Kyushu University Academic Staff Educational and Research Activities Database
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AKIOMI NAGASAKA Last modified date:2020.06.01

Assistant Professor / Department of Pharmacology and Toxicology
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Ph.D. Science
Country of degree conferring institution (Overseas)
Field of Specialization
Molecular Biology
Total Priod of education and research career in the foreign country
Outline Activities
Elucidation of intracellular signal pathways involved in pathogenesis of hearts
Research Interests
  • Search for molecules which involves in regression of cardiac hypertrophy
    keyword : Hypertrophy、Regression
  • Elucidate the roles of proton-sensing GPCRs in macrophages
    keyword : Proton-sensing GPCRs, Macrophages
  • Elucideate the role of proton-sensing GPRCRs in myocardial infarction.
    keyword : Proton-sensing, GPCR
Academic Activities
1. AKIOMI NAGASAKA, Yuki Ohba, Hitoshi Kurose, Nakaya Michio, Novel functions of GRK6 in macrophages by phosphorylating the non-GPCRs substrates, Macrophage, 2015.05, G protein-coupled receptor kinases (GRKs) were originally identified as molecules that phosphorylate G protein-coupled receptors (GPCRs) and play central roles in G protein-dependent physiological signalling. In addition, recent studies indicated that GRK.
1. NAGASAKA, A., Mogi, C., Ono, H., Nishi, T., Horii, Y., Ohba, Y., Nakaya, M., Okajima, F., Kurose, H., The proton-sensing G protein-coupled receptor T-cell death-associated gene 8 (TDAG8) shows cardioprotective effects against myocardial infarction, Scientific Reports, 10.1038/s41598-017-07573-2, 2017.08, [URL].
2. AKIOMI NAGASAKA, KAWANE KOHKI, YOSHIDA HIROKI, SHIGEKAZU NAGATA, Apaf-1-independent programmed cell death in mouse development, Cell Death Differ., 10.1038/cdd.2009.186, 17, 931-941, 2010.06.
1. 長坂 明臣, The roles of T-cell death-associated gene 8 (TDAG8), a proton-sensing GPCR, in myocardial infarction, Translational Research on Metabolic and Inflammatory Diseases and Cancer, 2019.12.
2. 長坂 明臣, 小野達貴, 仲矢 道雄, 黒瀬 等, プロトン感知性受容体(TDAG8)に着目した心筋梗塞時におけるpH低下の生理的影響の解析, 次世代を担う創薬・医療薬理シンポジウム2017, 2017.08.
3. 長坂 明臣, 小野 達貴, 仲矢 道雄, 黒瀬 等, 心筋梗塞時におけるプロトン感知性受容体TDAG8の役割解析, 第90回 日本薬理学会年会, 2017.03, [URL].
Membership in Academic Society
  • The Japanese Pharmacological Society
  • The Pharmaceutical Society of Japan
  • The Molecular Biology of Society of Japan
Educational Activities
I am in charge of Pharmacology Basic Practice IV, Small group seminar, and Presentation Practice I, II.