Updated on 2025/03/19

Information

 

写真a

 
KOHRO YUTA
 
Organization
Faculty of Pharmaceutical Sciences Department of Pharmaceutical Health Care and Sciences Associate Professor
Title
Associate Professor
Contact information
メールアドレス
Tel
0926426631
Profile
脊髄グリア細胞の多様性を切り口とした感覚情報伝達のメカニズム解明
Homepage
  • http://life-innov.phar.kyushu-u.ac.jp/

    薬理学分野では，生体の感覚制御（特に，痛みと痒み）の仕組みとその破綻による慢性感覚異常メカニズムを，遺伝子工学，細胞イメージング，電気生理学，光遺伝学，行動薬理学的実験技術などを組み合わせた分子～細胞～個体レベルの包括的な研究から明らかにしていきます。そして，現在の治療コンセプトを変えるような新しい疾患メカニズムの発見とその成果に基づく新薬開発を目指した産学官連携共同研究の実現にチャレンジします。加えて，痛みとかゆみなどを含む感覚やグリア細胞の生物学的役割や存在意義も探究していきます。

External link

Degree

  • Ph.D.

Research History

  • 2019.7-2021.3 University of Calgary, Visiting Professor 2021.4-2022.2 University of Calgary, Research Associate   

Research Interests・Research Keywords

  • Research theme： Functional analysis of subpopulation of spinal dorsal horn astrocytes

    Keyword： spinal dorsal horn, astrocytes, subpopulation

    Research period： 2015.8

  • Research theme： Analysis of function of spinal glial cells in neuropathic pain

    Keyword： Neuropathic pain, Glial cells, Spinal dorsal horn

    Research period： 2015.8

Awards

  • 日本生物学的精神医学会・日本神経化学大会合同年会優秀発表賞

    2016.9   日本神経化学会   領域特異的な脊髄後角アストロサイトによる感覚情報伝達への役割解明

Papers

  • Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity. Invited Reviewed International journal

    Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Keita Kohno, Keisuke Koga, Ryuichi Katsuragi, Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Shota Okada, Kazuya Momokino, Aogu Furusho, Kenji Hamase, Takumi Oti, Hirotaka Sakamoto, Kenichiro Hayashida, Ryosuke Kobayashi, Takuro Horii, Izuho Hatada, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

    Nature neuroscience   23 ( 11 )   1376 - 1387   2020.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41593-020-00713-4

  • Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry Reviewed International coauthorship International journal

    Kwok C.H.T., Harding E.K., Burma N.E., Markovic T., Massaly N., van den Hoogen N.J., Stokes-Heck S., Gambeta E., Komarek K., Yoon H.J., Navis K.E., McAllister B.B., Canet-Pons J., Fan C., Dalgarno R., Gorobets E., Papatzimas J.W., Zhang Z., Kohro Y., Anderson C.L., Thompson R.J., Derksen D.J., Morón J.A., Zamponi G.W., Trang T.

    Nature Communications   15 ( 1 )   2024.12

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Communications  

    Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinue chronic opioid use. The locus coeruleus (LC) is an important autonomic centre within the brain with a poorly defined role in opioid withdrawal. We show here that pannexin-1 (Panx1) channels expressed on microglia critically modulate LC activity during opioid withdrawal. Within the LC, we found that spinally projecting tyrosine hydroxylase (TH)-positive neurons (LCspinal) are hyperexcitable during morphine withdrawal, elevating cerebrospinal fluid (CSF) levels of norepinephrine. Pharmacological and chemogenetic silencing of LCspinal neurons or genetic ablation of Panx1 in microglia blunted CSF NE release, reduced LC neuron hyperexcitability, and concomitantly decreased opioid withdrawal behaviours in mice. Using probenecid as an initial lead compound, we designed a compound (EG-2184) with greater potency in blocking Panx1. Treatment with EG-2184 significantly reduced both the physical signs and conditioned place aversion caused by opioid withdrawal in mice, as well as suppressed cue-induced reinstatement of opioid seeking in rats. Together, these findings demonstrate that microglial Panx1 channels modulate LC noradrenergic circuitry during opioid withdrawal and reinstatement. Blocking Panx1 to dampen LC hyperexcitability may therefore provide a therapeutic strategy for alleviating the physical and aversive components of opioid withdrawal.

