Kyushu University Academic Staff Educational and Research Activities Database
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Atsunobu Takeda Last modified date:2020.12.02

Lecturer / Department of Ophthalmology, Graduate School of Medical Sciences
Department of Clinical Medicine
Faculty of Medical Sciences

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Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Research Interests
  • Clinical and basic research for uveitis
    Elucidation of the pathogenesis of choroidal neovascular diseases
    keyword : Ophthalmology, Uveitis, Choroidal neovascular diseases, Ocular immunology, Ocular inflammation
  • Suppression of subretinal fibrosis due to choroidal neovascularization
    keyword : age-related macular degeneration, choroidal neovascularization, innate immunity, cytokine
Academic Activities
1. Hasegawa E, Takeda A, Yawata N, Sonoda KH, The effectiveness of adalimumab treatment for non-infections uveitis., Immunol Med., 2019.06.
2. Takeda A, Sonoda KH, Ishibashi T, Epidemiology of Uveitis, Caused by HTLV-1, Toxoplasmosis, and Tuberculosis; The Three Leading Causes of Endemic Infectious Uveitis in Japan., Ocul Immunol Inflamm., 2017.12.
3. Atsunobu Takeda, Koh-hei Sonoda, Tatsuro Ishibashi, Regulation of Th1 and Th17 cell differentiation in uveitis, Inflammation and Regeneration, 2013.11.
1. Takeda A, Hasegawa E, Nakao S, Ishikawa K, Murakami Y, Hisatomi T, Arima M, Yawata N, Oda Y, Kimura K, Yoshikawa H, Sonoda KH., Vitreous levels of interleukin-35 as a prognostic factor in B-cell vitreoretinal lymphoma, Scientific Reports, 10.1038/s41598-020-72962-z , 10, 1, 15715, 2020.09.
2. Ito T, Takeda A, Fujiwara K, Hasegawa E, Nakao S, Ohishi Y, Oda Y, Yoshikawa H, Sonoda KH., Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma., Graefe’s Arch Clin Exp Opthalmol., 257, 5, 1029-1036, 2019.05.
3. Takeda A, Yamada H, Hasegawa E, Arima M, Notomi N, Myojin S, Yoshimura T, Hisatomi T, Enaida H, Yanai R, Kimura K, Ishibashi T, Sonoda KH., Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis., Jpn J Ophthalmol., 62, 3, 398-406, 2018.05.
4. Sato K, Takeda A, Hasegawa E, Jo YJ, Arima M, Oshima Y, Yanai R, Nakazawa T, Yuzawa M, Nakashizuka H, Shimada H, Kimura K, Ishibashi T, Sonoda KH., Interleukin-6 plays a crucial role in the development of subretinal fibrosis in a mouse model., Immunological Medicine, 41, 1, 23-29, 2018.01.
5. Taki R, Takeda A, Yoshikawa H, Fukuhara T, Arita R, Suehiro Y, Che I, Kumano Y, Nakamura T, Ishibashi T, Clinical features of systemic metastatic retinal lymphoma in Japanese patients., Ocul Immunol Inflamm., 25, 5, 654-662, 2017.10.
6. Takeda A, Yoshikawa H, Fukuhara T, Hikita S, Otomo T, Arita R, Oshima Y, Hisatomi T, Kimura K, Yoshida S, Kawano Y, Sonoda KH, Ishibashi T, Distinct profiles of soluble cytokine receptors between B-cell vitreoretinal lymphoma and uveitis, Invest Ophthalmol Vis Sci., 56, 12, 7516-7523, 2015.12.
7. Takeda A, Hasegawa E, Fukuhara T, Hirakawa S, Yamada H, Yang Y, Yoshimura T, Hisatomi T, Oshima Y, Yoshida H, Sonoda KH, Ishibashi T, EBI3 is pivotal for the initiation of experimental autoimmune uveitis., Experimental Eye Research, doi: 10.1016/j.exer.2014.06.004., 125, 107-113, 2014.08.
8. Yang Y, Takeda A, Yoshimura T, Oshima Y, Sonoda KH, Ishibashi T, IL-10 is significantly involved in HSP70-regulation of experimental subretinal fibrosis, Plos one, 8, 12, e80288, 2013.12.
9. Hasegawa E, Oshima Y, Takeda A, Saeki K, Yoshida H, Sonoda KH, Ishibashi T., IL-27 inhibits pathological ocular neovascularization due to laser burn., J Leukoc Biol, 22045869, 91, 2, 267-273, 2012.02.
10. Takeda A, Baffi JZ, Kleinman ME, Cho W, Nozaki M, Yamada K, Kaneko H, Albuquerque RJC, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Rich MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J., CCR3 is a therapeutic and diagnostic non-inflammatory target for neovascular age-related macular degeneration, Nature, 460, 7252, 225-230, 2009.07.
