Kyushu University Academic Staff Educational and Research Activities Database
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Ryu Matsuo Last modified date:2021.06.01

Associate Professor / Department of Health Care Administration and Management
Department of Basic Medicine
Faculty of Medical Sciences

Graduate School
Other Organization

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
Field of Specialization
internal medicine, stroke, geriatrics, epidemiology
Total Priod of education and research career in the foreign country
Research Interests
  • Epidemiology in Stroke
    keyword : stroke, epidemiology, cohort
  • Research for biomarkers in stroke
    keyword : biomarker, stroke
  • Genetic factor in Stroke
    keyword : genetics, stroke, SNP
  • Association between stroke and air pollution
    keyword : stroke, air pollution
  • Stroke and health economics
    keyword : Stroke, health economics
  • Disability-adjusted Long-term Prognosis in Ischemic Stroke Patients Using Stroke Registry
    keyword : Stroke, QOL, DALY, cohort
Academic Activities
1. Takuya Kiyohara, Ryu Matsuo, Jun Hata, Kuniyuki Nakamura, Yoshinobu Wakisaka, Masahiro Kamouchi , Takanari Kitazono, Tetsuro Ago, FSR Investigators., β-Cell Function and Clinical Outcome in Nondiabetic Patients With Acute Ischemic Stroke., Stroke, 2021.05.
2. Matsuo, Ryu; Ago, Tetsuro; Kiyuna, Fumi; Sato, Noriko; Nakamura, Kuniyuki; Kuroda, Junya; Wakisaka, Yoshinobu; Kitazono, Takanari, Smoking Status and Functional Outcomes After Acute Ischemic Stroke, Stroke, 10.1161/STROKEAHA.119.027230, 51, 3, 846-852, 2020.03, Background and Purpose—Smoking is an established risk factor for stroke; however, it is uncertain whether prestroke smoking status affects clinical outcomes of acute ischemic stroke. This study aimed to elucidate the association between smoking status and functional outcomes after acute ischemic stroke. Methods—Using a multicenter hospital-based stroke registry in Japan, we investigated 10 825 patients with acute ischemic stroke hospitalized between July 2007 and December 2017 who had been independent before stroke onset. Smoking status was categorized into those who had never smoked (nonsmokers), former smokers, and current smokers. Clinical outcomes included poor functional outcome (modified Rankin Scale score ≥2) and functional dependence (modified Rankin Scale score 2–5) at 3 months. We adjusted for potential confounding factors using a logistic regression analysis. Results—The mean age of patients was 70.2±12.2 years, and 37.0% were women. There were 4396 (42.7%) nonsmokers, 3328 (32.4%) former smokers, and 2561 (24.9%) current smokers. The odds ratio (95% CI) for poor functional outcome after adjusting for confounders increased in current smokers (1.29 [1.11–1.49] versus nonsmokers) but not in former smokers (1.05 [0.92–1.21] versus nonsmokers). However, among the former smokers, the odds ratio of poor functional outcome was higher in those who quit smoking within 2 years of stroke onset (1.75 [1.15–2.66] versus nonsmokers). The risk of poor functional outcome tended to increase as the number of daily cigarettes increased in current smokers (P for trend=0.002). All these associations were maintained for functional dependence. Conclusions—Current and recent smoking is associated with an increased risk of unfavorable functional outcomes at 3 months after acute ischemic stroke..
3. Matsuo, Ryu; Kamouchi, Masahiro; Fukuda, Haruhisa; Hata, Jun; Wakisaka, Yoshinobu; Kuroda, Junya; Ago, Tetsuro; Kitazono, Takanari, Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator for Ischemic Stroke Patients over 80 Years Old: The Fukuoka Stroke Registry, PLOS ONE, 10.1371/journal.pone.0110444, 9, 10, 2014.10.
