| 1. |
Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Tanaka K, Okubo K, Nakamura H, Hata J, Oishi Y, Kato I, Hirakata H, Iida M., Hyperhomocysteinemia and the development of chronic kidney disease in a general population: the Hisayama Study, Am J Kidney Dis, 44(3):437-445, 2004.09.  |
| 2. |
Hata J, Tanizaki Y, Kiyohara Y, Kato I, Kubo M, Tanaka K, Okubo K, Nakamura H, Oishi Y, Ibayashi S, Iida M., Ten year recurrence after first ever stroke in a Japanese community: the Hisayama Study, J Neurol Neurosurg Psychiatry, 10.1136/jnnp.2004.038166, 76(3):368-372, 2005.03. |
| 3. |
Ninomiya T, Kiyohara Y, Kubo M, Tanizaki Y, Doi Y, Okubo K, Wakugawa Y, Hata J, Oishi Y, Shikata K, Yonemoto K, Hirakata H, Iida M., Chronic kidney disease and cardiovascular disease in a general Japanese population: the Hisayama Study, Kidney Int, 10.1111/j.1523-1755.2005.00397.x, 68(1):228-236, 2005.07. |
| 4. |
Wakugawa Y, Kiyohara Y, Tanizaki Y, Kubo M, Ninomiya T, Hata J, Doi Y, Okubo K, Oishi Y, Shikata K, Yonemoto K, Maebuchi D, Ibayashi S, Iida M., C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population: the Hisayama Study, Stroke, 10.1161/01.STR.0000194958.88216.87, 37(1):27-32, 2006.01. |
| 5. |
Kubo M, Kiyohara Y, Ninomiya T, Tanizaki Y, Yonemoto K, Doi Y, Hata J, Oishi Y, Shikata K, Iida M., Decreasing incidence of lacunar vs other types of cerebral infarction in a Japanese population, Neurology, 10.1212/01.wnl.0000216132.95207.b4, 66(10):1539-1544, 2006.05. |
| 6. |
Kubo M, Hata J, Ninomiya T, Matsuda K, Yonemoto K, Nakano T, Matsushita T, Yamazaki K, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Sueishi K, Iida M, Nakamura Y, Kiyohara Y., A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction, Nat Genet, 10.1038/ng1945, 39(2):212-217, 2007.02. |
| 7. |
Hata J, Matsuda K, Ninomiya T, Yonemoto K, Matsushita T, Ohnishi Y, Saito S, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y, Kubo M., Functional SNP in an Sp1-binding site of AGTRL1 gene is associated with susceptibility to brain infarction, Hum Mol Genet, 10.1093/hmg/ddm005, 16(6):630-639, 2007.03. |
| 8. |
Doi Y, Kubo M, Ninomiya T, Yonemoto K, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y., Impact of Kir6.2 E23K polymorphism on the development of type 2 diabetes in a general Japanese population: the Hisayama Study, Diabetes, 10.2337/db06-1709, 56(11):2829-2833, 2007.11. |
| 9. |
Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M., Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. the Fukuoka Stroke Registry and the Hisayama Study, Cerebrovasc Dis, 10.1159/000121342, 25(5):417-422, 2008.01. |
| 10. |
Hagiwara N, Kitazono T, Kamouchi M, Kuroda J, Ago T, Hata J, Ninomiya T, Ooboshi H, Kumai Y, Yoshimura S, Tamaki K, Fujii K, Nagao T, Okada Y, Toyoda K, Nakane H, Sugimori H, Yamashita Y, Wakugawa Y, Kubo M, Tanizaki Y, Kiyohara Y, Ibayashi S, Iida M; Fukuoka Stroke Registry; Hisayama Study., Polymorphism in the sorbin and SH3-domain-containing-1 (SORBS1) gene and the risk of brain infarction in the Japanese population: the Fukuoka Stroke Registry and the Hisayama study, Eur J Neurol, 10.1111/j.1468-1331.2008.02105.x, 15(5):481-486, 2008.05. |
| 11. |
Arima H, Kubo M, Yonemoto K, Doi Y, Ninomiya T, Tanizaki Y, Hata J, Matsumura K, Iida M, Kiyohara Y., High-sensitivity C-reactive protein and coronary heart disease in a general population of Japanese: the Hisayama Study, Arterioscler Thromb Vasc Biol, 10.1161/ATVBAHA.107.157164, 28(7):1385-1391, 2008.07. |
| 12. |
Doi Y, Kubo M, Yonemoto K, Ninomiya T, Iwase M, Arima H, Hata J, Tanizaki Y, Iida M, Kiyohara Y., Fasting plasma glucose cutoff for diagnosis of diabetes in a Japanese population, J Clin Endocrinol Metab, 10.1210/jc.2007-2819, 93(9):3425-3429, 2008.09. |
| 13. |
Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y., Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population, Circulation, 10.1161/CIRCULATIONAHA.107.743211, 118(25):2672-2678, 2008.12. |
| 14. |
Doi Y, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Arima H, Liu Y, Rahman M, Iida M, Kiyohara Y., Seroprevalence of herpes simplex virus 1 and 2 in a population-based cohort in Japan, J Epidemiol, 10.2188/jea.je20080061, 19(2):56-62, 2009.01. |
| 15. |
Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M, Tanizaki Y, Ibayashi S, Iida M, Kiyohara Y., LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama Study, Stroke, 10.1161/STROKEAHA.108.529537, 40(2):382-388, 2009.02. |
| 16. |
Ikeda F, Doi Y, Yonemoto K, Ninomiya T, Kubo M, Shikata K, Hata J, Tanizaki Y, Matsumoto T, Iida M, Kiyohara Y., Hyperglycemia increases risk of gastric cancer posed by helicobacter pylori infection: a population-based cohort study, Gastroenterology, 10.1053/j.gastro.2008.12.045, 136(4):1234-1241, 2009.04. |
| 17. |
Matsushita T, Kubo M, Yonemoto K, Ninomiya T, Ashikawa K, Liang B, Hata J, Doi Y, Kitazono T, Ibayashi S, Iida M, Kiyohara Y, Nakamura Y., Lack of association between variations of PDE4D and ischemic stroke in the Japanese population, Stroke, 10.1161/STROKEAHA.108.527408, 40(4):1245-1251, 2009.04. |
| 18. |
Doi Y, Ninomiya T, Hata J, Yonemoto K, Arima H, Kubo M, Tanizaki Y, Iwase M, Iida M, Kiyohara Y., Proposed criteria for metabolic syndrome in Japanese based on prospective evidence: the Hisayama Study, Stroke, 10.1161/STROKEAHA.108.531319, 40(4):1187-1194, 2009.04. |
| 19. |
Wakugawa Y, Sugimori H, Nakane H, Hata J, Irie K, Kitazono T, Iida M., Flow volume and cross-sectional area of the extracranial vertebral arteries and its relation to vascular lesions or anatomical variations in the posterior circulation, Ultrasound Med Biol, 10.1016/j.ultrasmedbio.2009.01.006, 35(7):1068-1075, 2009.07. |
| 20. |
Osawa H, Doi Y, Makino H, Ninomiya T, Yonemoto K, Kawamura R, Hata J, Tanizaki Y, Iida M, Kiyohara Y., Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama Study, Cardiovasc Diabetol, 10.1186/1475-2840-8-60, 8:60, 2009.11. |
| 21. |
Arima H, Tanizaki Y, Yonemoto K, Doi Y, Ninomiya T, Hata J, Fukuhara M, Matsumura K, Iida M, Kiyohara Y., Impact of blood pressure levels on different types of stroke: the Hisayama Study, J Hypertens, 10.1097/HJH.0b013e328330e882, 27(12):2437-2443, 2009.12. |
| 22. |
Mukai N, Doi Y, Ninomiya T, Hata J, Yonemoto K, Iwase M, Iida M, Kiyohara Y., Impact of metabolic syndrome compared with impaired fasting glucose on the development of type 2 diabetes in a general Japanese population: the Hisayama Study, Diabetes Care, 10.2337/dc09-0896, 32(12):2288-2293, 2009.12. |
| 23. |
Arima H, Yonemoto K, Doi Y, Ninomiya T, Hata J, Tanizaki Y, Fukuhara M, Matsumura K, Iida M, Kiyohara Y., Development and validation of a cardiovascular risk prediction model for Japanese: the Hisayama Study, Hypertens Res, 10.1038/hr.2009.161, 32(12):1119-1122, 2009.12. |
| 24. |
Doi Y, Ninomiya T, Hata J, Fukuhara M, Yonemoto K, Iwase M, Iida M, Kiyohara Y., Impact of glucose tolerance status on development of ischemic stroke and coronary heart disease in a general Japanese population: the Hisayama Study, Stroke, 10.1161/STROKEAHA.109.564708, 41(2):203-209, 2010.02. |
| 25. |
