 2020.08, Background. Heart failure is the leading cause of death in dialysis patients. Cardiac arrest due to hypotension may also occur during dialysis therapy. If cardiac arrest is elicited, manual chest compressions (MCCs) should be started as soon as possible. However, all types of dialysis chairs are not stable for MCC, because there is no steady support between the backboard of the
dialysis chair and the floor. 'ese conditions may alter the effectiveness of MCC.
Methods. We investigated whether a round chair is effective in supporting the dialysis chair for MCC. Four adult males performed MCC on a mannequin placed on three dialysis chairs. MCC was performed in sets of 2 (each set was 100 times per minute) per person, with and without a round chair. A total of 4,800 compressions were performed by four executors.
Results. When the chair was not used as a stabilizer, the mean values of the fluctuation range were 20.8 ± 8.1 mm, 18.7 ± 5.5 mm, and 12.8 ± 1.8 mm, respectively. When the chair was used, the mean values of the fluctuation range were 6.1 ± 1.1 mm, 7.5 ± 2.1 mm, and 1.0 ± 0 mm, decreasing by 70%, 59%, and 92%. Conclusion. MCC performed with the stool under the backrest as a stabilizer was effective in supporting the dialysis chair..
3. Mizuno J, Otsuji M, Fukuoka Y, Tanaka Y, Ohishi M, Hata Y, Yokoyama T, Arita, H, Hanaoka K, Hybrid logistic function characterization of left ventricular pressure-time curve in left heart catheterization, Gazzetta Medica Italiana Archivio per le Scienze Mediche, DOI: 10.23736/S0393-3660.19.04036-1, 179, 5, 326-334, 2020.05, BACKGROUND: The left ventricular (LV) pressure-time curve (PTC) during one cardiac cycle in left heart catheterization includes much useful information for evaluating LV inotropism and lusitropism. Nonlinear regression analysis using the least-squares method is a valuable tool for elucidating the mechanism, summarizing information, eliminating noise, allowing speculation regarding unmeasured data, and separating the effects of multiple factors. We proposed that the isovolumic LV PTCs in some animal experiments have been presented with a hybrid logistic (HL) function which is the difference between two sigmoid logistic functions. In the present study, we applied some types of the HL function models for the clinical field and investigated which type of the HL function equation could precisely fit the LV PTCs in the human hearts.
METHODS: The 30 LV PTCs at 1 ms interval during one cardiac cycle in left heart catheterization in 10 patients were recorded and fitted with the four kinds of the HL function equations using the least-squares method;
P(t)=A/{1 + exp[-(4B/A)(t - C)]} - D/{1 + exp[-(4E/D)(t - F)]} + G (Eq. 1),
P(t)=A/{1 + exp[-(4B/A)(t - C)]} - D/{1 + exp[-(4E/D)(t - F)]} (Eq. 2),
P(t)=A/{1 + exp[-(4B/A)(t - C)]} - A/{1 + exp[-(4E/D)(t - F)]} + G (Eq. 3), and
P(t)=A/{1 + exp[- (4B/A)(t - C)]} - A/{1 + exp[-(4E/D)(t - F)]} (Eq. 4).
RESULTS: The mean correlation coefficients (r) of the best-fitted HL function curves with Eqs. 1, 2, 3, and 4 were 0.9983, 0.9977, 0.9979, and 0.9972, respectively. The r value of Eq. 1 was significantly largest among Eqs. 1-4.
CONCLUSIONS: The HL function model with seven parameters precisely fits the LV PTCs in the human hearts. The seven HL function parameters can reliably characterize the LV pressure and time course for evaluation of cardiac inotropism and lusitropism regardless of species.
KEY WORDS: Heart ventricles, pressure; Myocardial contraction; Cardiac catheterization.
