Kyushu University Academic Staff Educational and Research Activities Database
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Yuji Karashima Last modified date:2020.06.29

Associate Professor / Department of Anesthesiology and Critical Care Medicine
Operating Rooms
Kyushu University Hospital

Other Organization

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Research Interests
  • Antinociceptive effect of GIRK channel activity
    keyword : GIRK channel, pain
  • Development and Application of an Anesthesia Date Warehouse
    keyword : Anesthesia Data Warehouse
  • Basic research on TRP channels and pain
    keyword : TRP channels, pain, anesthetics
Academic Activities
1. TRP channels as novel cellular sensors..
1. Karashima Y, Prenen J, Talavera K, Janssens A, Voets T, Nilius B., Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1., Biophysical Journal, 98, 5, 773-83, 2010.03.
2. Talavera, K., Gees, M., Karashima, Y., Meseguer, V. M., Vanoirbeek, J. A., Damann, N., Everaerts, W., Benoit, M., Janssens, A., Vennekens, R., Viana, F., Nemery, B., Nilius, B., and Voets, T., Nicotine activates the chemosensory cation channel TRPA1, Nature Neuroscience, 2009 Sep 13. [Epub ahead of print], 2009.09, [URL].
3. Karashima, Y., Talavera, K., Everaerts, W., Janssens, A., Kwan, K.Y., Vennekens, R., Nilius, B., & Voets, T., TRPA1 acts as a cold sensor in vitro and in vivo., Proceedings of the National Academy of Sciences of the United States of America, 2009 Jan 27;106(4):1273-8. Epub 2009 Jan 14., 2009.01, [URL].
4. Masuyama, R., Vriens, J., Voets, T., Karashima, Y., Owsianik, G., Vennekens, R., Lieben, L., Torrekens, S., Moermans, K., Vanden Bosch, A., Bouillon, R., Nilius, B., & Carmeliet, G., TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts, Cell Metabolism, 2008 Sep;8(3):257-65., 2008.09, [URL].
5. Karashima, Y., Prenen, J., Meseguer, V., Owsianik, G., Voets, T., & Nilius, B., Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators, Pflügers Archiv, 2008 Oct;457(1):77-89. Epub 2008 May 7., 2008.10, [URL].
6. Meseguer, V., Karashima, Y., Talavera, K., D’Hoedt, D., Donovan-Rodriguez, T., Viana, F., Nilius, B., & Voets, T., Transient receptor potential channels in sensory neurons are targets of the antimycotic agent clotrimazole, The Journal of Neuroscience, 2008 Jan 16;28(3):576-86., 2008.01.
7. Karashima, Y., Damann, N., Prenen, J., Talavera, K., Segal, A., Voets, T., & Nilius, B., Bimodal action of menthol on the transient receptor potential channel TRPA1, The Journal of Neuroscience, 2007 Sep 12;27(37):9874-84., 2007.12, [URL].
8. Hirakawa, M., Karashima, Y., Watanabe, M., Kimura, C., Ito, Y., Oike, M., Protein kinase A inhibits lysophosphatidic acid-induced migration of airway smooth muscle cells, The Journal of Pharmacology and Experimental Therapeutics, Jun;321(3):1102-8. Epub 2007 Mar 8., 2007.06.
9. Karashima, Y., Oike, M., Takahashi, S. & Ito, Y., Propofol prevents endothelial dysfunction induced by glucose overload, British Journal of Pharmacology, 10.1038/sj.bjp.0704912, 137, 5, 683-691, 2002 Nov;137(5):683-91., 2002.11.
10. Hirakawa, M., Oike, M., Karashima, Y., & Ito, Y., Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium, The Journal of Physiology, 10.1113/j.physiol.2004.065334, 558, 2, 479-488, 2004 Jul 15;558(Pt 2):479-88. Epub 2004 May 21., 2004.07.
11. Hirakawa, M., Oike, M., Watanabe, M., Karashima, Y., & Ito, Y., Pivotal role of integrin alpha5beta1 in hypotonic stress-induced responses of human endothelium, The FASEBJ Journal, 2006 Oct;20(12):1992-9., 2006.10.
12. Irita, K., Noda, E., Karashima, Y., Okamoto, H. & Takahashi, S., Tension hemothorax caused by inadvertent insertion of an introducer/dilator into the vertebral artery, Journal of Cardiothoracic and Vascular Anesthesia, 10.1016/S1053-0770(99)90112-X, 13, 2, 241-242, 1999 Apr;13(2):241-2., 1999.04.
Membership in Academic Society
  • Japanese Society of Anesthesiologists
  • Japanese Society of Cardiovascular Anesthesiologists
  • European Society of Anaesthesiology
  • American Society of Anesthesiologists
  • Japan Society for Clinical Anesthesia
  • Japan society of circulation control in medicine
  • Japan Society of Pain Clinicians
  • the Japanese society of Intensive Care Medicine
  • The Japanese Society of Pediatric Anesthesiology
  • Society for Researches on Body Fluid and Metabolism
  • The Japan Society of Transfusion Medicine and Cell Therapy