Kyushu University Academic Staff Educational and Research Activities Database
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Masaki Katsuhisa Last modified date:2020.02.17

Lecturer / Department of Neurology, Neurological Institute, Graduate School of Medical Sciences
Kyushu University Hospital

Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Research Interests
  • TDP-43 proteinopathy in TMEV infection
    keyword : TMEV, TDP-43, multiple sclerosis, demyelination, amyotrophic lateral sclerosis
  • A novel model for treatment of hypertrophic pachymeninigitis
    keyword : hypertrophic pachymeningitis, LATY136F mutant mice
  • Expression of mutant α-synucelin in oligodendrocytes induces remarkable glial inflammation and demyelination
    keyword : αsynuclein oligodendrocyte neurodegeneration microglia astrocyte
  • Glial assenbly and their early disruption in demyelinating disorders
    keyword : connexin, astrocyte, oligodendrocyte, multiple sclerosis, glia assenbly
  • Neuroimmunology and neuropathological study of human demyelinating disorders
    keyword : multiple sclerosis, neuromyelitis optica, Balo's disease
Academic Activities
1. Hayashida S, Masaki K, Kira J, Extensive white matter pathology of longitudinally extensive myelitis in neuromyelitis optica, 2017.02.
2. Hayashida S, Masaki K, Matsushita T, Watanabe M, Yamasaki R, Murai H, Kira J , Holocord involvement with sparing of the peripheral white matter rim in longitudinally extensive spinal cord lesions of neuromyelitis optica, Clinical and Experimental Neuroimmunology, 2015.12.
3. Masaki K., Loss of connexins might cause extensive demyelination in Baló's disease, Clinical and Experimental Neuroimmunology, 2013.06.
4. Masaki K., Early disruption of glial communication via connexin gap junction in multiple sclerosis, Baló's disease and neuromyelitis optica., Neuropathology, 2015.10.
1. Masaki K, Sonobe Y, Ghadge G, Pytel P, Roos RP., TDP-43 proteinopathy in Theiler's murine encephalomyelitis virus infection., PLoS Pathogens, 2019.02.
2. Cui Y, Masaki K, Zhang X, Yamasaki R, Fujii T, Ogata H, Hayashida S, Yamaguchi H, Hyodo F, Eto H, Koyama S, Iinuma K, Yonekawa T, Matsushita T, Yoshida M, Yamada K, Kawano M, Malissen M, Malissen B, Kira J., A novel model for treatment of hypertrophic pachymeningitis., Ann Clin Transl Neurol, 2019.01.
3. Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, Okamoto K, Matsushita T, Kira JI., Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis., Front Neurosci., 2018.11.
4. Hayashida S, Masaki K, Yonekawa T, Suzuki SO, Hiwatashi A, Matsushita T, Watanabe M, Yamasaki R, Suenaga T, Iwaki T, Murai H, Kira JI., Early and extensive spinal white matter involvement in neuromyelitis optica., Brain Pathol. , 2017.05.
5. Watanabe M, Masaki K, Yamasaki R, Kawanokuchi J, Takeuchi H, Matsushita T, Suzumura A, Kira JI., Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation., Sci Rep. , 2016.12.
6. Cui Y, Masaki K, Yamasaki R, Imamura S, Suzuki SO, Hayashi S, Sato S, Nagara Y, Kawamura MF, Kira J., Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model., J Neuroinflammation, 10.1186/1742-2094-11-42., 6, 11, 42, 2014.03.
7. Masaki K, Suzuki SO, Matsushita T, Matsuoka T, Imamura S, Yamasaki R, Suzuki M, Suenaga T, Iwaki T, Kira J., Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica., PLOS ONE, e72919, 2013.08.
8. Masaki K, Suzuki SO, Matsushita T, Yonekawa T, Matsuoka T, Isobe N, Motomura K, Wu XM, Tabira T, Iwaki T, Kira J., Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction., Acta Neuropathologica, 123, 887-900, 2012.06.
1. Katsuhisa Masaki, Glial pathology of multiple sclerosis, neuromyelitis optica spectrum disorders; insight from human pathology and genetics, The 12th PACTRIMS, 2019.11.
2. Katsuhisa Masaki, Glial pathology of multiple sclerosis, neuromyelitis optica spectrum disorders and Baló’s disease
, 第60回日本神経学会学術大会, 2019.05.
3. Katsuhisa Masaki, Update and Review of Baló’s Concentric Sclerosis
, XXIII World Congress of Neurology, WCN2017, 2017.09.
4. Katsuhisa Masaki, Common and Distinct Features of Immunopathology Between MS and NMO, The 8th PACTRIMS, 2015.11.
5. Katsuhisa Masaki, Extensive Loss of Astrocytic Monocarboxylate Transporter 4 in Active Lesions of Multiple Sclerosis and Neuromyelitis Optica, The 31st ECTRIMS, 2015.10.
6. Katsuhisa Masaki, Connexin gap junction pathology in MS, Baló’s disease and NMO
, The 55th Annual Meeting of the Japanese Society of Neuropathology 日本神経病理学会, 2014.06.
7. Katsuhisa Masaki, Connexin gap junction pathology in active MS, Baló’s disease and NMO
, The 55th Annual Meeting of the Japanese Society of Neurology 日本神経学会学術大会, 2014.05.
8. Katsuhisa Masaki, Rapidly progressive multiple sclerosis and gliopathy, The 6th PACTRIMS, 2013.11.
9. Katsuhisa Masaki, Connexin gap junction pathology in active MS, Baló’s disease and NMO
, 第12回MSワークショップ, 2013.08.
10. Katsuhisa Masaki, Early disruption of astrocytic connexins in multiple sclerosis, Baló’s disease and neuromyelitis optica., The 28th ECTRIMS, 2012.10.
11. Masaki K and Kira J, Connexins in Demyelinating Disorders, The 35th Annual Meeting of the Japan Neuroscience Society, 2012.09.
12. Katsuhisa Masaki, Molecular pathology of astrocytopathy in Baló’s disease and tumefactive MS., The 5th PACTRIMS, 2012.09.
13. Katsuhisa Masaki, Anti-AQP4 antibody-independent astrocytopathy with extensive connexin loss in Balo’s concentric sclerosis and allied conditions, The 63rd American Academy of Neurology, 2011.04.
Other Educational Activities
  • 2020.02.
  • 2019.09.
  • 2018.12.