| 1. |
Usui N, Okuyama H, Kanamori Y, Nagata K, Hayakawa M, Inamura N, Takahashi S, Taguchi T, The lung to thorax transverse area ratio has a linear correlation with the observed to expected lung area to head circumference ratio in fetuses with congenital diaphragmatic hernias
, 49, 8, 1191-1196, 2014.08. |
| 2. |
Usui N, Nagata K, Hayakawa M, Okuyama H, Kanamori Y, Takahashi S, Inamura N, Taguchi T, Pneumothoraces As a Fatal Complication of Congenital Diaphragmatic Hernia in the Era of Gentle Ventilation
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, 24, 1, 31-38, 2014.01. |
| 3. |
Yuniartha R, Alatas FS, Nagata K, Kuda M, Yanagi Y, Esumi G, Yamaza T, Kinoshita Y, Taguchi T, Therapeutic potential of mesenchymal stem cell transplantation in a nitrofen-induced congenital diaphragmatic hernia rat model
, 30, 9, 907-914, 2014.09. |
| 4. |
Kouji Nagata, Genshiro Esumi, YOSHIAKI KINOSHITA, tomoaki taguchi, Current profile and ouotcome of 100 esophageal atresia patients in the Kyushu area of Japan, Open Journal of Pediatrics, 3, 3, 40-51, 2013.03, Objectives: Since Spitz et al reported the prognostic classification of esophageal atresia (EA) patients in 1994, decades have been past and there have been many advances in surgery and neonatology. Nevertheless, there have been very few reports according to the recent outcome of the neonates with EA, and otherwise, time has come to re-evaluate the credibility of this classification. The aim of this study was to validate the recent prognosis of the EA.
Methods: Patient data were collected from 22 cooperative facilities during the 5 year period from 2005 to 2009 in Kyushu area, Japan. Total of 100 EA patients were retrospectively reviewed according to their characteristics and the outcome. Patient who missed the characteristics and outcome was excluded from the respective data.
Results: Only 29.8% (28/94) was prenatally diagnosed and 52.0 (52/100) had associated anomalies including major congenital heart disease (CHD), abnormal chromosome, and others. According to the operation, primary anastomosis was performed 57.0% (57/100) and the staged operation was performed 34.0% (34/100). Survival rate in the neonatal period was 89.0% (89/100), and overall survival rate was 78.0% (78/100). According to the Spitz classification, if patients with associated anomalies were excluded, survival rate of group 1 (>1500g and no CHD) was 95.2% (59/62), group 2 (Conclusion: EA was proved to be rarely diagnosed prenatally. Primary outcome of the group 1 and group 3 in Spitz classification were fairly good, but group 2 was worse as ever. The comprehensive treatment strategy for EA patients with birth weight under 1500g or CHD should be reconsidered to improve the overall outcome.
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| 5. |
Kouji Nagata, tomoaki taguchi, Noriaki Usui, Yutaka Kanamori, Shigehiro Takahashi, Masahiro Hayakawa, Hiroomi Okuyama, Noboru Inamura, Yuji Fujino, The current profile and outcome of the congenital diaphragmatic hernia: The nationwide survey in
Japan., Journal of Pediatric Surgery, doi: 10.1016/j.jpedsurg.2012.12.017., 48, 4, 738-744, 2013.04, Abstract
BACKGROUND/PURPOSE:
Few nationwide surveys have been reported regarding the perinatal status, clinical course and postnatal outcome of cases with congenital diaphragmatic hernia (CDH). The aim of this study was to review the current profile and the outcomes of a large cohort of CDH cases in Japan.
METHODS:
A nationwide retrospective cohort study was conducted on neonates diagnosed to have CDH between January 2006 and December 2010. The questionnaires were sent to 159 representative regional institutions and 109 (68.6%) institutions responded to the preliminary survey which had 674 cases. Eleven institutions which had 60 CDH neonates did not respond to the second questionnaire, and 26 institutions had no cases. Finally, 614 CDH neonates from 72 institutions had been collected and were used in the detailed survey. The perinatal status, clinical course and the postnatal outcome were reviewed. Survival was defined as infants alive at hospital discharge, at the time of transfer or still in the hospital at the time of questionnaire, which was confirmed during the period from July 2011 to November 2011 by the investigators.
RESULTS:
Four hundred sixty-three (75.4%) of 614 CDH neonates survived in this study. The overall survival rate of neonates with isolated CDH was 84.0%. A total of 444 (72.0%) patients were prenatally diagnosed, and had a survival rate of 70.8%. Four hundred thirty-three (70.9%) patients were treated with high-frequency oscillatory ventilation (HFOV) as the initial ventilation, 344 (56.0%) patients received inhaled nitric oxide (iNO) and 43 (7.0%) required extracorporeal membrane oxygenation (ECMO). The overall survival rates of the CDH neonates who had been treated using HFOV, iNO and ECMO were 74.3%, 68.3% and 37.2%, respectively.
CONCLUSIONS:
This study demonstrated that the current status for CDH treatment in Japan and the overall survival rate were comparable to those of recent reports from other countries. |
| 6. |
Kouji Nagata, Kouji Masumoto, Genshirou Esumi, Risa Teshiba, Keigo Yoshizaki, Satoshi Fukumoto, Kazuaki Nonaka、 Tomoaki Taguchi, 「Cx43 play important roles in the lung development」, J Pediatr Surg , 44, 12, 2296-2301, 2009.12. |
