Kyushu University Academic Staff Educational and Research Activities Database
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Takamichi Ito Last modified date:2021.07.27





Homepage
https://kyushu-u.pure.elsevier.com/en/persons/takamichi-ito
 Reseacher Profiling Tool Kyushu University Pure
Phone
092-642-5586
Fax
092-642-5600
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Skin tumor, Skin surgery, Skin pathology
Total Priod of education and research career in the foreign country
01years00months
Research
Research Interests
  • Prognostic factors of malignant skin tumors
    keyword : skin tumor, malignant skin tumor, prognostic factor
    2013.04.
  • Pathology and etiology of hair diseases.
    keyword : hair, alopecia, hair growth
    2018.04.
Academic Activities
Reports
1. Ito T*, Tanaka Y, Murata M, Kaku-Ito Y, Furue K, Furue M. , BRAF heterogeneity of melanoma.

, Curr Treat Option Oncol. 22: 20., 2021, 2021.04.
2. Nakamura Y, Asai J, Igaki H, Inozume T, Namikawa K, Hayashi A, Fukushima S, Fujimura T, Ito T, Imafuku K, Tanaka R, Teramoto Y, Minagawa A, Miyagawa T, Miyashita A, Wada M, Koga H, Sugaya M., Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019., J Dermatol. 47:89-103, 2020., 2020.09.
3. Furue K, Ito T, Tsuji G, Nakahara T, Furue M. , The CCL20 and CCR6 axis in psoriasis.

, Scand J Immunol. 91: e12846, 2020. doi: 10.1111/sji.12846., 2020.04.
4. Furue K, Ulzii D, Tanaka Y, Ito T, Tsuji G, Kido-Nakahara M, Nakahara T, Furue M. , Pathogenic implication of epidermal scratch injury in psoriasis and atopic dermatitis.
, J Dermatol 47: 979-988, 2020., 2020.04.
5. Wada-Ohno M, Ito T, Furue M. , Adjuvant Therapy for Melanoma. , Curr Treat Options Oncol. , 2019.09.
6. Ito T*, Kaku-Ito Y, Furue M., The diagnosis and management of extramammary Paget's disease., Expert Rev Anticancer Ther, 18: 543-553, 2018, 2018.06.
Papers
1. Hashimoto H, Kaku-Ito Y, Furue M, Ito T. , Mucosal invasion, but not incomplete excision, has negative impact on long-term survival in patients with extramammary Paget’s disease.
, Front Oncol (in press), 2021.04.
2. Tanaka Y, Murata M, Oda Y, Furue M, Ito T*., Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?
, Biomedicines 9: 355., 2021, 2021.04.
3. Hashimoto H, Kaku-Ito Y, Furue M, Ito T. , The outcome of chemotherapy for metastatic extramammary Paget’s disease. , J Clin Med 10: 739., 2021, 2021.04.
4. Hashimoto H, Ito T, Ichiki T, Yamada Y, Oda Y, Furue M. , The clinical and histopathological features of cutaneous immune-related adverse events and their outcomes.
, J Clin Med 10: 728., 2021, 2021.04.
5. Fujimura T, Yoshino K, Kato H, Fujisawa Y, Nakamura Y, Yamamoto Y, Kurimoto K, Ito T, Matsushita S, Maekawa T, Ohuchi K, Amagai R, Muto Y, Kambayashi Y, Hashimoto A, Aiba S. , Case series of BRAF mutated advanced melanoma treated with encorafenib plus binimetinib combined therapy.
, J Dermatol 48: 397-400, 2021., 2021.04.
6. Ide T, Ito T, Wada-Ohno M, Furue M. , Preoperative screening CT/PET(-CT) scans for acral melanoma: Is it necessary?
, J Clin Med 10: 811., 2021, 2021.04.
7. Tanaka Y, Murata M, Shen CH, Furue M, Ito T*. , NECTIN4: A novel therapeutic target for melanoma.
, Int J Mol Sci 22: 976., 2021. , 2021.04.
8. Hashimoto H, Ito T, Yamada Y, Oda Y, Furue M. , Eosinophilic infiltration discriminates lichen-planus-like eruption caused by an immune checkpoint inhibitor from ordinary lichen planus. , J Dermatol 48: e102-103, 2021. , 2021.04.
