Updated on 2025/06/24

Information

 

写真a

 
YASUKOCHI TOMOYO
 
Organization
Faculty of Dental Science Department of Dental Science Associate Professor
Graduate School of Dental Science Department of Dental Science(Concurrent)
Graduate School of Dental Science (Concurrent)
School of Dentistry Department of Dentistry(Concurrent)
Title
Associate Professor
Contact information
メールアドレス
Profile
学部教育では、口腔生化学および歯科薬理学を担当している。  大学院教育および研究活動としては、主に、エピゲノム制御の観点から、周産期や各ライフステージにおける栄養素摂取と疾患罹患感受性の分子基盤に焦点を当てた研究を拡げ、がんを含めた生活習慣病や免疫疾患におけるエピゲノム制御機構、予防や治療に向けた栄養学的アプローチに取り組んでいる。さらに、各種疾患の病態や治療におけるエピゲノム制御機構、個体の代謝制御におけるTCA回路の役割について、その分子基盤を明らかにすることを目指して活動を行っている。
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Research Areas

  • Life Science / Oral pathobiological science

  • Life Science / Oral biological science

  • Life Science / Clinical pharmacy

Degree

  • D.D.S., Ph.D.

Research History

  • Kyushu University 歯学研究院OBT研究センター Associate Professor (In charge of graduate school) 

    2020.3 - Present

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  • Fukuoka University 薬学部 Associate Professor 

    2019.4 - 2020.2

  • Fukuoka University 薬学部 Lecturer 

    2014.10 - 2019.3

  • Kyushu University 大学院歯学研究院 Academic Researcher 

    2013.5 - 2014.9

  • Karolinska Institute, Sweden Department of Women's and Children's Health 日本学術振興会海外特別研究員 

    2012.4 - 2013.4

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    Country:Sweden

  • Karolinska Institute, Sweden Departmen of Women's and Children's Health Post doc 

    2011.11 - 2012.3

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    Country:Sweden

  • Kyushu University 大学院薬学研究院 Specially Appointed Assistant Professor 

    2008.4 - 2011.9

  • Kyushu University 大学院歯学研究院 日本学術振興会特別研究員PD 

    2007.4 - 2008.3

  • Kyushu University 大学院歯学研究院 日本学術振興会特別研究員DC2 

    2006.4 - 2007.3

  • 九州大学大学院薬学研究院 特任助教 カロリンスカ研究所 博士研究員 カロリンスカ研究所 学振海外特別研究員 九州大学大学院歯学研究院 学術研究員 福岡大学薬学部 講師 福岡大学薬学部 准教授   

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Education

  • Kyushu University   大学院歯学府   歯学専攻

    2003.4 - 2007.3

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    Country:Japan

  • Kyushu University   歯学部   歯学科

    1997.4 - 2003.3

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    Country:Japan

Research Interests・Research Keywords

  • Research theme: The role of Id4 on energy metabolism and epigenomic regulation

    Keyword: Id4, energy metabolism, epigenomics

    Research period: 2021.4 - 2030.3

  • Research theme: Analysis of TCA cycle by-path and itaconic acid in homeostasis regulation

    Keyword: itaconic acid, TCA cycle

    Research period: 2021.4 - 2030.3

  • Research theme: Molecular basis of predisposition to develop non-communicable diseases based on epigenetic modification in the womb

    Keyword: DOHaD, nutrition, non-communicable disease

    Research period: 2015.4 - 2030.3

  • Research theme: Identification of tissue-specific non-coding RNA networks in autoimmune disorder

    Keyword: non-coding RNA, autoimmune disorder

    Research period: 2015.4 - 2025.3

  • Research theme: Identification of tissue-specific non-coding RNA networks in cancer progression

    Keyword: non-coding RNA, cancer

    Research period: 2015.4 - 2025.3

  • Research theme: Analysis of molecular basis of biological defense system regulation through protease reaction

    Keyword: protease

    Research period: 2003.4 - 2027.3

Awards

  • 優秀研究者賞

    2025.3   公益財団法人新日本先進医療研究財団  

    安河内(川久保)友世

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    Award type:International academic award (Japan or overseas) 

    令和4年度研究助成金受領者の中で、優れた業績を発表している研究者に対して授与される賞である。

  • The 28th Federation Meeting of Korean Basic Medical Scientists 2021, Best Poster Award

    2021.6   The 28th Federation Meeting of Korean Basic Medical Scientists 2021  

  • 第6回ロート女性健康科学研究賞

    2015.5  

  • 第22回歯科基礎医学会賞(薬理学部門)

    2010.9   歯科基礎医学会  

  • The 6th General Meeting of the International Proteolysis Society, Travel Award

    2009.10   International Proteolysis Society  

  • 第50回歯科基礎医学会学術大会優秀ポスター賞(薬理学部門)

    2008.9   歯科基礎医学会  

  • The 5th General Meeting of the International Proteolysis Society, Travel Award

    2007.10   International Proteolysis Society  

  • 第49回歯科基礎医学会学術大会優秀ポスター賞(生化学部門)

    2007.8   歯科基礎医学会  

  • 第1回藤野博賞(大学院首席賞)

    2007.3   九州大学大学院歯学府  

  • 第9回病態と治療におけるプロテアーゼとインヒビター研究会奨励賞

    2004.7   病態と治療におけるプロテアーゼとインヒビター研究会(現:日本病態プロテアーゼ学会)  

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Papers

  • 4-Octyl Itaconate Attenuates Cell Proliferation by Cellular Senescence <i>via</i> Glutathione Metabolism Disorders and Mitochondrial Dysfunction in Melanoma Reviewed International coauthorship

    Hayashi Y., Saeki A., Yoshimoto S., Yano E., Yasukochi A., Kimura S., Utsunomiya T., Minami K., Aso Y., Hatakeyama Y., Lo Y.C., Hirata M., Jimi E., Kawakubo-Yasukochi T.

    Antioxidants &amp; Redox Signaling   42 ( 10-12 )   547 - 565   2025.2   ISSN:1523-0864 eISSN:1557-7716

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Mary Ann Liebert Inc  

    Aims: Itaconate (IA) is synthesized in the citric acid cycle via cis-aconitate decarboxylase (ACOD1); however, its biological significance in cancer remains incompletely understood. In previous studies, 4-octyl itaconate (OI) was used as a membrane-permeable form of IA, but little detailed verification of the difference in biological activities between IA and OI exists. Here, we investigated the direct effects of IA and OI on melanoma. Results: The proliferation of melanoma cells treated with OI was significantly suppressed in vitro, and our transcriptomic analysis revealed drastic changes in the expression of glutathione metabolism-related genes in OI-treated cells. Indeed, OI treatment decreased intracellular glutathione levels, followed by increased production of reactive oxygen species and expression of γH2AX, a marker of DNA damage, and β-galactosidase, a marker of cellular senescence. We further showed that the mitochondrial respiratory capacity in B16 cells was significantly decreased by OI treatment. OI administration also suppressed the growth of B16 tumor transplants in vivo, and the expression of γH2AX was increased in tumor tissues of OI-treated mice. In addition, minimal effects of OI treatment were observed in melanocytes and normal tissues. We also proved that not only exogenous IA, which enters intracellularly, but also endogenous IA has little effect on melanoma proliferation activity, via an investigation using Acod1-overexpressing transfectants and Acod1-deficient mice. Conclusion: This work revealed that OI disrupts the antioxidant system via the collapse of glutathione metabolism and inhibits cancer cell proliferation. Antioxid. Redox Signal. 42, 547-565.

    DOI: 10.1089/ars.2024.0629

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    Other Link: https://www.liebertpub.com/doi/pdf/10.1089/ars.2024.0629

  • The impact of environmental enrichment on energy metabolism in ovariectomized mice. Reviewed International coauthorship International journal

    Chaoran Ju, Ayano Ogura, Yoshikazu Hayashi, Yuko Kawabata, Fulvio D'Acquisto, Tomoyo Kawakubo-Yasukochi, Eijiro Jimi

    PloS one   20 ( 4 )   e0320180   2025

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Plos One  

    After menopause, a decline in ovarian function leads to various physical and psychological changes, potentially resulting in a range of pathological conditions, including abnormalities in energy metabolism. In recent years, environmental enrichment, which is characterized by positive and comfortable eustress, has been shown to improve various physiological and pathological conditions. This study investigated the effects of environmental factors on energy metabolism in a menopause model using an ovariectomized (OVX) mouse model. Wild-type female mice (8-week-old) were subjected to OVX or a sham operation and maintained under standard condition (SC), enriched environment (EE), or isolated (IS) condition for 4 weeks. OVX led to weight gain and disruption of circadian rhythms, along with changes in various metabolic parameters influenced by differences in housing environments; i.e., EE improved metabolic parameters, but IS deteriorated them. Physical activity and social interaction were factors that determined these differences. Menopause is usually a significant transitional period in a woman's life, and changes in the social environment during this period can contribute to a diverse range of physical and psychological symptoms. Consequently, when implementing interventions to alleviate menopause-related pathological conditions, not only physical symptoms but also the social context should be carefully considered.

