Kyushu University Academic Staff Educational and Research Activities Database
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Ihara Eikichi Last modified date:2024.06.03

Associate Professor / Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University
Department of Clinical Medicine
Faculty of Medical Sciences

Graduate School
Undergraduate School

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Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Gastroenterology, Endoscopy, Gastrointestinal motility disorder, Disorders of Gut-Brain Interaction
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
Outline of research:
Coordinated regulation of gastrointestinal (GI) motility contributes to general health and wellness when functioning normally but is also associated with morbidity and mortality when dysfunctional. Alterations in GI motility with resultant changes in transit can contribute to abdominal pain, intestinal cramping, diarrhea, constipation and urgency to defecate.The GI smooth muscle itself plays an important role in gastrointestinal (GI) motility. In overt inflammatory conditions of the bowel, such as infectious colitis and inflammatory bowel disease (IBD), there have been longstanding observations of altered motility and impaired function of the GI smooth muscle. While the inflammatory mediators are known to affect GI smooth muscle and impaired gastrointestinal motility, it still remains to be investigated how the inflammatory mediators affects GI smooth muscle. The research goals are to those mechanisms which possibly lead to generation of novel therapeutics for patients with GI motility disorders.
I give lectures on gastroenterology and metabolic gastroenterology to medical students in kyushu university. I also instruct, supervise and evaluate their clinical trainings. Alternatively, I teach gastroenterological endoscopy and radiology to gastroenterology trainees.
Research Interests
  • The research about chronic constipation
    keyword : Constipation
  • Elucidation of underlying pathogenesis of esophageal achalasia
    keyword : esophageal achalasia
  • Etiology and pathogenesis of esophageal motility disorders and their novel treatments
    keyword : Esophageal motility disorder, high-resolution manometry
  • The underlying mechanisms of regulation of lower esophageal sphincter tone.
    keyword : Lower esophageal sphincter、Mechanism of smooth muscle contraction、Myogenic tone regulation、Rho kinase
  • To elucidate the pathogenesis of Gastroesophageal reflux disease
    keyword : High resolution manometry、Esophageal impedance-pH monitoring、Gastroesophageal reflux disease、Esophageal motility disorders
  • The underlying mechanisms by which intestinal inflammation associated with various gastrointestinal (GI) disorders impairs contractile function of intestinal smooth muscle and GI motility.
    keyword : altered GI motility, intestinal smooth muscle, intestinal inflammation
Academic Activities
1. Ihara E, Akiho H, Nakamura K, Turner SR, MacDonald JA, MAPK signaling pathways represent a possible ideal target for generation of novel therapeutics for patients with gastrointestinal motility disorders. , World J Gastrointest Pathophysiol 2:19-25, 2011.07.
2. Akiho H, Ihara E, Nakamura. K, Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome. , World J Gastrointest Pathophysiol 1:97-105, 2010.07.
3. Ihara E and MacDonald JA, The regulation of smooth muscle contractility by zipper-interacting protein kinase. , Can J Physiol Pharmacol 85: 79-87., 2007.07.
1. Hamada, Shohei; Ihara, Eikichi; Ikeda, Hiroko; Muta, Kazumasa; Ogino, Haruei; Chinen, Takatoshi; Tanaka, Yoshimasa; Ogawa, Yoshihiro, Clinical Characterization of Vonoprazan-Refractory Gastroesophageal Reflux Disease, DIGESTION, 10.1159/000503340, 102, 2, 197-204, 2021.02.
2. Minoda, Yosuke; Ihara, Eikichi; Komori, Keishi; Ogino, Haruei; Otsuka, Yoshihiro; Chinen, Takatoshi; Tsuda, Yasuo; Ando, Koji; Yamamoto, Hidetaka; Ogawa, Yoshihiro, Efficacy of endoscopic ultrasound with artificial intelligence for the diagnosis of gastrointestinal stromal tumors, JOURNAL OF GASTROENTEROLOGY, 10.1007/s00535-020-01725-4, 55, 12, 1119-1126, 2020.12, BACKGROUND: Although endoscopic ultrasound (EUS) is reported to be suitable for determining the layer from which subepithelial lesions (SELs) originate, it is difficult to distinguish gastrointestinal stromal tumor (GIST) from non-GIST using only EUS images. If artificial intelligence (AI) can be used for the diagnosis of SELs, it should provide several benefits, including objectivity, simplicity, and quickness. In this pilot study, we propose an AI diagnostic system for SELs and evaluate its efficacy. METHODS: Thirty sets each of EUS images with SELs >/= 20 mm or