9. Matsukane R, Watanabe H, Minami H, Hata K, Suetsugu K, Tsuji T, Masuda S, Okamoto I, Nakagawa T, Ito T, Eto M, Mori M, Nakanishi Y, Egashira N. , Continuous monitoring of neutrophils to lymphocytes ratio for estimating the onset, severity, and subsequent prognosis of immune related adverse events. , Sci Rep 11: 1324., 2021 , 2021.04.
10. Fujisawa Y, Ito T, Kato H, Irie H, Kaji T, Maekawa T, Asai J, Yamamoto Y, Fujimura T, Nakai Y, Yasuda M, Matsuyama K, Muto I, Matsushita S, Uchi H, Nakamura Y, Uehara J, Yoshino K. , Outcome of combination therapy using BRAF and MEK inhibitors among Asian patients with advanced melanoma: An analysis of 112 cases.
, Eur J Cancer 145: 210-220, 2021, 2021.04.
11. Murata M, Ito T*, Tanaka Y, Kaku-Ito Y, Furue M. , NECTIN4 Expression in Extramammary Paget's Disease: Implication of a New Therapeutic Target.
, Int J Mol Sci 21:5891., 2020, 2020.04.
12. Furue K, Ito T, Tsuji G, Nakahara T, Furue M., Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytes. , J Dermatol Sci 99: 209-212, 2020, 2020.04.
13. Ito T*, Kaku-Ito Y, Wada-Ohno M, Furue M., Narrow margin excision for acral melanoma: Is it acceptable?, J Clin Med 9: 2266., 2020, 2020.04.
14. Tanaka Y, Ito T, Tsuji G, Furue M., Baicalein inhibits benzo[a]pyrene-induced toxic response by downregulating Src phosphorylation and by upregulating NRF2-HMOX1 system., Antioxidants (Basel) 9: 507., 2020, 2020.04.
15. Tsuji G, Hashimoto-Hachiya A, Yen V, Miake S, Takemura M, Mitamura Y, Ito T, Murata M, Furue M, Nakahara T., Aryl hydrocarbon receptor activation downregulates IL-33 expression in keratinocytes via ovo-like 1., J Clin Med., 2020.03.
16. Murata M, Ito T*, Yamamura K, Hashimoto-Hachiya A, Furue K, Furue M., OVOL2-mediated ZEB1 downregulation may prevent promotion of actinic keratosis to squamous cell carcinoma., J Clin Med, 2020.02.
17. Furue K, Ito T, Tanaka Y, Hashimoto-Hachiya A, Takemura M, Murata M, KIdo-Nakahara M, Tsuji G, Nakahara T, Furue M. , The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis Patients. , Int J Mol Sci, 2020.02.
18. Ito T*, Kaku-Ito Y, Murata M, Furue K, Shen CH, Oda Y, Furue M., Immunohistochemical BRAF V600E expression and intratumor BRAF V600E heterogeneity in acral melanoma: Implication in melanoma-specific survival., J Clin Med., 2020.03.
19. Tanaka Y, Uchi H, Ito T, Furue M., Indirubin-pregnane X receptor-JNK axis accelerates skin wound healing., Sci Rep., 2019.10.
20. Furue K, Ito T, Tanaka Y, Yumine A, Hashimoto-Hachiya A, Takemura M, Murata M, Yamamura K, Tsuji G, Furue M., Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon., J Dermatol Sci, 2019.09.
21. Ito T*, Kaku-Ito Y, Murata M, Ichiki T, Kuma Y, Tanaka Y, Ide T, Ohno F, Wada-Ohno M, Yamada Y, Oda Y, Furue M., Intra- and Inter-Tumor BRAF Heterogeneity in Acral Melanoma: An Immunohistochemical Analysis., Int J Mol Sci. , 2019.12.
22. Kaku-Ito Y, Ito T (co-first), Tsuji G, Nakahara T, Uchi H, Hagihara A, Furue M., Evaluation of mapping biopsies for extramammary Paget's disease: a retrospective study., J Am Acad Dermatol, 76: 1171-1177, 2018, 2018.06.
23. Ito T*, Tsuji G, Ohno F, Nakahara T, Uchi H, Furue M., Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma., Mod Pathol, 30: 919-927, 2017, 2017.06.
24. Yamada Y, Kinoshita I, Kohashi K, Yamamoto H, Kuma Y, Ito T, Koda K, Kisanuki A, Kurosawa M, Yoshimura M, Furue M, Oda Y., HIF-1α, MDM2, CDK4, and p16 expression in ischemic fasciitis, focusing on its ischemic condition., Virchows Arch, Virchows Arch 471: 117-122, 2017, 2017.07.
