Kyushu University Academic Staff Educational and Research Activities Database
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Toshiharu Ninomiya Last modified date:2021.06.15

Professor / Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
Department of Basic Medicine
Faculty of Medical Sciences


Other Organization


Homepage
https://kyushu-u.pure.elsevier.com/en/persons/toshiharu-ninomiya
 Reseacher Profiling Tool Kyushu University Pure
Phone
092-642-6151
Academic Degree
Ph.D. (Dr. of Medical Science) Faculty of Medicine, Kyushu University
Country of degree conferring institution (Overseas)
Yes Doctor
Field of Specialization
Epidemiology, Public health, Nephrology
Total Priod of education and research career in the foreign country
04years00months
Research
Research Interests
  • Epidemiology for dementia
    keyword : Dementia
    2010.09.
  • The identification of risk factors for cardiovascular disease
    keyword : Cardiovascular disease
    2010.09.
  • Epidemiology for diabetic nephropathy
    keyword : Diabetic nephropathy
    2010.05~2012.03.
  • Chronic kidney disease and Cardiovascular disease
    keyword : Chronic kidney disease
    2010.09.
Academic Activities
Books
1. Perkovic V, Ninomiya T, MacMahon S, Chalmers J., Renal and microalbuminuria data from ADVANCE: Role of Macro and Microcirculation in Target Organ Damage in Diabetes and Hypertension. , Chapter 9 Editors: Lévy BI and Struijker-Houdier HAJ Publishers : Wiley-Blackwell, Wiley and Sons, Oxford, UK, 2009., 2009.01.
Reports
1. Ninomiya T, Risk of stroke in kidney disease, Contrib Nephrol 179: 58-66, 2013, 2013.05.
2. Ninomiya T, Kiyohara Y., Albuminuria and chronic kidney disease in association with the metabolic syndrome., J Cardiometab Syndr 2: 104-107, 2007, 2007.02.
Papers
1. Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, Kanba S, Iwaki T, Kiyohara Y., Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly: The Hisayama Study., Hypertension, 58, 22-28, 2011.07.
2. van der Velde M, Matsushita K, Coresh J, Astor BC, Woodward M, Levey A, de Jong P, Gansevoort RT; the Chronic Kidney Disease Prognosis Consortium, van der Velde M, Matsushita K, Coresh J, Astor BC, Woodward M, Levey AS, de Jong PE, Gansevoort RT, Levey A, El-Nahas M, Eckardt KU, Kasiske BL, Ninomiya T, et al., Lower estimated glomerular filtration rate and higher albuminuria are associated with all-cause and cardiovascular mortality. A collaborative meta-analysis of high-risk population cohorts., Kidney Int, 79, 1341-1352, 2011.06.
3. Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y., Apolipoprotein Genotype for Prediction of Alzheimer’s Disease in Older Japanese: The Hisayama Study., J Am Geriatr Soc, 59, 1074-1079, 2011.06.
4. Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y., Albuminuria as a Risk Factor for Peripheral Arterial Disease in a General Population., J Atheroscler Thromb, 18, 705-712, 2011.05.
5. Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, Jong PE, Coresh J; The Chronic Kidney Disease Prognosis Consortium, Gansevoort RT, Matsushita K, van der Velde M, Astor BC, Woodward M, Levey AS, de Jong PE, Coresh J, El-Nahas M, Eckardt KU, Kasiske BL, Ninomiya T, Chalmers J, et al., Lower estimated GFR and higher albuminuria are associated with adverse kidney outcomes in both general and high-risk populations. A collaborative meta-analysis of general and high-risk population cohorts., Kidney Int, (in press), 2011.01.
6. Czernichow S, Zanchetti A, Turnbull F, Barzi F, Ninomiya T, Kengne AP, Lambers Heerspink HJ, Perkovic V, Huxley R, Arima H, Patel A, Chalmers J, Woodward M, Macmahon S, Neal B; on behalf of the Blood Pressure Lowering Treatment Trialists? Collaboration., The effects of blood pressure reduction and of different blood pressure-lowering regimens on major cardiovascular events according to baseline blood pressure: meta-analysis of randomized trials., J Hypertens, 29, 40649, 2011.01.