4. Masanori Tsukamoto, Hitoshi Yamanaka, Takashi Hitosugi, Takeshi Yokoyama, Endotracheal Tube Migration Associated With Extension During Tracheotomy, Anesth Prog.,, 67, 1, 3-8, 2020.04, Tracheotomy is occasionally performed to prevent postoperative airway obstruction especially for invasive surgical procedures involving head and neck cancer. When performed under general anesthesia, attention must be paid to avoid rupture of the tracheal tube cuff during the incision into the trachea. In this study, changes in the position of the endotracheal tube tip during extension of the head and neck for a tracheotomy were investigated. Twelve patients underwent placement of a tracheotomy during surgical procedures for oral cancer. After nasal intubation, the distance between the tube tip and the carina was measuring using a fiberoptic scope with the patient's head placed at an angle of 110°. Patients were repositioned for tracheotomy by placing a pillow under the shoulders and extending the head and neck at an angle of 140°. The distance measurements were subsequently repeated. The difference between the first and second measurements was calculated and analyzed statistically using a paired t test. On average the patients were 69.5 ± 9.0 years in age. The distance between the tube tip and the carina at an angle of 140° (3.6 ± 1.1 cm) was significantly longer than that at an angle of 110° (1.7 ± 1.0 cm) (p < 0.001). The migration in the positioning of the endotracheal tube tip was 1.9 ± 0.7 cm (range: 0.7–3.7 cm) upon extension. In 3 cases, the tube cuff was ruptured during incision of the trachea. The endotracheal tube tip may migrate in the cephalad direction approximately 2 cm as a result of the extension of the patient's head and neck during a tracheotomy. Therefore, consideration should be given to advancing the endotracheal tube tip towards the caudal side and to confirming the position of the tube and cuff during a tracheotomy..
5. Takunori SHIMAZAKI,Yoshifumi KAWAKUBO, Shinsuke HARA, Takashi HITOSUGI, Takeshi YOKOYAMA, Yoichiro MIKI, Blood Leakage Determination Using the Chromaticity of a Color Sensor, Advanced Biomedical Engineering, DOI:10.14326/abe.8.177, 8, 177-184, Advanced Biomedical Engineering
8: 177–184, 2019., 2019.12.
6. Kitamoto N, Hitosugi T, Kawakubo Y, Hayashi K, Yokoyama T., The measurement of blood pressure by the linear method compared to the deflation methods differently modifies the pulse oximeter alarm frequency., Blood Press Monit. 2020 Feb;25(1):13-17. , doi: 10.1097/MBP.0000000000000408., 25, 1, 13-17, 2019.12, BACKGROUND:
Noninvasive blood-pressure measurement device and pulse oximeter are important for patient monitoring. When these are placed on the same side, cuff inflation sometimes causes measurement failure by pulse oximeter.
The present study aimed to compare the pulse oximeter alarm frequency and pulse-wave disappearance duration between noninvasive blood-pressure measurement using the deflation method and that using the linear inflation method.
The study included 10 healthy subjects. The cuff for automatic sphygmomanometer was wrapped on one side of the upper arm and for pulse oximeter was attached to the thumb of the same side of upper limbs.
The alarm frequency was 0 and 26% using the linear inflation and the deflation methods, respectively. Additionally, the pulse-wave disappearance duration was significantly longer using the deflation method than that using the linear inflation method (10.0 ± 1.5 vs 1.7 ± 0.8 s). With the linear inflation method, this duration was or less 3 s. In the deflation method, an excess pressure of 40 mmHg was used, which caused the alarm to turn on. Additionally, the heart rate was found to influence the alarm occurrence during measurement using the deflation method.
Heart rate may influence alarm occurrence during blood-pressure measurement using the step deflation method. Using the linear inflation method, the risks of alarm occurrence and measurement failure are low, even when the pulse oximeter and blood-pressure measurement cuffs are installed on the same side, suggesting that this method is suitable for clinical use..
7. Tsukamoto M, Taura S, Hitosugi T, Yokoyama T., Comparison of the Performance of Mask Ventilation Between Face Masks With and Without Air Cushion., J Oral Maxillofac Surg. , doi: 10.1016/j.joms.2019.08.025., 77, 12, 2465.e1-2465.e5, 2019.12.
8. Tsukamoto M, Taura S, Yamanaka H, Hitosugi T, Kawakubo Y, Yokoyama T., Age-related effects of three inhalational anesthetics at one minimum alveolar concentration on electroencephalogram waveform., Aging Clin Exp Res. inpress, doi: 10.1007/s40520-019-01378-1., 2019.10, BACKGROUND:
The characteristics of electroencephalogram (EEG) profiles under general anesthesia may depend on age and type of anesthetic.
