Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Takahiro A. Kato Last modified date:2019.08.30

Lecturer / Department of Neuropsychiatry, Graduate School of Medical Sciences / Neuro-Psychiatry / Kyushu University Hospital


Papers
1. Masaru Tateno, Alan R. Teo, Wataru Ukai, Junichiro Kanazawa, Ryoko Katsuki, Hiroaki Kubo, Takahiro Kato, Internet addiction, smartphone addiction, and hikikomori trait in Japanese young adult
Social isolation and social network, Frontiers in Psychiatry, 10.3389/fpsyt.2019.00455, 10, JULY, 2019.01, Background: As the number of internet users increases, problems related to internet overuse are becoming more and more serious. Adolescents and youth may be particularly attracted to and preoccupied with various online activities. In this study, we investigated the relationship of internet addiction, smartphone addiction, and the risk of hikikomori, severe social withdrawal, in Japanese young adult. Methods: The subjects were 478 college/university students in Japan. They were requested to complete the study questionnaire, which consisted of questions about demographics, internet use, the Internet Addiction Test (IAT), the Smartphone Addiction Scale (SAS)-Short Version (SV), the 25-item Hikikomori Questionnaire (HQ-25), etc. We investigated the difference and correlation of the results between two groups based on the purpose of internet use or the total score of each self-rating scale, such as screened positive or negative for the risk of internet addiction, smartphone addiction, or hikikomori. Results: There was a trend that males favored gaming in their internet use while females used the internet mainly for social networking via smartphone, and the mean SAS-SV score was higher in females. Two-group comparisons between gamers and social media users, according to the main purpose of internet use, showed that gamers used the internet longer and had significantly higher mean IAT and HQ-25 scores. Regarding hikikomori trait, the subjects at high risk for hikikomori on HQ-25 had longer internet usage time and higher scores on both IAT and SAS-SV. Correlation analyses revealed that HQ-25 and IAT scores had a relatively strong relationship, although HQ-25 and SAS-SV had a moderately weak one. Discussion: Internet technology has changed our daily lives dramatically and altered the way we communicate as well. As social media applications are becoming more popular, users are connected more tightly to the internet and their time spent with others in the real world continues to decrease. Males often isolate themselves from the social community in order to engage in online gaming while females use the internet as to not be excluded from their communications online. Mental health providers should be aware of the seriousness of internet addictions and hikikomori..
2. Takahiro Kato, Shigenobu Kanba, Alan R. Teo, Hikikomori 
Multidimensional understanding, assessment, and future international perspectives, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12895, 73, 8, 427-440, 2019.08, Hikikomori, a severe form of social withdrawal, has long been observed in Japan mainly among youth and adolescents since around the 1970s, and has been especially highlighted since the late 1990s. Moreover, hikikomori-like cases have recently been reported in many other countries. Hikikomori negatively influences not only the individual's mental health and social participation, but also wider education and workforce stability, and as such is a novel urgent global issue. In this review, we introduce the history, definition, diagnostic evaluation, and interventions for hikikomori and also the international prevalence of hikikomori outside Japan. We propose a hypothesis regarding the globalization of hikikomori based on domestic and international perspectives. In addition, we introduce our latest assessment system for hikikomori (including the latest version of the ‘proposed diagnostic criteria of hikikomori for the future DSM/ICD diagnostic systems’) and propose therapeutic strategies, including family approaches and individualized therapies. Finally, we present future challenges that may lead to solutions for an internationalized hikikomori..
3. John C. Wong, Michelle J. Wan, Leoniek M. Kroneman, Takahiro Kato, Wing T. Lo, Paul W. Wong, Chan H. Gloria, Hikikomori phenomenon in East Asia
Regional perspectives, challenges and opportunities for social health agencies, Frontiers in Psychiatry, 10.3389/fpsyt.2019.00512, 10, JUN, 2019.01.
4. Seon Cheol Park, Eun Young Jang, Gyung Mee Kim, Ajit Avasthi, Sandeep Grover, Andi Jayalangkara Tanra, Takahiro Kato, Kok Yoon Chee, Mian Yoon Chong, Afzal Javed, Chay Hoon Tan, Norman Sartorius, Naotaka Shinfuku, Yong Chon Park, Establishing the cut-off score for aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients, Psychiatry and Clinical Psychopharmacology, 10.1080/24750573.2019.1626067, 2019.01, OBJECTIVE: We aimed to present the scalability and cut-off score for the presence of aggression on the Brief Psychiatric Rating Scale-Excited Component (BPRS-EC) in schizophrenia patients. METHODS: From the Research on Asian Psychotropic Prescription Patterns for Antipsychotics, 1,438 Asian patients with schizophrenia were recruited in present study. The Mokken analysis was used to evaluate scalability of the BPRS-EC. The receiver operating characteristic (ROC) curve was used to establish the optimal cut-off score for the presence of aggression on the BPRS-6 in schizophrenia patients. RESULTS: The Mokken model presented that the scalability of the BPRS-EC was considered to have a strong “unidimensionality” (coefficient of scalability = 0.57). The ROC curve showed that, with the cut-off score of 5, the total score on the BPRS-EC distinguished the absence and presence of aggression in schizophrenia patients. CONCLUSION: The BPRS-EC can be used as a supplementary scale for evaluating aggression in patients with schizophrenia..
5. Takahiro Kato, Ryoko Katsuki, Hiroaki Kubo, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Wakako Umene-Nakano, Masaru Tateno, Daiki Setoyama, Dongchon Kang, Motoki Watabe, Shinji Sakamoto, Alan R. Teo, Shigenobu Kanba, Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale
Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22), Psychiatry and Clinical Neurosciences, 10.1111/pcn.12842, 73, 8, 448-457, 2019.08, Aim: Understanding premorbid personality is important, especially when considering treatment selection. Historically, the premorbid personality of patients with major depression in Japan was described as Shuchaku-kishitsu [similar to Typus melancholicus], as proposed by Shimoda in the 1930s. Since around 2000, there have been increased reports in Japan of young adults with depression who have had premorbid personality differing from the traditional type. In 2005, Tarumi termed this novel condition ‘dysthymic-type depression,’ and more recently the condition has been called Shin-gata/Gendai-gata Utsu-byo [modern-type depression (MTD)]. We recently developed a semi-structured diagnostic interview to evaluate MTD. Development of a tool that enables understanding of premorbid personality in a short time, especially at the early stage of treatment, is desirable. The object of this study was to develop a self-report scale to evaluate the traits of MTD, and to assess the scale's psychometric properties, diagnostic accuracy, and biological validity. Methods: A sample of 340 participants from clinical and community settings completed measures. Psychometric properties were assessed with factor analysis. Diagnostic accuracy of the MTD traits was compared against a semi-structured interview. Results: The questionnaire contained 22 items across three subscales, thus we termed it the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22). Internal consistency, test–retest reliability, and convergent validity were all satisfactory. Among patients with major depression, the area under the curve was 0.757 (sensitivity of 63.1% and specificity of 82.9%) and the score was positively correlated with plasma tryptophan. Conclusion: The TACS-22 possessed adequate psychometric properties and diagnostic accuracy in an initial sample of Japanese adults. Additional research on its ability to support clinical assessment of MTD is warranted..
6. Ryoko Katsuki, Ayako Inoue, Sílvia Indias, Keita Kurahara, Nobuki Kuwano, Fumika Funatsu, Hiroaki Kubo, Shigenobu Kanba, Takahiro Kato, Clarifying deeper psychological characteristics of hikikomori using the rorschach comprehensive system
A pilot case-control study, Frontiers in Psychiatry, 10.3389/fpsyt.2019.00412, 10, JUN, 2019.01, Hikikomori, a form of severe social withdrawal more than 6 months, has increasingly become a crucial issue especially among adolescents. Loneliness, avoidant personality, Japanese culture-related attachment style ("amae"), and difficulty in expressing emotions are suggested to be related to hikikomori. However, deeper psychological aspects have not been well clarified. The Rorschach test is one of the most popular psychological assessment tools to evaluate deeper personality traits. The Rorschach Comprehensive System (CS) has been established as the most reliable scoring method. Until now, no CS research has been conducted focusing on hikikomori. Therefore, we herein conducted a pilot case-control study using CS in clinical cases with and without hikikomori condition. Participants were recruited from the Mood Disorder/Hikikomori Clinic at Kyushu University Hospital. Twenty-Two patients with hikikomori (HK patients) and 18 patients without hikikomori (non-HK patients) participated in the present study. All the 40 participants conducted the self-report Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II) personality questionnaire and CS. Regarding the SCID-II personality questionnaire, various personality traits including passive aggressive trait were significantly higher in HK patients. Among CS variables, HK patients showed higher scores on FC (Form Color) and SumT (total number of texture-related responses). In addition, frequency of SumT was higher in HK patients. The present results suggest that persons with hikikomori are more likely to express emotions indirectly and expect others to presume their feelings and thoughts. Persons with hikikomori may also have difficulty in becoming independent emotionally from primitive dependence and attachment on significant others. Further investigations with larger samples are warranted for validation..
