Kyushu University Academic Staff Educational and Research Activities Database
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Yoshinobu Wakisaka Last modified date:2022.05.09



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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/yoshinobu-wakisaka
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https://www.intmed2.med.kyushu-u.ac.jp
病態機能内科学・脳循環研究室のホームページ. .
Academic Degree
Doctor of Medical Science
Country of degree conferring institution (Overseas)
No
Field of Specialization
Internal medicine, Cerebrovascular Disease, Neuropathology
Total Priod of education and research career in the foreign country
03years00months
Research
Research Interests
  • 1) Investigating the clinical factors associated with functional outcome after stroke
    2) Investigating the association between stroke and dementia
    3) Investigating the mechanisms of endogenous tissue repair and functional recovery after acute ischemic stroke
    keyword : ischemic stroke, dementia, functional recovery, tissue repair
    2021.04~2026.03.
  • 1) Exploratory research for clinical factors predicting the outcome of acute ischemic stroke.
    2) Investigating the association between ischemic stroke and dementia.
    3) Exploratory research against underlying mechanisms for endogenous regeneration of central nervous system after acute ischemic stroke
    keyword : Ischemic stroke, dementia, endogenous regeneration
    2014.04~2020.03.
Academic Activities
Papers
1. Wakisaka Y, Matsuo R, Nakamura K, Ago T, Kamouchi M, Kitazono T, Pre-Stroke Cholinesterase Inhibitor Treatment Is Beneficially Associated with Functional Outcome in Patients with Acute Ischemic Stroke and Pre-Stroke Dementia: The Fukuoka Stroke Registry., Cerebrovasc Dis, 2021.04.
2. Wakisaka Y, Matsuo R, Hata J, Kuroda J, Kitazono T, Kamouchi M, Ago T, Adverse influence of pre-stroke dementia on shor-term functional outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry., Cerebrovasc Dis, 43, 82-89, 2017.01.
3. Wakisaka Y, Ago T, Kamouchi M, Kuroda J, Matsuo R, Hata J, Gotoh S, Isomura T, Awano H, Suzuki K, Fukuda K, Okada Y, Kiyohara Y, Ooboshi H, Kitazono T, Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke., Journal of Neurological Science, 340, 75-79, 2014.05, Background: Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke.
Methods: We prospectively included 171 patients with acute ischemic stroke within 24 hours after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset.
Results: Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2–5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5–2.0] ng/mL; p<0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p=0.03) than the lowest quartile.
Conclusions: High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke..
4. Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD., Critical role for CuZn-superoxide dismutase in preventing spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice., Stroke, 41, 790-797, 2010.04.
5. Wakisaka Y, Chu Y, Miller JD, Rosenberg GA, Heistad DD., Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice., J Cereb Blood Flow Metab, 30, 56-69, 2010.01.
6. Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD., Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage, J Cereb Blood Flow Metab, 28, 1175-1185, 2008.06.
7. Wakisaka Y, Furuta A, Masuda K, Morikawa W, Kuwano M, Iwaki T., Cellular Distribution of NDRG1 Protein in the Rat Kidney and Brain During Normal Postnatal Development., 2003.11.
8. Wakisaka Y, Furuta A, Tanizaki Y, Kiyohara Y, Iida M, Iwaki T., Age-associated prevalence and risk factors of Lewy body pathology in a general population: the Hisayama study., 2003.10.
Membership in Academic Society
  • World Stroke Organization