11. Kleinman ME*, Yamada K*, Takeda A*, Chandrasekaren V, Nozaki M, Baffi JZ, Albuquerque RJC, Yamasaki S, Itaya M, Pan Y, Appukutan B, Gibbs D, Yang Z, Kariko K, Ambati BK, Wilgus TA, DiPietro LA, Sakurai E, Zhang K, Smith JR, Taylor EW, Ambati J., Sequence- and target-independent suppression of angiogenesis by siRNA via TLR3, Nature, 452, 7187, 591-597, 2008.03.
12. Ambati BK, Nozaki M*, Singh N*, Takeda A*, Jani PD*, Suthar T, Albuquerque RJC, Richter E, Sakurai E, Newcomb MT, Kleinman ME, Caldwell RB, Lin Q, Ogura Y, Orecchia A, Samuelson DA, Agnew DW, Leger JS, Green WR, Mahasreshti PJ, Curiel DT, Kwan D, Marsh H, Ikeda S, Leiper LJ, Collinson JM, Bogdanovich S, Khurana TS, Shibuya M, Baldwin ME, Ferrara N, Gerber HP, De Falco S, Witta J*, Baffi JZ*, Raisler BJ*, Ambati J., Corneal avascularity is due to soluble VEGF receptor-1, Nature, 443, 7114, 993-997, 2006.10.
13. Yoshimura T, Takeda A, Hamano S, Miyazaki Y, Kinjyo I, Ishibashi T, Yoshimura A, Yoshida H, Two-sided roles of IL-27; induction of Th1 differentiation on naïve CD4+ T cells vs. suppression of pro-inflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism., J Immunol , 177, 8, 5377-5385, 2006.08.
14. Takeda A, Hamano S, Shiraishi H, Yoshimura T, Ogata H, Ishii K, Ishibashi T, Yoshimura A, Yoshida H., Hyperproliferation and hyperproduction of cytokines by WSX-1-overexpressing CD4+ T cells in response to TCR stimulation, Int Immunol, 17, 7, 889-897, 2005.07.
15. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H., Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment., J Immunol, 170, 10, 4886-4890, 2003.05.
16. Takeda A, Hata Y, Shiose S, Sassa Y, Honda M, Fujisawa K, Sakamoto T, Ishibashi T., Suppression of experimental choroidal neovascularization utilizing KDR selective receptor tyrosine kinase inhibitor, Graefe’s Arch Clin Exp Opthalmol, 10.1007/s00417-003-0688-7, 241, 9, 765-772, 2003.09.
1. Atsunobu Takeda, Takeru Yoshimura, Sayaka Hirakawa, Toshio Hisatomi, Yasuhiro Ikeda, Hiroshi Enaida, Yuji Oshima, Koh-hei Sonoda, Tatsuro Ishibashi, Pivotal roles of P2RX7 in the induction of Th1 and Th17 responses in experimental autoimmune uveitis, The Association for Research in Vision and Ophthalmology 2014, 2014.05.
2. Atsunobu Takeda, Takako Fukuhara, Kuniaki Hijioka, Koh-hei Sonoda, Tatsuro Ishibashi, Long-term efficacy of infliximab maintenance therapy in refractory uveitis of Behcet’s disease at Kyushu University Hospital: a 24-month follow-up study, World Ophthalmology Congress 2014, 2014.04.
3. Atsunobu Takeda, Takako Fukuhara, Kuniaki Hijioka, Shinichi Hikita, Takeru Yoshimura, Mitsuteru Akahoshi, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko Horiuchi, Yoichi Kawano, Koh-hei Sonoda, Tatsuro Ishibashi, Long-term efficacy of infliximab maintenance therapy in refractory uveitis of Behcet’s disease at Kyushu University Hospital: a 24-month follow-up study., The 6th joint meeting of China- Japan-Korea Ophthalmologists, 2013.09.
4. Atsunobu Takeda, Toshio Hisatomi, Yasuhiro Ikeda, Koh-Hei Sonoda, tatsuro ishibashi, Pivotal roles of EBI3 for the initiation and maintenance of experimental autoimmune uveitis., The Association for Research in Vision and Ophthalmology 2013, 2013.05.
5. Atsunobu Takeda, Hiroshi Tsukamoto, Hiroaki Niiro, tatsuro ishibashi, Serum Infliximab levels, baseline TNF-alpha, and the effectiveness of Infliximab therapy for uveitis in Behcet's disease., The 5th joint meeting of Japan-china-Koreaophthalmologists, 2012.11.
6. Atsunobu Takeda, Koh-hei Sonoda, Takeru Yoshimura, Toshio Hisatomi, Yasuhiro Ikeda, Hiroshi Enaida, Tatsuro Ishibashi, Pivotal roles of P2X7 in the induction of Th1 and Th17 responses in experimental autoimmune uveitis, World Ophthalmology Congress 2012, 2012.02.
Membership in Academic Society
  • The International Ocular Inflammation Society
  • Japanese Retina and Vitreous Society
  • The Japanese Society of Clinical Immunology
  • The Association for Research in Vision and Ophthalmology (ARVO)
Other Educational Activities
  • 2010.12.