7. Masaru Tateno, Dai Jin Kim, Alan R. Teo, Norbert Skokauskas, Anthony P.S. Guerrero, Takahiro Kato, Smartphone addiction in Japanese college students
Usefulness of the japanese version of the smartphone addiction scale as a screening tool for a new form of internet addiction, Psychiatry Investigation, 10.30773/pi.2018.12.25.2, 16, 2, 115-120, 2019.02, ObjectiveaaSmartphone use is pervasive among youth in Japan, as with many other countries, and is associated with spending time online and on social media anywhere at any time. This study aimed to test a Japanese version of the Smartphone Addiction Scale-Short Version (SAS-SV) among Japanese college students. MethodsaaThe subjects of this study were 602 college students in Japan. The study questionnaire consisted of questions about demographics (age, gender etc.), possession of a smartphone, internet use [length of internet use on weekdays and weekend, favorite social networking service (SNS) etc.], Young’s Internet Addiction Test (IAT), and the Smartphone Addiction Scale-Short Version (SAS-SV) translated into Japanese. ResultsaaThere was a total of 573 respondents (180 male, 393 female) who completed the questionnaire (mean 19.3±1.3 years). LINE was the most popular social media platform (52.0%) followed by Twitter (36.3%). The overall Internet Addiction Test (IAT) score was 45.3±13.2, with 4.5% classified as having severe addiction (IAT ≥70). The mean SAS-SV scores were 24.4±10.0 for males and 26.8±9.9 for females. Based on proposed cutoff scores, 22.8% of males and 28.0% of females screened positive for smartphone addiction. The total scores of the SAS-SV and the IAT was correlated significantly. ConclusionaaAs the number of smartphone users becomes higher, problems related to smartphone use also become more serious. Our results suggest that the Japanese version of SAS-SV may assist in early detection of problematic use of smartphones..
8. Takahiro Kato, Ryoko Katsuki, Hiroaki Kubo, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Wakako Umene-Nakano, Masaru Tateno, Daiki Setoyama, Dongchon Kang, Motoki Watabe, Shinji Sakamoto, Alan R. Teo, Shigenobu Kanba, Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale
Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22), Psychiatry and Clinical Neurosciences, 10.1111/pcn.12842, 2019.01, Aim: Understanding premorbid personality is important, especially when considering treatment selection. Historically, the premorbid personality of patients with major depression in Japan was described as Shuchaku-kishitsu [similar to Typus melancholicus], as proposed by Shimoda in the 1930s. Since around 2000, there have been increased reports in Japan of young adults with depression who have had premorbid personality differing from the traditional type. In 2005, Tarumi termed this novel condition ‘dysthymic-type depression,’ and more recently the condition has been called Shin-gata/Gendai-gata Utsu-byo [modern-type depression (MTD)]. We recently developed a semi-structured diagnostic interview to evaluate MTD. Development of a tool that enables understanding of premorbid personality in a short time, especially at the early stage of treatment, is desirable. The object of this study was to develop a self-report scale to evaluate the traits of MTD, and to assess the scale's psychometric properties, diagnostic accuracy, and biological validity. Methods: A sample of 340 participants from clinical and community settings completed measures. Psychometric properties were assessed with factor analysis. Diagnostic accuracy of the MTD traits was compared against a semi-structured interview. Results: The questionnaire contained 22 items across three subscales, thus we termed it the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22). Internal consistency, test–retest reliability, and convergent validity were all satisfactory. Among patients with major depression, the area under the curve was 0.757 (sensitivity of 63.1% and specificity of 82.9%) and the score was positively correlated with plasma tryptophan. Conclusion: The TACS-22 possessed adequate psychometric properties and diagnostic accuracy in an initial sample of Japanese adults. Additional research on its ability to support clinical assessment of MTD is warranted..
9. Hisaomi Suzuki, Masahiro Ohgidani, Nobuki Kuwano, Fabrice Chrétien, Geoffroy Lorin de la Grandmaison, Mitsumoto Onaya, Itaru Tominaga, Daiki Setoyama, Dongchon Kang, Masaru Mimura, Shigenobu Kanba, Takahiro Kato, Suicide and microglia
Recent findings and future perspectives based on human studies, Frontiers in Cellular Neuroscience, 10.3389/fncel.2019.00031, 13, 1-10, 2019.01, Suicide is one of the most disastrous outcomes for psychiatric disorders. Recent advances in biological psychiatry have suggested a positive relationship between some specific brain abnormalities and specific symptoms in psychiatric disorders whose organic bases were previously completely unknown. Microglia, immune cells in the brain, are regarded to play crucial roles in brain inflammation by releasing inflammatory mediators and are suggested to contribute to various psychiatric disorders such as depression and schizophrenia. Recently, activated microglia have been suggested to be one of the possible contributing cells to suicide and suicidal behaviors via various mechanisms especially including the tryptophan-kynurenine pathway. Animal model research focusing on psychiatric disorders has a long history, however, there are only limited animal models that can properly express psychiatric symptoms. In particular, to our knowledge, animal models of human suicidal behaviors have not been established. Suicide is believed to be limited to humans, therefore human subjects should be the targets of research despite various ethical and technical limitations. From this perspective, we introduce human biological studies focusing on suicide and microglia. We first present neuropathological studies using the human postmortem brain of suicide victims. Second, we show recent findings based on positron emission tomography (PET) imaging and peripheral blood biomarker analysis on living subjects with suicidal ideation and/or suicide-related behaviors especially focusing on the tryptophan-kynurenine pathway. Finally, we propose future perspectives and tasks to clarify the role of microglia in suicide using multi-dimensional analytical methods focusing on human subjects with suicidal ideation, suicide-related behaviors and suicide victims..
10. Lin SK*, Lin YF, Yang SY, He YL, Kato TA, Hayakawa K, Park YC, Sim K, Chiu HFK, Xiang YT, Chong MY, Tan CH, Inada T, Shinfuku N, Comparison of the Defined Daily Dose and Chlorpromazine Equivalent Methods in Antipsychotic Drug Utilization in Six Asian Countries, Neuropsychiatry, DOI: 10.4172/Neuropsychiatry.1000527 , 8, 6, 1847-1852, 2018.12.
11. Hiroaki Kubo, Hiromi Urata, Ryoko Katsuki, Miyako Hirashima, Shion Ueno, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Toshiko Mitsui, Shigenobu Kanba, Kotaro Otsuka, Takahiro Kato, Development of MHFA-based 2-h educational program for early intervention in depression among office workers
A single-arm pilot trial, PloS one, 10.1371/journal.pone.0208114, 13, 12, 2018.12, Objective In the workplace depression and suicide are serious mental health problems. A lack of knowledge and mental health skills along with the stigma toward mental health problems often results in delays in seeking professional help. Interventions targeting not only persons with mental health problems but also people around the individual are warranted in order to encourage supporting behavior within entire workplace. In the present study, we investigated the efficacy of our newly developed educational training program in the management with depression and suicidal risk in the workplace as a single-arm pilot trial. Methods The program is a two-hour (2-h) training course for employees based on the Mental Health First Aid (MHFA) program which aims to increase public mental health literacy. We conducted this program at a company workplace among 91 employees, and ultimately 83 participants completed the self-rated questionnaires. Changes in confidence and practical skills in early intervention of depression and suicide-prevention, and stigma toward mental health problems were evaluated using self-rated questionnaires at 3 time-points; pre-program, immediately post-program, and 1 month after the program. Results Confidence and practical skills were significantly improved even 1 month after the program, and stigma reduced just after the program. Conclusions Our pilot study suggests that the program has a positive impact on encouraging employees to support their co-workers with mental health problems, and is applicable for busy workers due to its short duration. A single-arm design, evaluation using self-rated questionnaire and short-term follow up period are the main limitations of the present study. Hence, future research is required to validate the effects of this program with control groups, and also to assess long-term effectiveness and objective changes such as absenteeism and sick leave..
12. Masaru Tateno, Nikolina Jovanović, Julian Beezhold, Kumi Uehara-Aoyama, Wakako Umene-Nakano, Takashi Nakamae, Naoki Uchida, Naoki Hashimoto, Saya Kikuchi, Yosuke Wake, Daisuke Fujisawa, Keisuke Ikari, Kotaro Otsuka, Katsuyoshi Takahashi, Gaku Okugawa, Norio Watanabe, Tomohiro Shirasaka, Takahiro Kato, Suicidal ideation and burnout among psychiatric trainees in Japan, Early Intervention in Psychiatry, 10.1111/eip.12466, 12, 5, 935-937, 2018.10, Aim: Burnout is a psychological condition that may occur in all workers after being exposed to excessive work-related stresses. We investigated suicidal ideation and burnout among Japanese psychiatric trainees as a part of the Burnout Syndrome Study (BoSS) International. Methods: In the Japanese branch, 91 trainees fully completed suicide ideation and behaviour questionnaire (SIBQ) and Maslach Burnout Inventory—General Survey (MBI-GS). Results: Passive suicidal ideation was reported by 38.5% of Japanese trainees and 22.0% of them had experienced active suicidal ideation. The burnout rate among Japanese subjects was 40.0%. These results were worse compared to the all 1980 trainees who fully completed the main outcome measure in BoSS International, 25.9%, 20.4% and 36.7%, respectively. Conclusions: Our results suggest a higher risk of suicide among Japanese residents. Japan has a higher suicide rate than other countries. Early detection of, and appropriate intervention for, suicidal ideation is important in preventing suicide in psychiatry residents..
