九州大学 研究者情報
論文一覧
田中 充(たなか みつる) データ更新日:2021.09.15

准教授 /  農学研究院 生命機能科学部門


原著論文
1. Reiko Nakao, Weilin Shen, Yasuka Shimajiri, Kumiko Kainou, Yuki Sato, Anayt Ulla, Kohta Ohnishi, Miyuki Ninomiya, Ayako Ohno, Takayuki Uchida, Mitsuru Tanaka, Kazuhito Akama, Toshiro Matsui & Takeshi Nikawa , Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle, npj Science of Food , https://doi.org/10.1038/s41538-021-00108-0, 5, Article number 25, 1-10, 2021.09.
2. Kazunori Nakagawa , Mitsuru Tanaka , Tae Hun Hahm , Huu-Nghi Nguyen , Toshiro Matsui , Yong-Xiang Chen , Yutaka Nakashima, Accumulation of Plasma-Derived Lipids in the Lipid Core and Necrotic Core of Human Atheroma: Imaging Mass Spectrometry and Histopathological Analyses, Arteriosclerosis, Thrombosis, and Vascular Biology, https://doi.org/10.1161/ATVBAHA.121.316154, in accept, 2021.09.
3. Xiaojing Sheng, Satoshi Nagaoka, Marika Hashimoto, Yusuke Amiya, Masato Beppu, Kenichiro Tsukamoto, Emiko Yanase, Mitsuru Tanaka, Toshiro Matsui, Identification of peptides in blood following oral administration of β-conglycinin to Wistar rats, Food Chemistry, 10.1016/j.foodchem.2020.128197, 341, 128197-128197, 2021.03.
4. Mitsuru Tanaka, Hayato Kiyohara, Atsuko Yoshino, Akihiro Nakano, Fuyuko Takata, Shinya Dohgu, Yasufumi Kataoka, Toshiro Matsui, Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice, npj Science of Food, 10.1038/s41538-020-0067-3, 4, 1, 2020.12, [URL].
5. Tae Hun Hahm*, Mitsuru Tanaka*, Huu-Nghi Nguyen, Ayaka Tsutsumi, Koichi Aizawa, Toshiro Matsui (*equal contribution), Matrix-assisted laser desorption/ionization mass spectrometry-guided visualization analysis of intestinal absorption of acylated anthocyanins in Sprague-Dawley rats, Food Chemistry, doi.org/10.1016/j.foodchem.2020.127586., 334, 1, 127586, 1-9, 2020.07.
6. Mitsuru Tanaka, Chung Hsuan, Masataka Oeki, Weilin Shen, Asuka Goda, Yusuke Tahara, Takeshi Onodera, Keisuke Sanematsu, Tomotsugu Rikitake, Eiji Oki, Yuzo Ninomiya, Rintaro Kurebayashi, Hideto Sonoda, Yoshihiko Maehara, Kiyoshi Toko, Toshiro Matsui , Identification of characteristic compounds of moderate volatility in breast cancer cell lines , PLOS ONE, https://doi.org/10.1371/journal.pone.0235442, 15, 6, e0235442, 2020.06.
7. Mitsuru Tanaka, Shinya Dohgu, Genki Komabayashi, Hayato Kiyohara, Fuyuko Takata, Yasufumi Kataoka, Takashi Nirasawa, Motohiro Maebuchi & Toshiro Matsui, Brain-transportable dipeptides across the blood-brain barrier in mice, Scientific Reports, https://doi.org/10.1038/s41598-019-42099-9, 9, 5769, 1-10, 2019.04.
8. Huu-Nghi Nguyen*; Tanaka, Mitsuru*; Li, Baorui; Ueno, Tomoya; Matsuda, Hideki; Matsui, Toshiro (*These authors contributed equally), Novel in situ visualisation of rat intestinal absorption of polyphenols via matrix-assisted laser desorption/ionisation mass spectrometry imaging, SCIENTIFIC REPORTS, 10.1038/s41598-019-39405-w, 9, 3166, 1-9, 2019.02.
9. Ayano Shimizu, Takakazu Mitani, Sachi Tanaka, Hiroshi Fujii, Motohiro Maebuchi, Yusuke Amiya, Mitsuru Tanaka, Toshiro Matsui, Soichiro Nakamura, Shigeru Katayama, Soybean-Derived Glycine-Arginine Dipeptide Administration Promotes Neurotrophic Factor Expression in the Mouse Brain, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.8b01581, 66, 30, 7935-7941, 2018.08, [URL].