This study investigated age-related differences in EEG waveforms between three inhalational anesthetics used at the same minimum alveolar concentration (MAC), which indicates the level of analgesia.
Patients with American Society of Anesthesiologists physical status I-II were divided into three groups according to age: pediatric (≦ 15 years); adult (16-64 years); and elderly (≧ 65 years). Each group was divided into three subgroups according to the inhalational anesthetic used: sevoflurane, isoflurane, and desflurane. Anesthesia was maintained at 1 MAC, followed by assessment of 95% spectral edge frequency (SEF95) values and amplitude of EEG waveform.
The 3 age groups comprised a total of 180 patients. The mean (± SD) EEG waveform amplitude and SEF95 values for sevoflurane in the pediatric, adult, and elderly age groups, respectively, were: 32.9 ± 2.9 µV and 16.7 ± 2.4 Hz; 16.4 ± 3.6 µV and 12.2 ± 1.3 Hz; and 11.0 ± 2.1 µV and 13.6 ± 1.6 Hz. EEG waveform amplitude and SEF95 values were significantly higher in the pediatric group than in the other groups. SEF95 value was higher in the elderly group than in the adult group. Similar results were obtained for isoflurane and desflurane.
The amplitude of the EEG waveform and SEF95 values varied with age, even at the same analgesic state in patients under general anesthesia. This age-dependent change in EEG waveform was observed for all three inhalational anesthetics, and should be considered in procedures requiring general anesthesia..
9. Awata N, Hitosugi T, Miki Y, Tsukamoto M, Kawakubo Y, Yokoyama T., Usefulness of a stool to stabilize dental chairs for cardiopulmonary resuscitation (CPR)., BMC Emerg Med., 10.1186/s12873-019-0258-x., 19, 1, 2019.08, BACKGROUND:
Cardiopulmonary resuscitation (CPR) requires immediate start of manual chest compression (MCC) and defibrillation as soon as possible. During dental surgery, CPR could be started in the dental chair considering difficulty to move the patient from the dental chair to the floor. However, all types of dental chairs are not stable for MCC. We previously developed a procedure to stabilize a dental chair by using a stool. EUROPEAN RESUSCITATION COUNCIL (ERC) guideline 2015 adopted our procedure when cardiac arrest during dental surgery. The objective of this study was to verify the efficacy of a stool as a stabilizer in different types of dental chairs.
Three health care providers participated in this study, and 8 kinds of dental chairs were examined. MCC were performed on a manikin that was laid on the backrest of a dental chair. A stool was placed under the backrest to stabilize the dental chair. The vertical displacement of the backrest by MCC was recorded by a camcorder and measured by millimeter. Next, the vertical displacement of the backrest by MCC were compared between with and without a stool.
In all 8 dental chairs, the method by using a stool significantly reduced the vertical displacements of the backrest by during MCC. The reduction ratio (mean [interquartile range]) varied between nearly 27 [20] and 87 [5] %. In the largest stabilization case, the displacement was 3.5 [0.5] mm with a stool versus 26 [5.5] mm without a stool (p <  0.001).
Our procedure to stabilize dental chairs by using a stool reduced the displacement of a backrest against MCC in all chairs.
Effective MCC could be performed in dental chairs by using a stool when sudden cardiac arrest occurs during dental surgery..
10. Masanori Tsukamoto, Takashi Hitosugi, Takeshi Yokoyama, Comparison of recovery in pediatric patients: a retrospective study, Clinical Oral Investigations, 10.1007/s00784-019-02993-y, 2019.07, Objective The recovery after general anesthesia is influenced by the choice of inhalational agent. Stimulations might make patient’s agitate. However, the recovery using no touch technique might be safer. In this study, we compared the recovery time, awakening end-tidal concentration, and respiratory complications among inhalational anesthetics in pediatric patients using no touch technique, retrospectively.
Material and methods The subjectswere pediatric patients aged 3 months to 11 years under general anesthesia using sevoflurane, isoflurane, or desflurane. Background, awakening end-tidal concentration, respiratory complications, the time of eye open, body movement, and extubation were recorded.
