Kyushu University Academic Staff Educational and Research Activities Database
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Hidehiro Toh Last modified date:2020.01.10





E-Mail
Homepage
http://www.bioreg.kyushu-u.ac.jp/labo/epigenome/
Academic Degree
Doctor of Agriculture
Field of Specialization
Genome Informatics
Research
Research Interests
  • Epigenomic research using next-generation sequencing
    keyword : Epigenetics, DNA methylation, Methylomics, Methylome, Small RNA (piRNA・siRNA・miRNA), Germ cell, Next-generation sequencing
    2011.04.
  • Comparative genomics of lactobacilli and bifidobacteria
    keyword : Probiotics, Intestinal flora, Microbiome, Microbiota
    2007.04.
Academic Activities
Papers
1. Okae H, Toh H, Sato T, Hiura H, Takahashi S, Shirane K, Kabayama Y, Suyama M, Sasaki H, Arima T, Derivation of human trophoblast stem cells, Cell Stem Cell, 22, 50-63, 2018.01.
2. Maenohara S, Unoki M, Toh H, Ohishi H, Sharif J, Koseki H, Sasaki H, Role of UHRF1 in de novo DNA methylation in oocytes and maintenance methylation in preimplantation embryos, PLoS Genetics, 13, e1007042, 2017.10.
3. Kabayama Y, Toh H, Katanaya A, Sakurai T, Chuma S, Kuramochi-Miyagawa S, Saga Y, Nakano T, Sasaki H, Roles of MIWI, MILI and PLD6 in small RNA regulation in mouse growing oocytes, Nucleic Acids Research, 45, 5387-5398, 2017.05.
4. Toh H, Shirane K, Miura F, Kubo N, Ichiyanagi K, Hayashi K, Saitou M, Suyama M, Ito T, Sasaki H, Software updates in the Illumina HiSeq platform affect whole-genome bisulfite sequencing, BMC Genomics, 18, 31, 2017.01.
5. Hamada H, Okae H, Toh H, Chiba H, Hiura H, Shirane K, Sato T, Suyama M, Yaegashi N, Sasaki H, Arima T, Allele-specific methylome and transcriptome analysis reveals widespread imprinting in the human placenta, The American Journal of Human Genetics, 99, 1045-1058, 2016.11.
6. Kubo N, Toh H, Shirane K, Shirakawa T, Kobayashi H, Sato T, Sone H, Sato Y, Tomizawa S, Tsurusaki Y, Shibata H, Saitsu H, Suzuki Y, Matsumoto N, Suyama M, Kono T, Ohbo K, Sasaki H, DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis, BMC Genomics, 16, 624, 2015.08.
7. Toh H, Oshima K, Nakano A, Takahata M, Murakami M, Takaki T, Nishiyama H, Igimi S, Hattori M, Morita H, Genomic adaptation of the Lactobacillus casei group, PLoS One, 8, e75073, 2013.10.
8. Shirane K, Toh H, Kobayashi H, Miura F, Chiba H, Ito T, Kono T, Sasaki H, Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases, PLoS Genetics, 9, e1003439, 2013.04.
9. Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H, Bifidobacteria can protect from enteropathogenic infection through production of acetate, Nature, 469, 543-547, 2011.01.
10. Morita H, Toh H (co-first author), Oshima K, Yoshizaki M, Kawanishi M, Nakaya K, Suzuki T, Miyauchi E, Ishii Y, Tanabe S, Murakami M, Hattori M, Complete genome sequence and comparative analysis of the fish pathogen Lactococcus garvieae, PLoS One, 6, e23184, 2011.08.
11. Toh H, Oshima K, Toyoda A, Ogura Y, Ooka T, Sasamoto H, Park SH, Iyoda S, Kurokawa K, Morita H, Itoh K, Taylor TD, Hayashi T, Hattori M, Complete genome sequence of the wild-type commensal Escherichia coli strain SE15 belonging to phylogenetic group B2, Journal of Bacteriology, 192, 1165-1166, 2010.02.
12. Oshima K, Toh H (co-first author), Ogura Y, Sasamoto H, Morita H, Park SH, Ooka T, Iyoda S, Taylor TD, Hayashi T, Itoh K, Hattori M, Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult, DNA Research, 15, 375-386, 2008.12.
13. Hongoh Y, Sharma VK, Prakash T, Noda S, Toh H, Taylor TD, Kudo T, Sakaki Y, Toyoda A, Hattori M, Ohkuma M, Genome of an endosymbiont coupling N2 fixation to cellulolysis within protist cells in termite gut, Science, 322, 1108-1109, 2008.11.
14. Morita H, Toh H, Fukuda S, Horikawa H, Oshima K, Suzuki T, Murakami M, Hisamatsu S, Kato Y, Takizawa T, Fukuoka H, Yoshimura T, Itoh K, O'Sullivan DJ, McKay LL, Ohno H, Kikuchi J, Masaoka T, Hattori M, Comparative genome analysis of Lactobacillus reuteri and Lactobacillus fermentum reveal a genomic island for reuterin and cobalamin production, DNA Research, 15, 151-161, 2008.06.
15. Nakabachi A, Yamashita A, Toh H, Ishikawa H, Dunbar HE, Moran NA, Hattori M, The 160-kilobase genome of the bacterial endosymbiont Carsonella, Science, 314, 267, 2006.10.
16. Toh H, Weiss BL, Perkin SA, Yamashita A, Oshima K, Hattori M, Aksoy S, Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host, Genome Research, 16, 149-156, 2006.02.
17. Toh H, Miura K, Shirai M, Hattori M, In silico inference of inclusion membrane protein family in obligate intracellular parasites chlamydiae, DNA Research, 10, 9-17, 2003.02.
18. Toh H, Kamikawaji N, Tana T, Muta S, Sasazuki T, Kuhara S, Magnitude of structural changes of the T-cell receptor binding regions determine the strength of T-cell antagonism: molecular dynamics simulations of HLA-DR4 (DRB1*0405) complexed with analogue peptide, Protein Engineering, 13, 423-429, 2000.06.
Membership in Academic Society
  • The Japanese Society for Epigenetics