Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Yukio Akasaki Last modified date:2022.05.31

Lecturer / Orthopedic Surgery / Kyushu University Hospital

1. Kuwahara M, Akasaki Y, Kurakazu I, Sueishi T, Toya M, Uchida T, Tsutsui T, Hirose R, Tsushima H, Teramura T, Nakashima Y., C10orf10/DEPP activates mitochondrial autophagy and maintains chondrocyte viability in the pathogenesis of osteoarthritis, FASEB J., 2021.05.
2. Soejima Y, Akasaki Y, Hamai S, Tsushima H, Kawahara S, Nakashima Y., Transverse osteotomy closer to tibial plateau is associated with larger postoperative change in valgus laxity after open-wedge high tibial osteotomy, Knee Surg Sports Traumatol Arthrosc., 2021.05.
3. Kurakazu I, Akasaki Y, Tsushima H, Sueishi T, Toya M, Kuwahara M, Uchida T, Lotz M K, Nakashima Y., TGFβ1 signaling protects chondrocytes against oxidative stress via FOXO1–autophagy axis., Osteoarthritis and Cartilage, 2021.05.
4. Takakura K, Akasaki Y, Kuramoto T, Onizuka Y, Hattori A, Hamai S, Tsushima H, Kawahara S, Nakashima Y, Kato T., Angular accuracy of plain radiographic measurements in leg alignment: Teleoroentgenogram versus orthoroentgenogram, J Orthop Sci., 2021.05.
5. Toya M, Akasaki Y, Sueishi T, Kurakazu I, Kuwahara M, Uchida T, Tsutsui T, Tsushima H, Yamada H, Lotz MK, Nakashima Y., G protein-coupled receptor kinase 5 deletion suppresses synovial inflammation in a murine model of collagen antibody-induced arthritis, Scientific Reports, 2021.05.
6. Ikemura S, Hagio S, Akasaki Y, Fujiwara T, Tsushima H, Nakashima Y., Frequency and risk factor analyses of bone erosion of the distal interphalangeal joint in patients with rheumatoid arthritis: a cross-sectional study, Acta Reumatol Port., 2021.05.
7. Sakuragi T, Yamada H, Haraguchi A, Kai K, Fukushi JI, Ikemura S, Akasaki Y, Fujiwara T, Tsushima H, Tsutsui T, Kondo M, Yoshikai Y, Okada S, Nakashima Y., Autoreactivity of Peripheral Helper T Cells in the Joints of Rheumatoid Arthritis, J Immunol., 2021.05.
8. Kuwashima U, Iwasaki K, Kurakazu I, Akasaki Y, Nakashima Y, Itoh M, Itou J, Okazaki K., Effect of osteoarthritis severity on survival and clinical outcomes after high tibial osteotomy, Knee, 2021.03.
9. Teng Y, Mizu-Uchi H, Xia Y, Akasaki Y, Akiyama T, Kawahara S, Nakashima Y., Axial But Not Sagittal Hinge Axis Affects Posterior Tibial Slope in Medial Open-wedge High Tibial Osteotomy: A Three-dimensional Surgical Simulation Study, Arthroscopy, 2021.02.
10. Akasaki Y, Kitade K, Motomura G, Hamai S, Ikemura S, Fujii M, Kawahara S, Nakashima Y., Morphological changes affecting ipsilateral and contralateral leg alignment after total hip arthroplasty, J Orthop, 2020.12.
11. Fujiwara T, Tokuda K, Momii K, Shiomoto K, Tsushima H, Akasaki Y, Ikemura S, Fukushi JI, Maki J, Kaku N, Akahoshi T, Taguchi T, Nakashima Y., Prognostic factors for the short-term mortality of patients with rheumatoid arthritis admitted to intensive care units, BMC Rheumatol, 2020.12.
12. Kawahara S, Mawatari T, Matsui G, Mizu-Uchi H, Hamai S, Akasaki Y, Tsushima H, Nakashima Y., Malrotation of whole-leg radiograph less than 10 degrees does not influence preoperative planning in open-wedge high tibial osteotomy, J Orthop Res, 2020.09.