Results A total of 170 patients were included in the study. There were no respiratory complications during emergence. Awakening end-tidal concentration in desflurane was 0.98%, sevoflurane (0.39%), and isoflurane (0.25%). In patients received
desflurane, the time of body movement, eye open, and extubation were significantly shorter than patients who received other anesthetics (p < 0.05).
Conclusions The recovery from desflurane was significantly shorter among three inhalational anesthetics with no touch technique. In addition, no airway-related complication occurred.
Clinical relevance The recovery from desflurane might be useful to predict emergence by end-tidal inhalational concentration..
11. Tsukamoto M, Yamanaka H, Yokoyama T., Predicting the appropriate size of the uncuffed nasotracheal tube for pediatric patients: a retrospective study., Clin Oral Investig. , 23, 1, 493-495, 2019.01.
12. Tsukamoto M, Yamanaka H, Yokoyama T., Age-related differences in recovery from inhalational anesthesia: a retrospective study., Aging Clin Exp Res., doi: 10.1007/s40520-018-0924-y., 30, 12, 1523-1527, 2018.12, INTRODUCTION:

It is important to understand the anesthetic requirements of elderly patients. However, little is known about age-related recovery from inhalational anesthetics. In this retrospective study, we compared age-related differences in recovery from three inhalational anesthetics in elderly subjects.

Patients were investigated as three age groups which can be defined as age ranges pediatric (< 15 years), adult (15-64 years), and elderly patients ( > 65 years) under general anesthesia using inhalational anesthetics. Anesthesia and surgery times, drug end-tidal concentrations, the time to first movement, time to eye opening, body movement, extubation, and discharge were recorded. The data were analyzed using a Kruskal-Wallis test and Steel-Dwass multiple comparisons.

A total of 594 patients were included in the study. In inhalational anesthetics such as sevoflurane, isoflurane, or desflurane, recovery from general anesthesia was not significantly different among age groups (P > 0.05). In inhalational group, recovery was significantly 5-40% faster in desflurane group than in other inhalational anesthetics groups (P < 0.05). There were 20% faster recovery in pediatric and adult groups with desflurane than in elderly with desflurane group. Drug end-tidal inhalational concentrations in pediatric group were significantly higher than that in adult and elderly groups of all inhalational anesthetics, respectively (P < 0.05).

In the current study, we have found that recovery from desflurane was faster in younger patients than in other inhalational anesthetics and aged patients..
13. Yamanaka H, Tsukamoto M, Hitosugi T, Yokoyama T., Changes in nasotracheal tube depth in response to head and neck movement in children., Acta Anaesthesiol Scand. , doi: 10.1111/aas.13207. , 62, 10, 1383-1388, 2018.11.
14. Kanako Esaki, Masanori Tsukamoto, Eiji Sakamoto, Takeshi Yokoyama, Effect of preoperative oral carbohydrate therapy on perioperative glucose metabolism during oral–maxillofacial surgery: randomised clinical trial, Asia Pacific Journal of Clinical Nutrition, Asia Pacific Journal of Clinical Nutrition, 2017.11.
15. Masanori Tsukamoto, Jun Hirokawa, T Yokoyama, Intraoperative fluid management in pediatric patients using bioelectrical impedance analysis during oral surgery, Pediatric Anesthesia and Critical Care Journal, 2017.11.
16. Azusa Nakashima, Nakano Hiroyuki, Tomohiro Yamada, Tomoki Sumida, T Yokoyama, Katsuaki Mishima, Yoshihide Mori, The relationship between lateral displacement of the mandible and scoliosis, Journal of Oral and Maxillofacial Surgery, DOI 10.1007/s10006-016-0607-9, in press, 2017.11.
17. I Morita, H Oyama, M Yasuo, M Toyot, Yoshinori Hayashi, T Yokoyama, N Kobayashi, Enantioselective Monoclonal Antibodies for Detecting Ketamine to Crack Down on Illicit Use, Biological and Pharmaceutical Bulletin, in press, 2017.11.