10. Vu Thi Hanh, Weilin Shen, Mitsuru Tanaka, Aino Siltari, Riita Korpela, Toshiro Matsui, Effect of Aging on the Absorption of Small Peptides in Spontaneously Hypertensive Rats, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b01727, 65, 29, 5935-5943, 2017.07, [URL].
11. Huu Nghi Nguyen*, Mitsuru Tanaka*, Genki Komabayashi, Toshiro Matsui (*equal contribution), The photobase generator nifedipine as a novel matrix for the detection of polyphenols in matrix-assisted laser desorption/ionization mass spectrometry, Journal of Mass Spectrometry, 10.1002/jms.3805, 51, 10, 938-946, 2016.10, [URL].
12. Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Satoshi Tajiri, Mitsuru Tanaka, Yoshinori Mine, Matsui Toshiro, Adenine attenuates the Ca2+ contraction-signaling pathway via adenine receptor-mediated signaling in rat vascular smooth muscle cells, Naunyn-Schmiedeberg's Arch Pharmacol, 10.1007/s00210-016-1264-0, 289, 999-1007, 2016.09.
13. Thanutchaporn Kumrungsee, Sayaka Akiyama, Jian Guo, Mitsuru Tanaka, Matsui Toshiro, Identification of peptides in wheat germ hydrolysate that demonstrate calmodulin-dependent protein kinase II inhibitory activity, Food Chemistry, dx.doi.org/10.1016/j.foodchem.2016.06.059, 213, 329-335, 2016.07.
14. Akiko Mizokami, Wang DaGuang, Mitsuru Tanaka, Gao Jing, Hiroshi Takeuchi, Matsui Toshiro, Hirata Masato, An extract from pork bones containing osteocalcin improves glucose metabolism in mice by oral administration., Bioscience, Biotechnology, and Biochemistry, 10.1080/09168451.2016.1214530, 11, 2176-2183, 2016.07.
15. Seong-Min Hong, Mitsuru Tanaka, Riho Koyanagi, Weilin Shen, Toshiro Matsui, Structural Design of Oligo-peptides for Intestinal Transport Model, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.6b00279., 64, 10, 2072-2079, 2016.03.
16. Kazuki Moriyasu, Takashi Ichinose, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya, The Dipeptides Ile-Tyr and Ser-Tyr Exert Distinct Effects on Catecholamine Metabolism in the Mouse Brainstem, International Journal of Peptides, http://dx.doi.org/10.1155/2016/6020786, 2016, 6020786, 1-5, 2016.02.
17. Vu Thi Hanh, Yutaro Kobayashi, Motohiro Maebuchi, Toshihiro Nakamori, Mitsuru Tanaka, Toshiro Matsui, Quantitative mass spectrometric analysis of dipeptides in protein hydrolysate by a TNBS derivatization-aided standard addition method, Food Chemistry, doi.org/10.1016/j.foodchem.2015.05.053, 190, 345-350, 2016.01.
18. Yusuke Ushida, Chutinan Boonyapichest, Hiroyuki Suganuma, Mitsuru Tanaka, Toshiro Matsui, Paracellular Transport of Sulforaphane Across Caco-2 Cell Monolayers, Food Science and Technology Research, doi: 10.3136/fstr.22.127, 22, 1, 127-134, 2016.01.
19. Jian Zhao, Aki Suyama, Hsuan Chung, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui, Ferulic acid enhances nitric oxide production through up-regulation of argininosuccinate synthase in inflammatory human endothelial cells, Life Sciences, http://dx.doi.org/10.1016/j.lfs.2015.12.044, 145, 224-232, 2016.01.
20. Mitsuru Tanaka, Eiji Tanaka, Noe Obinata, Toshiro Matsui, Visualization of Tocopherol Acetate Absorbed Inside Laminated Films by a
Matrix-assisted Laser Desorption/Ionization-imaging Mass Spectrometry, Food Science and Technology Research, doi: 10.3136/fstr.21.821, 21, 6, 821-826, 2015.11.
21. Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Mai Hyoguchi, Mitsuru Tanaka, Toshiro Matsui, Augmentation of ferulic acid-induced vasorelaxation with aging and its structure importance in thoracic aorta of spontaneously hypertensive rats, Naunyn-Schmiedeberg's Archives of Pharmacology, 10.1007/s00210-015-1171-9, 288, 1113-1117, 2015.09.
22. Mitsuru Tanaka, Seong Min Hong, Sayaka Akiyama, Qing Qiang Hu, Toshiro Matsui, Visualized absorption of anti-atherosclerotic dipeptide, Trp-His, in Sprague-Dawley rats by LC-MS and MALDI-MS imaging analyses, Molecular Nutrition and Food Research, 10.1002/mnfr.201500075, 59, 8, 1541-1549, 2015.08.