    DOI： 10.1038/s41467-024-50657-7

    Scopus

  • A method for selective and efficient isolation of gray matter astrocytes from the spinal cord of adult mice. Reviewed International journal

    Ryoma Iwasaki, Yuta Kohro, Makoto Tsuda

    Molecular brain   17 ( 1 )   25 - 25   2024.5

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Molecular Brain  

    A growing body of evidence indicates intra- and inter-regional heterogeneity of astrocytes in the brain. However, because of a lack of an efficient method for isolating astrocytes from the spinal cord, little is known about how much spinal cord astrocytes are heterogeneous in adult mice. In this study, we developed a new method for isolating spinal astrocytes from adult mice using a cold-active protease from Bacillus licheniformis with an astrocyte cell surface antigen-2 (ACSA-2) antibody. Using fluorescence-activated cell sorting, isolated spinal ACSA-2+ cells were divided into two distinct populations, ACSA-2high and ACSA-2low. By analyzing the expression of cell-type marker genes, the ACSA-2high and ACSA-2low populations were identified as astrocytes and ependymal cells, respectively. Furthermore, ACSA-2high cells had mRNAs encoding genes that were abundantly expressed in the gray matter (GM) but not white matter astrocytes. By optimizing enzymatic isolation procedures, the yield of GM astrocytes also increased. Therefore, our newly established method enabled the selective and efficient isolation of GM astrocytes from the spinal cord of adult mice and may be useful for bulk- or single-cell RNA-sequencing under physiological and pathological conditions.

    DOI： 10.1186/s13041-024-01097-3

    Scopus

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    Repository Public URL： https://hdl.handle.net/2324/7342431

  • Sex differences in plasma, adipose tissue, and central accumulation of cannabinoids, and behavioural effects of oral cannabis consumption in male and female C57BL/6 mice. Reviewed International journal

    Nada Sallam, Colleen Peterson, Samantha L Baglot, Yuta Kohro, Tuan Trang, Matthew N Hill, Stephanie L Borgland

    Int J Neuropsychopharmacol.   2023.9

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    Language：Japanese   Publishing type：Research paper (scientific journal)  

  • GPR55 contributes to neutrophil recruitment and mechanical pain induction after spinal cord compression in mice. Invited Reviewed International journal

    Teruaki Ono, Tomohiro Yamashita, Ryota Kano, Mariko Inoue, Shota Okada, Koki Kano, Schuichi Koizumi, Kazuhisa Iwabuchi, Yoshio Hirabayashi, Ichiro Matsuo, Yasuharu Nakashima, Hiroyuki Kamiguchi, Yuta Kohro, Makoto Tsuda

    Brain, behavior, and immunity   110   276 - 287   2023.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbi.2023.03.008

  • Spinal A 3 adenosine receptor activation acutely restores morphine antinociception in opioid tolerant male rats Invited Reviewed International journal

    Heather Leduc-Pessah, Cynthia Xu, Churmy Y Fan, Rebecca Dalgarno, Yuta Kohro, Sydney Sparanese, Nikita N Burke, Kenneth A Jacobson, Christophe Altier, Daniela Salvemini, Tuan Trang

    Journal of neuroscience research   2022.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/jnr.24869

  • Role of Primary Afferents in Arthritis Induced Spinal Microglial Reactivity Invited Reviewed International journal

    Charlie H T Kwok, Yuta Kohro, Michael Mousseau, Melissa S O'Brien, John R Matyas, Jason J McDougall, Tuan Trang

    Frontiers in immunology   2021.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2021.626884

  • Mechanical pain of the lower extremity after compression of the upper spinal cord involves signal transducer and activator of transcription 3-dependent reactive astrocytes and interleukin-6. Invited Reviewed International journal