    DOI: 10.1371/journal.pone.0320180

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  • Activation of NF-κB signaling regulates ovariectomy-induced bone loss and weight gain. Reviewed International journal

    Fei Huang, Jing Gao, Aonan Li, Akiko Mizokami, Miho Matsuda, Kazuhiro Aoki, Takenobu Katagiri, Tomoyo Kawakubo-Yasukochi, Eijiro Jimi

    Biochimica et biophysica acta. Molecular basis of disease   1870 ( 7 )   167320 - 167320   2024.6   ISSN:09254439

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Biochimica et Biophysica Acta - Molecular Basis of Disease  

    Postmenopausal women experience bone loss and weight gain. To date, crosstalk between estrogen receptor signals and nuclear factor-κB (NF-κB) has been reported, and estrogen depletion enhances bone resorption by osteoclasts via NF-κB activation. However, it is unclear when and in which tissues NF-κB is activated after menopause, and how NF-κB acts as a common signaling molecule for postmenopausal weight gain and bone loss. Therefore, we examined the role of NF-κB in bone and energy metabolism following menopause. NF-κB reporter mice, which can be used to measure NF-κB activation in vivo, were ovariectomized (OVX) and the luminescence intensity after OVX increased in the metaphyses of the long bones and perigonadal white adipose tissue, but not in the other tissues. OVX was performed on wild-type (WT) and p65 mutant knock-in (S534A) mice, whose mutation enhances the transcriptional activity of NF-κB. Weight gain with worsening glucose tolerance was significant in S534A mice after OVX compared with those of WT mice. The bone density of the sham group in WT or S534A mice did not change, whereas in the S534A-OVX group it significantly decreased due to the suppression of bone formation and increase in bone marrow adipocytes. Disulfiram, an anti-alcoholic drug, suppressed OVX-induced activation of NF-κB in the metaphyses of long bones and white adipose tissue (WAT), as well as weight gain and bone loss. Overall, the activation of NF-κB in the metaphyses of long bones and WAT after OVX regulates post-OVX weight gain and bone loss.

    DOI: 10.1016/j.bbadis.2024.167320

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  • Effects of Maternal Nutrition on Oral Health in Offspring Invited Reviewed

    Kawakubo-Yasukochi T, Hayashi Y, Hirata M

    Current Oral Health Reports   10 ( 3 )   69 - 74   2023.7   eISSN:2196-3002

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media LLC  

    Purpose of Review: According to the Developmental Origins of Health and Disease (DOHaD) theory, nutritional status in utero can permanently change body structure, function, and metabolism and eventually regulate the susceptibilities toward various diseases in later life. This review aims to examine and summarize the findings of previous reports, revealing how maternal nutrition during pregnancy and lactation affects oral health in offspring. Recent Findings: A limited number of studies have found an evident relationship between maternal nutrition and children’s oral health. Some evidence suggests that maternal nutrients such as sucrose, proteins, minerals, and vitamins are associated with oral and maxillofacial development, including bone and tooth size, and the risk of dental caries, periodontal disease, and oral cancer in offspring. Summary: The lessons of DOHaD theory from the perspective of the oral health of offspring reveal how in utero nutrients affect not only oral health but also total health throughout life. Oral disease and dysfunction can be prevented in the next generation by improving maternal nutrition during pregnancy and lactation periods.

    DOI: 10.1007/s40496-023-00338-z

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    Other Link: https://link.springer.com/article/10.1007/s40496-023-00338-z/fulltext.html

  • Id4 modulates salivary gland homeostasis and its expression is downregulated in IgG4- related disease via miR-486-5p Reviewed International journal

    Hayashi Y, Kimura S, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hatakeyama Y, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T.

    Biochemical et Biophysics Acta (BBA) - Molecular Cell Research   119404 ( 2 )   119404 - 119404   2023.2   ISSN:0167-4889

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    Salivary glands are physiologically orchestrated by the coordinated balance between cell differentiation, proliferation, apoptosis, and interactions between epithelial, mesenchymal endothelial, and neuronal cells, and they are frequent sites of manifestations of Sjögren's syndrome (SS) or IgG4-related disease (IgG4-RD). However, little is known about salivary gland homeostasis and its involvement in those diseases. Inhibitor of DNA binding/differentiation 4 (Id4) is an Id protein involved in the transcriptional control of many biological events, including differentiation. Studies of Id4-deficient mice revealed that Id4-deficient submandibular glands were smaller and exhibited accelerated differentiation, compared with those from wild-type littermates. In addition, dry mouth symptoms and Th17 expansion in splenocytes were also observed in the absence of Id4. Furthermore, Id4 levels in the salivary glands of patients with IgG4-RD, but not SS, were significantly decreased compared with those of healthy controls. miRNA-mRNA integrated analysis demonstrated that miR-486-5p was upregulated in IgG4-RD patients and that it might regulate Id4 in the lesion sites. Together, these results provide evidence for the inhibitory role of Id4 in salivary differentiation, and a critical association between Id4 downregulation and IgG4-RD.

    DOI: 10.1016/j.bbamcr.2022.119404

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  • Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and this is modified by osteocalcin administration in mice. Reviewed International journal

    Kawakubo-Yasukochi T, Yano E, Kimura S, Nishinakagawa T, Mizokami A, Hayashi Y, Hatakeyama Y, Ohe K, Yasukochi A, Nakamura S, Jimi E, Hirata M.

    Mol Metab   54   101360   2021.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: https://doi.org/10.1016/j.molmet.2021.101360

  • Anthracenyl functionalization of half-sandwich carbene complexes: In vitro anticancer activity and reactions with biomolecules Reviewed International journal

    Lee B, Sullivan M, @Yano E, Tong K, Hanif, M, #Kawakubo-Yasukochi T, Jamieson, S, Söhnel T, Goldstone D, Hartinger C.

    Inorg Chem   60 ( 19 )   14636 - 14644   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1021/acs.inorgchem.1c01675.

  • Adipocyte-specific GPRC6A ablation promotes diet-induced obesity by inhibiting lipolysis Reviewed International journal

    Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T, Otani T, Takeuchi H, Jimi E, Hirata M.

    J Biol Chem   296   100274   2021.1

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    DOI: doi: 10.1016/j.jbc.2021.100274.

  • Maternal folic acid depletion during early pregnancy increases sensitivity to squamous tumor formation in the offspring in mice Reviewed International journal

    Kawakubo-Yasukochi T., Morioka M., Ohe K., Yasukochi A., Ozaki Y., Hazekawa M., Nishinakagawa T., Ono K., Nakamura S., Nakashima M.

    J Dev Orig Health Dis   10 ( 6 )   683 - 691   2019.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1017/S2040174419000217.

    Repository Public URL: https://hdl.handle.net/2324/6776459

  • GLP-1 Signaling Is Required for Improvement of Glucose Tolerance by Osteocalcin Reviewed International journal

    Mizokami A, Mukai S, Gao J, Kawakubo-Yasukochi T, Otani T, Takeuchi H, Jimi E, Hirata M.

    J Endocrinol   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1530/JOE-19-0288

  • Evaluation of IC50 levels immediately after treatment with anticancer reagents using a real-time cell monitoring device Reviewed International journal

    Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.

    Exp Ther Med   18 ( 4 )   3197 - 3205   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/etm.2019.7876.

  • Regulation of collagen type XVII expression by miR203a-3p in oral squamous cell carcinoma cells Reviewed International journal

    Yasukochi A, Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Ono K, Nakashima M, Nakamura S.

    J Biochem   166 ( 2 )   163 - 173   2019.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvz024.

    Repository Public URL: https://hdl.handle.net/2324/6777135

  • Glypican-3 gene silencing for ovarian cancer using siRNA-PLGA hybrid micelles in a murine peritoneal dissemination model Reviewed International journal

    Hazekawa M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.

    J Pharmacol Sci   139 ( 3 )   231 - 239   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jphs.2019.01.009.

  • In vitro anti-inflammatory effects of the phenylbutyric acid metabolite phenylacetyl glutamine Reviewed International journal

    Hazekawa M, Ono K, Nishinakagawa T, Kawakubo-Yasukochi T, Nakashima M.

    Biol Pharm Bull   6 ( 41 )   961 - 966   2018.6

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  • miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment Reviewed International journal

    Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Yasukochi A, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M.

    Mol Carcinog   57 ( 2 )   295 - 302   2018.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/mc.22744.