Matsushita T, Ashikawa K, Yonemoto K, Hirakawa Y, Hata J, Amitani H, Doi Y, Ninomiya T, Kitazono T, Ibayashi S, Iida M, Nakamura Y, Kiyohara Y, Kubo M., Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke, Hum Mol Genet, 10.1093/hmg/ddp582, 19(6):1137-1146, 2010.03. |
| 26. |
Hata J, Doi Y, Ninomiya T, Tanizaki Y, Yonemoto K, Fukuhara M, Kubo M, Kitazono T, Iida M, Kiyohara Y., The effect of metabolic syndrome defined by various criteria on the development of ischemic stroke subtypes in a general Japanese population, Atherosclerosis, 10.1016/j.atherosclerosis.2009.10.044, 210(1):249-255, 2010.05. |
| 27. |
Matsushita T, Umeno J, Hirakawa Y, Yonemoto K, Ashikawa K, Amitani H, Ninomiya T, Hata J, Doi Y, Kitazono T, Iida M, Nakamura Y, Kiyohara Y, Kubo M., Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population, J Hum Genet, 10.1038/jhg.2010.45, 55(7):473-476, 2010.07. |
| 28. |
Nagata M, Ninomiya T, Doi Y, Yonemoto K, Kubo M, Hata J, Tsuruya K, Iida M, Kiyohara Y., Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study, Nephrol Dial Transplant, 10.1093/ndt/gfq062, 25(8):2557-2564, 2010.08. |
| 29. |
Matsuzaki T, Sasaki K, Tanizaki Y, Hata J, Fujimi K, Matsui Y, Sekita A, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T., Insulin resistance is associated with the pathology of Alzheimer disease: the Hisayama Study, Neurology, 10.1212/WNL.0b013e3181eee25f, 75(9):764-770, 2010.08. |
| 30. |
Maebuchi D, Arima H, Doi Y, Ninomiya T, Yonemoto K, Tanizaki Y, Kubo M, Hata J, Matsumura K, Iida M, Kiyohara Y., QT interval prolongation and the risks of stroke and coronary heart disease in a general Japanese population: the Hisayama Study, Hypertens Res, 10.1038/hr.2010.88, 33(9):916-921, 2010.09. |
| 31. |
Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y., Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study, Acta Psychiatr Scand, 10.1111/j.1600-0447.2010.01587.x, 122(4):319-325, 2010.10. |
| 32. |
Kawamura R, Doi Y, Osawa H, Ninomiya T, Hata J, Yonemoto K, Tanizaki Y, Iida M, Makino H, Kiyohara Y., Circulating resistin is increased with decreasing renal function in a general Japanese population: the Hisayama Study, Nephrol Dial Transplant, 10.1093/ndt/gfq155, 25(10):3236-3240, 2010.10. |
| 33. |
Usui T, Ninomiya T, Nagata M, Doi Y, Hata J, Fukuhara M, Kiyohara Y., Albuminuria as a risk factor for peripheral arterial disease in a general population: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.7682, 18(8):705-712, 2011.01. |
| 34. |
Hata J, Doi Y, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Hirakawa Y, Kitazono T, Kiyohara Y., Combined effects of smoking and hypercholesterolemia on the risk of stroke and coronary heart disease in Japanese: the Hisayama Study, Cerebrovasc Dis, 10.1159/000324392, 31(5):477-484, 2011.01. |
| 35. |
Yonemoto K, Doi Y, Hata J, Ninomiya T, Fukuhara M, Ikeda F, Mukai N, Iida M, Kiyohara Y., Body mass index and stroke incidence in a Japanese community: the Hisayama Study, Hypertens Res, 10.1038/hr.2010.220, 34(2):274-279, 2011.02. |
| 36. |
Shimazaki Y, Akifusa S, Takeshita T, Shibata Y, Doi Y, Hata J, Ninomiya T, Hirakawa Y, Kiyohara Y, Yamashita Y., Effectiveness of the salivary occult blood test as a screening method for periodontal status, J Periodontol, 10.1902/jop.2010.100304, 82(4):581-587, 2011.04. |
| 37. |
Ohara T, Ninomiya T, Kubo M, Hirakawa Y, Doi Y, Hata J, Iwaki T, Kanba S, Kiyohara Y., Apolipoprotein genotype for prediction of Alzheimer's disease in older Japanese: the Hisayama Study, J Am Geriatr Soc, 10.1111/j.1532-5415.2011.03405.x, 59(6):1074-1079, 2011.06. |
| 38. |
Ninomiya T, Ohara T, Hirakawa Y, Yoshida D, Doi Y, Hata J, Kanba S, Iwaki T, Kiyohara Y., Midlife and late-life blood pressure and dementia in Japanese elderly: the Hisayama Study, Hypertension, 10.1161/HYPERTENSIONAHA.110.163055, 58(1):22-28, 2011.07. |
| 39. |
Arima H, Anderson C, Omae T, Woodward M, Hata J, Murakami Y, Macmahon S, Neal B, Chalmers J; PROGRESS Collaborative Group., Effects of blood pressure lowering on major vascular events among patients with isolated diastolic hypertension: the Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trial, Stroke, 10.1161/STROKEAHA.110.606764, 42(8):2339-2341, 2011.08. |
| 40. |
Matsuzaki T, Sasaki K, Hata J, Hirakawa Y, Fujimi K, Ninomiya T, Suzuki SO, Kanba S, Kiyohara Y, Iwaki T., Association of Alzheimer disease pathology with abnormal lipid metabolism: the Hisayama Study, Neurology, 10.1212/WNL.0b013e31822e145d, 77(11):1068-1075, 2011.09. |
| 41. |
Ohara T, Doi Y, Ninomiya T, Hirakawa Y, Hata J, Iwaki T, Kanba S, Kiyohara Y., Glucose tolerance status and risk of dementia in the community: the Hisayama Study, Neurology, 10.1212/WNL.0b013e31822f0435, 77(12):1126-1134, 2011.09. |
| 42. |
Kamouchi M, Matsuki T, Hata J, Kuwashiro T, Ago T, Sambongi Y, Fukushima Y, Sugimori H, Kitazono T; FSR Investigators., Prestroke glycemic control is associated with the functional outcome in acute ischemic stroke: the Fukuoka Stroke Registry, Stroke, 10.1161/STROKEAHA.111.617415, 42(10):2788-2794, 2011.10. |
| 43. |
Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Ikeda F, Fukuhara M, Iwase M, Kiyohara Y., N-terminal pro-brain natriuretic peptide and risk of cardiovascular events in a Japanese community: the Hisayama Study, Arterioscler Thromb Vasc Biol, 10.1161/ATVBAHA.111.223669, 31(12):2997-3003, 2011.12. |
| 44. |
Gotoh S, Doi Y, Hata J, Ninomiya T, Mukai N, Fukuhara M, Kamouchi M, Kitazono T, Kiyohara Y., Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.13698, 19(11):977-985, 2012.01. |
| 45. |
Yoshida D, Ninomiya T, Doi Y, Hata J, Fukuhara M, Ikeda F, Mukai N, Kiyohara Y., Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama Study, J Epidemiol, 10.2188/jea.je20110083, 22(3):222-229, 2012.01. |
| 46. |
Doi Y, Ninomiya T, Hata J, Hirakawa Y, Mukai N, Iwase M, Kiyohara Y., Two risk score models for predicting incident type 2 diabetes in Japan, Diabet Med, 10.1111/j.1464-5491.2011.03376.x, 29(1):107-114, 2012.01. |
| 47. |
Mukai N, Doi Y, Ninomiya T, Hata J, Hirakawa Y, Fukuhara M, Iwase M, Kiyohara Y., Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting type 2 diabetes in community-dwelling Japanese subjects: the Hisayama Study, Diabet Med, 10.1111/j.1464-5491.2011.03378.x, 29(1):99-106, 2012.01. |
| 48. |
Kuwashiro T, Kamouchi M, Ago T, Hata J, Sugimori H, Kitazono T., The factors associated with a functional outcome after ischemic stroke in diabetic patients: the Fukuoka Stroke Registry, J Neurol Sci, 10.1016/j.jns.2011.09.012, 313(1-114, 2012.02. |
| 49. |
Iida M, Ikeda F, Ninomiya T, Yonemoto K, Doi Y, Hata J, Matsumoto T, Iida M, Kiyohara Y., White blood cell count and risk of gastric cancer incidence in a general Japanese population: the Hisayama Study, Am J Epidemiol, 10.1093/aje/kwr345, 175(6):504-510, 2012.03. |
| 50. |
Miyazaki M, Doi Y, Ikeda F, Ninomiya T, Hata J, Uchida K, Shirota T, Matsumoto T, Iida M, Kiyohara Y., Dietary vitamin a intake and incidence of gastric cancer in a general Japanese population: the Hisayama Study, Gastric Cancer, 10.1007/s10120-011-0092-7, 15(2):162-169, 2012.04. |
| 51. |