4. Matsuo, Ryu; Kamouchi, Masahiro; Ago, Tetsuro; Hata, Jun; Shono, Yuji; Kuroda, Junya; Wakisaka, Yoshinobu; Sugimori, Hiroshi; Kitazono, Takanari, Thrombolytic therapy with intravenous recombinant tissue plasminogen activator in Japanese older patients with acute ischemic stroke: Fukuoka Stroke Registry, GERIATRICS & GERONTOLOGY INTERNATIONAL, 10.1111/ggi.12205, 14, 4, 954-959, 2014.10.
5. Matsuo, Ryu; Ago, Tetsuro; Hata, Jun; Kuroda, Junya; Wakisaka, Yoshinobu; Sugimori, Hiroshi; Kitazono, Takanari; Kamouchi, Masahiro, Impact of the 1425G/A Polymorphism of PRKCH on the Recurrence of Ischemic Stroke: Fukuoka Stroke Registry, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 10.1016/j.jstrokecerebrovasdis.2013.11.011, 23, 6, 1356-1361, 2014.07.
6. Matsuo, Ryu; Ago, Tetsuro; Kamouchi, Masahiro; Kuroda, Junya; Kuwashiro, Takahiro; Hata, Jun; Sugimori, Hiroshi; Fukuda, Kenji; Gotoh, Seiji; Makihara, Noriko; Fukuhara, Masayo; Awano, Hideto; Isomura, Tetsu; Suzuki, Kazuo; Yasaka, Masahiro; Okada, Yasushi; Kiyohara, Yutaka; Kitazono, Takanari, Clinical significance of plasma VEGF value in ischemic stroke - research for biomarkers in ischemic stroke (REBIOS) study, BMC NEUROLOGY, 10.1186/1471-2377-13-32, 13, 2013.04.
1. Matsuo R, Ago T, Kiyuna, F, Sato, N, Nakamura, K, Wakisaka Y, Kamouchi M, Kitazono T., Smoking status and functional outcomes after acute ischemic stroke, 5th European Stroke Organisation Conference 2019 (ESOC2019), 2019.05.
2. Matuso R; Michikawa T; Ago T; Ueda K; Yamazaki S; Nitta H; Takami A; Kamouchi M; Kitazono T, Short-term exposure to fine particulate matter (PM2.5) and risk of ischemic stroke in Japan, 11th World Stroke Congress 2018, 2018.10.
3. Ago T, Matsuo R, Hata J, Wakisaka Y, Kuroda J, Kitazono T, Kamouchi M, Insulin resistance and clinical outcomes after acute ischemic stroke, 4th European Stroke Organisation Conference, 2018.05.
4. Michikawa T, Matsuo R, Ueda K, Ago T, Nitta H, Kitazono T, Kamouchi M, Short-term exposure to fine particulate matter increased hospital admissions for ischaemic stroke in Japan., Annual Scientific Conference of the International Society of Environmental Epidemiology 2017, 2017.09.
5. Matsuo R, Yamaguchi Y, Matsushita T, Fukuda K, Kiyuna F, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T, Impact of onset-to-door time on clinical outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry. , The 3rd European Stroke Organisation Conference 2017, 2017.05.
6. Matsuo R, Yamaguchi Y, Kamouchi M, Sugimori H, Shono Y, Ago T, Kitazono T. , Association between neurological symptoms at stroke onset and use of ambulance– the Fukuoka Stroke Registry., Asia Pacific Stroke Conference 2016, 2016.07.
7. Noichi Y, Matsuo R, Kamouchi M, Furukawa S, Kitamura T, Ito Y, Murao K, Arakawa S, Ago T, Kitazono T, Informed consent in a multicenter stroke registry: Fukuoka Stroke Registry. , Asia Pacific Stroke Conference 2016, 2016.07.
8. Kiyuna F, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T, Association between high-sensitivity CRP at stroke onset and clinical outcomes in patients with small vessel occlusion. , 2nd. European Stroke Organisation Conference 2016, 2016.05.
9. Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Pioglitazone treatment and long-term post-stroke prognosis in diabetic patients with acute ischemic stroke: the Fukuoka Stroke Registry. , Asia Pacific Stroke Conference 2015, 2015.10.
10. Matsuo R, Kamouchi M, Hata J, Wakisaka Y, Kuroda J, Ago T, Kitazono T, Association of high-sensitivity C-reactive protein at stroke onset with short-term clinical outcomes after ischemic stroke: the Fukuoka Stroke Registry, 1st . European Stroke Organisation Conference 2015, 2015.04.