    Repository Public URL: http://hdl.handle.net/2324/4071701

  • Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro Reviewed International journal

    Hazekawa M, Hideshima Y, Ono K, Nishinakagawa T, Kawakubo-Yasukochi T, Takatani-Nakase T, Nakashima M.

    Exp Ther Med   14 ( 5 )   4349 - 4355   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/etm.2017.5106.

  • Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth Reviewed International journal

    Hayashi Y, Kawakubo-Yasukochi T, Mizokami A, Hazekawa M, Yakura T, Naito M, Takeuchi H, Nakamura S, Hirata M.

    J Cancer   8 ( 13 )   2478 - 2486   2017.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.7150/jca.18648.

    Repository Public URL: http://hdl.handle.net/2324/4102271

  • Assessment of cytotoxicity of imatinib for oral squamous cell carcinoma by a real-time cell analysis system Reviewed International journal

    Hazekawa M, Morioka M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakamura S, Nakashima M

    eJBio   13 ( 1 )   56 - 62   2017.1

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  • Uncarboxylated osteocalcin increases serum nitric oxide levels and ameliorates hypercholesterolemia in mice fed an atherogenic diet Reviewed International journal

    Kondo A, Kawakubo-Yasukochi T, Mizokami A, Chishaki S, Takeuchi H, Hirata M.

    eJBio   13 ( 1 )   22 - 28   2016.12

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  • Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth Reviewed International journal

    Hayashi Y, Kawakubo-Yasukochi T, Mizokami A, Takeuchi H, Nakamura S, Hirata M.

    J Cancer   7 ( 12 )   1605 - 1609   2016.7

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    Repository Public URL: http://hdl.handle.net/2324/4071702

  • Maternal oral administration of osteocalcin protects offspring from metabolic impairment in adulthood Reviewed International journal

    Kawakubo-Yasukochi T, Kondo A, Mizokami A, Hayashi Y, Chishaki S, Nakamura S, Takeuchi H, Hirata M.

    Obesity   24 ( 4 )   895 - 907   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/oby.21447.

    Repository Public URL: http://hdl.handle.net/2324/5909133

  • Long-term oral administration of osteocalcin induces insulin resistance in male mice fed a high-fat, high-sucrose diet Reviewed International journal

    Yasutake Y, Mizokami A, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M.

    Am J Physiol Endocrinol Metab   310 ( 8 )   E662 - E675   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpendo.00334.2015.

  • Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination Reviewed International journal

    Morioka M, Kawakubo-Yasukochi T, Hayashi Y, Hazekawa M, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M.

    J Oral Biosci   58   33 - 38   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: http://hdl.handle.net/2324/5909143

  • Effect of collagen type I or human fibronectin on imatinib cytotoxicity in oral squamous cell carcinoma Reviewed International journal

    Morioka M, Hazekawa M, Kawakubo-Yasukochi T, Nishinakagawa T, Nakamura S, Nakashima M.

    Pharmacology and Pharmacy   7   255 - 263   2016.3

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  • The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes Reviewed International journal

    Kawakubo-Yasukochi T, Morioka M, Hayashi Y, Nishinakagawa T, Hazekawa M, Kawano S, Nakamura S, Nakashima M.

    J Oral Biosci   58   33 - 38   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: http://hdl.handle.net/2324/5909140

  • Promotion of insulin-induced glucose uptake in C2C12 myotubes by osteocalcin Reviewed International journal

    Tsuka S, Aonuma F, Higashi S, Ohsumi T, Nagano K, Mizokami A, Kawakubo-Yasukochi T, Masaki C, Hosokawa R, Hirata M, Takeuchi H.

    Biochem Biophys Res Commun   459 ( 3 )   437 - 442   2015.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2015.02.123.

  • Oral administration of osteocalcin improves glucose utilization by stimulating glucagon-like peptide-1 secretion Reviewed International journal

    Mizokami A, Yasutake Y, Higashi S, Kawakubo-Yasukochi T, Chishaki S, Takahashi I, Takeuchi H, Hirata M.

    Bone   69   68 - 79   2014.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bone.2014.09.006.

  • A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy Reviewed International journal

    Kataoka S, Baba A, Suda Y, Takii R, Hashimoto M, Kawakubo T, Asao T, Kadowaki T, Yamamoto K.

    FASEB J   28 ( 8 )   3564 - 3578   2014.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fj.14-252130.

    Repository Public URL: https://hdl.handle.net/2324/6777138

  • Role of cathepsin E in decidual macrophage of patients with recurrent miscarriage Reviewed International journal

    Goto S, Ozaki Y, Suzumori N, Yasukochi A, Kawakubo T, Furuno T, Nakanishi M, Yamamoto K, Sugiura-Ogasawara M.

    Mol Hum Reprod   20 ( 5 )   454 - 462   2014.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/molehr/gau008.

    Repository Public URL: https://hdl.handle.net/2324/6777136

  • Repression of cathepsin E expression increases the risk of mammary carcinogenesis and links to poor prognosis in breast cancer Reviewed International journal

    Kawakubo T, Yasukochi A, Toyama T, Takahashi S, Okamoto K, Tsukuba T, Nakamura S, Ozaki Y, Nishigaki K, Yamashita H, Yamamoto K.

    Carcinogenesis   35 ( 3 )   714 - 726   2014.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/carcin/bgt373.

    Repository Public URL: https://hdl.handle.net/2324/6777131

  • Proven in vitro evolution of protease cathepsin E-inhibitors and -activators at pH 4.5 using a paired peptide method Reviewed International journal

    Kitamura K, Komatsu M, Biyani M, Futakami M, Kawakubo T, Yamamoto K, Nishigaki K.

    J Pept Sci   18 ( 12 )   711 - 719   2012.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/psc.2453.

  • Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene Reviewed International journal

    Okamoto K, Okamoto Y, Kawakubo T, Iwata J, Yasuda Y, Tsukuba T, Yamamoto K.

    J Biochem   151 ( 3 )   263 - 272   2012.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/jb/mvr135.

    Repository Public URL: https://hdl.handle.net/2324/6777133

  • The role of cathepsin E in terminal differentiation of keratinocytes Reviewed International journal

    Kawakubo T, Yasukochi A, Okamoto K, Okamoto Y, Nakamura S, Yamamoto K.

    Biol Chem   392 ( 6 )   571 - 585   2011.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1515/BC.2011.060.

    Repository Public URL: http://hdl.handle.net/2324/4071689

  • In Vitro Selection of Cathepsin E-Activity-Enhancing Peptide Aptamers at Neutral pH Reviewed International journal

    Biyani M, Futakami M, Kitamura K, Kawakubo T, Suzuki M, Yamamoto K, Nishigaki K.

    Int J Pept   2011   834525   2011.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1155/2011/834525.

  • Peptide aptamer-based ELISA-like system for detection of cathepsin E in tissues and plasma Reviewed International journal

    Kitamura K, Biyani M, Futagami M, Ueno-Tsuji S, Suzuki M, Kawakubo T, Yamamoto K, Nishigaki K.

    J Mol Biomark Diagn   2   104   2011.3

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  • Cathepsin E enhances anticancer activity of doxorubicin on human prostate cancer cells showing resistance to TRAIL-mediated apoptosis Reviewed International journal

    Yasukochi A, Kawakubo T, Nakamura S, Yamamoto K.

    Biol Chem   391 ( 8 )   947 - 958   2010.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1515/BC.2010.087.

    Repository Public URL: http://hdl.handle.net/2324/4071691

  • Development of systemic in vitro evolution and its application to generation of peptide-aptamer-based inhibitors of cathepsin E Reviewed International journal

    Kitamura K, Yoshida C, Kinoshita Y, Kadowaki T, Takahashi Y, Tayama T, Kawakubo T, Naimuddin M, Salimullah M, Nemoto N, Hanada K, Husimi Y, Yamamoto K, Nishigaki K.

    J Mol Biol   387 ( 5 )   1186 - 1198   2009.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.jmb.2008.12.028.

    Repository Public URL: http://hdl.handle.net/2324/5909134

  • Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates Reviewed International journal

    Kawakubo T, Yasukochi A, Tsukuba T, Kadowaki T, Yamamoto K.

    Biochimie   90 ( 2 )   396 - 404   2008.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: http://hdl.handle.net/2324/4104131

  • Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface Reviewed International journal

    Kawakubo T, Okamoto K, Iwata J, Shin M, Okamoto Y, Yasukochi A, Nakayama KI, Kadowaki T, Tsukuba T, Yamamoto K.

    Cancer Res   67 ( 22 )   10869 - 10878   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: https://hdl.handle.net/2324/6777139

  • Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses Reviewed International journal

    Shin M, Kadowaki T, Iwata J, Kawakubo T, Yamaguchi N, Takii R, Tsukuba T, Yamamoto K.