Fukuhara M, Arima H, Ninomiya T, Hata J, Yonemoto K, Doi Y, Hirakawa Y, Matsumura K, Kitazono T, Kiyohara Y., Impact of lower range of prehypertension on cardiovascular events in a general population: the Hisayama Study, J Hypertens, 10.1097/HJH.0b013e328351d380, 30(5):893-900, 2012.05. |
| 52. |
Shikata K, Ninomiya T, Yonemoto K, Ikeda F, Hata J, Doi Y, Fukuhara M, Matsumoto T, Iida M, Kitazono T, Kiyohara Y., Optimal cutoff value of the serum pepsinogen level for prediction of gastric cancer incidence: the Hisayama Study, Scand J Gastroenterol, 10.3109/00365521.2012.658855, 47(6):669-675, 2012.06. |
| 53. |
Kumai Y, Kamouchi M, Hata J, Ago T, Kitayama J, Nakane H, Sugimori H, Kitazono T; FSR Investigators., Proteinuria and clinical outcomes after ischemic stroke, Neurology, 10.1212/WNL.0b013e318259e110, 78(24):1909-1915, 2012.06. |
| 54. |
Ikeda F, Ninomiya T, Doi Y, Hata J, Fukuhara M, Matsumoto T, Kiyohara Y., Smoking cessation improves mortality in Japanese men: the Hisayama Study, Tob Control, 10.1136/tc.2010.039362, 21(4):416-421, 2012.07. |
| 55. |
Ozawa M, Ninomiya T, Ohara T, Hirakawa Y, Doi Y, Hata J, Uchida K, Shirota T, Kitazono T, Kiyohara Y., Self-reported dietary intake of potassium, calcium, and magnesium and risk of dementia in the Japanese: the Hisayama Study, J Am Geriatr Soc, 10.1111/j.1532-5415.2012.04061.x, 60(8):1515-1520, 2012.08. |
| 56. |
Hillis GS, Hata J, Woodward M, Perkovic V, Arima H, Chow CK, Zoungas S, Patel A, Poulter NR, Mancia G, Williams B, Chalmers J., Resting heart rate and the risk of microvascular complications in patients with type 2 diabetes mellitus, J Am Heart Assoc, 10.1161/JAHA.112.002832, 1(5):e002832, 2012.10. |
| 57. |
Jardine MJ, Hata J, Woodward M, Perkovic V, Ninomiya T, Arima H, Zoungas S, Cass A, Patel A, Marre M, Mancia G, Mogensen CE, Poulter N, Chalmers J; ADVANCE Collaborative Group., Prediction of kidney-related outcomes in patients with type 2 diabetes, Am J Kidney Dis, 10.1053/j.ajkd.2012.04.025, 60(5):770-778, 2012.11. |
| 58. |
Hirakawa Y, Ninomiya T, Mukai N, Doi Y, Hata J, Fukuhara M, Iwase M, Kitazono T, Kiyohara Y., Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study, Am J Epidemiol, 10.1093/aje/kws178, 176(10):856-864, 2012.11. |
| 59. |
Doi Y, Ninomiya T, Hirakawa Y, Takahashi O, Mukai N, Hata J, Iwase M, Kitazono T, Oike Y, Kiyohara Y., Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama Study, Diabetes Care, 10.2337/dc12-0166, 36(1):98-100, 2013.01. |
| 60. |
Usui T, Ninomiya T, Nagata M, Takahashi O, Doi Y, Hata J, Fukuhara M, Kitazono T, Oike Y, Kiyohara Y., Angiopoietin-like protein 2 is associated with chronic kidney disease in a general Japanese population: the Hisayama Study, Circ J, 10.1253/circj.cj-12-1548, 77(9):2311-2317, 2013.01. |
| 61. |
Hata J, Arima H, Zoungas S, Fulcher G, Pollock C, Adams M, Watson J, Joshi R, Kengne AP, Ninomiya T, Anderson C, Woodward M, Patel A, Mancia G, Poulter N, MacMahon S, Chalmers J, Neal B; ADVANCE Collaborative Group., Effects of the endpoint adjudication process on the results of a randomised controlled trial: the ADVANCE trial, PLoS One, 10.1371/journal.pone.0055807, 8(2):e55807, 2013.01. |
| 62. |
Ninomiya T, Kojima I, Doi Y, Fukuhara M, Hirakawa Y, Hata J, Kitazono T, Kiyohara Y., Brachial-ankle pulse wave velocity predicts the development of cardiovascular disease in a general Japanese population: the Hisayama Study, J Hypertens, 10.1097/HJH.0b013e32835c5c23, 31(3):477-483, 2013.03. |
| 63. |
Matsuo R, Ago T, Kamouchi M, Kuroda J, Kuwashiro T, Hata J, Sugimori H, Fukuda K, Gotoh S, Makihara N, Fukuhara M, Awano H, Isomura T, Suzuki K, Yasaka M, Okada Y, Kiyohara Y, Kitazono T., Clinical significance of plasma vegf value in ischemic stroke: Research for Biomarkers in Ischemic Stroke (REBIOS) Study, BMC Neurol, 10.1186/1471-2377-13-32, 13:32, 2013.04. |
| 64. |
Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group., The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and western diet in 1980 and 2008, Circulation, 10.1161/CIRCULATIONAHA.113.001470, 127(14):1493-1502, 2013.04. |
| 65. |
Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y., Temporal trends in sudden unexpected death in a general population: the Hisayama Study, Am Heart J, 10.1016/j.ahj.2013.02.028, 165(6):932-938e1, 2013.06. |
| 66. |
Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y., White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study, Stroke, 10.1161/STROKEAHA.111.000704, 44(6):1512-1517, 2013.06. |
| 67. |
Anderson CS, Heeley E, Huang Y, Wang J, Stapf C, Delcourt C, Lindley R, Robinson T, Lavados P, Neal B, Hata J, Arima H, Parsons M, Li Y, Wang J, Heritier S, Li Q, Woodward M, Simes RJ, Davis SM, Chalmers J; INTERACT2 Investigators., Rapid blood-pressure lowering in patients with acute intracerebral hemorrhage, N Engl J Med, 10.1056/NEJMoa1214609, 368(25):2355-2365, 2013.06. |
| 68. |
Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y., Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009), Circulation, 10.1161/CIRCULATIONAHA.113.002424, 128(11):1198-1205, 2013.09. |
| 69. |
Hata J, Arima H, Rothwell PM, Woodward M, Zoungas S, Anderson C, Patel A, Neal B, Glasziou P, Hamet P, Mancia G, Poulter N, Williams B, Macmahon S, Chalmers J; ADVANCE Collaborative Group., Effects of visit-to-visit variability in systolic blood pressure on macrovascular and microvascular complications in patients with type 2 diabetes mellitus: the ADVANCE trial, Circulation, 10.1161/CIRCULATIONAHA.113.002717, 128(12):1325-1334, 2013.09. |
| 70. |
Sekita A, Arima H, Ninomiya T, Ohara T, Doi Y, Hirakawa Y, Fukuhara M, Hata J, Yonemoto K, Ga Y, Kitazono T, Kanba S, Kiyohara Y., Elevated depressive symptoms in metabolic syndrome in a general population of Japanese men: a cross-sectional study, BMC Public Health, 10.1186/1471-2458-13-862, 13:862, 2013.09. |
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Oku S, Takeshita T, Futatsuki T, Kageyama S, Asakawa M, Mori Y, Miyamoto T, Hata J, Ninomiya T, Kashiwazaki H, Yamashita Y., Disrupted tongue microbiota and detection of nonindigenous bacteria on the day of allogeneic hematopoietic stem cell transplantation, PLoS Pathog, 10.1371/journal.ppat.1008348, 16(3):e1008348, 2020.03. |
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Ohara T, Furuta Y, Hirabayashi N, Hata J, Hirakawa Y, Honda T, Yoshida D, Shibata M, Kitazono T, Ninomiya T., Elevated serum glycated albumin and glycated albumin : hemoglobin A1c ratio were associated with hippocampal atrophy in a general elderly population of Japanese: the Hisayama Study, J Diabetes Investig, 10.1111/jdi.13220, 11(4):971-979, 2020.07. |
| 199. |
Higashioka M, Sakata S, Honda T, Hata J, Yoshida D, Hirakawa Y, Shibata M, Goto K, Kitazono T, Osawa H, Ninomiya T., Small dense low-density lipoprotein cholesterol and the risk of coronary heart disease in a Japanese community, J Atheroscler Thromb, 10.5551/jat.51961, 27(7):669-682, 2020.07. |
| 200. |
Hirakawa Y, Hata J, Yoshinari M, Higashioka M, Yoshida D, Shibata M, Honda T, Sakata S, Kato H, Teramoto T, Maki H, Nishimoto S, Kitazono T, Ninomiya T., 30-minute postload plasma glucose levels during an oral glucose tolerance test predict the risk of future type 2 diabetes: the Hisayama Study, BMJ Open Diabetes Res Care, 10.1136/bmjdrc-2019-001156, 8(1):e001156, 2020.07. |
