Kyushu University Academic Staff Educational and Research Activities Database
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Tomoyo Kawakubo-Yasukochi Last modified date:2023.12.23

Associate Professor / Department of Dental Science
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
D.D.S., Ph.D.
Country of degree conferring institution (Overseas)
Field of Specialization
Pharmacology, Molecular Biology, Oncology
Total Priod of education and research career in the foreign country
Research Interests
  • The role of Id4 on energy metabolism and epigenomic regulation
    keyword : Id4, energy metabolism, epigenomics
  • Analysis of TCA cycle by-path and itaconic acid in homeostasis regulation
    keyword : itaconic acid, TCA cycle
  • Identification of tissue-specific non-coding RNA networks in autoimmune disorder
    keyword : non-coding RNA, autoimmune disorder
  • Identification of tissue-specific non-coding RNA networks in cancer progression
    keyword : non-coding RNA, cancer
  • Analysis of molecular basis of biological defense system regulation through protease reaction
    keyword : protease
  • Molecular basis of predisposition to develop non-communicable diseases based on epigenetic modification in the womb
    keyword : DOHaD, nutrition, non-communicable disease
Academic Activities
1. Kawakubo-Yasukochi T, Hayashi Y, Hirata M., Effects of Maternal Nutrition on Oral Health in Offspring, Current Oral Health Reports (accepted), 2023.06.
2. Otani T, Mizokami A, Kawakubo-Yasukochi T, Takeuchi H, Inai T, Hirata M., The roles of osteocalcin in lipid metabolism in adipose tissue and liver, Adv Biol Regul,, 2020.12.
3. Iwata J, Kawakubo T, Yamamoto K., An Endogenous Inhibitor of Angiogenesis and Tumor Growth, 2004.03.
4. Kadowaki T, Takii R, Yamatake K, Kawakubo T, Tsukuba T, Yamamoto K., A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells, 2007.09.
5. Kawakubo T, Yasukochi A, Yamamoto K., Cathepsin E as a potent anticancer protease, J Oral Biosci, 2011.03.
6. Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T., Emerging roles of cathepsin E in host defense mechanisms, Biochim Biophys Acta, 10.1016/j.bbapap.2011.05.022., 2012.01.
7. Kawakubo-Yasukochi T, Regulation of glycolipid metabolism during gestational period by incretin response -Aiming at establishment a metabolic syndrome prophylaxis beyond the generation-, J Soc Wom Health Sci Res, 2017.03.
8. Mizokami A, Kawakubo-Yasukochi T, Hirata M., Osteocalcin and its endocrine functions, Biochem Pharmacol, 10.1016/j.bcp.2017.02.001., 2017.05.
1. Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T., Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4- related disease via miR-486-5p, Biochemical et Biophysics Acta (BBA) - Molecular Cell Research, 10.1016/j.bbamcr.2022.119404, 119404, 2023.02.
2. Kawakubo-Yasukochi T, Yano E, Kimura S, Nishinakagawa T, Mizokami A, Hayashi Y, Hatakeyama Y, Ohe K, Yasukochi A, Nakamura S, Jimi E, Hirata M., Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and this is modified by osteocalcin administration in mice., Mol Metab,, 54, 101360, 2021.10.
3. Lee B, Sullivan M, Yano E, Tong K, Hanif, M, Kawakubo-Yasukochi T, Jamieson, S, Söhnel T, Goldstone D, Hartinger C., Anthracenyl functionalization of half-sandwich carbene complexes: In vitro anticancer activity and reactions with biomolecules, Inorg Chem, doi: 10.1021/acs.inorgchem.1c01675., 60, 19, 14636-14644, 2021.09.
4. Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T, Otani T, Takeuchi H, Jimi E, Hirata M., Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis, J Biol Chem, doi: 10.1016/j.jbc.2021.100274., 296, 100274, 2021.01.
5. Kawakubo-Yasukochi T., Morioka M., Ohe K., Yasukochi A., Ozaki Y., Hazekawa M., Nishinakagawa T., Ono K., Nakamura S., Nakashima M., Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice, J Dev Orig Health Dis, 10.1017/S2040174419000217., 10, 6, 683-691, 2019.12.
6. Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T, Otani T, Takeuchi H, Jimi E, Hirata M., GLP-1 Signaling Is Required for Improvement of Glucose Tolerance by Osteocalcin, J Endocrinol, 10.1530/JOE-19-0288, 2019.11.
7. Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M., Evaluation of IC50 levels immediately after treatment with anticancer reagents using a real-time cell monitoring device, Exp Ther Med, 10.3892/etm.2019.7876., 18, 4, 3197-3205, 2019.10.
8. Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S., Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells, J Biochem, 10.1093/jb/mvz024., 166, 2, 163-173, 2019.08.
9. Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M., Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model, J Pharmacol Sci, 10.1016/j.jphs.2019.01.009., 139, 3, 231-239, 2019.03.
10. Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Yasukochi A, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M., miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment, Mol Carcinog, 10.1002/mc.22744., 57, 2, 295-302, 2018.02.
11. Hazekawa M, Ono K, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M., In vitro anti-inflammatory effects of the phenylbutyric acid metabolite phenylacetyl glutamine, Biol Pharm Bull, 6, 41, 961-966, 2018.06.
12. Hazekawa M, Hideshima Y, Ono K, Nishinakagawa T, Kawakubo-Yasukochi T, Takatani-Nakase T, Nakashima M., Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro, Exp Ther Med, 10.3892/etm.2017.5106., 14, 5, 4349-4355, 2017.11.
13. Hayashi Y, Kawakubo-Yasukochi T, Mizokami A, Hazekawa M, Yakura T, Naito M, Takeuchi H, Nakamura S, Hirata M., Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth, J Cancer, 10.7150/jca.18648., 8, 13, 2478-2486, 2017.08.
14. Hazekawa M, Morioka M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakamura S, Nakashima M, Assessment of cytotoxicity of imatinib for oral squamous cell carcinoma by a real-time cell analysis system, eJBio, 13, 1, 56-62, 2017.01.
15. Kondo A, Kawakubo-Yasukochi T, Mizokami A, Chishaki S, Takeuchi H, Hirata M., Uncarboxylated osteocalcin increases serum nitric oxide levels and ameliorates hypercholesterolemia in mice fed an atherogenic diet , eJBio, 13, 1, 22-28, 2016.12.
16. Hayashi Y, Kawakubo-Yasukochi T, Mizokami A, Takeuchi H, Nakamura S, Hirata M., Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth, J Cancer, 7, 12, 1605-1609, 2016.07.
17. Kawakubo-Yasukochi T, Kondo A, Mizokami A, Hayashi Y, Chishaki S, Nakamura S, Takeuchi H, Hirata M., Maternal oral administration of osteocalcin protects offspring from metabolic impairment in adulthood, Obesity, 10.1002/oby.21447., 24, 4, 895-907, 2016.04.
18. Yasutake Y, Mizokami A, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M., Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet, Am J Physiol Endocrinol Metab, 10.1152/ajpendo.00334.2015., 310, 8, E662-E675, 2016.04.
19. Morioka M, Kawakubo-Yasukochi T, Hayashi Y, Hazekawa M, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M. , Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination , J Oral Biosci, 58, 33-38, 2016.03.
20. Kawakubo-Yasukochi T, Morioka M, Hayashi Y, Nishinakagawa T, Hazekawa M, Kawano S, Nakamura S, Nakashima M., The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes , J Oral Biosci, 58, 33-38, 2016.03.
21. Morioka M, Hazekawa M, Kawakubo-Yasukochi T, Nishinakagawa T, Nakamura S, Nakashima M., Effect of collagen type I or human fibronectin on imatinib cytotoxicity in oral squamous cell carcinoma, Pharmacology and Pharmacy, 7, 255-263, 2016.03.
22. Tsuka S, Aonuma F, Higashi S, Ohsumi T, Nagano K, Mizokami A, Kawakubo-Yasukochi T, Masaki C, Hosokawa R, Hirata M, Takeuchi H., Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin, Biochem Biophys Res Commun, 10.1016/j.bbrc.2015.02.123. , 459, 3, 437-442, 2015.04.