    Biol Chem   388 ( 11 )   1173 - 1181   2007.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    Repository Public URL: http://hdl.handle.net/2324/4071690

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Presentations

  • 4-octyl itaconate induces cellular senescence in cancer cells

    Hayashi Y, Saeki A, Hirata M, Jimi E, Kawakubo-Yasukochi T.

    第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会  2025.3 

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    Event date: 2025.3

    Language:English   Presentation type:Poster presentation  

  • The role of Id4 in salivary gland homeostasis

    Kimura S, Hayashi Y, Yano E, Yoshimoto S, Saeki A, Yasukochi A, Hirata M, Jimi E, Kawakubo-Yasukochi T.

    the 25th Korea-Japan Joint Seminar on Pharmacology  2024.11 

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    Event date: 2024.11

    Language:English   Presentation type:Poster presentation  

    Venue:Jeju, Korea  

  • Itaconate and itaconate analog: Antitumor activity in melanoma

    Saeki A, Hayashi Y, Yoshimoto S, Kimura S, Hirata M, Jimi E, Kawakubo-Yasukochi T.

    the 25th Korea-Japan Joint Seminar on Pharmacology  2024.11 

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    Event date: 2024.11

    Language:English   Presentation type:Poster presentation  

    Venue:Jeju, Korea  

  • 胎児期栄養環境と成熟後エネルギー代謝異常の因果メカニズムの追究 Invited

    安河内(川久保)友世、自見英治郎、平田雅人

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:長崎  

  • イタコン酸を用いたがん進展制御へのアプローチ

    林慶和、佐伯彩華、平田雅人、自見英治郎、安河内(川久保)友世

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:長崎  

  • グルタチオン代謝制御を介した4-オクチルイタコン酸の抗腫瘍効果

    佐伯彩華、林慶和、吉本尚平、安河内篤、平田雅人、自見英治郎、安河内(川久保)友世

    第66回歯科基礎医学会学術大会  2024.11 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Poster presentation  

    Venue:長崎  

  • Developmental Originの分子基盤解明に 向けて〜動物実験と疫学研究で分かりつつあること〜 Invited

    安河内(川久保)友世

    第12回新胎児学研究会  2024.11 

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    Event date: 2024.11

    Language:Japanese   Presentation type:Symposium, workshop panel (nominated)  

    Venue:福岡  

  • The role of itaconate in melanoma progression

    Saeki A, Hayashi Y, Yoshimoto S, Hirata M, Jimi E, Kawakubo-Yasukochi T.

    第83回日本癌学会学術総会  2024.9 

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    Event date: 2024.9

    Language:English   Presentation type:Poster presentation  

    Venue:福岡  

  • がんの増殖における4-オクチルイタコン酸の役割

    佐伯彩華、林慶和、吉本尚平、平田雅人、自見英治郎、安河内(川久保)友世

    令和6年度日本生化学会九州支部例会  2024.6 

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    Event date: 2024.6

    Language:Japanese   Presentation type:Poster presentation  

  • Pathophysiological role of Id4 for salivary gland homeostasis and IgG4-related diseases International conference

    Yoshikazu Hayashi, Soi Kimura, Ena Yano, Shohei Yoshimoto, Ayaka Saeki, Teppei Yasukuni, Atsushi Yasukochi, Yuji Hatakeyama, Masato Hirata, Eijiro Jimi, Tomoyo Kawakubo-Yasukochi

    8th Edition of International Conference on Dentistry and Oral Health  2024.3 

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    Event date: 2024.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:Singapore  

  • 創薬ターゲットとしての生体内分子〜オステオカルシンとイタコン酸〜 Invited

    安河内(川久保)友世

    北九州化学工学懇話会(KACE)第76回講演会  2023.12 

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    Event date: 2023.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:北九州市   Country:Japan  

  • 生活環境に起因する閉経後の骨粗鬆症やエネルギー代謝異常症の進展制御機構

    鞠超然、安河内(川久保)友世、高田、小倉綾乃、川端 由子、自見 英治郎

    第96回日本生化学会大会  2023.11 

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    Event date: 2023.10 - 2023.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • Regulation of hepatic fatty acid metabolism by Id4

    Zhu R, Hayashi Y, Kimura S, Yano E, Hatakeyama Y, Hirata M, Jimi E, Lo YC, Kawakubo-Yasukochi T.

    第96回日本生化学会大会  2023.10 

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    Event date: 2023.10 - 2023.11

    Language:English  

    Venue:福岡   Country:Japan  

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  • がん細胞増殖におけるイタコン酸の役割

    佐伯彩華, 林慶和, 吉本尚平, 畠山雄次, 平田雅人, 自見英治郎, 安河内(川久保)友世

    第96回日本生化学会大会  2023.11 

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    Event date: 2023.10 - 2023.11

    Language:Japanese  

    Venue:福岡   Country:Japan  

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  • The role of Id4 on energy metabolism in adipose tissue and liver

    Zhu R, Hayashi Y, Kimura S, Hatakeyama Y, Hirata M, Jimi E, Kawakubo-Yasukochi T.

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

    Language:English  

    Venue:東京   Country:Japan  

  • 閉経後の骨・エネルギー代謝異常の進展を制御する環境エンリッチメント

    鞠超然、安河内(川久保)友世、高田、小倉綾乃、川端由子、自見 英治郎

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Venue:東京   Country:Japan  

  • イタコン酸によるがん細胞抗酸化システムの制御

    佐伯彩華, 林慶和, 吉本尚平, 畠山雄次, 平田雅人, 自見英治郎, 安河内(川久保)友世

    第65回歯科基礎医学会学術大会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Venue:東京   Country:Japan  

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  • 九州大学歯学部・大学院歯学研究院における国際推進の取り組み Invited

    安河内(川久保)友世、自見 英治郎

    日本歯科保健医療国際協力学会 歯科医学系国際協力教育促進ワークショップ  2023.7 

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    Event date: 2023.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋   Country:Japan  

  • 唾液腺恒常性維持におけるId4の役割と唾液腺疾患への関与

    林慶和、木村宗惟、吉本尚平、矢野恵奈、自見英治郎、安河内(川久保)友世

    第128回日本解剖学会総会  2023.3 

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    Event date: 2023.3

    Language:Japanese  

    Venue:仙台   Country:Japan  

  • The role of Id4 in salivary gland and its involvement in the pathology of IgG4-related disease

    Kimura S, Hayashi Y, Yano E, Saeki A, Yasukochi A, Moriyama M, Nakamura S, Jimi E, Kawakubo-Yasukochi T.

    第96回日本薬理学会年会  2022.11 

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    Event date: 2022.11 - 2022.12

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 妊娠母体栄養がもたらす産仔の肝グリコーゲン分解異常とオステオカルシンによる回避

    安河内(川久保)友世、矢野恵奈、木村宗惟、溝上顕子、林慶和、安河内篤、中村誠司、自見英治郎、平田雅人

    第9回日本DOHaD学会  2022.10 

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    Event date: 2022.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:仙台   Country:Japan  

  • がん進展におけるイタコン酸の役割

    佐伯彩華、林慶和、自見英治郎、安河内(川久保)友世

    第64回歯科基礎医学会学術大会  2022.9 

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    Event date: 2022.9

    Language:Japanese  

    Venue:徳島   Country:Japan  

  • 唾液腺におけるId4の役割と病態への関与

    木村 宗惟、林慶和、佐伯彩華、安河内篤、中村誠司、自見英治郎、安河内(川久保) 友世

    第64回歯科基礎医学会学術大会  2022.9 

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    Event date: 2022.9

    Language:Japanese  

    Venue:徳島   Country:Japan  

  • Maternal high calorie diet during pregnancy induces abnormal hepatic glycogenolysis in the offspring and it is mitigated by osteocalcin

    @安河内(川久保) 友世、矢野 恵奈、木村 宗惟、溝上顕子、林慶和、安河内 篤、中村 誠司、自見 英治郎、 平田 雅人

    第95回日本薬理学会年会  2021.3 

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    Event date: 2022.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Physiological and Pathological Roles of Inhibitor of Differentiation 4 in the Salivary Gland International conference

    #Soi Kimura, @Tomoyo Kawakubo-Yasukochi, @Yoshikazu Hayashi, @Ena Yano, @Masafumi Moriyama, @Seiji Nakamura, @Eijiro Jimi

    The 5th KOB OBT joint international symposium 2021  2022.6 

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    Event date: 2021.11

    Language:English   Presentation type:Oral presentation (general)  

    Venue:Fukuoka   Country:Japan  

  • Physiological and Pathological Roles of Inhibitor of Differentiation 4 in the Salivary Gland International conference

    Soi Kimura, Tomoyo Kawakubo-Yasukochi, Yoshikazu Hayashi, Ena Yano, Masafumi Moriyama, Seiji Nakamura, Eijiro Jimi