13. Yuka Fujii, Yoshito Mizoguchi, Jun Masuoka, yayoi matsuda, Tatsuya Abe, Keizo Anzai, Yutaka Kunitake, Hiroshi Tateishi, Takayoshi Inaba, Toru Murakawa, Takahiro Kato, Akira Monji, Cushing's Syndrome and Psychosis
A Case Report and Literature Review, The primary care companion for CNS disorders, 10.4088/PCC.18br02279, 20, 5, 2018.09, Psychiatric complications of Cushing's syndrome include irritability, anxiety, depressed mood, and cognitive impairment. Psychosis is a rare manifestation of Cushing's syndrome; therefore, the literature on the subject is limited and consists mainly of clinical case reports. We report a case of Cushing's syndrome misdiagnosed as schizophrenia-like psychosis for more than 10 years. Transsphenoidal adenomectomy resulted in amelioration of psychiatric symptoms as well as improvement of cognitive ability. Clinicians should consider the presence of psychiatric symptoms predating the diagnosis of Cushing's syndrome, especially when these symptoms are persistent and treatment-resistant, as seen in the present case..
14. Yukako Nakagami, Hiroaki Kubo, Ryoko Katsuki, Tomomichi Sakai, Genichi Sugihara, Chisako Naito, Hiroyuki Oda, Kohei Hayakawa, Yuriko Suzuki, Daisuke Fujisawa, Naoki Hashimoto, Keiji Kobara, Tetsuji Cho, Hironori Kuga, Kiyoshi Takao, Yoko Kawahara, Yumi Matsumura, Toshiya Murai, Koichi Akashi, Shigenobu Kanba, Kotaro Otsuka, Takahiro Kato, Development of a 2-h suicide prevention program for medical staff including nurses and medical residents
A two-center pilot trial, Journal of Affective Disorders, 10.1016/j.jad.2017.08.074, 225, 569-576, 2018.08, Background Suicide is a crucial global health concern and effective suicide prevention has long been warranted. Mental illness, especially depression is the highest risk factor of suicide. Suicidal risk is increased in people not only with mental illness but also with physical illnesses, thus medical staff caring for physically-ill patients are also required to manage people with suicidal risk. In the present study, we evaluated our newly developed suicide intervention program among medical staff. Methods We developed a 2-h suicide intervention program for medical staff, based on the Mental Health First Aid (MHFA), which had originally been developed for the general population. We conducted this program for 74 medical staff members from 2 hospitals. Changes in knowledge, perceived skills, and confidence in early intervention of depression and suicide-prevention were evaluated using self-reported questionnaires at 3 points; pre-program, immediately after the program, and 1 month after program. Results This suicide prevention program had significant effects on improving perceived skills and confidence especially among nurses and medical residents. These significant effects lasted even 1 month after the program. Limitations Design was a single-arm study with relatively small sample size and short-term follow up. Conclusions The present study suggests that the major target of this effective program is nurses and medical residents. Future research is required to validate the effects of the program with control groups, and also to assess long-term effectiveness and actual reduction in suicide rates..
15. Norman Sartorius, Naotaka Shinfuku, Heok Eee Kua, Takahiro Kato, Alan R. Teo, Masaru Tateno, Tae Young Choi, Yatan Pal Singh Balhara, Shigenobu Kanba, Urban mental health in the twenty-first century, Advances in Psychiatry, 10.1007/978-3-319-70554-5_38, 657-678, 2018.08.
16. Tateno M*, Tateno Y, Kamikobe C, Monden R, Sakaoka O, Kanazawa J, Kato TA, Saito T, Internet addiction and ADHD traits among female college students in Japan, Journal of the Korean Academy of Child and Adolescent Psychiatry, doi: org/10.5765/jkacap.180011, 29, 3, 144-148, 2018.07.
17. Lucia Lin Liu, Tim M.H. Li, Alan R. Teo, Takahiro Kato, Paul W.C. Wong, Harnessing social media to explore youth social withdrawal in three major cities in China
Cross-sectional web survey, Journal of Medical Internet Research, 10.2196/mental.8509, 20, 5, 2018.05, Background: Socially withdrawn youth belong to an emerging subgroup of youth who are not in employment, education, or training and who have limited social interaction intention and opportunities. The use of the internet and social media is expected to be an alternative and feasible way to reach this group of young people because of their reclusive nature. Objective: The aim of this study was to explore the possibility of using various social media platforms to investigate the existence of the phenomenon of youth social withdrawal in 3 major cities in China. Methods: A cross-sectional open Web survey was conducted from October 2015 to May 2016 to identify and reach socially withdrawn youth in 3 metropolitan cities in China: Beijing, Shanghai, and Shenzhen. To advertise the survey, 3 social media platforms were used: Weibo, WeChat, and Wandianba, a social networking gaming website. Results: In total, 137 participants completed the survey, among whom 13 (9.5%) were identified as belonging to the withdrawal group, 7 (5.1%) to the asocial group, and 9 (6.6%) to the hikikomori group (both withdrawn and asocial for more than 3 months). The cost of recruitment via Weibo was US $7.27 per participant. Conclusions: Several social media platforms in China are viable and inexpensive tools to reach socially withdrawn youth, and internet platforms that specialize in a certain culture or type of entertainment appeared to be more effective in reaching socially withdrawn youth..
18. Takahiro Kato, Shigenobu Kanba, Is a socio-cultural analysis of depressive disorders a matter of concern? Response to Kaiya, American Journal of Psychiatry, 10.1176/appi.ajp.2018.17121404r, 175, 5, 483-484, 2018.05.
19. Alan R. Teo, Jason I. Chen, Hiroaki Kubo, Ryoko Katsuki, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Wakako Umene-Nakano, James E. Aikens, Shigenobu Kanba, Takahiro A Kato, Development and validation of the 25-item Hikikomori Questionnaire (HQ-25), Psychiatry and Clinical Neurosciences, 10.1111/pcn.12691, 2018.05, Aim: Hikikomori, a form of severe social withdrawal, is an emerging issue in mental health, for which validated measurement tools are lacking. The object was to develop a self-report scale of hikikomori, and assess its psychometric properties and diagnostic accuracy. Methods: A sample of 399 participants from clinical and community settings completed measures. Psychometric properties were assessed with factor analysis; diagnostic accuracy was compared against a semi-structured diagnostic interview. Results: The Hikikomori Questionnaire contained 25 items across three subscales representing socialization, isolation, and emotional support. Internal consistency, test-retest reliability, and convergent validity were all satisfactory. The area under the curve was 0.86 (95% confidence interval, 0.80-0.92). A cut-off score of 42 (out of 100) was associated with a sensitivity of 94%, specificity of 61%, and positive predictive value of 17%. Conclusion: The 25-item Hikikomori Questionnaire (HQ-25) possesses robust psychometric properties and diagnostic accuracy in an initial sample of Japanese adults. Additional research on its psychometric properties and ability to support clinical assessment of hikikomori is warranted..
20. Nobuki Kuwano, Takahiro Kato, Daiki Setoyama, Mina Sato-Kasai, Norihiro Shimokawa, Kohei Hayakawa, Masahiro Ohgidani, Noriaki Sagata, Hiroaki Kubo, Junji Kishimoto, Dongchon Kang, Shigenobu Kanba, Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder
An exploratory pilot case-control study, Journal of Affective Disorders, 10.1016/j.jad.2018.01.014, 231, 74-82, 2018.04, Background: Early intervention in depression has been critical to prevent its negative impact including suicide. Recent blood biomarker studies for major depressive disorder (MDD) have suggested that tryptophan-kynurenine and lipid related metabolites are involved in the pathophysiology of MDD. However, there have been limited studies investigating these blood biomarkers in first-episode drug-naïve MDD, which are particularly important for early intervention in depression. Methods: As an exploratory pilot case-control study, we examined the above blood biomarkers, and analyzed how these biomarkers are associated with clinical variables in first-episode drug-naïve MDD patients, based on metabolome/lipidome analysis. Results: Plasma tryptophan and kynurenine levels were significantly lower in MDD group (N = 15) compared to healthy controls (HC) group (N = 19), and plasma tryptophan was the significant biomarker to identify MDD group (area under the curve = 0.740). Lower serum high density lipoprotein-cholesterol (HDL-C) was the predictive biomarker for severity of depression in MDD group (R2 = 0.444). Interestingly, depressive symptoms were variously correlated with plasma tryptophan-kynurenine and lipid related metabolites. Moreover, plasma tryptophan-kynurenine metabolites and cholesteryl esters (CEs) were significantly correlated in MDD group, but not in HC group. Limitations: This study had small sample size, and we did not use the multiple test correction. Conclusions: This is the first study to suggest that not only tryptophan-kynurenine metabolites but also HDL-C and CEs are important blood biomarkers for first-episode drug-naïve MDD patients. The present study sheds new light on early intervention in clinical practice in depression, and further clinical studies especially large-scale prospective studies are warranted..