23. Takashi Ichinose, Kazuki Moriyasu, Akane Nakahata, Mitsuru Tanaka, Toshiro Matsui, Shigeki Furuya, Orally administrated dipeptide Ser-Tyr efficiently stimulates noradrenergic turnover in the mouse brain, Bioscience, Biotechnology, and Biochemistry, DOI: 10.1080/09168451.2015.1044932, 79, 9, 1542-1547, 2015.03.
24. Ha-Young Park, Yuri Kunitake, Naoto Hirasaki, Mitsuru Tanaka, Toshiro Matsui, Theaflavins enhance intestinal barrier of Caco-2 Cell monolayers through the expression of AMP-activated protein kinase-mediated Occludin, Claudin-1, and ZO-1, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1080/09168451.2014.951027, 79, 1, 130-137, 2015.01.
25. Thanutchaporn Kumrungsee, Tomomi Saiki, Sayaka Akiyama, Kentaro Nakashima, Mitsuru Tanaka, Yutaro Kobayashi, Toshiro Matsui, Inhibition of calcium-calmodulin complex formation by vasorelaxant basic dipeptides demonstrated by in vitro and in silico analyses, Biochimica et Biophysica Acta, 10.1016/j.bbagen.2014.07.020, 1840, 3073-3078, 2014.10.
26. Jennifer Kovacs-Nolan, Prithy Rupa, Toshiro Matsui, Mitsuru Tanaka, Toru Konishi, Yusuke Sauchi, Kenji Sato, Shin Ono, Yoshinori Mine, In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation, Journal of Agricultural and Food Chemistry, 10.1021/jf503257w, 62, 39, 9499-9506, 2014.10, © 2014 American Chemical Society. Glutathione (GSH) is the most prevalent low-molecular-weight thiol in mammalian cells and is crucial for antioxidant defense, nutrient metabolism, and the regulation of pathways essential for whole body homeostasis. GSH transport systems have been identified in the membranes of various tissues and organs, including the small intestine. However, little is known regarding GSH transport across intestinal epithelial cells. The current in vitro and ex vivo uptake study of GSH demonstrated that intact GSH can be transported across intestinal epithelial cells, suggesting that GSH uptake is not proton-dependent. It would appear that the initial uptake of GSH into cells is a rapid process. Furthermore, the visualized GSH after 60 min of transport by MALDI-MS imaging showed localization of intact GSH inside the intestinal wall. In vivo study found that ingested 13C-GSH was rapidly converted to GSSG and accumulated in red blood cells and liver, but was little present in plasma. The ingested GSH has potent nutraceutical benefits for human health to improve oxidative stress and defense in human..
27. Jian Zhao, Aki Suyama, Mitsuru Tanaka, Toshiro Matsui, Ferulic Acid Enhances the Vasorelaxant Effect of Epigallocatechin Gallate in Tumor Necrosis Factor-Alpha-induced Inflammatory Rat Aorta, The Journal of Nutritional Biochemistry, 10.1016/j.jnutbio.2014.03.013, 25, 7, 807-814, 2014.07.
28. Thanutchaporn Kumrungsee, Zhengquan Wang, Shinya Matsumura, Tomomi Saiki, Mitsuru Tanaka, Toshiro Matsui, Identification of peptides from soybean protein, glycinin, possessing suppression of intracellular Ca2+ concentration in vascular smooth muscle cells., Food Chemistry, http://dx.doi.org/10.1016/j.foodchem.2013.11.143, 152, 218-224, 2014.06.
29. Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Takahisa Miyamoto, Mitsuru Tanaka, Toshiro Matsui, Attenuation of L-Type Ca2+ Channel Expression and Vasomotor Response in the Aorta with Age in Both Wistar-Kyoto and Spontaneously Hypertensive Rats, PLOS ONE, DOI: 10.1371/journal.pone.0088975, 9, 2, e88975, 1-9, 2014.02.
30. Eduardo M. N. NAKASHIMA, Hu-Qiang QING, Mitsuru Tanaka, Toshiro Matsui, Improved Detection of Di-peptides by Liquid Chromatography-Tandem Mass Spectrometry with 2,4,6-Trinitrobenzene Sulfonate Conversion, Bioscience, Biotechnology, and Biochemistry, http://dx.doi.org/10.1271/bbb.130448, 77, 10, 2094-2099, 2013.10.
31. Seong-Min Hong, Mitsuru Tanaka, Saori Yoshii, Toshiro Matsui, Enhanced Visualization of Small Peptides Absorbed in Rat Small Intestine by Phytic-Acid-Aided Matrix-Assisted Laser Desorption/ Ionization-Imaging Mass Spectrometry, Analytical Chemistry, 10.1021/ac402252j, 85, 10033-10039, 2013.09.
