Kyushu University Academic Staff Educational and Research Activities Database
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Kaku Noriyuki Last modified date:2021.07.31



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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/noriyuki-kaku
 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
MD, PhD
Country of degree conferring institution (Overseas)
Yes
Field of Specialization
Pediatric emergency and critical care medicine
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Pediatric ECMO
    keyword : Pediatric, ECMO
    2019.04~2024.03.
  • Pediatric brain death and transplantation in Japan
    keyword : Pediatric brain death, transplantation
    2017.04~2022.03.
  • Epidemiology and outcome of pediatric out-of-hospital cardiac arrest
    keyword : child, out-of-hospital cardiac arrest
    2014.04~2020.03.
  • Establishing the education system of prehospital pediatric emergency care for EMS personnel
    keyword : prehospital pediatric emergency care
    2013.05~2020.03.
  • Shimulation training of pediaric medical emergencies and cardiopulmonary arrests
    keyword : Pediatric resuscitation, shimulation, off-the-job taining
    2010.04~2020.03.
Academic Activities
Papers
1. Noriyuki Kaku, Kenji Ihara, Yuichiro Hirata, Kenji Yamada, Sooyoung Lee, Hikaru Kanemasa, Yoshitomo Motomura, Haruhisa Baba, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara, Shouichi Ohga, Diagnostic potential of stored dried blood spots for inborn errors of metabolism
A metabolic autopsy of medium-chain acyl-CoA dehydrogenase deficiency, Journal of Clinical Pathology, 10.1136/jclinpath-2017-204962, 71, 10, 885-889, 2018.10, Aim It is estimated that 1-5% of sudden infant death syndrome (SIDS) cases might be caused by undiagnosed inborn errors of metabolism (IEMs); however, the postmortem identification of IEMs remains difficult. This study aimed to evaluate the usefulness of dried blood spots (DBSs) stored after newborn screening tests as a metabolic autopsy to determine the causes of death in infants and children who died suddenly and unexpectedly. Methods Infants or toddlers who had suddenly died without a definite diagnosis between July 2008 and December 2012 at Kyushu University Hospital in Japan were enrolled in this study. Their Guthrie cards, which had been stored for several years at 4-8°C, were used for an acylcarnitine analysis by tandem mass spectrometry to identify inborn errors of metabolism. Results Fifteen infants and children who died at less than 2 years of age and for whom the cause of death was unknown were enrolled for the study. After correcting the C0 and C8 values assuming the hydrolysation of acylcarnitine in the stored DBSs, the corrected C8 value of one case just exceeded the cut-off level for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency screening. Genetic and biochemical analyses confirmed this patient to have MCAD deficiency. Conclusion DBSs stored after newborn screening tests are a promising tool for metabolic autopsy. The appropriate compensation of acylcarnitine data and subsequent genetic and biochemical analyses are essential for the postmortem diagnosis of inborn errors of metabolism..
Educational
Other Educational Activities
  • 2020.01.
  • 2019.10.
  • 2019.09.
  • 2019.05.
  • 2018.07.
  • 2018.06.
  • 2018.09.
  • 2016.11.
  • 2016.09.