21. Kohei Hayakawa, Takahiro Kato, Motoki Watabe, Alan R. Teo, Hideki Horikawa, Nobuki Kuwano, Norihiro Shimokawa, Mina Sato-Kasai, Hiroaki Kubo, Masahiro Ohgidani, Noriaki Sagata, Hiroyuki Toda, Masaru Tateno, Naotaka Shinfuku, Junji Kishimoto, Shigenobu Kanba, Blood biomarkers of Hikikomori, a severe social withdrawal syndrome, Scientific Reports, 10.1038/s41598-018-21260-w, 8, 1, 2018.02, Hikikomori, a severe form of social withdrawal syndrome, is a growing social issue in Japan and internationally. The pathophysiology of hikikomori has not yet been elucidated and an effective treatment remains to be established. Recently, we revealed that avoidant personality disorder is the most common comorbidity of hikikomori. Thus, we have postulated that avoidant personality is the personality underpinning hikikomori. First, we herein show relationships between avoidant personality traits, blood biomarkers, hikikomori-related psychological features, and behavioural characteristics assessed by a trust game in non-hikikomori volunteers. Avoidant personality traits were negatively associated with high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) in men, and positively associated with fibrin degeneration products (FDP) and high sensitivity C-reactive protein (hsCRP) in women. Next, we recruited actual individuals with hikikomori, and compared avoidant personality traits, blood biomarkers, and psychological features between individuals with hikikomori and age-matched healthy controls. Individuals with hikikomori had higher avoidant personality scores in both sexes, and showed lower serum UA levels in men and lower HDL-C levels in women compared with healthy controls. This is the first report showing possible blood biomarkers for hikikomori, and opens the door to clarify the underlying biological pathophysiology of hikikomori..
22. Yohei Minami, Noriyuki Sonoda, Eiichi Hayashida, Hiroaki Makimura, Makoto Ide, Noriko Ikeda, Masahiro Ohgidani, Takahiro Kato, Yoshihiro Seki, Yasutaka Maeda, Shigenobu Kanba, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi, P66Shc Signaling Mediates Diabetes-Related Cognitive Decline, Scientific Reports, 10.1038/s41598-018-21426-6, 8, 1, 2018.02, Accumlating evidence have suggested that diabetes mellitus links dementia, notably of Alzheimer's disease (AD). However, the underlying mechanism remains unclear. Several studies have shown oxidative stress (OS) to be one of the major factors in the pathogenesis of diabetic complications. Here we show OS involvement in brain damage in a diabetic animal model that is at least partially mediated through an AD-pathology-independent mechanism apart from amyloid-β accumulation. We investigated the contribution of the p66Shc signaling pathway to diabetes-related cognitive decline using p66Shc knockout (-/-) mice. p66Shc (-/-) mice have less OS in the brain and are resistant to diabetes-induced brain damage. Moreover, p66Shc (-/-) diabetic mice show significantly less cognitive dysfunction and decreased levels of OS and the numbers of microglia. This study postulates a p66Shc-mediated inflammatory cascade leading to OS as a causative pathogenic mechanism in diabetes-associated cognitive impairment that is at least partially mediated through an AD-pathology-independent mechanism..
23. Takahiro Kato, Shigenobu Kanba, Alan R. Teo, Hikikomori
experience in Japan and international relevance, World Psychiatry, 10.1002/wps.20497, 17, 1, 105-106, 2018.02, 九州大学を拠点するひきこもり国際共同ネットワークによる成果の概要をまとめた報告である。.
24. Masaru Tateno, Alan R. Teo, Takahiro Kato, Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12672, 2018.01.
25. Mina Sato-Kasai, Takahiro Kato, Masahiro Ohgidani, Hideki Horikawa, Yoshito Mizoguchi, Akira Monji, Shigenobu Kanba, Modulating microglial activation as a possible therapeutic target for depression, Biomedical and Neurobiological Background, 10.1007/978-981-10-6580-4_18, 1, 209-219, 2018.01.
26. Tomonari Fujita, Yoshito Mizoguchi, Yutaka Kunitake, Hiroshi Tateishi, Takayoshi Inaba, Takahiro Kato, Akira Monji, Second-generation antipsychotic-induced hypoglycemia, The primary care companion for CNS disorders, 10.4088/PCC.17br02186, 20, 1, 2018.01, Complaints of hypoglycemia resemble the sedative effect of antipsychotics. As such, clinicians may overlook hypoglycemia in patients with psychiatric disorders. Here, a case of hypoglycemia associated with hyperinsulinemia induced by quetiapine in a female patient with bipolar disorder is reported. The case suggests that clinicians should be aware of the potential for hypoglycemia induced by second-generation antipsychotics..
27. Takayoshi Inaba, Rintaro Sogawa, Yoshito Mizoguchi, Hiroshi Tateishi, Yutaka Kunitake, Takahiro Kato, Akira Monji, Lamotrigine rechallenge in treatment-resistant bipolar disorder, The primary care companion for CNS disorders, 10.4088/PCC.17m02231, 20, 2, 2018.01, Background: Although lamotrigine may be useful for treating patients with treatment-resistant bipolar disorder, some lamotrigine-associated adverse effects, including mild to moderate skin rash, may prevent the continuation of treatment. Methods: We investigated lamotrigine rechallenge for the treatment of bipolar disorder. The present study was based on retrospective chart review of outpatients with bipolar disorder (DSM-5 criteria) who visited the hospital’s psychiatric department between July 2011 and August 2017. The review revealed 12 patients with bipolar disorder who underwent lamotrigine rechallenge following lamotrigine discontinuation due to various adverse reactions, including skin rash. None of the patients showed Stevens-Johnson syndrome. All patients suffered from treatment-resistant bipolar disorder that was refractory to treatments other than lamotrigine. For each patient, the severity of the adverse reaction to lamotrigine was weighed against the potential for therapeutic benefit. Results: In 9 of 12 cases, a positive outcome of lamotrigine rechallenge was observed. In all cases with initial skin rash with very slow titration of lamotrigine, rechallenge was successful with no recurrence of the rash. In the 3 cases for which lamotrigine was unsuccessful, lamotrigine was discontinued owing to movement disorders, ie, oral dyskinesia and action tremor, and liver dysfunction, respectively. Conclusions: The present results suggest that lamotrigine rechallenge may be a viable option for treatment-resistant bipolar disorder..
28. Masaru Tateno, Alan R. Teo, Masaki Shiraishi, Masaya Tayama, Chiaki Kawanishi, Takahiro Kato, Prevalence rate of Internet addiction among Japanese college students
Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12686, 2018.01, Aim: Due to variation in estimates of the prevalence of Internet addiction (IA) in prior research, we conducted two cross-sectional studies over 2years investigating the prevalence rate of IA in college students in Japan and reconsidered appropriate cut-off points of a self-rating scale to screen possible IA. Methods: This study was composed of two parts: survey I in 2014 and survey II in 2016, which were conducted in the same schools with an interval of 2years. The study questionnaire included questions about demographics and Internet use, and Young's Internet Addiction Test (IAT). Additionally, the subjects in survey II were asked about self-reported IA. Results: There were 1005 respondents in total with a mean age (± SD) of 18.9±1.3 years. The mean IAT scores remained stable between 2014 and 2016: 45.2±12.6 in survey I and 45.5±13.1 in survey II (overall mean IAT score of 45.4±13.0). With respect to self-reported IA in survey II, a total of 21.6% admitted to having IA (score of 5 or 6 on a 6-point Likert scale). We categorized these subjects as IA, and the remainder as non-IA. The mean IAT score showed a significant difference between these two groups (57.8±14.3 vs 42.1±10.7, P<0.001). Conclusion: The severity of IA symptoms among Japanese college students has appeared stable in recent years, with mean IAT scores of over 40. Our results suggest that a screening score cut-off of 40 on the IAT could be reconsidered and that 50 might be proposed for the cut-off..
29. Satoshi Akamine, Noriaki Sagata, Yasunari Sakai, Takahiro Kato, Takeshi Nakahara, Yuki Matsushita, Osamu Togao, Hiwatashi Akio, Masafumi Sanefuji, Yoshito Ishizaki, Hiroyuki Torisu, Hirotomo Saitsu, Naomichi Matsumoto, Toshiro Hara, Akira Sawa, Shinichi Kano, Masutaka Furue, Shigenobu Kanba, Chad A. Shaw, Shoichi Ohga, Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2, Epilepsia Open, 10.1002/epi4.12085, 3, 1, 81-85, 2018.01, Advance in the exome-wide sequencing analysis contributes to identifying hundreds of genes that are associated with early-onset epileptic encephalopathy and neurodevelopmental disorders. On the basis of massive sequencing data, functional interactions among different genes are suggested to explain the common molecular pathway underlying the pathogenic process of these disorders. However, the relevance of such interactions with the phenotypic severity or variety in an affected individual remains elusive. In this report, we present a 45-year-old woman with neurofibromatosis type 1 (NF1), infantile-onset epileptic encephalopathy, and severe developmental delay. Whole-exome sequencing identified de novo pathogenic mutations in NF1 and the Schaaf-Yang syndrome-associated gene, MAGEL2. Literature-curated interaction data predicted that NF1 and MAGEL2 proteins were closely connected in this network via their common interacting proteins. Direct conversion of fibroblasts into neurons in vitro showed that neuronal cells from 9 patients with NF1 expressed significantly lower levels of MAGEL2 (54%, p = 0.0047) than those from healthy individuals. These data provide the first evidence that pathogenic mutations of NF1 deregulate the expression of other neurodevelopmental disease-associated genes. De novo mutations in multiple genes may lead to severe developmental phenotypes through their cumulative effects or synergistic interactions..