| 201. |
Ueda E, Yasuda M, Fujiwara K, Hashimoto S, Ohno-Matsui K, Hata J, Ishibashi T, Ninomiya T, Sonoda KH., Five-year incidence of myopic maculopathy in a general Japanese population: the Hisayama Study, JAMA Ophthalmol, 10.1001/jamaophthalmol.2020.2211, 138(8):887-893, 2020.08. |
| 202. |
Yoshida D, Ohara T, Hata J, Shibata M, Hirakawa Y, Honda T, Furuta Y, Oishi E, Sakata S, Kanba S, Kitazono T, Ninomiya T., Lifetime cumulative incidence of dementia in a community-dwelling elderly population in Japan, Neurology, 10.1212/WNL.0000000000009917, 95(5):e508-e518, 2020.08. |
| 203. |
Inaishi J, Saisho Y, Hirakawa Y, Yoshida D, Hata J, Mukai N, Watanabe Y, Oda Y, Itoh H, Ninomiya T., Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals: the Hisayama Study, J Diabetes Investig, 10.1111/jdi.13232, 11(5):1197-1206, 2020.09. |
| 204. |
Mihara A, Ohara T, Hata J, Honda T, Chen S, Sakata S, Oishi E, Hirakawa Y, Nakao T, Kitazono T, Ninomiya T., Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community: the Hisayama Study, Atherosclerosis, 10.1016/j.atherosclerosis.2020.08.016, 311:52-59, 2020.10. |
| 205. |
Ishida Y, Yoshida D, Honda T, Hirakawa Y, Shibata M, Sakata S, Furuta Y, Oishi E, Hata J, Kitazono T, Ninomiya T., Influence of the accumulation of unhealthy eating habits on obesity in a general Japanese population: the Hisayama Study, Nutrients, 10.3390/nu12103160, 12(10):3160, 2020.10. |
| 206. |
Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ohara T, Hata J, Kokubo Y, Uchida K, Taki Y, Kumagai S, Yonemoto K, Yoshida H, Muto K, Momozawa Y, Akiyama M, Kubo M, Ikeda M, Kanba S, Kiyohara Y; JPSC-AD Study Group., Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD), Environ Health Prev Med, 10.1186/s12199-020-00903-3, 25(1):64, 2020.10. |
| 207. |
NCD Risk Factor Collaboration (NCD-RisC)., Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants, Lancet, 10.1016/S0140-6736(20)31859-6, 396(10261):1511-1524, 2020.11. |
| 208. |
Nagata T, Hata J, Sakata S, Oishi E, Honda T, Furuta Y, Ohara T, Yoshida D, Hirakawa Y, Shibata M, Ide T, Kitazono T, Tsutsui H, Ninomiya T., Serum N-terminal pro-B-type natriuretic peptide as a predictor for future development of atrial fibrillation in a general population: the Hisayama Study, Int J Cardiol, 10.1016/j.ijcard.2020.06.018, 320:90-96, 2020.12. |
| 209. |
Asayama K, Tabara Y, Oishi E, Sakata S, Hisamatsu T, Godai K, Kabayama M, Tatsumi Y, Hata J, Kikuya M, Kamide K, Miura K, Ninomiya T, Ohkubo T., Recent status of self-measured home blood pressure in the Japanese general population: a modern database on self-measured home blood pressure (MDAS), Hypertens Res, 10.1038/s41440-020-0530-1, 43(12):1403-1412, 2020.12. |
| 210. |
Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, Goto K, Kitazono T, Osawa H, Ninomiya T., The association of small dense low-density lipoprotein cholesterol and coronary heart disease in subjects at high cardiovascular risk, J Atheroscler Thromb, 10.5551/jat.55350, 28(1):79-89, 2021.01. |
| 211. |
Sasaki T, Oishi E, Nagata T, Sakata S, Chen S, Furuta Y, Honda T, Yoshida D, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T., N-terminal pro-B-type natriuretic peptide and incident CKD, Kidney Int Rep, 10.1016/j.ekir.2021.01.006, 6(4):976-985, 2021.01. |
| 212. |
NCD Risk Factor Collaboration (NCD-RisC)., Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight, Elife, 10.7554/eLife.60060, 10:e60060, 2021.03. |
| 213. |
Chen S, Honda T, Hata J, Sakata S, Furuta Y, Yoshida D, Shibata M, Ohara T, Hirakawa Y, Oishi E, Kitazono T, Ninomiya T., High serum folate concentrations are associated with decreased risk of mortality among Japanese adults, J Nutr, 10.1093/jn/nxaa382, 151(3):657-665, 2021.03. |
| 214. |
Igarashi Y, Nochioka K, Sakata Y, Tamai T, Ohkouchi S, Irokawa T, Ogawa H, Hayashi H, Fujihashi T, Yamanaka S, Shiroto T, Miyata S, Hata J, Yamada S, Ninomiya T, Yasuda S, Kurosawa H, Shimokawa H., Risk prediction for new-onset atrial fibrillation using the Minnesota code electrocardiography classification system, Int J Cardiol Heart Vasc, 10.1016/j.ijcha.2021.100762, 34:100762, 2021.03. |
| 215. |
Kimura Y, Yoshida D, Hirakawa Y, Hata J, Honda T, Shibata M, Sakata S, Uchida K, Kitazono T, Ninomiya T., Dietary fiber intake and risk of type 2 diabetes in a general Japanese population: the Hisayama Study, J Diabetes Investig, 10.1111/jdi.13377, 12(4):527-536, 2021.04. |
| 216. |
Yamasaki K, Hata J, Ide T, Nagata T, Sakata S, Yoshida D, Honda T, Hirakawa Y, Nakano T, Kitazono T, Tsutsui H, Ninomiya T., Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study, Environ Health Prev Med, 10.1186/s12199-021-00970-0, 26(1):47, 2021.04. |
| 217. |
Ohara T, Yoshida D, Hata J, Shibata M, Honda T, Furuta Y, Hirabayashi N, Kitazono T, Nakao T, Ninomiya T., Current status of the certification of long-term care insurance among individuals with dementia in a Japanese community: the Hisayama Study, Psychiatry Clin Neurosci, 10.1111/pcn.13204, 75(5):182-184, 2021.05. |
| 218. |
Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Kitazono T, Nakashima Y, Ninomiya T., Prevalence and mortality of sarcopenia in a community-dwelling older Japanese population: the Hisayama Study, J Epidemiol, 10.2188/jea.JE20190289, 31(5):320-327, 2021.05. |
| 219. |
Takeshita T, Matsumoto K, Furuta M, Fukuyama S, Takeuchi K, Ogata H, Asakawa M, Kageyama S, Hata J, Ninomiya T, Inoue H, Yamashita Y., Airflow limitation and tongue microbiota in community-dwelling elderly individuals, ERJ Open Res, 10.1183/23120541.00616-2020, 7(2):00616-, 2021.05. |
| 220. |
Hata J, Nagata T, Sakata S, Oishi E, Furuta Y, Hirakawa Y, Honda T, Yoshida D, Kitazono T, Ninomiya T., Risk prediction model for incident atrial fibrillation in a general Japanese population: the Hisayama Study, Circ J, 10.1253/circj.CJ-20-0794, 85(8):1373-1382, 2021.07, Background: The risk prediction of incident atrial fibrillation (AF) is useful to prevent AF and its complications. The aim of this study is to develop a new risk prediction model for incident AF using the prospective longitudinal data from a general Japanese population.
Methods and Results: A total of 2,442 community-dwelling AF-free residents aged ≥40 years were followed up from 1988 to 2012 (46,422 person-years). The development of AF was confirmed by a standard 12-lead electrocardiogram at repeated health examinations and by medical records at clinics or hospitals. The risk prediction model for incident AF was developed using a Cox proportional hazards model. During the follow up, 230 AF events were confirmed. Age, sex, systolic blood pressure, waist circumference, estimated glomerular filtration rate, abnormal cardiac murmur, high R-wave amplitude, and arrhythmia other than AF were selected for inclusion in the model. This model showed good discrimination (Harrell's c statistics: 0.785) and calibration (Greenwood-Nam-D'Agostino test: P=0.87) for AF risk at 10 years.