23. Mizokami A, Yasutake Y, Higashi S, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M., Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion, Bone, 10.1016/j.bone.2014.09.006. , 69, 68-79, 2014.12.
24. Kataoka S, Baba A, Suda Y, Takii R, Hashimoto M, Kawakubo T, Asao T, Kadowaki T, Yamamoto K., A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy, FASEB J, 10.1096/fj.14-252130., 28, 8, 3564-3578, 2014.08.
25. Goto S, Ozaki Y, Suzumori N, Yasukochi A, Kawakubo T, Furuno T, Nakanishi M, Yamamoto K, Sugiura-Ogasawara M., Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage, Mol Hum Reprod, 10.1093/molehr/gau008., 20, 5, 454-462, 2014.05.
26. Kawakubo T, Yasukochi A, Toyama T, Takahashi S, Okamoto K, Tsukuba T, Nakamura S, Ozaki Y, Nishigaki K, Yamashita H, Yamamoto K., Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer, Carcinogenesis, 10.1093/carcin/bgt373., 35, 3, 714-726, 2014.03.
27. Kitamura K, Komatsu M, Biyani M, Futakami M, Kawakubo T, Yamamoto K, Nishigaki K., Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method, J Pept Sci, 10.1002/psc.2453. , 18, 12, 711-719, 2012.12.
28. Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K., Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene, J Biochem, 10.1093/jb/mvr135. , 151, 3, 263-272, 2012.03.
29. Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K., The role of cathepsin E in terminal differentiation of keratinocytes, Biol Chem, 10.1515/BC.2011.060., 392, 6, 571-585, 2011.04.
30. Biyani M, Futakami M, Kitamura K, Kawakubo T, Suzuki M, Yamamoto K, Nishigaki K., In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH, Int J Pept, 10.1155/2011/834525. , 2011, 834525, 2011.03.
31. Kitamura K, Biyani M, Futagami M, Ueno-Tsuji S, Suzuki M, Kawakubo T, Yamamoto K, Nishigaki K. , Peptide aptamer-based ELISA-like system for detection of cathepsin E in tissues and plasma, J Mol Biomark Diagn , 2, 104, 2011.03.
32. Yasukochi A, Kawakubo T, Nakamura S, Yamamoto K., Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis, Biol Chem, 10.1515/BC.2010.087., 391, 8, 947-958, 2010.08.
33. Kitamura K, Yoshida C, Kinoshita Y, Kadowaki T, Takahashi Y, Tayama T, Kawakubo T, Naimuddin M, Salimullah M, Nemoto N, Hanada K, Husimi Y, Yamamoto K, Nishigaki K., Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E, J Mol Biol, 10.1016/j.jmb.2008.12.028., 387, 5, 1186-1198, 2009.04.
34. Kawakubo T, Yasukochi A, Tsukuba T, Kadowaki T, Yamamoto K., Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates, Biochimie, 90, 2, 396-404, 2008.02.
35. Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama KI, Kadowaki T, Tsukuba T, Yamamoto K., Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface, Cancer Res, 67, 22, 10869-10878, 2007.11.
36. Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, Tsukuba T, Yamamoto K., Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses, Biol Chem, 388, 11, 1173-1181, 2007.11.
1. Tomoyo Kawakubo-Yasukochi T, Ena Yano, Soi Kimura, Seiji Nakamura, Eijiro Jimi, Association of maternal folic acid shortage during early pregnancy with carcinogenic risk in the offspring, The 28th Federation Meeting of Korean Basic Medical Scientists 2021 (The 23rd Korea-Japan Joint Seminar on Pharmacology (23rd KJJSP)), 2021.06.
Membership in Academic Society
  • Japanese Association for Oral Biology
  • The Japanese Pharmacological Society
  • Japanese Cancer Association
  • Japanese Society for Proteases in Pathophysiology
  • The Japanese Biochemical Society
  • The Japan Society for Developmental Origins of Health and Disease
Other Educational Activities
  • 2016.10.
  • 2016.11.