    Teruaki Ono, Yuta Kohro, Keita Kohno, Hidetoshi Tozaki-Saitoh, Yasuharu Nakashima, Makoto Tsuda

    Brain, behavior, and immunity   2020.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbi.2020.07.025

  • Sensitization of spinal itch transmission neurons in a mouse model of chronic itch requires an astrocytic factor. Invited Reviewed International journal

    Keisuke Koga, Ryo Yamagata, Keita Kohno, Takuya Yamane, Miho Shiratori-Hayashi, Yuta Kohro, Hidetoshi Tozaki-Saitoh, MakotoTsuda

    Journal of Allergy and Clinical Immunology   2019.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1016/j.jaci.2019.09.034

  • Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents Reviewed

    Keita Kohno, Junko Kitano, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

    Biological and Pharmaceutical Bulletin   41 ( 7 )   1096 - 1102   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Neuropathic pain, a highly debilitating chronic pain following nerve damage, is a reflection of the aberrant functioning of a pathologically altered nervous system. Previous studies have implicated activated microglia in the spinal dorsal horn (SDH) as key cellular intermediaries in neuropathic pain. Microgliosis is among the dramatic cellular alterations that occur in the SDH in models of neuropathic pain established by peripheral nerve injury (PNI), but detailed characterization of SDH microgliosis has yet to be realized. In the present study, we performed a short-pulse labeling of proliferating cells with ethynyldeoxyuridine (EdU), a marker of the cell cycle S-phase, and found that EdU+ microglia in the SDH were rarely observed 32h after PNI, but rapidly increased to the peak level at 40h post-PNI. Numerous EdU+ microglia persisted for the next 20h (60h post-PNI) and decreased to the baseline on day 7. These results demonstrate a narrow time window for rapidly inducing a proliferation burst of SDH microglia after PNI, and these temporally restricted kinetics of microglial proliferation may help identify the molecule that causes microglial activation in the SDH, which is crucial for understanding and managing neuropathic pain.

    DOI： 10.1248/bpb.b18-00278

  • Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin Reviewed

    Kohei Yoshihara, Tsuyoshi Matsuda, Yuta Koro, Hidetoshi Saitoh, Kazuhide Inoue, Tsuda Makoto

    Journal of Pharmacological Sciences   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    The role of astrocytes in the spinal dorsal horn (SDH) for sensory information processing under normal conditions is poorly understood. In this study, we investigated whether SDH astrocytes respond to noxious and innocuous stimuli to the skin of normal mice using in vivo two-photon Ca2+ imaging under anesthesia. We found that noxious stimulation evoked by intraplantar formalin injection provoked an elevation in intracellular Ca2+ levels in SDH astrocytes. By contrast, neither instantaneous noxious pinching nor innocuous stimuli (cooling or brushing) to the hindpaw elicited astrocytic Ca2+ responses. Thus, SDH astrocytes could respond preferentially to a strong and/or sustained noxious stimulus.

    DOI： 10.1016/j.jphs.2018.04.007

  • Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats Reviewed

    Ryoichi Tashima, Keisuke Koga, Misuzu Sekine, Kensho Kanehisa, Yuta Koro, Keiko Tominaga, Katsuyuki Matsushita, Hidetoshi Saitoh, Yugo Fukazawa, Kazuhide Inoue, Hiromu Yawo, Hidemasa Furue, Tsuda Makoto