Conclusions: The new risk prediction model showed good performance on the individual risk assessment of the future onset of AF in a general Japanese population. As this model included commonly used clinical parameters, it may be useful for determining the requirements for the careful evaluation of AF, such as frequent electrocardiogram examinations in clinical settings, and subsequent reductions in the risk of AF-related complications.. |
| 221. |
Yoshikawa T, Hata J, Sakata S, Nagata T, Hirakawa Y, Hirooka Y, Tsutsui H, Kitazono T, Ninomiya T., Serum high-sensitivity C-reactive protein levels and the development of atrial fibrillation in a general Japanese population: the Hisayama Study, Circ J, 10.1253/circj.CJ-20-0751, 85(8):1365-1372, 2021.07. |
| 222. |
Honda T, Ohara T, Yoshida D, Shibata M, Ishida Y, Furuta Y, Oishi E, Hirakawa Y, Sakata S, Hata J, Nakao T, Ninomiya T., Development of a dementia prediction model for primary care: the Hisayama Study, Alzheimers Dement (Amst), 10.1002/dad2.12221, 13(1):e12221, 2021.07. |
| 223. |
Kiyohara T, Matsuo R, Hata J, Nakamura K, Wakisaka Y, Kamouchi M, Kitazono T, Ago T; FSR Investigators., β-cell function and clinical outcome in nondiabetic patients with acute ischemic stroke, Stroke, 10.1161/STROKEAHA.120.031392, 52(8):2621-2628, 2021.08. |
| 224. |
Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T., Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study, Diabetologia, 10.1007/s00125-021-05459-7, 64(8):1775-1784, 2021.08. |
| 225. |
Michiko Furuta, Kenji Takeuchi, Toru Takeshita, Yukie Shibata, Shino Suma, Shinya Kageyama, Mikari Asakawa, Jun Hata, Daigo Yoshida, Yoshihiro Shimazaki, Toshiharu Ninomiya, Yoshihisa Yamashita, 10-year trend of tooth loss and associated factors in a Japanese population-based longitudinal study., BMJ open, 10.1136/bmjopen-2020-048114, 11, 8, e048114, 2021.08, OBJECTIVES: We examined the trend in the number of missing teeth in a Japanese community over a 10-year period and the potential associated explanatory factors. DESIGN: Prospective cohort study. SETTING: A population-based study conducted in 2007, 2012 and 2017 in Japan (Hisayama Study). PARTICIPANTS: Residents of a Japanese community aged 40-79 years undergoing dental examination in 2007 (n=2665), 2012 (n=2325) and 2017 (n=2285). OUTCOME MEASURES: The number of missing teeth, periodontal condition, dental caries experience, dental plaque index and oral health behaviours were evaluated each year. The longitudinal analysis of variation in these factors were assessed using mixed models. RESULTS: The age-adjusted and sex-adjusted mean number of missing teeth decreased with time (6.80 in 2007, 6.01 in 2012 and 4.99 in 2017). The mean clinical attachment level (CAL), prevalence of periodontitis and dental plaque index decreased over the study period, while dental caries experience slightly increased. The level of oral health behaviour increased over time. Poisson mixed models showed that changes in mean CAL and dental caries experience were positively associated with the change in the number of missing teeth over time. Linear mixed models showed that changes in dental plaque index and no regular dental visit were positively associated with changes in mean CAL. CONCLUSIONS: These findings suggest that a decreasing trend regarding the number of missing teeth in Japan might be associated with improvements in the periodontal condition due to changes in oral hygiene level and oral health behaviour.. |
| 226. |
Oishi E, Hata J, Honda T, Sakata S, Chen S, Hirakawa Y, Yoshida D, Shibata M, Ohara T, Furuta Y, Kitazono T, Ninomiya T., Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study, Hypertens Res, 10.1038/s41440-021-00673-7, 44(9):1221-1229, 2021.09. |
| 227. |
Sasaki T, Izumaru K, Hata J, Sakata S, Oishi E, Nagata T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T., Serum NT-proBNP levels and histopathological myocardial fibrosis in autopsied cases from a Japanese community: the Hisayama Study, J Cardiol, 10.1016/j.jjcc.2021.03.014, 78(3):237-243, 2021.09. |
| 228. |
NCD Risk Factor Collaboration (NCD-RisC)., Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, Lancet, 10.1016/S0140-6736(21)01330-1, 398(10304):957-980, 2021.09. |
| 229. |
Sasaki T, Nakagawa K, Hata J, Hirakawa Y, Shibata M, Nakano T, Tsuboi N, Oda Y, Kitazono T, Yokoo T, Ninomiya T., Pathologic diabetic nephropathy in autopsied diabetic cases with normoalbuminuria from a Japanese community-based study, Kidney Int Rep, 10.1016/j.ekir.2021.09.007, 6(12):3035-3044, 2021.09. |
| 230. |
Nakamura K, Yoshida D, Honda T, Hata J, Shibata M, Hirakawa Y, Furuta Y, Kishimoto H, Ohara T, Chen S, Kitazono T, Nakashima Y, Ninomiya T., Midlife and late-life diabetes and sarcopenia in a general older Japanese population: the Hisayama Study, J Diabetes Investig, 10.1111/jdi.13550, 12(10):1899-1907, 2021.10. |
| 231. |
Shibata M, Ohara T, Hosoi M, Hata J, Yoshida D, Hirabayashi N, Morisaki Y, Nakazawa T, Mihara A, Nagata T, Oishi E, Anno K, Sudo N, Ninomiya T., Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study, J Gerontol B Psychol Sci Soc Sci, 10.1093/geronb/gbaa196, 76(9):1756-1766, 2021.10. |
| 232. |
Fukuda K, Matsuo R, Kamouchi M, Kiyuna F, Sato N, Nakamura K, Hata J, Wakisaka Y, Ago T, Imaizumi T, Kai H, Kitazono T; FSR Investigators., Day-by-day blood pressure variability in the subacute stage of ischemic stroke and long-term recurrence, Stroke, 10.1161/STROKEAHA.120.033751, 53(1):70-78, 2022.01. |
| 233. |
Maki K, Hata J, Sakata S, Oishi E, Furuta Y, Nakano T, Oda Y, Kitazono T, Ninomiya T., Serum uric acid levels and nephrosclerosis in a population-based autopsy study: the Hisayama Study, Am J Nephrol, 10.1159/000521426, 53(1):69-77, 2022.01. |
| 234. |
Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M, Ishida N, Suga Y, Ishizaki J, Ishimiya M, Nakamura H, Komai K, Nakamura H, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group., Diabetes mellitus, elevated hemoglobin A1c, and glycated albumin are associated with the presence of all-cause dementia and Alzheimer's disease: the JPSC-AD study, J Alzheimers Dis, 10.3233/JAD-215153, 85(1):235-247, 2022.01. |
| 235. |
Yagita K, Honda H, Ohara T, Hamasaki H, Koyama S, Noguchi H, Mihara A, Nakazawa T, Hata J, Ninomiya T, Iwaki T., A comparative study of site-specific distribution of aging-related tau astrogliopathy and its risk factors between Alzheimer disease and cognitive healthy brains: the Hisayama Study, J Neuropathol Exp Neurol, 10.1093/jnen/nlab126, 81(2):106-116, 2022.01. |
| 236. |
Honda T, Ishida Y, Oda M, Noguchi K, Chen S, Sakata S, Oishi E, Furuta Y, Yoshida D, Hirakawa Y, Hata J, Kitazono T, Ninomiya T., Changes in body weight and concurrent changes in cardiovascular risk profiles in community residents in Japan: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.59394, 29(2):252-267, 2022.02. |
| 237. |
Nakanishi Y, Furuta Y, Hata J, Yubi T, Oishi E, Sakata S, Hirakawa Y, Wakisaka Y, Ago T, Kitazono T, Ninomiya T., Long-term trends in the 5-year risk of recurrent stroke over a half century in a Japanese community: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.63344, 29(12):1759-1773, 2022.02. |
| 238. |
Honda T, Chen S, Hata J, Yoshida D, Hirakawa Y, Furuta Y, Shibata M, Sakata S, Kitazono T, Ninomiya T., Development and validation of a risk prediction model for atherosclerotic cardiovascular disease in Japanese adults: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.61960, 29(3):345-361, 2022.03. |
| 239. |
Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T., Multiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama Study, J Neurol Neurosurg Psychiatry, 10.1136/jnnp-2021-326611, 93(3):263-271, 2022.03. |
| 240. |
Asada M, Shibata M, Hirabayashi N, Ohara T, Furuta Y, Nakazawa T, Honda T, Hata J, Hosoi M, Sudo N, Yamaura K, Ninomiya T., Association between chronic low back pain and regional brain atrophy in a Japanese older population: the Hisayama Study, Pain, 10.1097/j.pain.0000000000002612, 163(11):2185-2193, 2022.03. |
| 241. |
Kimura Y, Yoshida D, Ohara T, Hata J, Honda T, Hirakawa Y, Shibata M, Oishi E, Sakata S, Furuta Y, Chen S, Uchida K, Nakao T, Kitazono T, Ninomiya T., Long-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama Study, BMC Geriatr, 10.1186/s12877-022-02939-2, 22(1):257, 2022.03. |
| 242. |
Ma J, Furuta M, Uchida K, Takeshita T, Kageyama S, Asakawa M, Takeuchi K, Suma S, Sakata S, Hata J, Sohn W, Ninomiya T, Yamashita Y., Yogurt product intake and reduction of tooth loss risk in a Japanese community, J Clin Periodontol, 10.1111/jcpe.13593, 49(4):345-352, 2022.04. |
| 243. |
Ohara T, Hata J, Tanaka M, Honda T, Yamakage H, Inoue T, Hirakawa Y, Kusakabe T, Shibata M, Kitazono T, Nakao T, Satoh-Asahara N, Ninomiya T., Association of daily sleep duration with the incident dementia by serum soluble TREM2 in a community, J Am Geriatr Soc, 10.1111/jgs.17634, 70(4):1147-1156, 2022.04. |
| 244. |
Furuta M, Takeuchi K, Takeshita T, Shibata Y, Suma S, Kageyama S, Asakawa M, Shimazaki Y, Hata J, Ninomiya T, Yamashita Y., Baseline periodontal status and modifiable risk factors are associated with tooth loss over a 10-year period: estimates of population attributable risk in a Japanese community, J Periodontol, 10.1002/JPER.21-0191, 93(4):526-536, 2022.04. |
| 245. |
Ueda E, Hirabayashi N, Ohara T, Hata J, Honda T, Fujiwara K, Furuta Y, Shibata M, Hashimoto S, Nakamura S, Nakazawa T, Nakao T, Kitazono T, Ninomiya T, Sonoda KH., Association of inner retinal thickness with prevalent dementia and brain atrophy in a general older population: the Hisayama Study, Ophthalmol Sci, 10.1016/j.xops.2022.100157, 2(2):100157, 2022.04. |
| 246. |
Thyreau B, Tatewaki Y, Chen L, Takano Y, Hirabayashi N, Furuta Y, Hata J, Nakaji S, Maeda T, Noguchi-Shinohara M, Mimura M, Nakashima K, Mori T, Takebayashi M, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group., Higher-resolution quantification of white matter hypointensities by large-scale transfer learning from 2D images on the JPSC-AD cohort, Hum Brain Mapp, 10.1002/hbm.25899, Online ahead of print, 2022.05. |
| 247. |
Washio Y, Sakata S, Fukuyama S, Honda T, Kan-O K, Shibata M, Hata J, Inoue H, Kitazono T, Matsumoto K, Ninomiya T., Risks of mortality and airflow limitation in Japanese with preserved ratio impaired spirometry, Am J Respir Crit Care Med, 10.1164/rccm.202110-2302OC, Online ahead of print, 2022.05. |
| 248. |
Honda T, Hirakawa Y, Hata J, Chen S, Shibata M, Sakata S, Furuta Y, Higashioka M, Oishi E, Kitazono T, Ninomiya T., Active commuting, commuting modes and the risk of diabetes: 14-year follow-up data from the Hisayama Study, J Diabetes Investig, 10.1111/jdi.13844, 13(10):1677-1684, 2022.05. |
| 249. |
Gerard Temprano‐Sagrera, Colleen M. Sitlani, William P. Bone, Miguel Martin‐Bornez, Benjamin F. Voight, Alanna C. Morrison, Scott M. Damrauer, Paul S. de Vries, Nicholas L. Smith, Maria Sabater‐Lleal, Abbas Dehghan, Adam S Heath, Alanna C Morrison, Alex P Reiner, Andrew Johnson, Anne Richmond, Annette Peters, Astrid van Hylckama Vlieg, Barbara McKnight, Bruce M Psaty, Caroline Hayward, Cavin Ward‐Caviness, Christopher O’Donnell, Daniel Chasman, David P Strachan, David A Tregouet, Dennis Mook‐Kanamori, Dipender Gill, Florian Thibord, Folkert W Asselbergs, Frank W.G. Leebeek, Frits R Rosendaal, Gail Davies, Georg Homuth, Gerard Temprano, Harry Campbell, Herman A Taylor, Jan Bressler, Jennifer E Huffman, Jerome I Rotter, Jie Yao, James F Wilson, Joshua C Bis, Julie M Hahn, Karl C Desch, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Lisa R Yanek, Marcus E Kleber, Maria Sabater‐Lleal, Martina Mueller, Maryam Kavousi, Massimo Mangino, Melissa Liu, Michael R Brown, Matthew P Conomos, Min‐A Jhun, Ming‐Huei Chen, Moniek P.M. de Maat, Nathan Pankratz, Nicholas L Smith, Patricia A Peyser, Paul Elliot, Paul S de Vries, Peng Wei, Philipp S Wild, Pierre E Morange, Pim van der Harst, Qiong Yang, Ngoc‐Quynh Le, Riccardo Marioni, Ruifang Li, Scott M Damrauer, Simon R Cox, Stella Trompet, Stephan B Felix, Uwe Völker, Weihong Tang, Wolfgang Koenig, J. Wouter Jukema, Xiuqing Guo, Sara Lindstrom, Lu Wang, Erin N Smith, William Gordon, Astrid van Hylckama Vlieg, Mariza de Andrade, Jennifer A Brody, Jack W Pattee, Jeffrey Haessler, Ben M Brumpton, Daniel I Chasman, Pierre Suchon, Ming‐Huei Chen, Constance Turman, Marine Germain, Kerri L Wiggins, James MacDonald, Sigrid K Braekkan, Sebastian M Armasu, Nathan Pankratz, Rabecca D Jackson, Jonas B Nielsen, Franco Giulianini, Marja K Puurunen, Manal Ibrahim, Susan R Heckbert, Theo K Bammler, Kelly A Frazer, Bryan M McCauley, Kent Taylor, James S Pankow, Alexander P Reiner, Maiken E Gabrielsen, Jean‐François Deleuze, Chris J O’Donnell, Jihye Kim, Barbara McKnight, Peter Kraft, John‐Bjarne Hansen, Frits R Rosendaal, John A Heit, Bruce M Psaty, Weihong Tang, Charles Kooperberg, Kristian Hveem, Paul M Ridker, Pierre‐Emmanuel Morange, Andrew D Johnson, Christopher Kabrhel, David‐Alexandre Trégouët, Nicholas L Smith, Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten‐Jacobs, Anne‐Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir, Christopher D Anderson, Michael Chong, Hieab HH Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M Bartz, Oscar R Benavente, Steve Bevan, Giorgio B Boncoraglio, Robert D Brown, Adam S Butterworth, Caty Carrera, Cara L Carty, Daniel I Chasman, Wei‐Min Chen, John W Cole, Adolfo Correa, Ioana Cotlarciuc, Carlos Cruchaga, John Danesh, Paul IW de Bakker, Anita L DeStefano, Marcel den Hoed, Qing Duan, Stefan T Engelter, Guido J Falcone, Rebecca F Gottesman, Raji P Grewal, Vilmundur Gudnason, Stefan Gustafsson, Jeffrey Haessler, Tamara B Harris, Ahamad Hassan, Aki S Havulinna, Susan R Heckbert, Elizabeth G Holliday, George Howard, Fang‐Chi Hsu, Hyacinth I Hyacinth, M Arfan Ikram, Erik Ingelsson, Marguerite R Irvin, Xueqiu Jian, Jordi Jiménez‐Conde, Julie A Johnson, J Wouter Jukema, Masahiro Kanai, Keith L Keene, Brett M Kissela, Dawn O Kleindorfer, Charles Kooperberg, Michiaki Kubo, Leslie A Lange, Carl D Langefeld, Claudia Langenberg, Lenore J Launer, Jin‐Moo Lee, Robin Lemmens, Didier Leys, Cathryn M Lewis, Wei‐Yu Lin, Arne G Lindgren, Erik Lorentzen, Patrik K Magnusson, Jane Maguire, Ani Manichaikul, Patrick F McArdle, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Toshiharu Ninomiya, Martin J O’Donnell, Bruce M Psaty, Sara L Pulit, Kristiina Rannikmäe, Alexander P Reiner, Kathryn M Rexrode, Kenneth Rice, Stephen S Rich, Paul M Ridker, Natalia S Rost, Peter M Rothwell, Jerome I Rotter, Tatjana Rundek, Ralph L Sacco, Saori Sakaue, Michele M Sale, Veikko Salomaa, Bishwa R Sapkota, Reinhold Schmidt, Carsten O Schmidt, Ulf Schminke, Pankaj Sharma, Agnieszka Slowik, Cathie LM Sudlow, Christian Tanislav, Turgut Tatlisumak, Kent D Taylor, Vincent NS Thijs, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Steffen Tiedt, Stella Trompet, Christophe Tzourio, Cornelia M van Duijn, Matthew Walters, Nicholas J Wareham, Sylvia 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Norrving, Soichi