18. Tomokazu Nagasawa, Yoshifumi Kawakubo, Keisuke Hayashi, Masanobu Tsurumoto, Norihisa Kitamoto, Masanori Tsukamoto, Takeshi Yokoyama., Comparing Data Analysis for Hemodynamic Monitoring in the Vigileo and LiDCORapid Models, International Journal of New Technology and Research (IJNTR), 3, 9, 114-120, International Journal of New Technology and Research (IJNTR)
ISSN:2454-4116, Volume-3, Issue-9, September 2017 Pages 114-120, 2017.09, Abstract— Currently, the standard method of cardiac output monitoring is to use a Swan-Ganz catheter. This catheter can lead to complications, and therefore the benefits over risks are being analyzed. In order to have a continuous monitoring of cardiac output or circulatory dynamics in a less invasive form, two different devices were developed. The first device that was developed is the Vigileo monitor (Vigileo) (Edwards Lifesciences corporation, CA, USA) and the second device is the LiDCORapid (Lidcolimited, London, UK). The comparison analysis of the cardiac output was measured between the Vigileo and LiDCORapid. A blood pressure calibrator made by BIO-TEK INSTRUMENTS called BIO-TEK601A was used for the artificial pressure source. Aortic pressure (Ao) and radial artery pressure (Rd) was obtained through the BIO-TEK601A. The CO was displayed from the data that was divided into each model, gender, age and input waveform. For statistical evaluation of the experimental data, Mann-Whitney U-test or Wilcoxon Signed rank sum test were used. The CO results from the Vigileo model were less dependent on the Ao or Rd pressure compared to the LiDCORapid model. The Vigileo was determined to have less variability with CO results compared to the LiDCORapid model..
19. S Sako, S Tokunaga, M Tsukamoto, J Yoshino, N Fujimura, T Yokoyama, Swallowing action immediately before intravenous fentanyl at induction of anesthesia prevents fentanyl-induced cough: a randomized controlled study, Journal of Anesthesia, DOI: 10.1007/s00540-016-2300-4, vol 31, No 2, 212-218, 2017.04.
20. T Yokoyama, Takashi Hitosugi, Saori Koyama, Masanori Tsukamoto, Kanako Esaki, Low-dose carperitide (α-human A-type natriuretic peptide) alleviates hemoglobin concentration decrease during prolonged oral surgery: a randomized controlled study, Journal of Anesthesia, 325-329, 2017.03.
21. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Risk Factors for Postoperative Shivering After Oral and Maxillofacial Surgery, Journal of Oral and Maxillofacial Surgery, 74, 12, 2359-2362, 2016.12.
22. Y Hayashi, S Morinaga, X Liu, J Zang, Wu Z, T Yokoyama, H Nakanishi, An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic Beading through Activation of BK Channels in Mouse Cortical Neurons., Mediators of Inflammation, 2016.11.
23. Masanori Tsukamoto, Takashi Hitosugi, Kanako Esaki, Takeshi Yokoyama, Body composition and hemodynamics changes in special needs patients, J Dent Anesth Pain Med, 16, 3, 193-197, 2016.03.
24. T Yokoyama, S Fujiwara, A Noguchi, U Imaizumi, Y Morimoto, KI Yoshida, S Ito, Masanori Tsukamoto, The effect of adrenaline or noradrenaline with or without lidocaine on the contractile response of lipopolysaccharide-treated rat thoracic aortas, Biomedical Research, 27, 2, 453-457, 2016.02.
25. SJFujiwara, K Tachihara, S Mori, K Ouchi, S Itakura, M Yasuda, Takashi Hitosugi, U Imaizumi, Y Miki, Toyoguchi I, Yoshida KI, T Yokoyama, Influence of the marvelous™ three-way stopcock on the natural frequency and damping coefficient in blood pressure transducer kits., Journal of Clinical Monitoring and Computing, 2016.12.
26. S Fujiwara, K Tachihara, S Mori, K Ouchi, C Yokoe, U Imaizumi, Y Morimoto, Y Miki, I Toyoguchi, KI Yoshida, T Yokoyama, Effect of using a Planecta™ port with a three-way stopcock on the natural frequency of blood pressure transducer kits., J Clin Monit Comput.