13. Yoshimoto K, Fukushi JI, Tsushima H, Kamura S, Miyahara HA, Mizu-Uchi H, Akasaki Y, Nakashima Y., Does Preparation of the Subtalar Joint for Primary Union Affect Clinical Outcome in Patients Undergoing Intramedullary Nail for Rheumatoid Arthritis of the Hindfoot and Ankle?, J Foot Ankle Surg. 59(5):984-987. 2020, 2020.04.
14. Sueishi T, Akasaki Y, Goto N, Kurakazu I, Toya M, Kuwahara M, Uchida T, Hayashida M, Tsushima H, Bekki H, Lotz MK, Nakashima Y., GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signalling., Arthritis Rheumatol, 2020.04.
15. Goto N, Akasaki Y, Okazaki K, Kuwashima U, Iwasaki K, Kawamura H, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Nakashima Y., The influence of post-operative knee coronal alignment parameters on long-term patient-reported outcomes after closed-wedge high tibial osteotomy., J Orthop, 2020.01.
16. Akasaki Y, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Horikawa T, Nakashima Y., Patient-specific prediction of joint line convergence angle after high tibial osteotomy using a whole-leg radiograph standing on lateral-wedge insole., Knee Surg Sports Traumatol Arthrosc, 2019.12.
17. Kurakazu I, Akasaki Y, Hayashida M, Tsushima H, Goto N, Sueishi T, Toya M, Kuwahara M, Okazaki K, Duffy T, Lotz MK, Nakashima Y., FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling., J Biol Chem, 2019.11.
18. Horikawa T, Kubota K, Hara S, Akasaki Y., Distal tuberosity osteotomy in open-wedge high tibial osteotomy does not exacerbate patellofemoral osteoarthritis on arthroscopic evaluation., Knee Surg Sports Traumatol Arthrosc, 2020.06.
19. Kuwashima U, Okazaki K, Iwasaki K, Akasaki Y, Kawamura H, Mizu-Uchi H, Hamai S, Nakashima Y., Patient reported outcomes after high tibial osteotomy show comparable results at different ages in the mid-term to long-term follow-up., J Orthop Sci. 2019 Jan 11., 2018.12.
20. Goto N, Okazaki K, Akiyama T, Akasaki Y, Mizu-Uchi H, Hamai S, Nakamura S, Nakashima Y., Alignment factors affecting the medial meniscus extrusion increases the risk of osteoarthritis development., Knee Surg Sports Traumatol Arthrosc. 2018 Nov 19., 2018.12.
21. Ushio T, Okazaki K, Osaki K, Takayama Y, Sagiyama K, Mizu-Uchi H, Hamai S, Akasaki Y, Honda H, Nakashima Y., Degenerative changes in cartilage likely occur in the medial compartment after anterior cruciate ligament reconstruction., Knee Surg Sports Traumatol Arthrosc. 2019 Mar 16., 2018.12.
22. Matsushita Y, Hamai S, Okazaki K, Murakami K, Ma Y, Kiyohara M, Mizu-Uchi H, Akasaki Y, Nakashima Y., Recreational sports, workout and gym activities after total knee arthroplasty: Asian cohort study., J Orthop. 16(1):41-44. 2018, 2018.12.
23. Ushio T, Mizu-Uchi H, Okazaki K, Miyama K, Akasaki Y, Ma Y, Nakashima Y., Medial soft tissue contracture does not always exist in varus osteoarthritis knees in total knee arthroplasty., Knee Surg Sports Traumatol Arthrosc. 2019 May;27(5):1642-1650., 2018.12.
24. Ma Y, Mizu-Uchi H, Ushio T, Hamai S, Akasaki Y, Murakami K, Nakashima Y., Bony landmarks with tibial cutting surface are useful to avoid rotational mismatch in total knee arthroplasty., Knee Surg Sports Traumatol Arthrosc. 2019 May;27(5):1570-1579., 2018.12.