Ogishima, Eugenio A Parati, Leema Reddy Peddareddygari, Nancy L Pedersen, Joanna Pera, Markus Perola, Alessandro Pezzini, Silvana Pileggi, Raquel Rabionet, Iolanda Riba‐Llena, Marta Ribasés, Jose R Romero, Jaume Roquer, Anthony G Rudd, Antti‐Pekka Sarin, Ralhan Sarju, Chloe Sarnowski, Makoto Sasaki, Claudia L Satizabal, Mamoru Satoh, Naveed Sattar, Norie Sawada, Gerli Sibolt, Ásgeir Sigurdsson, Albert Smith, Kenji Sobue, Carolina Soriano‐Tárraga, Tara Stanne, O Colin Stine, David J Stott, Konstantin Strauch, Takako Takai, Hideo Tanaka, Kozo Tanno, Alexander Teumer, Liisa Tomppo, Nuria P Torres‐Aguila, Emmanuel Touze, Shoichiro Tsugane, Andre G Uitterlinden, Einar M Valdimarsson, Sven J van der Lee, Henry Völzke, Kenji Wakai, David Weir, Stephen R Williams, Charles DA Wolfe, Quenna Wong, Huichun Xu, Taiki Yamaji, Dharambir K Sanghera, Olle Melander, Christina Jern, Daniel Strbian, Israel Fernandez‐Cadenas, W T Longstreth, Arndt Rolfs, Jun Hata, Daniel Woo, Jonathan 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Hirabayashi N, Hata J, Furuta Y, Ohara T, Shibata M, Hirakawa Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Ninomiya T., Association between diabetes and gray matter atrophy patterns in a general older Japanese population: the Hisayama Study, Diabetes Care, 10.2337/dc21-1911, 45(6):1364-1371, 2022.06. |
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Mihara A, Ohara T, Hata J, Chen S, Honda T, Tamrakar S, Isa A, Wang D, Shimizu K, Katakura Y, Yonemoto K, Nakao T, Kitazono T, Ninomiya T., Association of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community, Sci Rep, 10.1038/s41598-022-16242-y, 12(1):12427, 2022.07. |
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Noguchi-Shinohara M, Ono K, Yuki-Nozaki S, Iwasa K, Yokogawa M, Komai K, Thyreau B, Tatewaki Y, Taki Y, Shibata M, Ohara T, Hata J, Ninomiya T, Yamada M., Association of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study, Sci Rep, 10.1038/s41598-022-16190-7, 12(1):12129, 2022.08. |
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Liu Y, Zhang Y, Thyreau B, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) Study Group., Altruistic social activity, depressive symptoms, and brain regional gray matter volume: voxel-based morphometry analysis from 8,695 old adults, J Gerontol A Biol Sci Med Sci, 10.1093/gerona/glac093, 77(9):1789-1797, 2022.09. |
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Sasaki T, Sakata S, Oishi E, Furuta Y, Honda T, Hata J, Tsuboi N, Kitazono T, Yokoo T, Ninomiya T., Day-to-day blood pressure variability and risk of incident chronic kidney disease in a general Japanese population, J Am Heart Assoc, 10.1161/JAHA.122.027173, 11(19):e027173, 2022.10. |
| 255. |
Fujiwara K, Yasuda M, Hata J, Nakano S, Hashimoto S, Ueda E, Nakamura S, Murakami Y, Nakamuro T, Iwase A, Araie M, Tawara A, Kubota T, Yoshitomi T, Ninomiya T, Sonoda KH., Prevalence of glaucoma and its systemic risk factors in a general Japanese population: the Hisayama Study, Transl Vis Sci Technol, 10.1167/tvst.11.11.11, 11(11):11, 2022.11. |
| 256. |
Mishra A, Malik R, Hachiya T, Jürgenson T, Namba S, Posner DC, Kamanu FK, Koido M, Le Grand Q, Shi M, He Y, Georgakis MK, Caro I, Krebs K, Liaw YC, Vaura FC, Lin K, Winsvold BS, Srinivasasainagendra V, Parodi L, Bae HJ, Chauhan G, Chong MR, Tomppo L, Akinyemi R, Roshchupkin GV, Habib N, Jee YH, Thomassen JQ, Abedi V, Cárcel-Márquez J, Nygaard M, Leonard HL, Yang C, Yonova-Doing E, Knol MJ, Lewis AJ, Judy RL, Ago T, Amouyel P, Armstrong ND, Bakker MK, Bartz TM, Bennett DA, Bis JC, Bordes C, Børte S, Cain A, Ridker PM, Cho K, Chen Z, Cruchaga C, Cole JW, de Jager PL, de Cid R, Endres M, Ferreira LE, Geerlings MI, Gasca NC, Gudnason V, Hata J, He J, Heath AK, Ho YL, Havulinna AS, Hopewell JC, Hyacinth HI, Inouye M, Jacob MA, Jeon CE, Jern C, Kamouchi M, Keene KL, Kitazono T, Kittner SJ, Konuma T, Kumar A, Lacaze P, Launer LJ, Lee KJ, Lepik K, Li J, Li L, Manichaikul A, Markus HS, Marston NA, Meitinger T, Mitchell BD, Montellano FA, Morisaki T, Mosley TH, Nalls MA, Nordestgaard BG, O'Donnell MJ, Okada Y, Onland-Moret NC, Ovbiagele B, Peters A, Psaty BM, Rich SS, et al., Stroke genetics informs drug discovery and risk prediction across ancestries, Nature, 10.1038/s41586-022-05165-3, 611(7934):115-123, 2022.11. |
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Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S, Posner DC, Mosconi K, Robinson-Cohen C, Mason AM, Bolton TR, Tao R, Allara E, Schubert P, Chen L, Staley JR, Staplin N, Altay S, Amiano P, Arndt V, Ärnlöv J, Barr ELM, Björkelund C, Boer JMA, Brenner H, Casiglia E, Chiodini P, Cooper JA, Coresh J, Cushman M, Dankner R, Davidson KW, de Jongh RT, Donfrancesco C, Engström G, Freisling H, de la Cámara AG, Gudnason V, Hankey GJ, Hansson PO, Heath AK, Hoorn EJ, Imano H, Jassal SK, Kaaks R, Katzke V, Kauhanen J, Kiechl S, Koenig W, Kronmal RA, Kyrø C, Lawlor DA, Ljungberg B, MacDonald C, Masala G, Meisinger C, Melander O, Moreno Iribas C, Ninomiya T, Nitsch D, Nordestgaard BG, Onland-Moret C, Palmieri L, Petrova D, Garcia JRQ, Rosengren A, Sacerdote C, Sakurai M, Santiuste C, Schulze MB, Sieri S, Sundström J, Tikhonoff V, Tjønneland A, Tong T, Tumino R, Tzoulaki I, van der Schouw YT, Monique Verschuren WM, Völzke H, Wallace RB, Wannamethee SG, Weiderpass E, Willeit P, Woodward M, Yamagishi K, Zamora-Ros R, Akwo EA, Pyarajan S, Gagnon DR, Tsao PS, Muralidhar S, Edwards TL, Damrauer SM, Joseph J, Pennells L, Wilson PWF, Harrison S, et al., Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and mendelian randomization analyses, Circulation, 10.1161/CIRCULATIONAHA.122.060700, 146(20):1507-1517, 2022.11. |
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Maki K, Ohara T, Hata J, Shibata M, Hirabayashi N, Honda T, Sakata S, Furuta Y, Akiyama M, Yamasaki K, Tatewaki Y, Taki Y, Kitazono T, Mikami T, Maeda T, Ono K, Mimura M, Nakashima K, Iga JI, Takebayashi M, Ninomiya T; Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) study group., CKD, brain atrophy, and white matter lesion volume: the Japan Prospective Studies Collaboration for Aging and Dementia, Kidney Med, 10.1016/j.xkme.2022.100593, 5(3):100593, 2022.12. |
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Tomooka S, Oishi E, Asada M, Sakata S, Hata J, Chen S, Honda T, Suzuki K, Watanabe H, Murayama N, Wada N, Kitazono T, Ninomiya T., Serum lipopolysaccharide-binding protein levels and the incidence of metabolic syndrome in a general Japanese population: the Hisayama Study, J Epidemiol, 10.2188/jea.JE20220232, Online ahead of print., 2022.12. |
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Hashimoto S, Yasuda M, Fujiwara K, Ueda E, Nakamura S, Hirakawa Y, Higashioka M, Hata J, Ninomiya T, Sonoda KH., Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study, Graefes Arch Clin Exp Ophthalmol, 10.1007/s00417-022-05839-8, 261(3):641-649, 2023.03. |
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NCD Risk Factor Collaboration (NCD-RisC)., Diminishing benefits of urban living for children and adolescents' growth and development, Nature, 10.1038/s41586-023-05772-8, 615(7954):874-883, 2023.03. |
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Tajimi T, Furuta Y, Hirabayashi N, Honda T, Hata J, Ohara T, Shibata M, Nakao T, Kitazono T, Nakashima Y, Ninomiya T., Association of gait speed with regional brain volumes and risk of dementia in older Japanese: the Hisayama study, Arch Gerontol Geriatr, 10.1016/j.archger.2022.104883, 106:104883, 2023.03. |
