Kyushu University Academic Staff Educational and Research Activities Database
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Hosokawa Kentaro Last modified date:2023.11.22





Homepage
https://kyushu-u.elsevierpure.com/en/persons/kentaro-hosokawa
 Reseacher Profiling Tool Kyushu University Pure
https://www.lab.med.kyushu-u.ac.jp/scr/
Department of Stem Cell Biology and Medicine,
Graduate School of Medical Sciences, Kyushu University
Website of Lab. introduction .
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
stem cell biology
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
I am studying hematopoietic tissue. The main targets are hematopoietic stem cells and mesenchymal stem cells. In order to clarify the mechanism of maintaining the self-renewal ability of these cells, we are conducting research using cell biological and histological methods as well as data science approaches.
We carry out research activities as "one team" while instructing undergraduate students, master's and doctoral students.
Research
Research Interests
  • Analysis of signal networks in hematopoietic microenvironment
    keyword : Niche, Hematopoietic stem cell, Mesenchymal stem cell
    2020.06~2025.06.
  • Functional analysis of telomere binding proteins for self-renewal mechanism of bone marrow hematopoietic stem cells
    keyword : hematopoietic stem cell, telomere binding protein, energy metabolism
    2014.04~2027.03.
Academic Activities
Reports
1. Hosokawa K, Arai F., The role of telomere binding molecules for normal and abnormal hematopoiesis., Int J Hematol., doi: 10.1007/s12185-018-2432-4, 2018.05, [URL].
Papers
1. Hosokawa Kentaro, MacArthur BD, Ikushima YM, Toyama H, Masuhiro Y, Hanazawa S, Suda T, Fumio Arai, The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age., Nature Communications, 10.1038/s41467-017-00935-4, 8, 1, 2017.10.
2. Hosokawa Kentaro, Fumio Arai, Yoshihara H, Iwasaki H, Nakamura Y, Gomei Y, Suda T, Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells., Blood., 2010.07.
3. Hosokawa Kentaro, Fumio Arai, Yoshihara H, Iwasaki H, Hembree M, Yin T, Nakamura Y, Gomei Y, Takubo K, Shiama H, Matsuoka S, Li L, Suda T, Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow., Cell Stem Cell., 2010.03.
4. Hosokawa Kentaro, Fumio Arai, Yoshihara H, Nakamura Y, Gomei Y, Iwasaki H, Miyamoto K, Shima H, Ito K, Suda T, Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction., Biochem Biophys Res Commun., 2007.11.
Presentations
1. 細川 健太郎, 森本 早紀, 國﨑 祐哉, 今西 春香, 上原 康史, 兵田 朋子, 新井 文用, Foxp2 is essential for the quiescent state and self-renewal capacity of hematopoietic stem cells., International Society for Experimental Hematology, 2017.08.
2. 細川 健太郎, Benjamin MacArthur, 生島 芳子, 花澤 重正, 須田 年生, 新井 文用, Shelterin component protection of telomeres 1 (Pot1) plays a critical role in the self-renewal of HSCs., Joint symposium of PNU and Kyushu Univ, 2015.08.
3. 細川 健太郎, 生島 芳子, Benjamin MacArthur, 須田 年生, 新井 文用, POT1 regulates self-renewal activity of cord blood hematopoietic stem cells, International Society for Experimental Hematology, 2014.08, [URL].
4. 細川 健太郎, 生島 芳子, Benjamin MacArthur, 須田 年生, 新井 文用, Pot1 regulates hematopoietic stem cell activity during aging, 幹細胞シンポジウム, 2014.05.
Membership in Academic Society
  • American Society of Hematology
  • International Society for Experimental Hematology
  • THE JAPANESE SOCIETY OF HEMATOLOGY
  • Stem Cell Research Symposium
Awards
  • Analysis of normal hematopoiesis and metabolic control mechanism of leukemic stem cells by telomere binding factors
  • Functional analysis of telomere binding factors for energy metabolism of leukemic stem cells
  • Protection of telomeres 1 (Pot1) regulates hematopoietic stem cell activity during ageing.
Educational
Educational Activities
1. Initial research support and guidance in the laboratory assignment of a third-year student at Kyushu University School of Medicine or department of life sciences
2. Support and guidance for graduation research at Kyushu University Graduate School of Medicine, fourth grader
3. Support and guidance for graduate studies of master's or doctoral students at Kyushu University Graduate School of Medicine