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Yoshiko Miura, Controlled Polymerization for the development of bioconjugate polymers and materials, Journal of Materials Chemistry B, 10.1039/C9TB02418B, 2020, 8, 2010-2019, 2020.01, Controlled polymerization through living radical polymerization is widely studied. Controlled polymerization enables synthetic polymers with precise structures, which have the potential for excellent bio-functional materials. This review summarizes the applications of controlled polymers, especially those via living radical polymerization, to biofunctional materials and conjugation with biomolecules. In the case of polymer ligands like glycopolymers, the polymers control the interactions with proteins and cells based on the precise polymer structures. Living radical polymerization enables the conjugation of polymers to proteins, antibodies, nucleic acids and cells. Those polymer conjugations are a sophisticated method to modify bio-organisms. The polymer conjugations expand the potential of biofunctional materials and are useful for understanding biology.. |
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Yoshiko Miura, Design and synthesis of well-defined glycopolymers for the control of biological functionalities, Polymer Journal, Polymer Journal (2012), 1 – 11
10.1038/pj.2012.4, 2012.04, This review addresses the design and synthesis of synthetic glycopolymers. Glycopolymers with pendant saccharides exhibit high affinities for proteins owing to their multivalency. Glycopolymers have molecular recognition abilities and amphiphilicity and can be applied as biomaterials and in bioassays. Most synthetic glycopolymers are prepared from polymerizable saccharide derivatives, and the rest are prepared by saccharide addition to a polymer backbone. Because sugar-recognizing proteins have precise structures, the living polymerization of glycopolymers is important in the fabrication of well-defined multiple ligands of saccharides. Glycopolymers with narrow polydispersity are useful for determining the interactions between saccharides and proteins. The living polymerization of glycopolymers provides hybrid materials by the terminal modification of the polymers. The glycopolymers of block polymers, star polymers and polymer brushes have been investigated for use in novel biomaterials.. |