30. Yu Tao Xiang, Takahiro Kato, Taishiro Kishimoto, Gabor S. Ungvari, Helen F.K. Chiu, Tian Mei Si, Shu Yu Yang, Senta Fujii, Chee H. Ng, Naotaka Shinfuku, Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009), Asia-Pacific Psychiatry, 10.1111/appy.12277, 9, 4, 2017.12, Introduction: To date no study has compared the treatment patterns for schizophrenia specifically between China and Japan. This study examined the cross-national differences in the use of psychotropic drugs and electroconvulsive therapy (ECT) in schizophrenia. Method: Data on 3248 schizophrenia inpatients (n = 1524 in China and n = 1724 in Japan) were collected by either chart review or interviews during the designated 3 study periods between 2001 and 2009. Patients' socio-demographic and clinical characteristics, prescriptions of psychotropic drugs, and ECT use were recorded using a standardized protocol and data collection procedure. Results: Multivariate analyses revealed that compared to their Japanese counterparts, Chinese inpatients had a shorter length of current hospitalization, were significantly less frequently prescribed second-generation antipsychotics (except clozapine), antipsychotic polypharmacy, benzodiazepines, and mood stabilizers, and more likely to receive clozapine, antidepressants, and ECT. Discussion: Substantial variations in inpatient treatment patterns for schizophrenia were found between China and Japan. The common use of ECT and clozapine in Chinese inpatients and the frequent use of antipsychotic polypharmacy and high antipsychotic doses in Japanese inpatients need to be addressed..
31. Paul W.C. Wong, Lucia L. Liu, Tim M.H. Li, Takahiro Kato, Alan R. Teo, Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?, Asian Journal of Psychiatry, 10.1016/j.ajp.2017.10.026, 30, 175-176, 2017.12.
32. Yoshinori Haraguchi, Yoshito Mizoguchi, Masahiro Ohgidani, Yoshiomi Imamura, Toru Murakawa-Hirachi, Hiromi Nabeta, Hiroshi Tateishi, Takahiro Kato, Akira Monji, Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia, Journal of Neuroinflammation, 10.1186/s12974-017-1033-0, 14, 1, 2017.12, Background: Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of Alzheimer's disease (AD) is related to the inflammatory responses mediated by microglia. Intracellular Ca2+ signaling is important for microglial functions such as release of NO and cytokines. In addition, alteration of intracellular Ca2+ signaling underlies the pathophysiology of AD, while it remains unclear how donepezil, an acetylcholinesterase inhibitor, affects intracellular Ca2+ mobilization in microglial cells. Methods: We examined whether pretreatment with donepezil affects the intracellular Ca2+ mobilization using fura-2 imaging and tested the effects of donepezil on phagocytic activity by phagocytosis assay in rodent microglial cells. Results: In this study, we observed that pretreatment with donepezil suppressed the TNFα-induced sustained intracellular Ca2+ elevation in both rat HAPI and mouse primary microglial cells. On the other hand, pretreatment with donepezil did not suppress the mRNA expression of both TNFR1 and TNFR2 in rodent microglia we used. Pretreatment with acetylcholine but not donepezil suppressed the TNFα-induced intracellular Ca2+ elevation through the nicotinic α7 receptors. In addition, sigma 1 receptors were not involved in the donepezil-induced suppression of the TNFα-mediated intracellular Ca2+ elevation. Pretreatment with donepezil suppressed the TNFα-induced intracellular Ca2+ elevation through the PI3K pathway in rodent microglial cells. Using DAF-2 imaging, we also found that pretreatment with donepezil suppressed the production of NO induced by TNFα treatment and the PI3K pathway could be important for the donepezil-induced suppression of NO production in rodent microglial cells. Finally, phagocytosis assay showed that pretreatment with donepezil promoted phagocytic activity of rodent microglial cells through the PI3K but not MAPK/ERK pathway. Conclusions: These suggest that donepezil could directly modulate the microglial function through the PI3K pathway in the rodent brain, which might be important to understand the effect of donepezil in the brain..
33. Noriaki Sagata, Takahiro Kato, Shin Ichi Kano, Masahiro Ohgidani, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Ashley M. Wilson, Koko Ishizuka, Shiori Kato, Takeshi Nakahara, Makiko Nakahara-Kido, Daiki Setoyama, Yasunari Sakai, Shoichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients
A pilot study, Scientific Reports, 10.1038/s41598-017-14440-7, 7, 1, 2017.12, Direct conversion technique to produce induced-neuronal (iN) cells from human fibroblasts within 2 weeks is expected to discover unknown neuronal phenotypes of neuropsychiatric disorders. Here, we present unique gene expression profiles in iN cells from patients with neurofibromatosis type 1 (NF1), a single-gene multifaceted disorder with comparatively high co-occurrence of autism spectrum disorder (ASD). Microarray-based transcriptomic analysis on iN cells from male healthy controls and male NF1 patients (NF1-iN cells) revealed that 149 genes expressions were significantly different (110 upregulated and 39 downregulated). We validated that mRNA of MEX3D (mex-3 RNA binding family member D) was lower in NF1-iN cells by real-time PCR with 12 sex-mixed samples. In NF1-iN cells on day 14, higher expression of FOS mRNA was observed with lower expression of MEX3D mRNA. Interestingly, BCL2 mRNA was higher in NF1-iN cells on day 5 (early-period) but not on day 14. Our data suggest that aberrant molecular signals due to NF1 mutations may disturb gene expressions, a subset of which defines continuum of the neuronal phenotypes of NF1 with ASD. Further translational studies using induced pluripotent stem (iPS) cell-derived neuronal cells are needed to validate our preliminary findings especially confirming meanings of analysis using early-period iN cells..
34. Masahiro Ohgidani, Takahiro Kato*, Masako Hosoi, Tsuda Makoto, Kohei Hayakawa, Chie Hayaki, Rie Iwaki, Noriaki Sagata, Ryota Hashimoto, Kazuhide Inoue, Nobuyuki Sudo, Shigenobu Kanba, Fibromyalgia and microglial TNF-α
Translational research using human blood induced microglia-like cells, Scientific Reports, 10.1038/s41598-017-11506-4, 7, 1, 2017.12, Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes. In this study, we created the iMG cells from 14 patients with fibromyalgia and 10 healthy individuals, and compared the activation of iMG cells between two groups at the cellular level. The expression of tumor necrosis factor (TNF)-α at mRNA and protein levels significantly increased in ATP-stimulated iMG cells from patients with fibromyalgia compared to cells from healthy individuals. Interestingly, there was a moderate correlation between ATP-induced upregulation of TNF-α expression and clinical parameters of subjective pain and other mental manifestations of fibromyalgia. These findings suggest that microglia in patients with fibromyalgia are hypersensitive to ATP. TNF-α from microglia may be a key factor underlying the complex pathology of fibromyalgia..
35. Takahiro Kato*, Shigenobu Kanba, Modern-type depression as an "adjustment" disorder in Japan
The intersection of collectivistic society encounteringanindividualisticperformance-basedsystem, American Journal of Psychiatry, 10.1176/appi.ajp.2017.17010059, 174, 11, 1051-1053, 2017.11, うつ病の現代における課題に関して、特に適応の障害という観点から論じた論文である。.
36. Takahiro Kato, Masahiro Ohgidani, Shigenobu Kanba, Translational research on neuropsychiatrie disorders
Focusing on microglia hypothesis, Brain and Nerve, 69, 9, 1007-1015, 2017.09, Microglia - immune cells in the brain - have recently been highlighted to understand the pathophysiology of psychiatric disorders such as schizophrenia, depression, and autism. In this review paper, we introduce the microglia hypothesis for psychiatric disorders. In addition, we introduce our novel translational research approach to psychiatric disorders using microglia-like (iMG) cells directly induced from human blood, these iMG cells can be produced from peripheral monocytes within two weeks using two cytokines: granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-34 (IL-34)..
37. Yutaka Kunitake, Yoshito Mizoguchi, Rintaro Sogawa, Jun Matsushima, Takahiro Kato, Toshiro Kawashima, Akira Monji, Effect of excessive coffee consumption on the clinical course of a patient with bipolar disorder
A case report and literature review, Clinical Neuropharmacology, 10.1097/WNF.0000000000000222, 40, 4, 160-162, 2017.07, Objective The aim of this study was to examine the impact of excessive caffeine consumption on therapeutic outcomes in bipolar disorder. Methods and Results We report on a case of a patient with bipolar disorder whose psychiatric symptoms were ameliorated with the elevation of lithium concentrations after the reduction of excessive daily coffee consumption, and we review the relevant literatures. Conclusions Excessive coffee consumption may exacerbate the therapeutic course of bipolar disorder through its effects on the mechanisms underlying bipolar disorder itself, as well as by affecting the blood concentration of lithium..
38. Kohei Hayakawa, Takahiro Kato, Shigeru Imamura, Naofumi Kasai, Shigenobu Kanba, Progressive brain atrophy and cognitive decline along with multiple episodes of delirium, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12527, 71, 6, 418-419, 2017.06.