7. Zoungas S, Patel A, Chalmers J, de Galan BE, Li Q, Billot L, Woodward M, Ninomiya T, Neal B, MacMahon S, Grobbee DE, Kengne AP, Marre M, Heller S; ADVANCE Collaborative Group., Severe hypoglycemia and risks of vascular events and death., N Engl J Med, 363, 1410-1418, 2010.01.
8. Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y., Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study., Acta Psychiatr Scand, 122, 319-325, 2010.01.
9. Ninomiya T, Zoungas S, Neal B, Woodward M, Patel A, Perkovic V, Cass A, Cooper M, Grobbee D, Hamet P, Harrap S, Liu L, Mancia G, Mogensen CE, Poulter N, Rodgers A, Williams B, MacMahon S, Chalmers J; ADVANCE Collaborative Group., Efficacy and safety of routine blood pressure lowering in older patients with diabetes: results from the ADVANCE trial., J Hypertens, 28, 1141-1149, 2010.01.
10. Nakano T, Ninomiya T, Sumiyoshi S, Fujii H, Doi Y, Hirakata H, Tsuruya K, Iida M, Kiyohara Y, Sueishi K., Association of kidney function with coronary atherosclerosis and calcification in autopsy samples from Japanese elders: the Hisayama study., Am J Kidney Dis, 55, 21-30, 2010.01.
11. Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y., Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study., Nephrol Dial Transplant, 25, 2557-2564, 2010.01.
12. Jun M, Heerspink HJ, Ninomiya T, Gallagher M, Bellomo R, Myburgh J, Finfer S, Palevsky PM, Kellum JA, Perkovic V, Cass A., Intensities of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis., Clin J Am Soc Nephrol, 5, 956-963, 2010.01.
13. Jardine MJ, Ninomiya T, Perkovic V, Cass A, Turnbull F, Gallagher MP, Zoungas S, Lambers Heerspink HJ, Chalmers J, Zanchetti A., Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial., J Am Coll Cardiol, 56, 956-965, 2010.01.
14. Heerspink HJ, Ninomiya T, Perkovic V, Woodward M, Zoungas S, Cass A, Cooper M, Grobbee DE, Mancia G, Mogensen CE, Neal B, Chalmers J; ADVANCE Collaborative Group., Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease., Eur Heart J, 31, 2888-2896, 2010.01.
15. Czernichow S, Ninomiya T, Huxley R, Kengne AP, Batty GD, Grobbee DE, Woodward M, Neal B, Chalmers J., Impact of blood pressure lowering on cardiovascular outcomes in normal weight, overweight, and obese individuals: the Perindopril Protection Against Recurrent Stroke Study trial., Hypertension, 55, 1193-1198, 2010.01.
16. de Galan BE, Perkovic V, Ninomiya T, Pillai A, Patel A, Cass A, Neal B, Poulter N, Harrap S, Mogensen CE, Cooper M, Marre M, Williams B, Hamet P, Mancia G, Woodward M, Glasziou P, Grobbee DE, MacMahon S, Chalmers J; ADVANCE Collaborative Group., Lowering blood pressure reduces renal events in type 2 diabetes., J Am Soc Nephrol, 20, 883-892, 2009.01.
17. Zoungas S, de Galan BE, Ninomiya T, Grobbee D, Hamet P, Heller S, MacMahon S, Marre M, Neal B, Patel A, Woodward M, Chalmers J; ADVANCE Collaborative Group, Cass A, Glasziou P, Harrap S, Lisheng L, Mancia G, Pillai A, Poulter N, Perkovic V, Travert F., Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial., Diabetes Care, 32, 2068-2074, 2009.01.