25. Murakami K, Hamai S, Okazaki K, Gondo H, Wang Y, Ikebe S, Higaki H, Shimoto T, Mizu-Uchi H, Akasaki Y, Nakashima Y., Knee kinematics in bi-cruciate stabilized total knee arthroplasty during squatting and stair-climbing activities., J Orthop. 15(2):650-654. 2018, 2018.12.
26. Murakami K, Hamai S, Okazaki K, Wang Y, Ikebe S, Higaki H, Shimoto T, Mizu-Uchi H, Akasaki Y, Nakashima Y., In vivo kinematics of gait in posterior-stabilized and bicruciate-stabilized total knee arthroplasties using image-matching techniques., Int Orthop. 42(11):2573-2581. 2018, 2018.12.
27. Matsuzaki T, Alvarez-Garcia O, Mokuda S, Nagira K, Olmer M, Gamini R, Miyata K, Akasaki Y, Su AI, Asahara H, Lotz MK., FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis., Sci Transl Med. 14;10(428). 2018, 2018.03.
28. Ma Y, Mizu-Uchi H, Okazaki K, Ushio T, Murakami K, Hamai S, Akasaki Y, Nakashima Y., Effects of tibial baseplate shape on rotational alignment in total knee arthroplasty: three-dimensional surgical simulation using osteoarthritis knees., Arch Orthop Trauma Surg. 138(1):105-114. 2018, 2018.01.
29. Ushio T, Okazaki K, Mizu-Uchi H, Hamai S, Akasaki Y, Nakashima Y., Anterior cruciate ligament reconstruction in a patient who has received systemic steroids for autoimmune disease., Asia Pac J Sports Med Arthrosc Rehabil Technol. 5;11:12-14. 2017, 2017.06.
30. Yamada H, Haraguchi A, Sakuraba K, Okazaki K, Fukushi JI, Mizu-Uchi H, Akasaki Y, Esaki Y, Kamura S, Fujimura K, Kondo M, Miyahara H, Nakashima Y, Yoshikai Y., Th1 is the predominant helper T cell subset that produces GM-CSF in the joint of rheumatoid arthritis., RMD Open. 13;3(1):e000487. 2017, 2017.06.
31. Matsuzaki T, Akasaki Y, Olmer M, Alvarez-Garcia O, Reixach N, Buxbaum JN, Lotz MK., Transthyretin deposition promotes progression of osteoarthritis., Aging Cell. 16(6):1313-1322. 2017, 2017.06.
32. Kuwashima U, Mizu-Uchi H, Okazaki K, Hamai S, Akasaki Y, Murakami K, Nakashima Y., Three-dimensional analysis of accuracy of patient-matched instrumentation in total knee arthroplasty: Evaluation of intraoperative techniques and postoperative alignment., J Orthop Sci. 22(6):1077-1083. 2017, 2017.06.
33. Goto N, Okazaki K, Akasaki Y, Ishihara K, Murakami K, Koyano K, Ayukawa Y, Yasunami N, Masuzaki T, Nakashima Y., A single intra-articular injection of fluvastatin-PLGA microspheres reduces cartilage degradation in rabbits with experimental osteoarthritis., J Orthop Res. 35(11):2465-2475. 2017, 2017.06.
34. Haraguchi A, Nakashima Y, Miyahara H, Esaki Y, Okazaki K, Fukushi JI, Hirata G, Ikemura S, Kamura S, Sakuraba K, Fujimura K, Akasaki Y, Yamada H., Minimum 10-year results of cementless total hip arthroplasty in patients with rheumatoid arthritis., Mod Rheumatol. 27(4):598-604. 2017, 2017.04.
35. Ishihara K, Okazaki K, Akiyama T, Yukio Akasaki, Yasuharu Nakashima, Characterisation of osteophytes as an autologous bone graft source: An experimental study in vivo and in vitro., Bone Joint Res, 2017.02.
36. Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Yukio Akasaki, Matsukawa T, Saito M, Neo M, Marmorstein LY, Lotz MK, Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage., Arthritis and Rheumatology, 2017.01.