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Honda T, Chen S, Hata J, Shibata M, Furuta Y, Oishi E, Sakata S, Kitazono T, Ninomiya T., Changes in the eicosapentaenoic acid to arachidonic acid ratio in serum over 10 years in a Japanese community: the Hisayama Study, J Atheroscler Thromb, 10.5551/jat.63727, 30(6):589-600, 2023.06. |
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Nakazawa T, Ohara T, Hirabayashi N, Furuta Y, Hata J, Shibata M, Honda T, Kitazono T, Nakao T, Ninomiya T., Association of white matter lesions and brain atrophy with the development of dementia in a community: the Hisayama Study, Psychiatry Clin Neurosci, 10.1111/pcn.13533, 77(6):330-337, 2023.06. |
| 265. |
Emi Ueda, Miho Yasuda, Kohta Fujiwara, Sawako Hashimoto, Takanori Honda, Shun Nakamura, Jun Hata, Toshiharu Ninomiya, Koh-Hei Sonoda, Association between choroidal thickness and myopic maculopathy in a Japanese population: the Hisayama Study, Ophthalmology Science, 10.1016/j.xops.2023.100350, 100350-100350, 2023.06. |
| 266. |
Higashioka M, Hirakawa Y, Hata J, Honda T, Sakata S, Shibata M, Kitazono T, Osawa H, Ninomiya T., Serum Mac-2 binding protein glycosylation isomer concentrations are associated with incidence of type 2 diabetes, J Clin Endocrinol Metab, 10.1210/clinem/dgad011, 108(7):e425-e433, 2023.06. |
| 267. |
Naoki Hirabayashi, Takanori Honda, Jun Hata, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Yasuko Tatewaki, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Jun-Ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Association between frequency of social contact and brain atrophy in community-dwelling older people without dementia: the JPSC-AD Study., Neurology, 2023.07, BACKGROUND AND OBJECTIVES: Epidemiological evidence has shown that social isolation, a low frequency of social contact with others, is associated with the risk of dementia and late-life depressive symptoms. Therefore, we hypothesized that low frequency of social contact may be involved in brain atrophy, and depressive symptoms may play some role in this relationship. We aimed to evaluate the association between low frequency of social contact and the volumes of various brain regions and to assess the extent to which depressive symptoms mediate these relationships from a large population-based multisite cohort study. METHODS: Dementia-free community-dwelling Japanese aged ≥65 years underwent brain MRI scans and a comprehensive health examination. Frequency of contact with non-cohabiting relatives and friends was determined by asking a single question with four categories: everyday, several times a week, several times a month, and seldom. Total and regional brain volumes, intracranial volume (ICV) and white matter lesions volume were estimated using FreeSurfer software. The associations between frequency of social contact and brain volumes per ICV were examined using analyses of covariance. Mediation analyses were conducted to calculate the proportion of the associations explained by depressive symptoms. RESULTS: We included 8,896 participants. The multivariable-adjusted mean of the total brain volume in the group with the lowest frequency of social contact was significantly lower compared to that in the group with the highest frequency (67.3% vs 67.8%), with a significant increasing trend across the groups (p value for trend |
| 268. |
Shogyoku Bun, Kouta Suzuki, Hidehito Niimura, Ryo Shikimoto, Hisashi Kida, Mao Shibata, Takanori Honda, Tomoyuki Ohara, Jun Hata, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Kenji Nakashima, Jun‐ichi Iga, Minoru Takebayashi, Toshiharu Ninomiya, Masaru Mimura, Gender and age influence the association between gait speed and mild cognitive impairment in community‐dwelling Japanese older adults: from the Japan Prospective Studies Collaboration for Ageing and Dementia (JPSC‐AD), Psychogeriatrics, 10.1111/psyg.13013, 2023.08, Background
Studies have shown that decreased gait speed is associated with impaired cognitive function. However, whether this association is equivalent across ages or genders in the older population remains unclear. Thus, we examined the association between mild cognitive impairment (MCI) and gait speed emphasising the influence of age and gender.
Methods
Overall, 8233 Japanese participants aged ≥65 years were enrolled in this cross‐sectional study between 2016 and 2018. After stratification by gender and age group, the participants' gait speeds were divided into quintiles, and the difference in MCI prevalence at each gait speed quintile was calculated. Logistic regression analyses were performed to assess the odds of MCI for each quintile and to assess the influence of age and gender.
Results
Males had a consistently higher prevalence of MCI than females. The odds of MCI were increased as gait speed decreased. Logistic regression analyses revealed that in the multivariable‐adjusted model 2, the odds ratios (95% confidence interval; CI) for MCI were 2.02 (1.47–2.76) for females and 1.75 (1.29–2.38) for males in the slowest gait speed quintiles compared to the fastest quintile. In the stratified analyses, only males showed an age‐dependent increase in the associations between gait speed and MCI, while females exhibited comparable associations across age groups.
Conclusions
Reduced gait speed was associated with increased odds of MCI, and this association may vary according to gender and age. Therefore, gait speed could serve as a valuable screening tool for MCI, with gender‐ and age‐dependent clinical implications.. |
| 269. |
Ayumi Tachibana, Jun-Ichi Iga, Yasuko Tatewaki, Benjamin Thyreau, Hongkun Chen, Tomoki Ozaki, Taku Yoshida, Yuta Yoshino, Hideaki Shimizu, Takaaki Mori, Yoshihiko Furuta, Mao Shibata, Tomoyuki Ohara, Jun Hata, Yasuyuki Taki, Shigeyuki Nakaji, Tetsuya Maeda, Kenjiro Ono, Masaru Mimura, Kenji Nakashima, Minoru Takebayashi, Toshiharu Ninomiya, Shu-Ichi Ueno, Late-life high blood pressure and enlarged perivascular spaces in the putaminal regions of community-dwelling Japanese plder persons., Journal of geriatric psychiatry and neurology, 10.1177/08919887231195235, 8919887231195235-8919887231195235, 2023.08, BACKGROUND: Enlarged perivascular spaces (EPVS) of the brain may be involved in dementia, such as Alzheimer's disease and cerebral small vessel disease (CSVD). Hypertension has been reported to be a risk factor for dementia and CSVD, but the association between blood pressure (BP) and perivascular spaces is still unclear. The aim of this study was to determine the association between BP and EPVS volumes and to examine the interactions of relevant factors. METHODS: A total of 9296 community-dwelling subjects aged ≥65 years participated in a brain magnetic resonance imaging and health status screening examination. Perivascular volume was measured using a software package based on deep learning that was developed in-house. The associations between BP and EPVS volumes were examined by analysis of covariance and multiple regression analysis. RESULTS: Mean EPVS volumes increased significantly with rising systolic and diastolic BP levels (P for trend = .003, P for trend<.001 respectively in addition mean epvs volumes increased significantly for every systolic and diastolic bps p values these significant associations were still observed the sensitivity analysis after excluding subjects with dementia. conclusions: present data suggest that higher bp levels are associated greater cognitively normal older people.. id="gencho_ronbuns10236632" class="qir_handle_link"> |