39. Daisuke Ikawa, Manabu Makinodan, Keiko Iwata, Masahiro Ohgidani, Takahiro Kato, Yasunori Yamashita, Kazuhiko Yamamuro, Sohei Kimoto, Michihiro Toritsuka, Takahira Yamauchi, Shin ichi Fukami, Hiroki Yoshino, Kazuki Okumura, Tatsuhide Tanaka, Akio Wanaka, Yuji Owada, Masatsugu Tsujii, Toshiro Sugiyama, Kenji Tsuchiya, Norio Mori, Ryota Hashimoto, Hideo Matsuzaki, Shigenobu Kanba, Toshifumi Kishimoto, Microglia-derived neuregulin expression in psychiatric disorders, Brain, Behavior, and Immunity, 10.1016/j.bbi.2017.01.003, 61, 375-385, 2017.03, Several studies have revealed that neuregulins (NRGs) are involved in brain function and psychiatric disorders. While NRGs have been regarded as neuron- or astrocyte-derived molecules, our research has revealed that microglia also express NRGs, levels of which are markedly increased in activated microglia. Previous studies have indicated that microglia are activated in the brains of individuals with autism spectrum disorder (ASD). Therefore, we investigated microglial NRG mRNA expression in multiple lines of mice considered models of ASD. Intriguingly, microglial NRG expression significantly increased in BTBR and socially-isolated mice, while maternal immune activation (MIA) mice exhibited identical NRG expression to controls. Furthermore, we observed a positive correlation between NRG expression in microglia and peripheral blood mononuclear cells (PBMCs) in mice, suggesting that NRG expression in human PBMCs may mirror microglia-derived NRG expression in the human brain. To translate these findings for application in clinical psychiatry, we measured levels of NRG1 splice-variant expression in clinically available PBMCs of patients with ASD. Levels of NRG1 type III expression in PBMCs were positively correlated with impairments in social interaction in children with ASD (as assessed using the Autistic Diagnostic Interview-Revised test: ADI-R). These findings suggest that immune cell-derived NRGs may be implicated in the pathobiology of psychiatric disorders such as ASD..
40. Takahiro Kato, Aye M. Myint, Johann Steiner, Editorial: Minding glial cells in the novel understandings of mental illness, Frontiers in Cellular Neuroscience, 10.3389/fncel.2017.00048, 11, 2017.02.
41. Masahiro Ohgidani, Takahiro Kato, Yoshinori Haraguchi, Toshio Matsushima, Yoshito Mizoguchi, Toru Murakawa-Hirachi, Noriaki Sagata, Akira Monji, Shigenobu Kanba, Microglial CD206 gene has potential as a state marker of bipolar disorder, Frontiers in Immunology, 10.3389/fimmu.2016.00676, 7, JAN, 2017.01, The pathophysiology of bipolar disorder, especially the underlying mechanisms of the bipolarity between manic and depressive states, has yet to be clarified. Microglia, immune cells in the brain, play important roles in the process of brain inflammation, and recent positron emission tomography studies have indicated microglial overactivation in the brain of patients with bipolar disorder. We have recently developed a technique to induced microglia-like (iMG) cells from peripheral blood (monocytes). We introduce a novel translational approach focusing on bipolar disorder using this iMG technique. We hypothesize that immunological conditional changes in microglia may contribute to the shift between manic and depressive states, and thus we herein analyzed gene profiling patterns of iMG cells from three patients with rapid cycling bipolar disorder during both manic and depressive states, respectively. We revealed that the gene profiling patterns are different between manic and depressive states. The profiling pattern of case 1 showed that M1 microglia is dominant in the manic state compared to the depressive state. However, the patterns of cases 2 and 3 were not consistent with the pattern of case 1. CD206, a mannose receptor known as a typical M2 marker, was significantly downregulated in the manic state among all three patients. This is the first report to indicate the importance of shifting microglial M1/M2 characteristics, especially the CD206 gene expression pattern between depressive and manic states. Further translational studies are needed to dig up the microglial roles in the underlying biological mechanisms of bipolar disorder..
42. Takahiro Kato, Alan R. Teo, Masaru Tateno, Motoki Watabe, Hiroaki Kubo, Shigenobu Kanba, Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?, Psychiatry and Clinical Neurosciences, 10.1111/pcn.12481, 71, 1, 75-76, 2017.01.
43. Mina Sato-Kasai, Takahiro Kato, Masahiro Ohgidani, Yoshito Mizoguchi, Noriaki Sagata, Shogo Inamine, Hideki Horikawa, Kohei Hayakawa, Norihiro Shimokawa, Sota Kyuragi, Yoshihiro Seki, Akira Monji, Shigenobu Kanba, Aripiprazole inhibits polyI
C-induced microglial activation possibly via TRPM7, Schizophrenia Research, 10.1016/j.schres.2016.08.022, 178, 1-3, 35-43, 2016.12, Viral infections during fetal and adolescent periods, as well as during the course of schizophrenia itself have been linked to the onset and/or relapse of a psychosis. We previously reported that the unique antipsychotic aripiprazole, a partial D2 agonist, inhibits the release of tumor necrosis factor (TNF)-α from interferon-γ-activated rodent microglial cells. Polyinosinic-polycytidylic acid (polyI:C) has recently been used as a standard model of viral infections, and recent in vitro studies have shown that microglia are activated by polyI:C. Aripiprazole has been reported to ameliorate behavioral abnormalities in polyI:C-induced mice. To clarify the anti-inflammatory properties of aripiprazole, we investigated the effects of aripiprazole on polyI:C-induced microglial activation in a cellular model of murine microglial cells and possible surrogate cells for human microglia. PolyI:C treatment of murine microglial cells activated the production of TNF-α and enhanced the p38 mitogen-activated protein kinase (MAPK) pathway, whereas aripiprazole inhibited these responses. In addition, polyI:C treatment of possible surrogate cells for human microglia markedly increased TNF-α mRNA expression in cells from three healthy volunteers. Aripiprazole inhibited this increase in cells from two individuals. PolyI:C consistently increased intracellular Ca2 + concentration ([Ca2 +]i) in murine microglial cells by influx of extracellular Ca2 +. We demonstrated that transient receptor potential in melastatin 7 (TRPM7) channels contributed to this polyI:C-induced increase in [Ca2 +]i. Taken together, these data suggest that aripiprazole may be therapeutic for schizophrenia by reducing microglial inflammatory reactions, and TRPM7 may be a novel therapeutic target for schizophrenia. Further studies are needed to validate these findings..
44. Takahiro A. Kato, Can “Pokémon GO” rescue shut-ins (hikikomori) from their isolated world?, Psychiatry and Clinical Neurosciences, 2016.11.
45. Ohgidani M, Kato TA*, Sagata N, Hayakawa K, Shimokawa N, Sato-Kasai M, Kanba S, TNF-α from hippocampal microglia directly induces working memory deficits by acute stress in mice, Brain, Behavior, and Immunity, 10.1016/j.bbi.2015.08.022. , 55, 17-24, 2016.07.
46. Maruo, J, Haraguchi, Y, Tateishi H, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Abnormal behaviours during pramipexole treatment for Cotard's syndrome: a case report, Psychogeriatrics , 10.1111/psyg.12148. , 16, 4, 283-286, 2016.07.
47. Haraguchi Y*, Mizoguchi Y, Noguchi T, Arai T, Fukuyaa J, Kato TA, Kawashima T, Monji A*, A patient with Alzheimer’s disease complicated by elderly-onset Cushing’s syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia, Psychogeriatrics , 10.1111/psyg.12146., 16, 4, 274-276, 2016.07.
48. Kato TA*, Kanba S, Teo AR*, A 39-Year-Old “Adultolescent”: Understanding Social Withdrawal in Japan. Perspectives in Global Mental Health, American Journal of Psychiatry, 10.1176/appi.ajp.2015.15081034., 173, 2, 112-114, 2016.02.
49. Tateishi H, Hirachi T, Maruo J, Haraguchi Y, Noguchi T, Mizoguchi Y, Kato TA, Kawashima T, Monji A, Neurocognitive Disorders in Chronic Kidney Disease: A Case Report and Literature Review, Psychosomatics, 10.1016/j.psym.2015.07.007., 57, 1, 107-12, 2016.01.
50. Kato TA*, Kanba S, Boundless syndromes in modern society – An interconnected world producing novel psychopathology in the 21st century, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12368. , 70, 1, 1-2, 2016.01.
51. Kato TA*, Hashimoto R, Hayakawa K, Kubo H, Watabe M, Teo AR, Kanba S, The multidimensional anatomy of “modern type depression” in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5. Frontier Review, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358., 70, 1, 7-23, 2016.01.
52. Hashimoto N*, Suzuki Y, Kato TA, Fujisawa D, Sato R, Aoyama-Uehara K, Fukasawa M, Asakura S, Kusumi I, Otsuka K, The effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan, Psychiatry and Clinical Neuroscience, 10.1111/pcn.12358. , 70, 1, 62-70, 2016.01.
53. Hirachi T, Ishii H, Tada Y, Noguchi T, Haraguchi Y, Tateishi H, Mizoguchi Y, Kato TA, Kawashima T, Monji A*, Mania occurring during systemic lupus erythematosus relapse and its amelioration on clinical and neuroimaging follow-up, Lupus, 10.1177/0961203315570161., 24, 9, 990-993, 2015.08.
54. Teo AR, Stufflebam K, Saha S, Fetters MD, Tateno M, Kanba S, Kato TA, Psychopathology Associated with Social Withdrawal: Idiopathic and Co-Morbid Presentations, Psychiatry Research, 10.1016/j.psychres.2015.04.033., 228, 1, 182-183, 2015.07.
55. Ohgidani M, Kato TA*, Kanba S, Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: A novel translational research tool for psychiatric disorders, Frontiers in Cellular Neuroscience, 10.3389/fncel., 9, 184, 2015.05.
56. Guest PC, Iwata K, Kato TA, Steiner J, Schmitt A, Turck CW, Martins-de-Souza D* (Contributed equally), MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2015.00180. , 9, 180, 2015.05.
