Kyushu University Academic Staff Educational and Research Activities Database
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Yukio Akasaki Last modified date:2021.08.06





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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/yukio-akasaki
 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Doctor of Medical Science
Field of Specialization
Orthopedic Surgery
Outline Activities
Surgecal and pharmacological treatment for knee joint disorders and rhuematoid arthritis
Research on the pathogenesis and treatment of osteoarthritis
Research on the surgical treatment for knee joint disorders
Research
Research Interests
  • GRK5 inhibition as a new therapeutic target for arthritis
    keyword : GRK5
    2018.04.
  • The anti-inflammtory effects of intra-articularly injected statins on osteoarthritis
    keyword : statins intra-articular osteoarthritis anti-inflammation
    2009.04.
  • Activation of FOXO transcription factor for inhibition of cartilage degradation
    keyword : FOXO transcription factor
    2015.04.
  • Transthyretin and Amyloid deposition in osteoarthritis
    keyword : Amyloid Transthyretin
    2015.04.
Academic Activities
Papers
1. Akasaki Y, Kitade K, Motomura G, Hamai S, Ikemura S, Fujii M, Kawahara S, Nakashima Y., Morphological changes affecting ipsilateral and contralateral leg alignment after total hip arthroplasty, J Orthop, 2020.12.
2. Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Uchida T, Hayashida M, Tsushima H, Bekki H, Lotz MK, Nakashima Y., GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signalling., Arthritis Rheumatol, 2020.04.
3. Goto N, Akasaki Y, Okazaki K, Kuwashima U, Iwasaki K, Kawamura H, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Nakashima Y., The influence of post-operative knee coronal alignment parameters on long-term patient-reported outcomes after closed-wedge high tibial osteotomy., J Orthop, 2020.01.
4. Akasaki Y, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Horikawa T, Nakashima Y., Patient-specific prediction of joint line convergence angle after high tibial osteotomy using a whole-leg radiograph standing on lateral-wedge insole., Knee Surg Sports Traumatol Arthrosc, 2019.12.
5. Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y., FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling., J Biol Chem, 2019.11.
6. Horikawa T, Kubota K, Hara S, Akasaki Y., Distal tuberosity osteotomy in open-wedge high tibial osteotomy does not exacerbate patellofemoral osteoarthritis on arthroscopic evaluation., Knee Surg Sports Traumatol Arthrosc, 2020.06.
7. Yukio Akasaki, Reixach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Yukihide Iwamoto, Buxbaum JN, Lotz MK, Transthyretin deposition in articular cartilage: A novel mechanism in the pathogenesis of osteoarthritis., Arthritis and Rheumatology, 2015.05.
8. Yukio Akasaki, Hiroshi Sugimori, MOMII KENTA, Tomohiko Akahoshi, Matsuura Suguru, Yukihide Iwamoto, Yoshihiko Maehara, Makoto Hashizume, A simple predictive formula for the blood requirement in patients with high-energy blunt injuries transferred within one hour post-trauma., Acute Medicine & Surgery, 2:82-91 2015, 2015.04.
9. Yukio Akasaki, Alvarez-Garcia O, Saito M, Caramés B, Yukihide Iwamoto, Lotz MK, FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes., Arthritis and Rheumatology, 66(12):3349-3358, 2014, 2014.12.
10. Yukio Akasaki, Hasegawa A, Saito M, Asahara H, Yukihide Iwamoto, Lotz MK, Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis., Osteoarthritis and Cartilage, 22(1):162-170, 2014, 2014.01.
11. Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Miura H, Iwamoto Y, Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation, Osteoarthritis and Cartilage. , 2009 17:235-43, 2009.02.
12. Akasaki Y, Matsuda S, Shimoto T, Miura H, Higaki H, Iwamoto Y, Contact stress analysis of the conforming post-cam mechanism in posterior-stabilized total knee arthroplasty, Journal of Arthroplasty, 2008 23:736-43, 2008.08.
13. Akasaki Y, Matsuda S, Miura H, Okazaki K, Moro-Oka TA, Mizu-Uchi H, Iwamoto Y, Total knee arthroplasty following failed high tibial osteotomy: mid-term comparison of posterior cruciate-retaining versus posterior stabilized prosthesis, Knee Surgery Sports Traumatology Arthroscopy, 2009.05.
Presentations
1. Takuya Sueishi, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Masakazu Toya, Masanari Kuwahara, Yasuharu Nakashima, The regulation of cartilage degradation by GRK-5 during osteoarthritis development, Orthopaedic Research Society 2019 Annual Meeting, 2019.02.
2. Yukio Akasaki, Martin K. Lotz, Tokio Matsuzaki, Oscar Alvarez-Garcia, KEN OKAZAKI, Yasuharu Nakashima, Transthyretin and Amyloid deposition in Osteoarthritis, The ORS 2017 Annual Meeting , 2017.03.
3. Yukio Akasaki, Alvarez-Garcia O, Reixach N, Buxbaum JN, Yukihide Iwamoto, Lotz MK, Transthyretin and amyloid in cartilage aging and osteoarthritis, The 2015 Osteoarthritis Research Society International (OARSI) World Congress, 2015.04.
4. Yukio Akasaki, Reixach N, Alvarez-Garcia O, Olmer M, Yukihide Iwamoto, Buxbaum J, Lotz MK, Transthyretin and Amyloid in Cartilage Aging and Osteoarthritis., The 2014 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting. , 2014.11.
5. Yukio Akasaki, Lotz M, Downregulated Forkhead-Box Class O Transcription Factors Attenuate Oxidative Stress Resistance In Human Chondrocytes., The 2013 American College of Rheumatology/Association of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting, 2013.10.
6. Yukio Akasaki, Liu-Bryan R, Terkeltaub R, Lotz M, Dysregulated FOXO Transcription Factors in Articular Cartilage in Aging and Osteoarthritis., The 2013 Osteoarthritis Research Society International (OARSI) World Congress, 2013.04.
7. Yukio Akasaki, Matsuda S, Kawahara S, Yukihide Iwamoto, Inhibition of geranylgeranylation reduces MCP-1 production in IL-1β-stimulated human synoviocytes., The 2012 Annual Meeting of the Orthopaedic Research Society, 2012.02.
8. Akasaki Y, Matsuda S, Nakayama K, Mizu-uchi H, Fukagawa S, Iwamoto Y., Statin induces chondrogenic differentiation in bone marrow stromal cells., 53th Annual Meeting of the Orthopaedic Research Society, 2007.02.
9. Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Hiroaki Mitsuyasu, Miura H, Iwamoto Y., Statin prevents cartilage degradation and synovial inflammation in experimental osteoarthritis., 54th Annual Meeting of the Orthopaedic Research Society., 2008.03.
10. Yukio Akasaki, Shuichi Matsuda, Nakayama K, Fukagawa S, Mitsuyasu H, Hiromasa Miura, Yukihide Iwamoto, The Effect of Intra-articularly Injected Statin on Cartilage Degradation and Synovial Inflammation in Experimental Osteoarthritis., The 7th Biennial ISAKOS Congress, 2009.04.
11. Yukio Akasaki, Shuichi Matsuda, Koichi Nakayama, Shingo Fukagawa, Hiromasa Miura, Yukihide Iwamoto , Statins prevent production of monocyte chemoattractant protein-1 and matrix-metalloproteinase-3 in IL-1β stimulated synoviocytes through inhibition of protein isoprenylation
, 55th Annual Meeting of the Orthopaedic Research Society, 2009.02.