27. Fujiwara S, Tachihara K, Mori S, Yamamoto T, Yokoe C, Imaizumi U, Morimoto Y, Miki Y, Toyoguchi I, Yoshida KI, Yokoyama T, Frequency characteristics of pressure transducer kits with inserted pressure-resistant extension tubes., Journal of Clinical Monitoring and Computing, 2017.11.
28. Ju Mizuno, Mikiya Otsuji, Takeshi Yokoyama, Hideko Arita, Kazuo Hanaoka, Half-logistic function model for first half of descending phase of cardiomyocyte cytoplasmic Ca2+ concentration ([Ca2+]i)-time curve(CaTCIII) in isolated Aeqorin-injected mouse left vantricular papillary muscle, Acta Cardiologica Sinica, 32, 1, 65-74, 2016.01.
29. Fujiwara S, Kawakubo, Yokoyama T, Effect of planecta and ROSE™ on the frequency characteristics of blood pressure-transducer kits., Journal of Clinical Monitoring and Computing, 10.1007/s10877-014-9650-y., 29, 6, 681-689, 2015.12.
30. Hiroko Fujino, Shoko Itoda, Kanako Esaki, Masanori Tsukamoto, Saori Sako, Kazuki Matsuo, Eiji Sakamoto, Kunio Suwa, Takeshi Yokoyama, Intra-operative administration of low-dose IV glucose attenuates post-operative insulin resistance, Asia Pac J Clin Nutr , 10.6133/apjcn.2014.23.3.10, 23, 3, 400-407, 2014.09, Background & Aims: Insulin sensitivity often decreases after surgery in spite of normal insulin secretion, and may worsen the outcome. This post-operative insulin resistance increases according to the magnitude of surgical invasion. However, supplementation of carbohydrates before surgery attenuates the post-operative insulin re- sistance. This study aimed to investigate the effect of intra-operative administration of low-dose glucose on the post-operative insulin resistance. Methods: Patients undergoing maxillofacial surgery were randomly assigned to two groups throughout the surgical procedure: The glucose group receiving acetated Ringer solution with 1.5% glucose and the control group receiving acetated Ringer solution without glucose. Insulin resistance quantified by the mean glucose infusion rate (the glucose infusion rate) was evaluated by glucose clamp using the STG-22TM instrument on the previous day and on the next day of surgery. Blood glucose level was monitored continuously during surgery. In addition, serum insulin, ketone bodies and 3-methylhistidine were measured during periopera- tive period. Results: Patients in the glucose group (n=11) received 0.15±0.06 g/kg/h of glucose during surgery, while patients in the control group (n=11) received no glucose. In both groups, however, the mean blood glucose levels were maintained stable at less than 150 mg/dL during and after surgery. The serum ketone bodies signifi- cantly increased after surgery in the control group (p=0.0035), while it decreased significantly in the glucose group (p=0.043). The reduction rate in the glucose infusion rate was significantly lower in the glucose group, 43.320.7%, than that in the control group, 57.79.3% (p=0.041). Conclusions: Intra-operative small-dose of glucose administration may suppress ketogenesis and attenuate the post-operative insulin resistance without caus- ing hyperglycemia..
31. 林 良憲, 古賀由佳, Xinwen Zhang, Christoph Peters, Yuchio Yanagawa, 武 洲, 横山 武志, 中西 博, Autophagy in superficial spinal dorsal horn accelerates the cathepsin B-dependent morphine antinociceptive tolerance., Neuroscience, 10.1016/j.neuroscience.2014.06.037., 275, 384-394, 2014.09, Opioids are the most widely used analgesics in the treatment of severe acute and chronic pain. However, opioids have many adverse side effects, including the development of antinociceptive tolerance after long-term use. The antinociceptive tolerance of opioids has limited their clinical use. A recent study has reported that autophagy is responsible for morphine-induced neuronal injury. However, little is known about the role of autophagy in morphine antinociceptive tolerance. In the present study, chronic morphine administration was found to induce the expression of autophagy-related proteins, including Beclin1 and microtubule-associated protein light chain 3 (LC3)-II, in GABAergic interneurons in the superficial layer (lamina I-II) of the spinal cord. A single intrathecal administration of autophagy inhibitors, 3-methyladenine (3MA) or wortmannin, inhibited the development of antinociceptive tolerance in a dose-dependent manner. Autophagy in the lamina I-II neurons was associated with increased level of cathepsin B (CatB), a lysosomal cysteine protease. The pharmacological blockade or gene deletion of CatB markedly prevented the development of morphine antinociceptive tolerance. Furthermore, the intrathecal administration of 3MA suppressed the upregulation of CatB 5 days after morphine administration. Finally, CatB deficiency inhibited the increased release probability of glutamate in the lamina I neurons after chronic morphine treatment. These observations suggest that the dysfunction of spinal GABAergic system induced by CatB-dependent excessive autophagy is partly responsible for morphine antinociceptive tolerance following chronic treatment..