18. Zoungas S, Ninomiya T, Huxley R, Cass A, Jardine M, Gallagher M, Patel A, Vasheghani-Farahani A, Sadigh G, Perkovic V., Systematic review: sodium bicarbonate treatment regimens for the prevention of contrast-induced nephropathy., Ann Intern Med, 151, 631-638, 2009.01.
19. Turnbull FM, Abraira C, Anderson RJ, Byington RP, Chalmers JP, Duckworth WC, Evans GW, Gerstein HC, Holman RR, Moritz TE, Neal BC, Ninomiya T, Patel AA, Paul SK, Travert F, Woodward M., Intensive glucose control and macrovascular outcomes in type 2 diabetes., Diabetologia, 52, 2288-2298, 2009.01.
20. Ninomiya T, Perkovic V, de Galan BE, Zoungas S, Pillai A, Jardine M, Patel A, Cass A, Neal B, Poulter N, Mogensen CE, Cooper M, Marre M, Williams B, Hamet P, Mancia G, Woodward M, Macmahon S, Chalmers J; ADVANCE Collaborative Group., Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes., J Am Soc Nephrol, 20, 1813-1821, 2009.01.
21. Ninomiya T, Perkovic V, Verdon C, Barzi F, Cass A, Gallagher M, Jardine M, Anderson C, Chalmers J, Craig JC, Huxley R., Proteinuria and stroke: a meta-analysis of cohort studies., Am J Kidney Dis, 53, 417-425, 2009.01.
22. Ninomiya T, Donnan G, Anderson N, Bladin C, Chambers B, Gordon G, Sharpe N, Chalmers J, Woodward M, Neal B; PROGRESS Collaborative Group., Effects of the end point adjudication process on the results of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS)., Stroke, 40, 2111-2115, 2009.01.
23. Heerspink HJ, Ninomiya T, Zoungas S, de Zeeuw D, Grobbee DE, Jardine MJ, Gallagher M, Roberts MA, Cass A, Neal B, Perkovic V., Effect of lowering blood pressure on cardiovascular events and mortality in patients on dialysis: a systematic review and meta-analysis of randomised controlled trials., Lancet, 373, 1009-1015, 2009.01.
24. Du X, Ninomiya T, de Galan B, Abadir E, Chalmers J, Pillai A, Woodward M, Cooper M, Harrap S, Hamet P, Poulter N, Lip GY, Patel A; ADVANCE Collaborative Group., Risks of cardiovascular events and effects of routine blood pressure lowering among patients with type 2 diabetes and atrial fibrillation: results of the ADVANCE study., Eur Heart J, 30, 1128-1135, 2009.01.
25. Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, Liu Y, Rahman M, Iida M, Kiyohara Y., Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan., J Epidemiol, 19, 56-62, 2009.01.
26. Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y., Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama study., Stroke, 40, 1187-1194, 2009.01.
27. Turnbull F, Woodward M, Neal B, Barzi F, Ninomiya T, Chalmers J, Perkovic V, Li N, MacMahon S; Blood Pressure Lowering Treatment Trialists' Collaboration., Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials., Eur Heart J, 29, 2669-2680, 2008.01.
28. Turnbull F, Neal B, Ninomiya T, Algert C, Arima H, Barzi F, Bulpitt C, Chalmers J, Fagard R, Gleason A, Heritier S, Li N, Perkovic V, Woodward M, MacMahon S; Blood Pressure Lowering Treatment Trialists' Collaboration., Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trials., BMJ, 336, 1121-1123, 2008.01.
29. Perkovic V, Verdon C, Ninomiya T, Barzi F, Cass A, Patel A, Jardine M, Gallagher M, Turnbull F, Chalmers J, Craig J, Huxley R., The relationship between proteinuria and coronary risk: a systematic review and meta-analysis., PLoS Med, 5, e207, 2008.01.
30. Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, Marre M, Cooper M, Glasziou P, Grobbee D, Hamet P, Harrap S, Heller S, Liu L, Mancia G, Mogensen CE, Pan C, Poulter N, Rodgers A, Williams B, Bompoint S, de Galan BE, Joshi R, Travert F; ADVANCE Collaborative Group., Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes., N Engl J Med, 358, 2560-2572, 2008.01.
31. Ninomiya T, Kiyohara Y, Tokuda Y, Doi Y, Arima H, Harada A, Ohashi Y, Ueshima H; Japan Arteriosclerosis Longitudinal Study Group., Impact of kidney disease and blood pressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal Study., Circulation, 118, 2694-2701, 2008.01.
32. Katafuchi R, Ninomiya T, Mizumasa T, Ikeda K, Kumagai H, Nagata M, Hirakata H., The improvement of renal survival with steroid pulse therapy in IgA nephropathy., Nephrol Dial Transplant, 23, 3915-3920, 2008.01.
33. Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, Harrap S, Poulter N, Marre M, Cooper M, Glasziou P, Grobbee DE, Hamet P, Heller S, Liu LS, Mancia G, Mogensen CE, Pan CY, Rodgers A, Williams B; ADVANCE Collaborative Group., Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial., Lancet, 370, 829-840, 2007.01.
34. Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Tsuruya K, Sueishi K, Tsuneyoshi M, Iida M, Kiyohara Y., Prehypertension increases the risk for renal arteriosclerosis in autopsies: the Hisayama Study., J Am Soc Nephrol, 18, 2135-2142, 2007.01.
35. Ninomiya T, Kubo M, Doi Y, Yonemoto K, Tanizaki Y, Rahman M, Arima H, Tsuryuya K, Iida M, Kiyohara Y., Impact of metabolic syndrome on the development of cardiovascular disease in a general Japanese population: the Hisayama study., Stroke, 38, 2063-2069, 2007.01.
36. Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y., A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction., Nat Genet, 39, 212-217, 2007.01.
37. Ninomiya T, Kiyohara Y, Kubo M, Yonemoto K, Tanizaki Y, Doi Y, Hirakata H, Iida M., Metabolic syndrome and CKD in a general Japanese population: the Hisayama Study., Am J Kidney Dis, 48, 383-391, 2006.01.
38. Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, Doi Y, Hata J, Shikata K, Iida M., Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population., Neurology, 66, 1539-1544, 2006.01.
39. Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M., Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study., Kidney Int, 10.1111/j.1523-1755.2005.00397.x, 68, 1, 228-236, 2005.01.
40. Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Hata J, Oishi Y, Kato I, Hirakata H, Iida M., Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama study., Am J Kidney Dis, 10.1053/j.ajkd.2004.05.024, 44, 3, 437-445, 2004.01.
41. Tsuruya K, Tokumoto M, Ninomiya T, Hirakawa M, Masutani K, Taniguchi M, Fukuda K, Kanai H, Hirakata H, Iida M., Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways., Am J Physiol Renal Physiol, 10.1152/ajprenal.00311.2002, 285, 2, F208-F218, 2003.01.
42. Ninomiya T, Kanai H, Hirakawa M, Arimura Y, Masutani K, Kashiwagi M, Nakamura S, Koga Y, Fukuda K, Hirakata H., Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis., Am J Kidney Dis, 10.1053/ajkd.2002.29925, 39, 1, E4, 2002.01.
43. Ninomiya T, Takimoto H, Matsuzaki G, Hamano S, Yoshida H, Yoshikai Y, Kimura G, Nomoto K., Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma., Immunology, 10.1046/j.1365-2567.2000.00938.x, 99, 2, 187-194, 2000.01.
Membership in Academic Society
  • American Society of Nephrology
  • International Society of Hypertension
Awards
  • The fixed combination of perindopril and indapamide has a greater effect on cardiovascular outcomes in patients with type 2 diabetes and albuminuria.
  • Chronic kidney disease and Cardiovascular disease in a genral Japanese population: the Hisayama Study