25. Yamada Y, Kuda M, Kohashi K, Yamamoto H, Takemoto J, Ishii T, Iura K, Maekawa A, Bekki H, Ito T, Otsuka H, Kuroda M, Honda Y, Sumiyoshi S, Inoue T, Kinoshita N, Nishida A, Yamashita K, Ito I, Komune S, Taguchi T, Iwamoto Y, Oda Y., Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes., Virchows Arch, Virchows Arch 470: 373-380, 2017, 2017.07.
26. Hiraki-Hotokebuchi Y, Yamada Y, Kohashi K, Yamamoto H, Endo M, Setsu N, Yuki K, Ito T, Iwamoto Y, Furue M, Oda Y., Alteration of PDGFRβ-Akt-mTOR Pathway Signaling in Fibrosarcomatous Transformation of Dermatofibrosarcoma Protuberans., Hum Pathol, Hum Pathol 67: 60-68, 2017, 2017.09.
27. Kuma Y, Yamada Y, Yamamoto H, Kohashi K, Ito T, Furue M, Oda Y., A Novel Fusion Gene CRTC3-MAML2 in Hidradenoma: Clinicopathological and Histopathological Significance., Hum Pathol, Hum Pathol 70: 55-61, 2017, 2017.12.
28. Tsuji G, Hashimoto-Hachiya A, Kiyomatsu-Oda M, Takemura M, Ohno F, Ito T, Morino-Koga S, Mitoma C, Nakahara T, Uchi H, Furue M., Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis., Cell Death Dis, Cell Death Dis 8: e2931, 2017, 2017.07.
29. Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiou MH, Lin YH, Memberg M, Stiewe T, Ito S, Wakamatsu K, Alkalay I, Ben-Neriah Y., CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation., Proc Natl Acad Sci USA, 114: E8035-E8044, 2017, 2017.09.
30. Wada M, Ito T, Tsuji G, Nakahara T, Uchi H, Hagihara A, Furue M., Acral lentiginous melanoma versus other melanoma: a single-center analysis in Japan., J Dermatol, J Dermatol 44: 932-8, 2017, 2017.08.
31. Itoh E, Nakahara T, Murata M, Ito T, Onozuka D, Furumura M, Hagihara A, Furue M., Chronic spontaneous urticaria: implications of subcutaneous inflammatory cell infiltration in an intractable clinical course., J Allergy Clin Immunol, J Allergy Clin Immunol 139: 363-366, 2017, 2017.01.
32. Ito T, Kohashi K, Yamada Y, Iwasaki T, Maekawa A, Kuda M, Hoshina D, Abe R, Furue M, Oda Y., Prognostic Significance of Forkhead Box M1 (FOXM1) Expression and Antitumor Effect of FOXM1 Inhibition in Angiosarcoma., J Cancer, J Cancer 7: 823-830, 2016, 2016.04.
33. Ito T, Kohashi K, Yamada Y, Maekawa A, Kuda M, Furue M, Oda Y, Prognostic significance of forkhead box M1 (FoxM1) expression and antitumor effect of FoxM1 inhibition in melanoma., Histopathology, 69: 63–71, 2016, 2016.06.
34. Ito T*, Uchi H, Nakahara T, Tsuji G, Oda Y, Hagihara A, Furue M., Cutaneous angiosarcoma of the head and face: a single-center analysis of treatment outcomes in 43 patients in Japan., J Cancer Res Clin Oncol, J Cancer Res Clin Oncol 142: 1387-1394, 2016, 2016.06.
35. Ito T*, Tsuji G, Uchi H, Nakahara T, Hashimoto-Hachiya A, Yoshida Y, Yamamoto O, Oda Y, Furue M., Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma., Am J Pathol, 186: 1036-1043, 2016, 2016.04.
36. Ito T*, Inatomi Y, Nagae K, Nakano-Nakamura M, Nakahara T, Furue M, Uchi H., Narrow-margin excision is a safe, reliable treatment for well-defined, primary pigmented basal cell carcinoma: an analysis of 288 lesions in Japan., J Eur Acad Dermatol Venereol, J Eur Acad Dermatol Venereol 29: 1828-31, 2015, 2015.09.