    The 5th KOB OBT joint international symposium 2021  2022.6 

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    Event date: 2021.11

    Language:English  

    Venue:Fukuoka   Country:Japan  

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  • Association of maternal folic acid shortage during early pregnancy with carcinogenic risk in the offspring International conference

    @Tomoyo Kawakubo-Yasukochi T, @Ena Yano, #Soi Kimura, @Seiji Nakamura, @Eijiro Jimi

    The 28th Federation Meeting of Korean Basic Medical Scientists 2021 (The 23rd Korea-Japan Joint Seminar on Pharmacology (23rd KJJSP))  2021.6 

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    Event date: 2021.6

    Language:English   Presentation type:Oral presentation (general)  

    Venue:オンライン   Country:Korea, Republic of  

  • Distinctive non-cording RNA profile in the serum of IgG4-related disease patient International conference

    #Soi Kimura, @Tomoyo Kawakubo-Yasukochi, @Yoshikazu Hayashi, @Ena Yano, @Masafumi Moriyama, @Seiji Nakamura, @Eijiro Jimi

    The 28th Federation Meeting of Korean Basic Medical Scientists 2021 (The 23rd Korea-Japan Joint Seminar on Pharmacology (23rd KJJSP))  2021.6 

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    Event date: 2021.6

    Language:English   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:オンライン   Country:Korea, Republic of  

  • 口腔扁平上皮癌におけるBP180の局在

    安河内篤、森岡政彦、@川久保-安河内友世、中島学、中村誠司

    第59回歯科基礎医学会学術大会  2017.9 

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    Event date: 2020.9

    Language:Japanese  

    Venue:松本   Country:Japan  

  • 胎内栄養環境に基づく糖脂質代謝制御とオステオカルシンの関与

    @安河内(川久保) 友世、溝上顕子、木村 宗惟、中村 誠司、自見 英治郎、 平田 雅人

    第62回歯科基礎医学会学術大会  2020.9 

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    Event date: 2020.9

    Language:English  

    Venue:鹿児島(web開催)   Country:Japan  

  • 脂肪細胞表面受容体GPRC6Aの食事誘発性肥満における役割

    溝上 顕子、大谷 崇仁、松田 美穂、@安河内(川久保) 友世、竹内 弘、自見 英治郎、 平田 雅人

    第62回歯科基礎医学会学術大会  2020.9 

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    Event date: 2020.9

    Language:English  

    Venue:鹿児島(web開催)   Country:Japan  

  • IgG4関連疾患病態形成における非コードRNAの役割

    木村宗惟、@安河内(川久保)友世、中村誠司、自見英治郎

    第62回歯科基礎医学会学術大会  2020.9 

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    Event date: 2020.9

    Language:English  

    Venue:鹿児島(web開催)   Country:Japan  

  • PBA投与後血清中に誘導される抗炎症活性本体の解明

    小野和彦、櫨川舞、西中川拓也、@安河内(川久保)友世、中島学

    日本薬学会第138年会  2018.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • オステオカルシンが制御する胎内栄養環境応答と疾病素因形成

    @安河内(川久保)友世, 溝上顕子, 平田雅人

    第93回日本薬理学会年会  2020.3 

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    Event date: 2020.3

    Language:Japanese  

    Venue:誌上開催   Country:Japan  

  • The effect of maternal folic acid deficienncy during early pregnancy on the carcinogen sensitivity of offspring in mice International conference

    @Kawakubo-Yasukochi T, Morioka M, Yasukochi A, Hazekawa M, Nishinakagawa T, Ono K, Nakamura S, Nakashima M.

    The 11th DOHaD World Congress (DOHaD2019)  2019.10 

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    Event date: 2019.10

    Language:English  

    Venue:Melbourne   Country:Australia  

  • The effect of maternal uncarboxylated osteocalcin on the metabolic properties of next generation International conference

    @Kawakubo-Yasukochi T, Kondo A, Mizokami A, Hirata M.

    The 11th DOHaD World Congress (DOHaD2019)  2019.10 

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    Event date: 2019.10

    Language:English  

    Venue:Melbourne   Country:Australia  

  • miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment

    @Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Nishinakagawa T, Yasukochi A, Nakamura S, Nakashima M.

    第92回日本薬理学会年会  2019.3 

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    Event date: 2019.3

    Language:Japanese  

    Venue:大阪   Country:Japan  

  • 妊娠母体が飲用する胎盤通過性オステオカルシンが胎児の糖脂質代謝関連臓器のエピジェネティックな変化に及ぼす影響 Invited

    @安河内(川久保)友世

    DIJFカンファレンス  2018.10 

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    Event date: 2018.10

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:東京   Country:Japan  

  • 抗炎症作用を有するピーマン葉水抽出エキス中の成分探索

    櫨川舞、小野和彦、西中川拓也、@安河内(川久保)友世、中島学

    日本薬学会第138年会  2018.3 

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    Event date: 2018.3

    Language:Japanese  

    Venue:金沢   Country:Japan  

  • Microenvironmental communications within oral squamous cell carcinoma defined by exosomes

    Morioka M, @Kawakubo-Yasukochi T, Hazekawa M, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M.

    第65回国際歯科研究学会日本部会総会・学術大会  2017.11 

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    Event date: 2017.11

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Therapeutic effects of self-assembled siRNA-PLGA hybrid conjugate micelles for ovarian cancer

    Hazekawa M, Morioka M, Nishinakagawa T, @Kawakubo-Yasukochi T, Nakamura S, Nakashima M.

    第76回日本癌学会学術総会  2017.9 

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    Event date: 2017.9

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 非コードRNAによる口腔癌の進展制御

    @川久保-安河内友世、森岡政彦、安河内篤、中村誠司、中島学

    2017.9 

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    Event date: 2017.9 - 2020.9

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:松本   Country:Japan  

  • 口腔扁平上皮癌におけるAT1受容体拮抗薬の影響

    森岡政彦、@川久保-安河内友世、中村誠司、中島学

    第59回歯科基礎医学会学術大会  2017.9 

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    Event date: 2017.9

    Language:Japanese  

    Venue:松本   Country:Japan  

  • 妊娠母体が摂取したオステオカルシンが次世代に及ぼす影響

    @川久保-安河内友世、近藤皓彦、溝上顕子、平田雅人

    第6回日本DOHaD学会学術集会  2017.8 

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    Event date: 2017.8

    Language:Japanese  

    Venue:東京   Country:Japan  

  • Preparation of self-assembled siRNA-PLGA hybrid conjugate micelles as GPC-3 gene silencing therapy for ovarian cancer International conference

    Hazekawa M, Morioka M, Nishinakagawa T, @Kawakubo-Yasukochi T, Nakamura S, Nakashima M.

    The 6th Pharmaceutical Sciences World Congress 2017  2017.5 

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    Event date: 2017.5

    Language:English  

    Venue:Stockholm   Country:Sweden  

  • 口腔扁平上皮癌細胞由来エクソソームによるがん微小環境制御とリンパ行性転移の規定

    森岡政彦、@安河内(川久保)友世、中村誠司

    第71回日本口腔科学会学術集会  2017.4 

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    Event date: 2017.4

    Language:Japanese  

    Venue:愛媛   Country:Japan  

  • Exosome-mediated crosstalk determines invasiveness and organotropic metastasis in oral squamous carcinoma International conference

    Morioka M, @Kawakubo-Yasukochi T, Hazekawa M, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M.

    The 5th ASHNO Congress 2017, Congress of Asian Society of Head and Neck Oncology  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:Bali   Country:Indonesia  

  • The significance of BP180 expression in oral squamous carcinoma cell invasion International conference

    Yasukochi A, Morioka M, @Kawakubo-Yasukochi T, Nakashima M, Nakamura S.

    The 5th ASHNO Congress 2017, Congress of Asian Society of Head and Neck Oncology  2017.3 

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    Event date: 2017.3

    Language:English  

    Venue:Bali   Country:Indonesia  

  • 卵巣がんにおける siRNA-PLGA ハイブリッドミセル製剤の遺伝子抑制による治療効果

    Hazekawa M, Nishinakagawa T, @Kawakubo-Yasukochi T, Nakashima M.

    第90回日本薬理学会年会  2017.3 

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    Event date: 2017.3

    Language:Japanese  

    Venue:長崎   Country:Japan  

  • Exosomes from oral squamous carcinoma cells define the tropism of invasiveness and lymphatic dissemination International conference

    Morioka M, @Kawakubo-Yasukochi T, Nakamura S, Nakashima M.

