Kyushu University Academic Staff Educational and Research Activities Database
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Hisako TAKIGAWA-IMAMURA Last modified date:2020.06.04

Assistant Professor / Bioregulation
Department of Basic Medicine
Faculty of Medical Sciences

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Doctor of Philosophy
Country of degree conferring institution (Overseas)
Field of Specialization
Mathematical Biology, Developmental Biology
Total Priod of education and research career in the foreign country
Outline Activities
Theoretical investigation in developmental biology.
Research Interests
  • Phosphatidylinositol 3-Phosphate 5-kinase, FAB1 and Rho-of-Plant 10coordinately mediate root hair shank hardening in Arabidopsis
    keyword : Arabidopsis, Mathematical model, root hair
  • Mechanical modeling for intestinal villi formation
    keyword : intestine, villi, mathematical model, buckling
  • Modeling of the cell shape change during lung morphogenesis
    keyword : lung, morphogenesis, Eisuke transgenic mouse, ERK, FGF10
  • Numerical simulation for the uplift pattern of leaf epidermal cells
    keyword : Arabidopsis, Mathematical model, pavement cell, guard cell
  • Mathematical modeling of the epidermis pattern of dicot plants
    keyword : mathematical mode, epidermis, dicotyledon
  • Building vascularized tissues in vitro
    keyword : organ culture, vascular endothelial cells, angiogenesis, lung
  • Imaging FGF-signaling in lung morphogenesis
    keyword : lung, morphogenesis, Eisuke transgenic mouse, ERK, FGF10
  • Application of microfluidics for the imaging of angiogenesis in tooth germ
    keyword : microfluidics, angiogenesis, tooth germ
  • Microfluidics-generated biomolecules gradient for bioimaging
    keyword : microfluidics, morphogen, bioimaging
  • The role of VEGF in cell migration during angiogenesis
    keyword : angiogenesis, cell migration, angiogenesis
  • Mathematical model of cap stage formation of tooth germ

    keyword : tooth germ, mathematical model, buckling
Academic Activities
1. Katsumi Fumoto, Hisako Takigawa-Imamura, Kenta Sumiyama, Tomoyuki Kaneiwa, and Akira Kikuchi, Modulation of apical constriction by Wnt signal is required for the lung epithelial shape transition, Development, 10.1242/dev.141325, 2017.12, In lung development the apically constricted columnar epithelium forms numerous buds during the pseudoglandular stage and subsequently changes the shape into flat or cuboidal pneumocytes that compose the air sacs during the canalicular and saccular (canalicular-saccular) stages, yet the impact of cell shapes on tissue morphogenesis remains unclear. The expression of Wnt components were decreased in the canalicular-saccular stages, and genetically constitutive activation of Wnt signaling impaired air sac formation by inducing apical constriction in the epithelium as seen in the pseudoglandular stage. Organ culture models also demonstrated that Wnt signaling induces apical constriction through the apical actomyosin cytoskeletal organization. Mathematical modeling revealed that apical constriction induces bud formation and loss of apical constriction is required for the formation of an air sac-like structure. MAP/Microtubule affinity-regulating kinase (MARK1) was identified as a downstream molecule of Wnt signaling and required for the apical cytoskeletal organization and bud formation. These results suggest that Wnt signaling is required for bud formation by inducing apical constriction during the pseudoglandular stage, while loss of Wnt signaling is for air sac formation in the canalicular-saccular stages..
1. 今村寿子, Observation of FGF response in lung epithelium and modeling for
branching morphogenesis, 新学術領域研究「上皮管腔組織形成」第2回国際シンポジウム, 2015.08, The differences in cellular behavior underlying morphogenesis are governed by signaling interactions in the growing tissue. In lung branching morphogenesis, for instance, the high sensitivity of cells to the distribution of diffusive signals within the developing tissue is considered to be the principle mechanism guiding shape change. Here I investigated the response and sensitivity of lung epithelium to FGF10 that mediates epithelial branching to realize the tissue-specific shape. I demonstrated that uptake of FGF10 by epithelial explants of the pseudoglandular stage lung in Matrigel was sensitive over a wide range of FGF10 concentrations in the gel. It was also indicated that MAP kinase activity downstream of FGF10 was affected by the epithelial explant size and shape as well as the FGF10 concentration. These cellular responses of lung epithelium to FGF10 were higher in E13 than E14. To assess how these cellular responses result in shape formation of the lung epithelium, I constructed a framework employing a mathematical model in which an epithelial tip splits depending on the proliferative and chemotactic activities. Experimental results on lung epithelium were incorporated into the model and how the ordered structure of lung emerges will be discussed..
Membership in Academic Society
  • The Biophysical Society of Japan
  • Molecular Biology Society of Japan
  • Japanese Society of Developmental Biologists
  • Japanese Society for Mathematical Biology
Educational Activities
Histology and Anatomy