32. Takeshi Yokoyama, Eiji Sakamoto, Fumiyasu Yamasaki, Koichi Yamashita, Tomoaki Yatabe, KunioSuwa, Remifentanil Has Sufficient Hypnotic and Amnesic Effect for Induction of Anesthesia by Itself, Open Journal of Anesthesiology, 4, 1, 8-12, 2014.01.
33. Mizuno J, Otsuji M, Hanaoka K, Arita H, Yokoyama T, Intracellular Ca2+ transient Phase II can be assessed by half-Logistic function model in isolated aequorin-injected mouse left ventricular papillary muscle., Journal of Acta Cardiologica Sinica, in press, 2013.05.
34. Yamanaka W, Takeshita T, Shibata Y, Matsuo K, Eshima N, Yokoyama T, Yamashita Y., Compositional stability of a salivary bacterial population against supragingival microbiota shift following periodontal therapy., PLoS One. , 2012;7(8):e42806., 2012.08.
35. Hayashi Y, Kawaji K, Sun L, Zhang X, Koyano K, Yokoyama T, Kohsaka S, Inoue K, Nakanishi H., Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain., J Neurosci. , 31, 48, 17370-82, 2011.11.
36. Akihiro Mori, Peter Lee, Takeshi Yokoyama, Hitomi Oda, Kaori Saeki, Yohei Miki, Satoshi Nozawa, Daigo Azakami, Yutaka Momota, Yuki Makino, Takako Matsubara, Motohisa Osaka, Katsumi Ishioka, Toshiro Arai, Toshinori Sako, Evaluation of artificial pancreas technology for continuous blood glucose monitoring in dogs, J Artif Organs, 14, 2, 133-9, 2011.02.
37. Takashi Furuno, Fumiyasu Yamasaki, Takeshi Yokoyama, Kyoko Sato, Takayuki Sato, Yoshinori Doi, Tetsuro Sugiura, Effects of various doses of aspirin on platelet activity and endothelial function, Heart and Vessels, in press, 2010.07.
38. Mizokami A, Tanaka H, Ishibashi H, Umebayashi H, Fukami K, Takenawa T, Nakayama KI, Yokoyama T, Nabekura J, Kanematsu T, Hirata M, GABAA receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice, Journal of Neurochemistry 2010;114:302-10, 2010.05.
39. Akinobu Imoto, Takeshi Yokoyama, Kunio Suwa, Fumiyasu Yamasaki, Tomoaki Yatabe, Reiko Yokoyama, Koichi Yamashita, Eva Sellden, Bolus oral or continuous enteral amino acids reduces hypothermia during anesthesia in rats
, Journal of Nutrition Science Vitaminology, 56, 2, 104-108, 2010.04.
40. Ushida T, Yokoyama T, Kishida Y, Hosokawa M, Taniguchi S, Inoue S, Takemasa R, Suetomi K, Arai Y-CP, McLaughlin M, Tani T, Incidence and risk factors of postoperative delirium in cervical spine surgery, Spine , 34, 23, 2500-2504, 2009.11.
41. Takeshi Yokoyama, Reiko Yokoyama, Satoshi Nomura, Satoshi Matsumoto, Ryoji Fujiyama, Syun-ichi Kiyooka, Synthesis of (S)-Ketamine via [1,3]-Chirality Transfer of a Stereocenter Created by Enantioselective Aldol Reaction, Bull. Chem. Soc. Jpn. , 82, 12, 1528-1532, 2009.09.
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