Kyushu University Academic Staff Educational and Research Activities Database
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TOSHIYUKI HAYAKAWA Last modified date:2024.05.16

Associate Professor / Division for Arts and Science, Faculty of Arts and Science
Division for Experimental Natural Science
Faculty of Arts and Science

Graduate School

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Field of Specialization
Evolutionary biology, Anthropology, Glycobiology, Evolutionary medicine
Total Priod of education and research career in the foreign country
Research Interests
  • Genetic basis of cumulative cultural evolution in anatomically modern humans
    keyword : Culture, cumulative cultural evolution, collective brain, collective intelligence, psychosocial stress
  • Evolution of the genes involved in mental activity
    keyword : mental activity, social activity, evolution
  • Evolution of Siglec-11 and Siglec-16 in primates
    keyword : Microglia, Mental diseases, Brain
  • Human-specific inactivation of CMP-N-acetylneuraminic acid hydroxylase
    keyword : Malaria, Co-evolution
Academic Activities
1. TOSHIYUKI HAYAKAWA, Ajit Varki, Human-specific Changes in Sialic Acid Biology. Post-Genome Biology of Primates, Primatology Monographs , Springer, 123-148, 2012.03.
1. Toshiyuki Hayakawa, Masahiro Terahara, Naoko T. Fujito, Takumi Matsunaga, Kosuke M. Teshima, Masaya Hane, Ken Kitajima, Chihiro Sato, Naoyuki Takahata, Yoko Satta, Lower promoter activity of the ST8SIA2 gene has been favored in evolving human collective brains, PLoS ONE, 10.1371/journal.pone.0259897, 16, e0259897, 2021.12.
2. Naoko T. Fujito, Yoko Satta, Masaya Hane, Atsushi Matsui, Kenta Yashima, Ken Kitajima, Chihiro Sato, Naoyuki Takahata, Toshiyuki Hayakawa, Positive selection on schizophrenia-associated ST8SIA2 gene in post-glacial Asia, PLoS ONE, 13, 7, e0200278, 2018.07.
3. Toshiyuki Hayakawa, Zahra Khedri, Flavio Schwarz, Corinna Landing, Suh-Yuen Liang, Hai Yu, Xi Chen, Naoko T. Fujito, Yoko Satta, Ajit Varki, Takashi Angata, Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates, BMC Evolutionary Biology, 2017.11.
4. X. Wang, N. Mitra, P. Cruz, L. Deng, NISC Comparative Sequencing Program, N. Varki, T. Angata, E.D. Green, J. Mullikin, TOSHIYUKI HAYAKAWA, A. Varki, Evolution of Siglec-11 and Siglec-16 genes in Hominins, Mol. Biol. Evol. , 29, 8, 2073-2086, 2012.08.
5. TOSHIYUKI HAYAKAWA, S.-I. Tachibana, K. Hikosaka, N. Arisue, A. Matsui, T. Horii, K. Tanabe, Age of the last common ancestor of extant Plasmodium parasite lineages, Gene , 502, 1, 36-39, 2012.07.
6. TOSHIYUKI HAYAKAWA, N. Arisue, T. Udono, H. Hirai, J. Sattabongkot, T. Toyama, T. Tsuboi, T. Horii, K. Tanabe, Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees, PLoS ONE , 4, 10, e7412, 2009.10.
7. TOSHIYUKI HAYAKAWA, R. Culleton, H. Otani, T. Horii, K. Tanabe, Big bang in the evolution of extant malaria parasites, Mol. Biol. Evol. , 25, 10, 2233-2239, 2008.10.
8. TOSHIYUKI HAYAKAWA, I. Aki, A. Varki, Y. Satta, N. Takahata, Fixation of the human-specific CMP-N-acetylneuraminic acid hydroxylase pseudogene and implications of haplotype diversity for human evolution, Genetics , 172, 2, 1139-1146, 2006.02.
9. T. Angata, TOSHIYUKI HAYAKAWA, M. Yamanaka, A. Varki, M. Nakamura, Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates, FASEB J. , 20, 12, 1964-1973, 2006.10.
10. T. K. Altheide, TOSHIYUKI HAYAKAWA, T. S. Mikkelsen, S. Diaz, N. Varki, A. Varki, System-wide genomic and biochemical comparisons of sialic acid biology among primates and rodents: Evidence for two modes of rapid evolution, J. Biol. Chem. , 281, 35, 25689-25702, 2006.09.
11. TOSHIYUKI HAYAKAWA, T. Angata, A. L. Lewis, T. S. Mikkelsen, N. M. Varki, A. Varki, A human-specific gene in microglia, Science , 309, 5741, 1693, 2005.09.
12. The Chimpanzee Sequencing and Analysis Consortium, Initial sequence of the chimpanzee genome and comparison with the human genome, Nature, 437, 7055, 69-87, 2005.09.
13. TOSHIYUKI HAYAKAWA, T. K. Altheide, A. Varki, Genetic basis of human brain evolution: accelerating along the primate speedway, Dev. Cell , 8, 1, 2-4, 2005.01.
14. H.-H. Chou, TOSHIYUKI HAYAKAWA, S. Diaz, M. Krings, E. Indriati, M. Leakey, S. Paabo, Y. Satta, N. Takahata, A. Varki, Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution, Proc. Natl. Acad. Sci. USA , 99, 18, 11736-11741, 2002.09.
15. TOSHIYUKI HAYAKAWA, Y. Satta, P. Gagneux, A. Varki, N. Takahata, Alu-mediated inactivation of the human CMP-N-acetylneuraminic acid hydroxylase gene, Proc. Natl. Acad. Sci. USA , 98, 20, 11399-11404, 2001.09.
1. Toshiyuki Hayakawa, Adaptive evolution of the ST8SIA2 gene in anatomically modern humans, Sialoglyco 2022, 2022.09.
2. Toshiyuki Hayakawa, Interaction between genes and social environments in anatomically modern humans, The 14th International Congress of Physiological Anthropology 2019, 2019.09.
3. Fujito, N., Y. Satta, M. Hane, A. Matsui, K. Yashima, K. Kitajima, C. Sato, N. Takahata, T. Hayakawa, Adaptive evolution of mental activity-related STX gene in the out-of-Africa migration., International Symposium on Evolutionary Genomics and Bioinformatics, 2017.11.
4. Fujito, N., Y. Satta, M. Hane, A. Matsui, K. Yashima, K. Kitajima, C. Sato, N. Takahata, T. Hayakawa, Adaptive evolution of mental activity-related STX gene in the out-of-Africa migration., Society for Molecular Biology and Evolution Meeting, 2017.07.
5. TOSHIYUKI HAYAKAWA, Evolution of sialic acid biology in the primate lineage, International Primatological Society XXIII Congress Kyoto 2010, 2010.09.
6. TOSHIYUKI HAYAKAWA, Evolution of sialic acid biology in primates, Hominization conference 2009 Primate Genomics for Globalization of Collaboration Program: Post-genome biology of primates as the hub-research for understanding our species and neighbors, 2010.03.