    eNeuro   5 ( 1 )   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    Neuropathic pain is caused by peripheral nerve injury (PNI). One hallmark symptom is allodynia (pain caused by normally innocuous stimuli), but its mechanistic underpinning remains elusive. Notably, whether selective stimulation of non-nociceptive primary afferent Aβ fibers indeed evokes neuropathic pain-like sensory and emotional behaviors after PNI is unknown, because of the lack of tools to manipulate Aβ fiber function in awake, freely moving animals. In this study, we used a transgenic rat line that enables stimulation of non-nociceptive Aβ fibers by a light-activated channel (channelrhodopsin-2; ChR2). We found that illuminating light to the plantar skin of these rats with PNI elicited pain-like withdrawal behaviors that were resistant to morphine. Light illumination to the skin of PNI rats increased the number of spinal dorsal horn (SDH) Lamina I neurons positive to activity markers (c-Fos and phosphorylated extracellular signal-regulated protein kinase; pERK). Whole-cell recording revealed that optogenetic Aβ fiber stimulation after PNI caused excitation of Lamina I neurons, which were normally silent by this stimulation. Moreover, illuminating the hindpaw of PNI rats resulted in activation of central amygdaloid neurons and produced an aversion to illumination. Thus, these findings provide the first evidence that optogenetic activation of primary afferent Aβ fibers in PNI rats produces excitation of Lamina I neurons and neuropathic pain-like behaviors that were resistant to morphine treatment. This approach may provide a new path for investigating circuits and behaviors of Aβ fiber-mediated neuropathic allodynia with sensory and emotional aspects after PNI and for discovering novel drugs to treat neuropathic pain.

    DOI： 10.1523/ENEURO.0450-17.2018

  • Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours Reviewed International journal

    Keisuke Koga, Kensho Kanehisa, Yuta Kohro, Miho Shiratori-Hayashi, Hidetoshi Saitoh, Kazuhide Inoue, Hidemasa Furue, Makoto Tsuda

    SCIENTIFIC REPORTS   7   2017.7

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-017-04972-3

  • Specific activation of inhibitory interneurons in the spinal dorsal horn suppresses repetitive scratching in mouse models of chronic itch Reviewed International journal

    Kensho Kanehisa, Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Saitoh, Yuta Kohro, Kenji Takamori, Makoto Tsuda

    Journal of Dermatological Science   2017.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1016/j.jdermsci.2017.05.017

  • Peripheral Nerve Injury: a Mouse Model of Neuropathic Pain Invited Reviewed International journal

    Takahiro Masuda, Yuta Kohro, Kazuhide Inoue, Makoto Tsuda

    Bio-protocol   2017.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.21769/BioProtoc.2252

  • Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia Reviewed International journal

    Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Akamine Takahiro, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W salter, Kazuhide Inoue, Shigehiro Ohdo

    NATURE COMMUNICATIONS   7   2016.10

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ncomms13102

  • Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain Reviewed International journal

    Takahiro Masuda, Yui Ozono, Satsuki Mikuriya, Yuta Kohro, Hidetoshi Tozaki-Saitoh, Ken Iwatsuki, Hisayuki Uneyama, Reiko Ichikawa, Michael W salter, Makoto Tsuda, Kasuhide Inoue

    NATURE COMMUNICATIONS   7   2016.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/ncomms12529

  • Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury Reviewed International journal

    Ryoichi Tashima, Daisuke Tomiyama, Miho Shiratori, Tomohiro Yamashita, Yuta Kohro, Hidetoshi Saitoh, Kazuhide Inoue, Makoto Tsuda

    SCIENTIFIC REPORTS   6   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep23701

  • A new minimally-invasive method for microinjection into the mouse spinal dorsal horn. Reviewed International journal

    Yuta Kohro, Emi Sakaguchi, Ryoichi Tashima, Hidetoshi Saitoh, Hideyuki Okano, Kazuhide Inoue, Takahiro Masuda et al.

    Scientific Reports   2015.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： doi: 10.1038/srep14306.

  • STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch Reviewed International journal

    Miho Shiratori, Keisuke Koga, Hidetoshi Saitoh, Yuta Kohro, Honami Toyonaga, Chiharu Yamaguchi, Ayumi Hasegawa, Takeshi Nakahara, Junichi Hachisuka, Shizuo Akira, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

    NATURE MEDICINE   21 ( 8 )   927 - 931   2015.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/nm.3912

  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats.

    Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW, Inoue K

    BRAIN   134 ( 4 )   2011.4

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    Language：English  

  • Role of PAF Receptor in Proinflammatory Cytokine Expression in the Dorsal Root Ganglion and Tactile Allodynia in a Rodent Model of Neuropathic Pain

    Shigeo Hasegawa, Yuta Kohro, Miho Shiratori, Satoshi Ishii, Takao Shimizu, Makoto Tsuda, Kazuhide Inoue

    PLOS ONE   5 ( 5 )   2010.5

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    Language：English  

    DOI： 10.1371/journal.pone.0010467

  • Activation of cytosolic phospholipase A2 in dorsal root ganglion neurons by Ca2+/calmodulin-dependent protein kinase II after peripheral nerve injury.

    Shigeo Hasegawa, Yuta Kohro, Makoto Tsuda, Kazuhide Inoue

    Mol Pain   2009.5

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    Language：English  

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Books

  • 実験医学別冊「ウイルスベクターによる遺伝子導入実験ガイド」 マウス脊髄後角の細胞を標的とした遺伝子導入法

    高露雄太、津田誠（Role：Joint author）

    羊土社  2020.11 

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    Language：Japanese   Book type：Scholarly book

Presentations

  • マウス脊髄灰白質アストロサイトの新たな単離法の確立

    Yuta Kohro, Ryoma Iwasaki, Makoto Tsuda

    Neuro2024  2024.7  日本神経化学会

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    Event date： 2024.7

    Language：English   Presentation type：Poster presentation  

    Venue：福岡   Country：Japan  

  • ACSA2抗体と低温活性プロテアーゼを用いた新たな脊髄アストロサイト高純度単離法の確立

    岩﨑 令真、高露 雄太、津田 誠

    日本薬学会第144年会  2024.3 

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    Event date： 2024.3

    Language：Japanese  

    Country：Japan  

  • アストロサイト－神経相互作用を介した下行性疼痛制御機構の解明

    高露雄太、松田烈士、吉原康平、川邉陸、内山瑳和子、津田誠

    第45回日本疼痛学会  2023.12 

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    Event date： 2023.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 脊髄アストロサイト集団を介した下行性疼痛制御機構の新たな役割

    高露雄太、津田誠

    第53回日本神経精神薬理学会年会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • ノルアドレナリンによる新たな疼痛制御機構の解明 Invited

    高露雄太

    第26回　痛みの研究会  2023.9 

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    Event date： 2023.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Modulation of mechanosensory behavior by a subpopulation of spinal astrocytes

    Yuta Kohro, Makoto Tsuda

    第66回日本神経化学会大会  2023.7 

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    Event date： 2023.7

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 脊髄アストロサイトから紐解く感覚情報伝達の調節メカニズム

    高露雄太、松田烈士、吉原康平、津田誠

    第100回生理学会  2023.3 

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    Event date： 2023.3

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • 中枢末梢連関障害に起因する非細胞自律性神経機能障害の新展開

    高露雄太、松田烈士、吉原康平、津田誠

    第96回日本薬理学会年会  2022.12 

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    Event date： 2022.11 - 2022.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Country：Japan  

  • Sensitizing mechanosensory information by a population of spinal dorsal horn astrocytes International conference

    Yuta Kohro, Tsuyoshi Matsuda, Kohei Yoshihara, Ryuichi Katsuragi,Takaaki Oka, Ryoichi Tashima, Sho Muneta, Takuya Yamane, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Verdon Taylor, Kazuhide Inoue, Makoto Tsuda

    17th World Congress on Pain  2018.9 

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    Event date： 2018.9

    Language：English  

    Venue：Boston   Country：United States  

  • The role of region-specific spinal dorsal horn astrocytes in sensory information processing

    Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

    第60回日本神経化学大会  2017.9 

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    Event date： 2017.9

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：仙台   Country：Japan  

  • D-セリンシグナルを介した脊髄後角アストロサイトによる触覚情報の変調作用

    高露雄太, 桂木龍一, 岡嵩晃, 棟田翔, 田島諒一, 齊藤 秀俊, 御子柴克彦, 井上和秀, 津田 誠

    第39回日本疼痛学会  2017.6 

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    Event date： 2017.6

    Language：Japanese  

    Venue：神戸   Country：Japan  

  • Modality-specific sensory information processing by spinal dorsal horn astrocytes through D-serine signaling

    Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Katsuhiko Mikoshiba, Kazuhide Inoue, Makoto Tsuda

    第90回薬理学会年会  2017.3 

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    Event date： 2017.3

    Language：Japanese  

    Venue：長崎   Country：Japan  

  • Activation of spinal dorsal horn astrocytes modulates the processing of tactile sensation International conference

    Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

    Society for Neuroscience 2016  2016.11 

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    Event date： 2016.11

    Language：English  

    Venue：San Diego   Country：United States  

  • Modality-specific sensory information processing by spinal dorsal horn astrocytes International conference

    Yuta Kohro, Ryuichi Katsuragi, Takaaki Oka, Sho Muneta, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Kazuhide Inoue, Makoto Tsuda

    16th World Congress on Pain  2016.9 

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    Event date： 2016.9

    Language：English  

    Venue：Yokohama   Country：Japan  

  • 脊髄後角アストロサイトの活動変化は触覚情報を変調させる

    高露 雄太, 桂木龍一, 岡嵩晃, 棟田翔, 田島諒一, 齊藤 秀俊, 井上 和秀, 津田 誠

    第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会  2016.9 

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    Event date： 2016.9

    Language：Japanese  

    Venue：福岡   Country：Japan  

  • DREADDを用いた脊髄アストロサイトの感覚情報伝達における機能解析

    高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

    第38回日本疼痛学会  2016.6 

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    Event date： 2016.6

    Language：Japanese  

    Venue：札幌   Country：Japan  

  • 脊髄アストロサイトの活動変化は感覚情報を様式特異的に変調させる

    高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

    第89回日本薬理学会年会  2016.3 

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    Event date： 2016.3

    Language：Japanese  

    Venue：横浜   Country：Japan  

  • 光遺伝学的手法による神経障害性アロディニアの新たな評価法

    田島諒一, 古賀啓祐, 高露雄太, 八尾寛, 井上和秀, 古江秀昌, 津田 誠

    平成27年度生理研研究会  2015.12 

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    Event date： 2015.12

    Language：Japanese  

    Venue：岡崎   Country：Japan  

  • 脊髄アストロサイト特異的遺伝子導入法を用いた感覚情報伝達における機能解析

    高露 雄太, 桂木 龍一, 岡 嵩晃, 田島 諒一, 齊藤 秀俊, 井上 和秀, 津田 誠ら

    痛み研究会2015  2015.12 

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    Event date： 2015.12

    Language：Japanese  

    Venue：岡崎   Country：Japan  

  • 光遺伝学的手法による神経障害性アロディニアの新規評価法

    田島諒一, 古賀啓祐, 高露雄太, 八尾寛, 井上和秀, 古江秀昌, 津田 誠

    第68回日本薬理学会西南部会  2015.11 

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    Event date： 2015.11

    Language：Japanese  

    Venue：下関   Country：Japan  

  • STAT3-dependent reactive astrocytes in the spinal dorsal horn contribute to the maintenance of chronic itch in mice International conference

    Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hashisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

    Society for Neuroscience 2015  2015.10 

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    Event date： 2015.10

    Language：English  

    Venue：Chicago   Country：Japan  

  • Astrocytic lipocalin-2 in the spinal dorsal horn is required for chronic itch International conference

    Miho Shiratori-Hayashi, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Takeshi Nakahara, Junichi Hashisuka, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

    8th World Congress on Itch  2015.9 

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    Event date： 2015.9

    Language：English  

    Venue：Nara   Country：Japan  

  • Essential role for STAT3-dependent reactive astrocytes in maintenance of chronic itch

    Miho Shiratori-Hayashi, Keisuke Koga, Hidetoshi Tozaki-Saitoh, Yuta Kohro, Junichi Hashisuka, Hideyuki Okano, Masutaka Furue, Kazuhide Inoue, Makoto Tsuda