57. Watabe M*, Kato TA*, Teo AR, Horikawa H, Tateno M, Hayakawa K, Shimokawa N, Kanba S (: These authors contributed equally to this work), Relationship between trusting behaviors and psychometrics associated with social network and depression among young generation: a pilot study, PLoS ONE, 10.1371/journal.pone.0120183., 10, 4, e0120183, 2015.04.
58. Teo AR*, Fetters MD,Stufflebam S, Tateno M, Balhara YBS, Choi TY, Kanba S, Mathews CA, Kato TA*, Identification of the Hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries, International Journal of Social Psychiatry, 10.1177/0020764014535758. , 61, 1, 64-72, 2015.02.
59. Teo AR*, Kato TA, The prevalence and correlates of severe social withdrawal in Hong Kong. (Letter to the Editor) , International Journal of Social Psychiatry, 10.1177/0020764014554923. , 61, 1, 102, 2015.02.
60. Mizoguchi Y*, Kato TA, Horikawa H, Monji A, Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia, Frontiers in Cellular Neuroscience, 10.3389/fncel.2014.00370., 8, 370, 2014.11.
61. Yamamura K, Kato S, Kato TA, Mizoguchi Y, Monji A, Kanba S, Furue M, Takeuchi S, Anti-allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells, Journal of Dermatology, 10.1111/1346-8138.12578. , 41, 9, 808-14, 2014.08.
62. Mizoguchi Y*, Kato TA, Seki Y, Ohgidani M, Sagata N, Horikawa H, Yamauchi Y, Sato-Kasai M, Hayakawa K, Inoue R, Kanba S, Monji A, BDNF induces sustained intracellular Ca2+ elevation through the upregulation of surface TRPC3 channels in rodent microglia, Journal of Biological Chemistry, 10.1074/jbc.M114.555334., 289, 26, 18549-18555, 2014.06.
63. Suzuki Y*, Kato TA, Sato R, Fujisawa D, Aoyama-Uehara K, Hashimoto N, Yonemoto N, Fukasawa M, Otsuka K, Effectiveness of brief suicide management training program for medical residents in Japan: A cluster randomized controlled trial. Epidemiology and Psychiatric Sciences, Epidemiology and Psychiatric Sciences, 10.1017/S2045796013000334. , 23, 2, 167-76, 2014.06.
64. Ohgidani M, Kato TA*, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S, Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease, Scientific Reports, 10.1038/srep04957., 4, 4957, 2014.05.
65. Hayakawa K, Kato TA*, Kojiro M, Monji A, Kanba S, Minocycline, a microglial inhibitor, diminishes terminal patients’ delirium? , American Journal of Geriatric Psychiatry, 10.1016/j.jagp.2013.11.003., 22, 3, 314-315, 2014.03.
66. Farooq K, Lydall GJ, Malik A, Ndetei DM; ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D, ISOSCCIP Group (including Kato TA & Kanba S), Bhugra D: Why medical students choose psychiatry - a 20 country cross-sectional survey, BMC Medical Education, 10.1186/1472-6920-14-12., 14, 12, 2014.01.
67. Yoshihiro Seki, Kato TA, Monji A, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model., Schizophrenia Research , 151, 1-3, 20-28, 2013.12.
68. Fujisawa D*, Suzuki Y, Kato TA, Hashimoto N, Sato R, Aoyama-Uehara K, Fukasawa M, Tomita M, Kashima H, Otsuka K, Suicide intervention skills among medical residents, Academic Psychiatry, 10.1176/appi.ap.10110154., 37, 6, 402-407, 2013.11.
69. Fujisawa D, Suzuki Y, Kato TA, Hashimoto N, Sato R, Aoyama-Uehara K, Fukasawa M, Tomita M, Watanabe K, Kashima H, Otsuka K, Suicide intervention skills among medical residents., Academic Psychiatry, 10.1176/appi.ap.10110154., 37, 6, 402-407, 2013.11.
70. Kato TA, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry., Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 4, 139, 2013.10.
71. Kato TA*, Watabe M, Kanba S, Neuron-glia interaction as a possible glue to translate the mind-brain gap: A novel multi-dimensional approach toward psychology and psychiatry, Frontiers in Psychiatry (Frontiers in Neuropsychiatric Imaging and Stimulation), 10.3389/fpsyt.2013.00139., 4, 139, 2013.10.
72. Kato TA, Balhara YPS, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan., International Review of Psychiatry, 25, 4, 378-384, 2013.09.
73. Kato TA*, Balhara YPS*, Chawla JM, Tateno M, Kanba S, Undergraduate medical students' attitudes toward psychiatry: an international cross-sectional survey between India and Japan, International Review of Psychiatry, 10.3109/09540261.2013.812959., 25, 4, 378-384, 2013.08.
74. Kato TA*, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia, Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053. , 7, 53, 2013.07.
75. Suzuki Y, Kato TA, Sato R, Fujisawa D, Aoyama-Uehara K, Hashimoto N, Yonemoto N, Fukasawa M, Otsuka K, Effectiveness of brief suicide management training program for medical residents in Japan: A cluster randomized controlled trial, Epidemiology and Psychiatric Sciences, Epidemiol Psychiatr Sci, 2013.07.
76. Kato TA, Hayakawa K, Monji A, Kanba S, Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders and Microglia., Frontiers in Integrative Neuroscience, 10.3389/fnint.2013.00053, 7, 53, 2013.07.
77. Kato TA*, Kanba S, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach, Frontiers in Human Neuroscience, 10.3892/or.2013.2354. , 7, 13, 2013.06.
78. Monji A*, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S, Neuroinflammation in schizophrenia especially focused on the role of microglia, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 10.1016/j.pnpbp.2011.12.002. , 42, 115-121, 2013.04.
79. Watabe M, Kato TA, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S, Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange., Scientific Reports 3, 1685, 2013, 3, 1683, 2013.04.
80. Kato A. Takahiro, Kanba Shigenobu, Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach., Frontiers in Human Neuroscience, 10.3389/fnhum.2013.00013, 7, 13, [http://www.frontiersin.org/Human_Neuroscience/10.3389/fnhum.2013.00013/abstract], 2013.02, The unconscious mind-brain relationship remains unresolved. From the perspective of neuroscience, neuronal networks including synapses have been dominantly believed to play crucial roles in human mental activities, while glial contribution to mental activities has long been ignored. Recently, it has been suggested that microglia, glial cells with immunological/inflammatory functions, play important roles in psychiatric disorders. Newly revealed microglial roles, such as constant direct contact with synapses even in the normal brain, have defied the common traditional belief that microglia do not contribute to neuronal networks. Recent human neuroeconomic investigations with healthy volunteers using minocycline, an antibiotic with inhibitory effects on microglial activation, suggest that microglia may unconsciously modulate human social behaviors as "noise." We herein propose a novel unconscious mind structural system in the brain centering on microglia from a neuropsychoanalytic approach. At least to some extent, microglial activation in the brain may activate unconscious drives as "psychological immune memory/reaction" in the mind, and result in various emotions, traumatic reactions, psychiatric symptoms including suicidal behaviors, and (psychoanalytic) transference during interpersonal relationships. Microglia have the potential to bridge the huge gap between neuroscience, biological psychiatry, psychology and psychoanalysis as a key player to connect the conscious and the unconscious world..
81. Umene-Nakano Wakako, Kato A. Takahiro, Kikuchi S, Tateno M, Fujisawa D, Hoshuyama T, Nakamura J, Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan., PLoS ONE, 10.1371/journal.pone.0055189, 8, 2, e55189, 2013.02.
82. Kato TA, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344, 2013.01.
83. Tateno M,Park TW, Kato TA, Umene-Nakano W, Saito T, Hikikomori as a possible clinical term in psychiatry: a questionnaire survey, BMC Psychiatry, 12, 169, 2012.10.
84. Kato TA*, Watabe M*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [* These authors equally contributed to this work.], Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors., PLoS ONE, 7, 7, e40461, 2012.07.
85. Watabe M*, Kato TA*, Monji A, Horikawa H, Kanba S [* These authors equally contributed to this work.], Does minocycline, an antibiotic with inhibitory effects on microglial activation, sharpen a sense of trust in social interaction?, Psychopharmacology, 220.0, 3.0, 551-557, 2012.04.
86. Monji A, Kato TA, Mizoguchi Y, Horikawa H, Seki Y, Kasai M, Yamauchi Y, Yamada S, Kanba S, Neuroinflammation in schizophrenia especially focused on the role of microglia., Prog Neuropsychopharmacol Biol Psychiatry, 10.1016/j.pnpbp.2011.12.002., 42, 115-121, 2011.12.
87. Kato TA, Shinfuku N, Sartorius N, Kanba S, Are Japan's hikikomori and depression in young people spreading abroad? [Correspondence], The Lancet, 378.0, 9796.0, 1070.0, 2011.08, None..
88. Kato TA, Shinfuku N, Fujisawa D, Tateno M, Ishida T, Akiyama T, Sartorius N, Teo AR, Choi TY, Wand APF, Balhara YPS, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Umene-Nakano W, Horikawa H, Matsumoto R, Kuga H, Tanaka M, Kanba S, Introducing the Concept of Modern Depression in Japan; an International Case Vignette Survey., Journal of Affective Disorders, 135.0, 1-3, 66-76, 2011.07.
89. Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S, Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)- stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia., Schizophrenia Research, 129.0, 2−3, 172-182, 2011.07.
90. Kato TA, Tateno M, Shinfuku N, Fujisawa D, Teo AR, Sartorius N, Akiyama T, Ishida T, Choi TY, Balhara YPS, Matsumoto R, Umene-Nakano W, Fujimura Y, Wand A, Chang JPC, Chang RYF, Shadloo B, Ahmed HU, Lerthattasilp T, Kanba S, Does the 'hikikomori' syndrome of social withdrawal exist outside Japan?: A preliminary international investigation., Social Psychiatry and Psychiatric Epidemiology, 2011.06.
91. Kato TA, Monji A, Mizoguchi Y, Hashioka S, Horikawa H, Seki Y, Kasai M, Utsumi H, Kanba S, Anti-inflammatory properties of antipsychotics via microglia modulations; Are antipsychotics a 'fire extinguisher' in the brain of schizophrenia?, Mini-Reviews in Medicinal Chemistry, 11.0, 7.0, 565-574, 2011.06.
92. Mizoguchi Y, Monji A, Kato TA, Horikawa H, Seki Y, Kasai M, Kanba S, Yamada S, Possible Role of BDNF-Induced Microglial Intracellular Ca2+ Elevation in the Pathophysiology of Neuropsychiatric Disorders., Mini-Reviews in Medicinal Chemistry, 11.0, 7.0, 575-581, 2011.06.
93. Kato S, Kato TA, Nishie H, Nishima S, Iwanaga T, Monji A, Nakano M, Takeshita H, Furue M, Successful treatment of chronic urticaria with a Japanese herbal medicine, yokukansan., Journal of Dermatology, 37.0, 12.0, 1066-1067, 2010.12.
94. Kato TA, Tateno M, Nakano Y, Balhara YPS, Teo AR, Fujisawa D, Sasaki R, Ishida T, Kanba S, Impact of biopsychosocial factors on psychiatric training in Japan and overseas: Are psychiatrists oriented to mind, brain, or sociocultural issues?, Psychiatry and Clinical Neurosciences, 64.0, 5.0, 520–530, 2010.10.
95. Kato TA, Suzuki Y, Sato R, Fujisawa D, Uehara K, Hashimoto N, Sawayama Y, Hayashi J, Kanba S, Otsuka K, Development of two-hour suicide intervention program among medical residents: First pilot trial., Psychiatry and Clinical Neurosciences, 64.0, 5.0, 531–540, 2010.10.
96. Horikawa H, Kato TA, Mizoguchi Y, Monji A, Seki Y, Gotoh L, Ohkuri T, Yonaha M, Ueda T, Hashioka S, Kanba S, Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracelluar calcium., Prog Neuropsychopharmacol Biol Psychiatry, 37.0, 12.0, 1306–1316, 2010.10.
97. Tateno M, Kato T, Nakano W, Teo AR, Nakagawa A, Miyajima K, Kanba S, Nakamura J, Saito T, Attitudes of early-career psychiatrists in Japan toward child and adolescent psychiatry and their career decision., Psychiatry and Clinical Neurosciences, 64.0, 2.0, 199-201, 2010.04.
98. Tateno M, Kato T, Nakano W, Kanba S, Nakamura J, Saito T, Differences in the preferred route of administration of haloperidol for acute schizophrenia among young psychiatrists in two regions of Japan., Asian Journal of Psychiatry, 3.0, 60–63, 2010.01.
99. Mizoguchi Y, Monji A, Kato T, Seki Y, Gotoh L, Horikawa H, Suzuki SO, Iwaki T, Yonaha M, Hashioka S, Kanba S, Brain-derived neurotrophic factor (BDNF) induces sustained elevation of intracellular Ca2+ in rodent microglia., Journal of Immunology, 183.0, 12.0, 7778-7786, 2009.12.
100. Tateno M, Sugiura K, Uehara K, Fujisawa D, Zhao Y, Hashimoto N, Takahashi H, Yoshida N, Kato T, Nakano W, Wake Y, Shirasaka T, Kobayashi S, Sato S, Attitude of young psychiatrists toward coercive measures in psychiatry: A case vignette study in Japan., International Journal of Mental Health Systems, 3.0, 1.0, 20.0, 2009.09.
101. Monji A, Kato T, Kanba S, Cytokines and Schizophrenia-Microglia Hypothesis of Schizophrenia-., Psychiatry and Clinical Neurosciences, 63.0, 3.0, 257-265, 2009.06.
102. Monji A, Takita M, Samejima T, Takaishi T, Hashimoto K, Matsunaga H, Oda M, Sumida Y, Mizoguchi Y, Kato T, Horikawa H, Kanba S, Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease., Prog Neuropsychopharmacol Biol Psychiatry, 33.0, 2.0, 308-311, 2009.03.
103. Kato T, Mizoguchi Y, Monji A, Horikawa H, Suzuki S, Seki Y, Iwaki T, Hashioka S, Kanba S, Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro., Journal of Neurochemistry, 106.0, 2.0, 815-825, 2008.07.
104. Bian Q, Kato T, Monji A, Hashioka S, Mizoguchi Y, Horikawa H, Kanba S, The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon- gamma., Prog Neuropsychopharmacol Biol Psychiatry, 32.0, 1.0, 42-48, 2008.01.
105. Kato T, Monji A, Hashioka S, Kanba S, Risperidone significantly inhibits interferon- gamma -induced microglial activation in vitro., Schizophrenia Research, 92.0, 1ー3, 108-115, 2007.05.
106. Hashioka S., Han Y.H., Fujii S., Kato T., Monji A., Utsumi H., Sawada M., Nakanishi H., Kanba S, Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit amyloid beta and interferon-gamma-induced microglial activation., Free Radic Biol Med, 42.0, 7.0, 945-954, 2007.04.
107. Hashioka S, Han YH, Fujii S, Kato T, Monji A, Utsumi H, Sawada M, Nakanishi H, Kanba S, Phospholipids modulate superoxide and nitric oxide production by lipopolysaccharide and phorbol 12-myristate-13-acetate-activated microglia., Neurochem Int, 50.0, 3.0, 499-506, 2007.02.
108. Ohara T, Monji A, Onitsuka T, Maekawa T, Hirano Y, Hirano S, Hashioka S, Kato T, Yoshida I, Kanba S, Interictal psychosis after stroke with forced normalization., J Neuropsychiatry Clin Neurosci, 18.0, 4.0, 557-559, 2006.09.
109. Horikawa H, Monji A, Sasaki M, Maekawa T, Onitsuka T, Nitazaka Y, Hirano Y, Hirano S, Hashioka S, Kato T, Yoshida I, Kanba S, Different SPECT findings before and after Capgras' syndrome in interictal psychosis., Epilepsy Behav, 9.0, 1.0, 189-192, 2006.08.
110. Monji A, Tashiro K, Yoshida I, Hashioka S, Kato T, Kanba S, Laminin and its related peptides for the treatment of Alzheimer's disease., Current Medicinal Chemistry-Central Nervous System Agents, 5.0, 243-247, 2005.01.
111. Kato T, Hanada T, Takano K, Antoku Y, and Nose Y, A Question and Answer E-Mail System for Responding to Query from the General Public with Which the System Manager Can Identify Delayed Replies., J Med Syst, 24.0, 1.0, 21-28, 2000.02.
112. Seki Y, Kato TA*, Monji A*, Mizoguchi Y, Horikawa H, Sato-Kasai M, Yoshiga D, Kanba S, Aripiprazole and minocycline, but not haloperidol, suppress oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model, Schizophrenia Research, 151, 1-3, 20-28.
113. Isomura S, Monji A, Sasaki K, Baba S, Onitsuka T, Ohara T, Mizoguchi Y, Kato TA, Horikawa H, Seki Y, Kanba S:, A case of FTD with catatonia-like signs that temporarily resolved with zolpidem, Neurology: Clinical Practice, 3, 354-357.
114. Watabe M*, Kato TA*, Tsuboi S, Ishikawa K, Hashiya K, Monji A, Utsumi H, Kanba S [*Double Corresponding authors who were equally contributed to this work.]: , Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange, Scientific Reports, 10.1038/srep01685., 3, 1685.
115. Umene-Nakano W*, Kato TA, Kikuchi S, Tateno M, Fujisawa D, Nationwide Survey of Work Environment, Work-Life Balance and Burnout among Psychiatrists in Japan, PLoS ONE, 10.1371/journal.pone.0055189., 8, 2, e55189.
116. Kato TA*, Yamauchi Y, Horikawa H, Monji A, Mizoguchi Y, Seki Y, Hayakawa K, Utsumi H, Kanba S, Neurotransmitters, Psychotropic Drugs and Microglia: Clinical Implications for Psychiatry, Current Medicinal Chemistry, 20, 3, 331-344.
117. Kato TA, Introducing Hikikomori from multidimensional perspectives. Interview, World Child & Adolescent Psychiatry (WPA, Child and Adolescent Psychiatry Section's Official Journal), 7, 12-16.
118. Kano S-I, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Horiuchi Y, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P*, Sawa A*, Kai M*, Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy, Current Molecular Medicine, 15, 2, 138-45.
119. Tateno M, Teo AR, Shirasaka T, Tayama M, Watabe M, Kato TA, Internet addiction and self-evaluated ADHD traits among Japanese college students, Psychiatry and Clinical Neurosciences.