32. Chihiro Hashimoto, Yuri Iwaihara, Si Jing Chen, Tanaka Mitsuru, Toshiaki Watanabe, Toshiro Matsui, Highly-Sensitive Detection of Free Advanced Glycation End-Products by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry with 2,4,6-Trinitrobenzene Sulfonate Derivatization, Analytical Chemistry, 10.1021/ac400294q, 85, 4289-4295, 2013.04.
33. Mitsuru Tanaka, Jian Zhao, Aki Suyama, and Toshiro Matsui, Epigallocatechin Gallate Promotes the Vasorelaxation Power of the Antiatherosclerotic Dipeptide Trp-His in Contracted Rat Aorta, Journal of Agricultural and Food Chemistry, 10.1021/jf3010228, 60, 9048-9054, 2012, 60, 9048-9054, 2012.09.
34. Yutaro Kobayashi, Toshihiko Fukuda, Mitsuru Tanaka, Toshiro Matsui, The anti-atherosclerotic di-peptide, Trp-His, inhibits the phosphorylation of voltage-dependent L-type Ca2+ channels in rat vascular smooth muscle cells, FEBS Open Bio, 10.1016/j.fob.2012.04.005, 2, 83-88, 2012.04.
35. S. Tokuda, T. Fukuda, Y. Kobayashi, M. Tanaka, T. Matsui, Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of sprague-dawley rats., Biosci. Biotechnol. Biochem., 10.1271/bbb.110806, 76, 4, 828-830, 2012.04.
36. Eduardo M.N. Nakashima, Akihiro Kudo, Yuri Iwaihara, Mitsuru Tanaka, Kiyoshi Matsumoto, Toshiro Matsui, Application of 13C stable isotope labeling liquid chromatographymultiple reaction monitoringtandem mass spectrometry method for determining intact absorption of bioactive dipeptides in rats, Analytical Biochemistry, doi:10.1016/j.ab.2011.02.037, 414, 109-116, 2011.03.
37. Zhengquan Wang, Shimpei Watanabe, Yutaro Kobayashi, Mitsuru Tanaka, Toshiro Matsui, Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like l-type Ca2+ channels, Peptides, doi:10.1016/j.peptides.2010.07.013, 31, 11, 2060-2066, 2010.08.
38. T. Matsui, M. Sato, M. Tanaka, Y. Yamada, S. Watanabe, Y. Fujimoto, K. Imaizumi, K. Matsumoto, Vasodilating di-peptide Trp-His can prevent atherosclerosis in apolipoprotein E-deficient mice., Br. J. Nutr., 103, 309-313, 2010.02.
39. M. Tanaka, S. Watanabe, Z. Wang, T. Matsui, K. Matsumoto, His-Arg-Trp potently attenuates contracted tension of thoracic aorta of Sprague-Dawley rats through the suppression of extracellular Ca2+ influx., Peptides , 30, 1502-1507, 2009.08.
40. Y. Ushida, T. Matsui, M. Tanaka, K. Matsumoto, H. Hosoyama, A. Mitomi, Y. Sagesaka, T. Kakuda, Endothelium-dependent vasorelaxation effect of rutin-free tartary buckwheat extract in isolated rat thoracic aorta., J. Nutr. Biochem., 19, 700-707, 2008.10.
41. M. Tanaka, M. Tokuyasu, T. Matsui, K. Matsumoto, Endothelium-independent vasodilation effect of di- and tri-peptides in thoracic aorta of SpragueDawley rats., Life Sci., 82, 869-875, 2008.04.
42. M. Tanaka, T. Matsui, Y. Ushida, K. Matsumoto, Vasodilating effect of di-peptides in thoracic aortas from spontaneously hypertensive rats., Biosci. Biotechnol. Biochem., 70, 2292-2295, 2006.09.
43. T. Ueno, M. Tanaka, T. Matsui, K. Matsumoto, Determination of antihypertensive small peptides, Val-Tyr and Ile-Val-Tyr, by fluorometric high-performance liquid chromatography combined with a double heart-cut column-switching technique., Anal. Sci. , 10.2116/analsci.21.997, 21, 8, 997-1000, 2005.08.
44. T. Matsui, T. Ueno, M. Tanaka, H. Oka, T. Miyamoto, K. Osajima, K. Matsumoto, Antiproliferative action of an angiotensin I-converting enzyme inhibitory peptide, Val-Tyr, via an L-type Ca2+ channel inhibition in cultured vascular smooth muscle cells., Hypertens. Res., 10.1291/hypres.28.545, 28, 6, 545-552, 2005.06.

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