37. Hamai S, Okazaki K, Ikebe S, Murakami K, Higaki H, Nakahara H, Shimoto T, Mizu-Uchi H, Yukio Akasaki, Yukihide Iwamoto, In Vivo Kinematics of Healthy and Osteoarthritic Knees During Stepping Using Density-Based Image-Matching Techniques., J Appl Biomech, 2016.03.
38. Kuwashima U, Hamai S, Okazaki K, Ikebe S, Higaki H, Mizu-Uchi H, Yukio Akasaki, Murakami K, Yukihide Iwamoto, Contact stress analysis of the anterior tibial post in bi-cruciate stabilized and mobile-bearing posterior stabilized total knee arthroplasty designs., J Mech Behav Biomed Mater, 2016.03.
39. Jun-ichi Fukushi, Yasuharu Nakashima, Okazaki K, Yamada H, Mawatari T, Ohishi M, Oyamada A, Yukio Akasaki, Yukihide Iwamoto, Outcome of Joint-Preserving Arthroplasty for Rheumatoid Forefoot Deformities., Foot & Ankle International, 2016.03.
40. Yasuharu Nakashima, Ohishi M, Okazaki K, Jun-ichi Fukushi, Oyamada A, Hara D, Doi T, Yukio Akasaki, Yamada H, Yukihide Iwamoto, Delayed diagnosis of ankylosing spondylitis in a Japanese population., Modern Rheumatology, 2016.01.
41. Alvarez-Garcia O, Olmer M, Akagi R, Yukio Akasaki, Fisch KM, Shen T, Su AI, Lotz MK, Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy., Osteoarthritis and Cartilage, 2016.04.
42. Yukio Akasaki, Reixach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Yukihide Iwamoto, Buxbaum JN, Lotz MK, Transthyretin deposition in articular cartilage: A novel mechanism in the pathogenesis of osteoarthritis., Arthritis and Rheumatology, 2015.05.
43. Yukio Akasaki, Hiroshi Sugimori, MOMII KENTA, Tomohiko Akahoshi, Matsuura Suguru, Yukihide Iwamoto, Yoshihiko Maehara, Makoto Hashizume, A simple predictive formula for the blood requirement in patients with high-energy blunt injuries transferred within one hour post-trauma., Acute Medicine & Surgery, 2:82-91 2015, 2015.04.
44. Yukio Akasaki, Alvarez-Garcia O, Saito M, Caramés B, Yukihide Iwamoto, Lotz MK, FoxO Transcription Factors Support Oxidative Stress Resistance in Human Chondrocytes., Arthritis and Rheumatology, 66(12):3349-3358, 2014, 2014.12.
45. Yukio Akasaki, Hasegawa A, Saito M, Asahara H, Yukihide Iwamoto, Lotz MK, Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis., Osteoarthritis and Cartilage, 22(1):162-170, 2014, 2014.01.
46. Caramés B, Kiosses WB, Yukio Akasaki, Brinson DC, Eap W, Koziol J, Lotz MK, Glucosamine activates autophagy in vitro and in vivo., Arthritis and Rheumatology, 65(7):1843-52, 2013, 2013.06.
47. Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Miura H, Iwamoto Y, Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation, Osteoarthritis and Cartilage. , 2009 17:235-43, 2009.02.
48. Akasaki Y, Matsuda S, Shimoto T, Miura H, Higaki H, Iwamoto Y, Contact stress analysis of the conforming post-cam mechanism in posterior-stabilized total knee arthroplasty, Journal of Arthroplasty, 2008 23:736-43, 2008.08.
49. Akasaki Y, Matsuda S, Miura H, Okazaki K, Moro-Oka TA, Mizu-Uchi H, Iwamoto Y, Total knee arthroplasty following failed high tibial osteotomy: mid-term comparison of posterior cruciate-retaining versus posterior stabilized prosthesis, Knee Surgery Sports Traumatology Arthroscopy, 2009.05.