    Kyudai Oral Bioscience 2017  2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Uncarboxylated osteocalcin prevents cancer progression through multiple mechanisms including immune system International conference

    Hayashi Y, @Kawakubo-Yasukochi T, Mizokami A, Nakamura S, Hirata M

    Kyudai Oral Bioscience 2017  2017.2 

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    Event date: 2017.2

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • オステオカルシンを用いた次世代生活習慣病改善へのアプローチ Invited

    @安河内(川久保)友世、近藤皓彦、溝上顕子、竹内弘、平田雅人

    第37回日本肥満学会  2016.10 

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    Event date: 2016.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • NF-κBシグナル伝達の活性化は卵巣摘出による骨量減少と体重増加を調節する

    黄 菲, 高 靖, 松田 美穂, 青木 和広, 片桐 岳信, 安河内 友世, 自見 英治郎

    日本骨代謝学会学術集会プログラム抄録集  2024.6  (一社)日本骨代謝学会

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MISC

  • Effects of Maternal Nutrition on Oral Health in Offspring Reviewed

    Kawakubo-Yasukochi T, Hayashi Y, Hirata M.

    Current Oral Health Reports (accepted)   2023.6

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • The roles of osteocalcin in lipid metabolism in adipose tissue and liver Reviewed

    Otani T, Mizokami A, @Kawakubo-Yasukochi T, Takeuchi H, Inai T, Hirata M.

    Adv Biol Regul   2020.12

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: https://doi.org/10.1016/j.jbior.2020.100752

  • 次世代肥満を制御する妊娠期オステオカルシンの有用性 Reviewed

    安河内(川久保)友世、溝上顕子、平田雅人

    2017.10

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  • 骨基質蛋白質による次世代生活習慣病の予防を目指して

    安河内(川久保) 友世、溝上 顕子、平田 雅人

    Medical Science Digest   2017.5

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Osteocalcin and its endocrine functions Reviewed

    Mizokami A, Kawakubo-Yasukochi T, Hirata M.

    Biochem Pharmacol   2017.5

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.bcp.2017.02.001.

  • Regulation of glycolipid metabolism during gestational period by incretin response -Aiming at establishment a metabolic syndrome prophylaxis beyond the generation-

    Kawakubo-Yasukochi T

    J Soc Wom Health Sci Res   2017.3

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  • オステオカルシンとエネルギー代謝 Reviewed

    溝上顕子、安河内(川久保)友世、竹内弘、平田雅人

    骨粗鬆症治療   2017.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • オステオカルシンとインスリン分泌 Reviewed

    溝上顕子、川久保(安河内)友世、竹内弘、平田雅人

    日薬理誌 (Folia Pharmacol Jpn)   2015.3

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • Emerging roles of cathepsin E in host defense mechanisms Reviewed

    Yamamoto K, Kawakubo T, Yasukochi A, Tsukuba T.

    Biochim Biophys Acta   2012.1

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

    DOI: 10.1016/j.bbapap.2011.05.022.

  • Cathepsin E as a potent anticancer protease Reviewed

    Kawakubo T, Yasukochi A, Yamamoto K.

    J Oral Biosci   2011.3

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells Reviewed

    Kadowaki T, Takii R, Yamatake K, Kawakubo T, Tsukuba T, Yamamoto K.

    2007.9

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    Language:English   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • An Endogenous Inhibitor of Angiogenesis and Tumor Growth Reviewed

    Iwata J, Kawakubo T, Yamamoto K.

    2004.3

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  • オステオカルシンのホルモン作用 Reviewed

    溝上顕子、安河内(川久保)友世、大谷崇仁、平田雅人

    糖尿病・内分泌代謝科   2022.4

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • オステオカルシンのホルモン作用 Reviewed

    溝上顕子, 安河内(川久保)友世, 大谷崇仁, 平田雅人

    2022.4

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    Language:Japanese   Publisher:糖尿病・内分泌代謝科  

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Industrial property rights

Patent   Number of applications: 8   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Japanese Society for Proteases in Pathophysiology

  • Japanese Cancer Association

  • Japanese Association for Oral Biology

  • 日本薬理学会

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  • 日本生化学会

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  • 日本DOHaD学会

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  • International Proteolysis Society

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Committee Memberships

  • 日本生化学会九州支部例会   Councilor   Domestic

    2025.6 - Present   

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    Committee type:Academic society

  • 歯科基礎医学会   代議員、広報委員   Domestic

    2024.4 - Present   

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    Committee type:Academic society

  • 日本薬理学会   国際対応アソシエイツ   Domestic

    2023.4 - Present   

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    Committee type:Academic society

  • 九州大学   男女共同参画推進室室員  

    2023.4 - 2025.3   

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    Committee type:Other

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  • 日本病態プロテアーゼ学会   Councilor   Domestic

    2020.9 - Present   

  • 九州大学   学務委員会委員  

    2020.7 - 2022.6   

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    Committee type:Other

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  • 九州大学   国際連携推進室担当、部局国際推進室副室長  

    2020.4 - 2024.3   

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    Committee type:Other

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  • 九州大学   ハラスメント相談員  

    2020.4 - 2022.3   

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    Committee type:Other

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  • 九州大学   障害者支援推進専門委員会委員  

    2020.4 - 2022.3   

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    Committee type:Other

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  • 九州大学   放射線安全委員会委員  

    2020.4 - 2022.3   

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    Committee type:Other

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Research Projects

  • 胎内栄養環境が規定する成熟後の肥満・異所性脂肪蓄積の素因形成メカニズム

    Grant number:25K02802  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    安河内 友世

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    Grant type:Scientific research funding

    本研究では、妊娠中に高脂肪高ショ糖食や各種ビタミン欠乏食・過剰食を摂取した母親マウスの産仔について、網羅的解析により得られる DNAメチル化や遺伝子発現変化を統合的に解析することで、疾患感受性遺伝子の同定を行い、それら遺伝子についての機能解析を行う。またその結果に基づき、妊娠母体あるいは臍帯血中の当該栄養素と産子の代謝パラメータとの相関について、ヒトでの検証(出生コホートを用いた解析)を行う。

    CiNii Research

  • 原因不明不育症患者におけるプロゲステロン応答に着目した新たな流産予防戦略の開発

    Grant number:25K12705  2025.4 - 2029.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    後藤 志信, 市川 智子, 杉浦 真弓, 吉原 紘行, 尾崎 康彦, 川久保友世

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    Grant type:Scientific research funding

    本邦では不育症は5%と欧米より高頻度であり、不育症の克服は少子化対策に直結する。25原因不明患者に対し、欧州のRCTで流産回数が多く性器出血を伴う患者へのプロゲステロン(P4)腟錠の有効性が報告されたが、妊娠年齢の高齢化が進んでいる本邦において流産を繰り返す前に治療効果のある患者を選び出し流産を予防する戦略を開発することが重要である。本研究ではP4シグナルに関連する遺伝子多型が不育症病態におけるP4感受性に関わっているとの仮説のもと、P4応答群と不応群とでゲノムワイド関連解析(GWAS)を用いて遺伝子多型を同定する。これらの成果はヒト妊娠維持メカニズムの新たな解明に発展できる。

  • 植物由来天然化合物の探索とその応用

    2024.9 - 2030.3

    エシカルライフ株式会社 

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    Authorship:Principal investigator  Grant type:Joint research

  • Investigation on obesity predisposition and its patho-physiological properties regulated by transgenerational epigenomic regulation

    Grant number:24K02868  2024.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    平田 雅人, 安河内 友世

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    Grant type:Scientific research funding

    生活習慣病の多くは肥満に起因する。一旦発症すると治療効果が得難いことから、その制圧には肥満の予防策を講じることが重要である。ところが今、肥満予防には、生後の取り組みに加えて新たな視点が必要となっている。
    申請者は現在までに、動物実験で妊娠母体の栄養状態によって次世代の仔に肥満が現れる事を認め、肥満の仔で生じているエピゲノム異常の共通項を肥満感受性エピゲノムとした。そこで本研究では、細胞や動物を用いた生物学実験とヒト疫学研究を組み合わせて母体の栄養(因)と児の肥満発症素因(果)の関係について検証し、肥満感受性や肥満症多様性を決定する世代を超えるエピゲノム変化の同定と検証を行う。

    CiNii Research

  • 女性ホルモン欠乏によるNF-κB活性化機構と骨・エネルギー代謝制御の解明

    Grant number:24K02612  2024.4 - 2027.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    自見 英治郎, 安河内 友世, 片桐 岳信

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    閉経後の女性では、骨密度の低下と共に脂肪の増加による体重増加が起こる。我々は卵巣摘出マウスモデルにNF-κB阻害剤を投与すると、骨量の減少が抑制されるだけでなく、体重増加も抑制することを報告した。以上のような学術的背景と独自の研究成果に基づき、骨量減少と体重増加に重要な女性ホルモンの欠乏で起きるNF-κBシグナルの活性化組織・細胞を同定し、特異的にNF-κBシグナルを抑制できれば、閉経後の骨量減少とエネルギー代謝の悪化に対する革新的な治療法や予防法が確立できると考えた。本研究成果は、新たな骨代謝とエネルギー代謝間のクロストークを提唱するだけでなく、国民のQOLの延伸に貢献できる。