37. Ito T*, Wada M, Nagae K, Nakano-Nakamura M, Nakahara T, Furue M, Uchi H., Triple-marker PCR assay of sentinel lymph node as a prognostic factor in melanoma., J Eur Acad Dermatol Venereol, J Eur Acad Dermatol Venereol 29: 912-918, 2015., 2015.05.
38. Ito T*, Kaku Y, Nagae K, Nakano-Nakamura M, Nakahara T, Oda Y, Hagihara A, Furue M, Uchi H., Tumor thickness as a prognostic factor in extramammary Paget's disease., J Dermatol, J Dermatol 42: 269-75, 2015, 2015.03.
39. Ito T*, Wada M, Nagae K, Nakano-Nakamura M, Nakahara T, Hagihara A, Furue M, Uchi H., Acral lentiginous melanoma: Who benefits from sentinel lymph node biopsy?, J Am Acad Dermatol, 72: 71-77, 2015, 2015.01.
40. Sakaizawa K, Ashida A, Uchiyama A, Ito T, Fujisawa Y, Ogata D, Matsushita S, Fujii K, Fukushima S, Shibayama Y, Hatta N, Takenouchi T, Uehara J, Okuyama R, Yamazaki N, Uhara H., Clinical characteristics associated with BRAF, NRAS and KIT mutations in Japanese melnoma patients., J Dermatol Sci, J Dermatol Sci 80: 33–7, 2015, 2015.04.
41. Zhu L, Ito T, Nakahara T, Nagae K, Fuyuno Y, Nakao M, Akahosi M, Nakagawa R, Tu Y, Uchi H, Furue M., Upregulation of S100P, receptor for advanced glycation end products and ezrin in malignant melanoma., J Dermatol, J Dermatol 40: 973-979, 2013, 2013.12.
42. Zhu L, Kohda F, Nakahara T, Chiba T, Tsuji G, Hachisuka J, Ito T, Tu Y, Moroi Y, Uchi H, Furue M., Aberrant expression of S100A6 and matrix metalloproteinase 9, but not S100A2, S100A4, and S100A7, is associated with epidermal carcinogenesis., J Dermatol Sci, J Dermatol Sci 72:311-9, 2013, 2013.12.
43. Ito T*, Moroi Y, Oba J, Nakahara T, Takeuchi S, Uchi H, Takahara M, Masuda T, Furue M., The prognostic value of RT-PCR assay of sentinel lymph node biopsy for patients with cutaneous melanoma: A single center analysis in Japan., Melanoma Res, Melanoma Res 22: 38-44, 2012, 2012.01.
Presentations
1. Ito T, Kohashi K, Yamada Y, Furue M, Oda Y., Prognostic significance of forkhead box M1 (FOXM1) expression and antitumor effect of FOXM1 inhibition in melanoma., International Investigative Dermatology 2018, 2018.05.
2. Ito T, Tsuji G, Ohno F, Nakahara T, Uchi H, Furue M., Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma from Bowen's disease., The 76th Annual Meeting of the Society for Investigative Dermatology., 2017.04.
3. Ito T., [The 17th Galderma Award] Acral lentiginous melanoma: Who benefits from sentinel lymph node biopsy?, The 41st Annual Meeting of the Japanese Society for Investigative Dermatology, 2016.12.
4. [The best poster award] Survival analysis of angiosarcoma of head and neck..
5. [The best abstract award] Acral lentiginous melanoma: Who benefits from sentinel lymph node biopsy?.
6. Ito T, Yamamoto O, Oda Y, Furue M., Interesting educational cases: a red nodule on the forehead of an 83-year-old woman., The 3rd Eastern Asia Dermatology Congress. 2014/09/24-26. Jeju, Korea, 2014.09.
7. Ito T, Yoshida Y, Furue M, Yamamoto O, Yellow plaque on the chest., The 12th Korean Dermatopathology Symposium, 2013.05.
8. [The best poster award] Sentinel lymph node biopsy for malignant melanoma: a single-center analysis in Japan..
Awards
  • The 17th Galderma Award. Acral lentiginous melanoma: Who benefits from sentinel lymph node biopsy?
  • The Excellent Presentation Award. The 34th Annual Meeting of Japanese Cosmetic Dermatology Society.
  • The Best Poster Award. The 115th Annual Meeting of Japanese Dermatology Society
  • The Best Abstract Award. The 114th Annual Meeting of Japanese Dermatology Society
  • The Best Poster Award. The 109th Annual Meeting of Japanese Dermatology Society.