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Kenichirou Yamashita Last modified date:2019.07.02

Assistant Professor / Department of Neurology, Neurological Institute, Kyushu University School of Medicine
Neurological Institute
Faculty of Medical Sciences

Academic Degree
Field of Specialization
Outline Activities
fMRI study in Alzheimer disease patients
Research Interests
  • functional connectivity change in Alzheimer disease patients using resting-state functional MRI
    keyword : Alzheimer disease, resting-state functional MRI
Academic Activities
1. Ken-ichiro Yamashita, Taira Uehara, Pukovisa Prawiroharjo, Koji Yamashita, Osamu Togao, Akio Hiwatashi, Yoshihide Taniwaki, Hidetsuna Utsunomiya, Takuya Matsushita, Ryo Yamasaki, Jun-ichi Kira, Functional Connectivity Change between Posterior Cingulate Cortex and Ventral Attention Network Relates to the Impairment of Orientation for Time in Alzheimer’s Disease Patients. , Brain imaging and behavior, 10.1007/s11682-018-9860-x, 2018.06, Alzheimer’s disease (AD) patients exhibit various cognitive dysfunctions, including impairment of orientation for time (OT). The
brain regions underlying OT impairment remain to be elucidated. A previous single-photon emission computed tomography
study has indicated hypoperfusion of the posterior cingulate cortex (PCC) in relation to deterioration of OT. In this study, we
investigated whole brain functional connectivity changes of PCC using resting-state functional magnetic resonance imaging.
Voxel-based functional connectivity with PCC was analyzed in OT-poor or OT-good AD patients, classified according to the
mean OTscores of the Mini-Mental State Examination subscale. The connectivities of dorsal frontal lobe, and lateral parietal and
lateral temporal lobes with PCC in the right hemisphere were reduced in the OT-poor AD group compared with the OT-good AD
group. A subtraction connectivity map of OT score differences (OT-good minus OT-poor) revealed the right middle temporal
gyrus near the temporo-parietal junction as a significantly connected region with PCC. These results suggest that the right
posterior part of the middle temporal gyrus may play an important role in OT in conjunction with PCC, and that disconnection
between PCC and the right ventral attention network may cause OT disturbance in AD patients..
Membership in Academic Society
  • Society for Neuroscience
  • Japan Society of Dementia Research
  • The Japanese Society of Internal Medicine
  • Japanese Society of Neurology
Other Educational Activities
  • 2018.06.