    CiNii Research

  • エネルギー代謝に関与するACOD1およびイタコン酸の機能解析

    2024.4 - 2025.3

    群馬大学生体調節研究所 内分泌・代謝学共同研究拠点 

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    Authorship:Principal investigator  Grant type:Joint research

  • 胎内栄養が規定する肥満素因の最上流エピゲノム〜動物実験とヒト疫学研究による解明〜

    2023

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    Grant type:Donation

  • 胎内栄養環境が規定する肥満感受性エピゲノムの証明

    2023

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  • 肝オステオカルシンによる糖・脂質代謝異常の世代間ドミノ制御機構の解明

    2023

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    Grant type:Donation

  • 胎内栄養環境が規定する肥満症病態形成メカニズム〜実験的検証と出生コホート疫学調査による包括的理解〜

    2023

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    Grant type:Donation

  • 出生コホート調査と生物学的実験の融合による肥満素因世代間継承メカニズムの証明

    Grant number:22KK0263  2022 - 2025

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Fostering Joint International Research (A)

    安河内 友世

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    Authorship:Principal investigator  Grant type:Scientific research funding

    本課題では、申請者が実験動物や培養細胞を用いた生物学的実験によって明らかにした「妊娠母体の摂取栄養素と産仔の肥満・肥満症の素因(エピゲノム異常)との相関」について、GUSTO (Growing up in Singapore towards Healthy Outcomes) および S-PRESTO (Singapore Preconception Study of Long-Term Maternal and Child Outcome)の出生コホートデータベースを活用することで、疫学研究(ヒト)を主体とした検証を行い、妊娠母体が摂取する栄養素が制御する経世代エピゲノムを必要十分に実証する。

    CiNii Research

  • 妊娠母体栄養が定義する肥満素因と肥満症多様性の経世代エピゲノム解析

    Grant number:22K09914  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    安河内 友世

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    Authorship:Principal investigator  Grant type:Scientific research funding

    近年、肥満に伴う生体反応の多様性が認められており、症状が顕在化している個体およびその集団だけで病態の因果を理解することに限界が生じている。
    申請者は現在までに、妊娠期に過栄養または食餌性葉酸欠乏を負荷した母体の産仔はいずれも肥満感受性が上昇し、ゲノムには共通する特定のDNAメチル化変化が生じていること、しかし、顕在化する耐糖能障害の誘因や、肝・脂肪の組織像、血清脂質パラメータは異なることを見出している。
    そこで、本研究では、肥満感受性を決定する経世代エピゲノム変化の同定と、その検証を行い、母体の栄養(因)と仔の疾患発症素因(果)の因果関係の分子基盤について科学的に実証し、肥満症多様性の謎に迫る。

    CiNii Research

  • Novel therapeutic strategies for the treatment of recurrent pregnancy loss by elucidating the function of endometrium and decidua with a focus on insulin response

    Grant number:22K09575  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    後藤 志信, 尾崎 康彦, 安河内 友世

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    不育症の発症頻度は妊娠女性の約5%と決して稀ではなく、その25%は胎児染色体が正常を示す原因不明である。原因不明不育症患者の約3割はインスリン抵抗性高値を示すことや、インスリンが子宮内膜や脱落膜に作用し様々な免疫学的・生化学的反応を引き起こすことが知られているが、インスリンがどのように不育症に関わっているかは不明である。本研究では過剰分泌されたインスリンがサイトカインやプロテアーゼの異常反応による脱落膜化障害と絨毛浸潤抑制引き起こし流産に至る、という仮説を臨床検体及びin vitroの実験系で検証し、インスリン応答に着目した妊娠維持メカニズムの分子解明による新たな不育症治療戦略の開拓を目指す。

    CiNii Research

  • 脂肪細胞の分化と恒常性維持におけるId4の役割

    2022

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  • 胎内栄養が定義するエネルギー代謝異常の経世代エピゲノム解析

    2022

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    Grant type:Donation

  • 非コードRNAを用いたドライマウス創薬戦略

    2022

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  • 肝オステオカルシンによる肥満発生阻止機構の解明

    2022

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    Grant type:Donation

  • 胎内栄養環境によるNASH発癌素因形成の分子基盤

    2022

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    Grant type:Donation

  • 胎内栄養環境が惹起する次世代エネルギー代謝異常症の分子基盤解明とオステオカルシンによる回避機構の解析

    2021

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  • 胎内栄養環境に規定される生活習慣病素因形成メカニズムの解析

    2021

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  • 妊娠母体の消化管ホルモン応答が制御する次世代グリコーゲン異化制御機構の解明

    2021

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  • Studies on the effect of maternal uncarboxylated osteocalcin on the metabolic properties of next generation

    Grant number:20H03854  2020 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    Hirata Masato

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    An increasing amount of evidence indicates that an adverse perinatal environment contributes to a higher risk of metabolic disorders in later life of the offspring. We show that a maternal high-fat-high-sucrose diet during pregnancy causes metabolic disorders in the offspring via hypermethylation of the liver Pygl gene, encoding glycogen phosphorylase L, which mediates hepatic glycogenolysis. The lower expression of Pygl induced by the maternal diet causes the hepatic accumulation of glycogen and triglyceride in the offspring, which remains in adulthood. The administration of osteocalcin during pregnancy upregulates Pygl expression via both direct and indirect epigenomic pathways, resulting in the mitigation of the maternal diet-induced obesity and abnormal glucose and lipid metabolism in adulthood. We propose that maternal energy status is reflected in the hepatic glycogenolysis capacity of the offspring via epigenetic modification of Pygl and osteocalcin regulates glycogenolysis.

    CiNii Research

  • Immunologic specificity based pathogenesis of IgG4-related diseases and validation in mouse models of the disease

    Grant number:20H00553  2020 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

    Nakamura Seiji

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

    IgG4-related diseases is a unique systemic disease characterized by mass formation and consequent dysfunction of multiple organs, as well as severe fibrosis with infiltrating T cells, B cells, and macrophages. Currently, no effective treatment is available. In this study, we focused on a subset of unique T cells, B cells, and macrophages and performed single-cell RNA sequencing as well as T-B receptor sequencing to obtain a comprehensive, unbiased view of tissue infiltrating cells. As a result, we identified characteristic T and B cell subsets. We also focused on macrophages expressing Toll-like receptor 7 and tested whether it is possible to generate mice that can reproduce the pathology by stimulating them with TLR7 agonist.

    CiNii Research

  • 胎内でのエピゲノム修飾に基づく口腔癌発症素因形成の分子基盤

    Grant number:19K10052  2019 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    安河内 友世

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    Authorship:Principal investigator  Grant type:Scientific research funding

    近年、生活習慣病胎児期起源説(DOHaD: Developmental Origins of Health and Disease)、すなわち妊娠母体の栄養状態が児の将来の生活習慣病発症リスクを規定していることが様々な疫学調査によって実証されつつある。
    申請者は最近、妊娠母体の葉酸欠乏が胎児の発がん遺伝子にメチル化異常を誘導すること明らかにした。
    そこで本研究では、妊娠母体が摂取するOne carbon metabolism 関連栄養素の摂取量に着目した動物実験を行うことで、扁平上皮癌発症素因が胎内で規定されている可能性をエピジェネティックな観点から検証する。

    CiNii Research

  • 胎生期栄養環境によるエピゲノム制御とがん発症素因形成の分子基盤の解明

    2019

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    Grant type:Donation

  • 母体のOne carbon metabolismに基づく次世代癌発症ヒエラルキーの解明

    2018

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    Grant type:Donation

  • IgG4関連疾患の病因解明とマウス疾患モデルの作製による検証

    Grant number:17H01603  2017 - 2019

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 胎内における肥満インプリンティング機構の解析?エピジェネティックな観点から?

    2017

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    Grant type:Donation

  • 妊娠母体が飲用する胎盤通過性オステオカルシンが胎児の糖脂質代謝関連臓器のエピジェネティックな変化に及ぼす影響

    2017

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    Grant type:Donation

  • 組織特異的non-coding RNAが制御する癌の病態形成メカニズムの解析

    Grant number:16K11496  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • がん進展における組織特異的非コードRNAネットワークの探索

    2016

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    Grant type:Donation

  • 妊娠期オステオカルシン摂取による次世代糖脂質代謝異常の予防戦略

    2016

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    Grant type:Donation

  • 口腔扁平上皮癌の浸潤・転移を規定する唾液中短鎖非コードRNAの同定と機能解析

    2016

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    Grant type:Donation

  • インクレチン応答による腫瘍進展制御機構の解明

    2015 - 2017

    福岡大学推奨研究プロジェクト助成金

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • インクレチン応答による妊娠期糖脂質代謝の正常化戦略?世代を越えたメタボリックシンドローム予防法の確立を目指して?