    第58回日本神経化学大会  2015.9 

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    Event date： 2015.9

    Language：Japanese  

    Venue：大宮   Country：Japan  

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MISC

  • ミクログリアと神経障害性疼痛

    増田 隆博, 津田 誠, 齊藤 秀俊, 山下 智大, 高露 雄太, 井上 和秀

    細胞   2016.8

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    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

Industrial property rights

Patent   Number of applications: 1   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • The Japanese Society for Neurochemistry

  • The Japanese Pharmacological Society

  • Society for Neuroscience

  • Japanese Association for Study of Pain

  • International Association for the Study of Pain

Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2023

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • Screening of academic papers

    Role(s)： Peer review

    2022

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：9

  • Screening of academic papers

    Role(s)： Peer review

    2021

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

  • Screening of academic papers

    Role(s)： Peer review

    2020

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2019

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

  • Screening of academic papers

    Role(s)： Peer review

    2018

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    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

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Research Projects

  • 脊髄白質アストロサイトの形態および機能解析

    Grant number：24K09659  2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 上原記念財団　研究奨励金

    2023

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    Grant type：Donation

  • 山口記念科学技術振興財団　研究助成金

    2023

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    Grant type：Donation

  • 脊髄後角アストロサイト亜集団形成メカニズムの解明

    Grant number：18K14821  2018 - 2022

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 慢性疼痛における糖脂質シグナルの作動機序解明と創薬に向けた研究

    2016 - 2020

    AMED-CREST

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    Authorship：Coinvestigator(s)  Grant type：Contract research

  • 感覚情報伝達に対する脊髄後角アストロサイトの役割解明

    Grant number：16K18885  2016 - 2017

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

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Class subject

  • 薬学基礎実習Ⅳ

    2024.6 - 2024.8   Summer quarter

  • 薬物治療学Ⅱ

    2024.6 - 2024.8   Summer quarter

  • 薬学基礎実習Ⅳ

    2024.6 - 2024.8   Summer quarter

  • 医療薬学演習Ⅰ

    2024.4 - 2024.9   First semester

  • 医療薬学演習Ⅱ

    2024.4 - 2024.9   First semester

  • 薬物治療学Ⅱ

    2023.6 - 2023.8   Summer quarter

  • 薬学基礎実習IV

    2022.10 - 2023.3   Second semester

  • 薬学基礎実習IV

    2017.10 - 2018.3   Second semester

  • 医療薬学演習II

    2017.4 - 2017.9   First semester

  • 医療薬学演習I

    2017.4 - 2017.9   First semester

  • 薬学基礎実習Ⅳ

    2016.10 - 2017.3   Second semester

  • 医療薬学演習II

    2016.4 - 2016.9   First semester

  • 医療薬学演習I

    2016.4 - 2016.9   First semester

  • 薬学基礎実習Ⅳ

    2015.10 - 2016.3   Second semester

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FD Participation

  • 2024.7   Role：Participation   Title：第5回創薬産学官連携セミナー（新モダリティ）

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.11   Role：Participation   Title：第２回薬学部局FD講演会「機関間連携」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.8   Role：Participation   Title：馬出地区４部局合同男女共同参画FD

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2023.3   Role：Participation   Title：「TF（ティーチング・フェロー）経験を通じて 大学院生の教育能力を高める」

    Organizer：University-wide

  • 2022.11   Role：Participation   Title：「アカデミア創薬」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.4   Role：Participation   Title：令和４年度 第１回全学ＦＤ（新任教員の研修）The 1st All-University FD (training for new faculty members) in FY2022

    Organizer：University-wide

  • 2018.5   Role：Participation   Title：「総合的創薬ソリューションプロバイダーによる創薬研究支援の新たな形」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2017.3   Role：Participation   Title：情報セキュリティ対策について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2016.4   Role：Participation   Title：外国人留学生受入に係る説明会

    Organizer：[Undergraduate school/graduate school/graduate faculty]

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Other educational activity and Special note

  • 2024  Class Teacher  学部

Travel Abroad

  • 2016.11

    Staying countory name 1：United States   Staying institution name 1：Johns Hopkins University