    2015

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    Grant type:Donation

  • オステオカルシンを用いた前立腺癌制圧戦略

    2015

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    Grant type:Donation

  • インクレチンによる小腸粘膜や膵臓の恒常性維持に関する研究

    Grant number:26861554  2014 - 2015

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • プロテアーゼに着眼した神経幹細胞と癌幹細胞の自己複製能機序異同の解明

    2014 - 2015

    Japan Society for the Promotion of Science  Postdoctoral Fellowships for Research Abroad

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    Authorship:Principal investigator  Grant type:Joint research

  • GLP-1応答による周産期・新生児期糖代謝機構の解明-Osteocalcinの医薬応用を目指して-

    2013

    九州大学教育研究プログラム・研究拠点形成プロジェクト(P&P)研究経費

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    Authorship:Principal investigator  Grant type:On-campus funds, funds, etc.

  • プロテアーゼに着眼した神経幹細胞と癌幹細胞の自己複製能機序異同の解明

    Grant number:24-医歯薬-192  2012 - 2013

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 周産期・発育期脳障害の可塑性におけるリソソーム酵素の役割

    2011

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    Grant type:Donation

  • 周産期・発育期脳障害の可塑性におけるリソソーム酵素の役割

    2011

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    Grant type:Donation

  • 乳癌の発生・進展におけるカテプシン E の役割と乳癌の発症予防に関する研究

    Grant number:22591438  2010 - 2012

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid)  Grant type:Scientific research funding

  • 唾液腺分化過程におけるカテプシンEの役割と唾液腺悪性腫瘍の新規診査技術の開発

    Grant number:22791790  2010 - 2011

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists(A)or(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 歯周病と全身疾患の連関の分子機構の解明と分子標的治療薬の開発

    Grant number:22390350  2010 - 2011

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 蛋白質高速分子進化技術による歯周病の分子標的治療薬及び早期診断キットの開発

    Grant number:21659430  2009

    Grants-in-Aid for Scientific Research  Grant-in-Aid for challenging Exploratory Research

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • カテプシンEによる乳癌制御機構の解明

    2008

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    Grant type:Donation

  • 乳癌診断のための高速バイオマーカー診断キットの開発

    2008

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    Grant type:Donation

  • カテプシンEによる乳癌制御メカニズムの解明

    2008

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    Grant type:Donation

  • プロテアーゼ反応を介する生体防御システム制御の分子基盤の確立と臨床応用への展開

    Grant number:19209058  2007 - 2009

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • アポトーシスによる癌の増殖・転移の制御と分子標的療法の開発

    Grant number:医歯薬18-9582  2006 - 2007

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • アポトーシスによる癌の増殖・転移の制御と分子標的療法の開発

    2006 - 2007

    Japan Society for the Promotion of Science  Research Fellowships for Young Scientists

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    Authorship:Principal investigator  Grant type:Joint research

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Educational Activities

  • 学部2年生に対する口腔生化学の講義の一部と実習を担当。
    学部4年生に対する歯科薬理学の講義の一部(悪性腫瘍)を担当。
    その他、大学院生への研究指導を行っている。

Class subject

  • スタートアップ倫理学

    2023.4 - Present   Full year

  • 口腔脳機能病態学

    2021.4 - Present   Full year

  • 歯科薬理学

    2020.4 - Present   Full year

  • 口腔生化学

    2020.4 - Present   Full year

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2025  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験   Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2024  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  博多メディカル専門学校・歯科衛生士科・薬理学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  博多メディカル専門学校・歯科衛生士科・薬理学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  博多メディカル専門学校・歯科衛生士科・薬理学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  香蘭女子短期大学・食物栄養学科・解剖生理生化学実験  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2014  博多メディカル専門学校・歯科衛生士科・薬理学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2010  香蘭女子短期大学・食物栄養学科・生化学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2010  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2009  香蘭女子短期大学・食物栄養学科・生化学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2009  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2008  香蘭女子短期大学・食物栄養学科・生化学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2008  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2007  香蘭女子短期大学・食物栄養学科・生化学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2007  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2006  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2005  福岡医科歯科技術専門学校・歯科衛生士科・微生物学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

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Teaching Student Awards

  • 藤野博賞

    Year and month of award:2025.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:佐伯彩華

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  • 九州大学学術研究活動表彰

    Year and month of award:2025.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:佐伯彩華

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  • Special Poster Presentation Award

    Year and month of award:2024.11

    Classification of award-winning students:Doctoral student   Name of award-winning student:佐伯彩華

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  • 銅賞

    Year and month of award:2024.6

    Classification of award-winning students:Doctoral student   Name of award-winning student:佐伯彩華

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  • 優秀賞

    Year and month of award:2023.9

    Classification of award-winning students:Doctoral student   Name of award-winning student:佐伯彩華

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  • モリタ賞(生化学部門)

    Year and month of award:2017.9

    Classification of award-winning students:Doctoral student   Name of award-winning student:近藤皓彦

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  • 藤野博賞

    Year and month of award:2017.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:林慶和

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  • Best Poster Award

    Year and month of award:2017.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:森岡政彦

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  • 九州大学学術研究活動表彰

    Year and month of award:2017.3

    Classification of award-winning students:Doctoral student   Name of award-winning student:林慶和

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  • 最優秀賞

    Year and month of award:2016.9

    Classification of award-winning students:Doctoral student   Name of award-winning student:森岡政彦

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  • モリタ賞(病理学部門)

    Year and month of award:2016.8

    Classification of award-winning students:Doctoral student   Name of award-winning student:森岡政彦

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  • JADR/GC Young Investigator Award

    Year and month of award:2015.10

    Classification of award-winning students:Doctoral student   Name of award-winning student:林慶和

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  • 先端歯学スクール 2015 優秀発表賞

    Year and month of award:2015.9

    Classification of award-winning students:Doctoral student   Name of award-winning student:林慶和

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  • 優秀ポスター賞

    Year and month of award:2011.4

    Classification of award-winning students:Doctoral student   Name of award-winning student:安河内篤

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  • Travel Award

    Year and month of award:2007.10

    Classification of award-winning students:Doctoral student   Name of award-winning student:安河内篤

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Other educational activity and Special note

  • 2016  Special Affairs  平成28年度 薬剤師継続学習通信教育 前期スクーリング講座講師(佐賀県薬剤師会)「免疫抑制剤の基礎知識」

     詳細を見る

    平成28年度 薬剤師継続学習通信教育 前期スクーリング講座講師(佐賀県薬剤師会)「免疫抑制剤の基礎知識」

  • 2016  Special Affairs  第49回薬学部卒後教育講座(福岡大学市民カレッジ)講師「骨代謝からみた生活習慣病」

     詳細を見る

    第49回薬学部卒後教育講座(福岡大学市民カレッジ)講師「骨代謝からみた生活習慣病」

Outline of Social Contribution and International Cooperation activities

  • International Affair

Social Activities

  • 薬剤師継続学習通信教育講座 平成28年度 前期スクーリング講座

    Role(s):Lecturer

    一般社団法人 佐賀県薬剤師会男女共同参画委員会  薬剤師継続学習通信教育講座 平成28年度 前期スクーリング講座  佐賀県薬剤師会館  2016.11

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    Type:Lecture

    「免疫抑制剤の基礎知識」

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  • 薬学部卒後教育講座(福岡大学市民カレッジ)

    Role(s):Lecturer

    福岡大学  薬学部卒後教育講座(福岡大学市民カレッジ)  福岡大学薬学部  2016.10

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    Audience:Researchesrs, General

    Type:Lecture

    「骨代謝からみた生活習慣病」

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Media Coverage

  • 産経新聞web版びっくりサイエンスの記事に、研究成果が取り上げられた。 Newspaper, magazine

    産経新聞  2021.11

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    産経新聞web版びっくりサイエンスの記事に、研究成果が取り上げられた。

Travel Abroad

  • 2025.1 - 2025.3

    Staying countory name 1:Singapore   Staying institution name 1:シンガポール国立大学

  • 2024.2 - 2024.5

    Staying countory name 1:Singapore   Staying institution name 1:シンガポール国立大学

  • 2023.8 - 2023.11

    Staying countory name 1:Taiwan, Province of China   Staying institution name 1:国立台湾大学

  • 2013.11 - 2015.4

    Staying countory name 1:Sweden   Staying institution name 1:Karolinska Institute

Year of medical license acquisition

  • 2003