Updated on 2024/10/29

Information

 

写真a

 
TANAKA YASUTAKE
 
Organization
Faculty of Agriculture Department of Bioscience and Biotechnology Assistant Professor
School of Agriculture Department of Bioresource and Bioenvironment（Concurrent）
Graduate School of Bioresource and Bioenvironmental Sciences Department of Bioscience and Biotechnology（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
0928024745
Profile
研究 　現在主に行っている研究テーマは『病態モデル動物を用いた新規な高コレステロール血症発症機構に関する研究』です。 　高コレステロール血症モデル動物である外因性高コレステロール血症(ExHC)ラットの遺伝子解析により高コレステロール血症発症機構の解明を行っています。現在は原因遺伝子同定の過程で発見したSmek2遺伝子について、その機能の解析を行っています。また、Smek2を利用した新たな疾患モデル動物の作製にも取り組んでいます。 教育 　おもに、大学院生の修士論文および博士論文指導を行っています。また、学部学生は卒論指導および学生実験を行っています。
External link

Research Areas

  • Life Science / Nutrition science and health science

Degree

  • 修士（農学）（九州大学）

  • Ph.D. (Agriculture) (Kyushu university)

Research History

  • Kyushu University Faculty of Agriculture Assistant Professor

    2020.4 - Present

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  • 平成23年4月～平成26年3月 日本学術振興会特別研究員（DC1） 平成28年3月～平成29年3月 北海道大学大学院農学研究院（食品栄養学研究室）博士研究員 平成29年4月～平成30年9月 国立循環器病研究センター研究所（生化学部）流動研究員

Research Interests・Research Keywords

  • Research theme：Creation of novel pathological model animal by controlling the novel metabolic regulating gene Smek2

    Keyword：Smek2, non-infectious diseases, pathological model animals, lipid metabolism, carbohydrate metabolism, amino acid metabolism

    Research period： 2020.4 - 2020.5

Papers

  • Quantities of vitamin D in Japanese meals using gas chromatography-mass spectrometry (GC-MS) and prediction of their sources by multiple logistic regression analysis

    Wang, S; Nakamura, Y; Shirouchi, B; Hashimoto, Y; Tanaka, Y; Nakao, A; Goromaru, R; Iwamoto, M; Sato, M

    JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION   2024.9   （ ISSN:2193-4126 eISSN:2193-4134 ）

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    Publisher：Journal of Food Measurement and Characterization  

    Vitamin D is a hormone-like vitamin that plays a primary physiological role in regulating calcium metabolism. In addition to endogenous synthesis through sunlight exposure, dietary supplementation with vitamin D is indispensable for maintaining optimal vitamin D levels. To ensure precision and efficacy in quantifying daily vitamin D intake among the Japanese people, we established a method to measure vitamin D in food. This method optimizes instrument costs and streamlines cumbersome processes. Initially, thin-layer chromatography (TLC) was used to separate vitamin D from food samples, followed by a quantitative analysis using gas chromatography-mass spectrometry (GC-MS) with deuterated vitamin D as an internal standard. Despite the elevated temperature conditions of GC-MS, which lead to the generation of thermal decomposition compounds, the method remains accurate and effective, with an limit of quantitation (LOQ) as low as 0.8 ng for vitamin D. Subsequently, we applied this method to quantify the vitamin D content in 120 meal samples. The meals, designed by a registered dietitian (RD), were served in the dormitory and cafeteria of a Japanese company. The total vitamin D content {mean ± standard deviation (SD)} was 14.7 ± 13.7 µg/day. The measured total vitamin D content in the meal samples, showing a congruent range of 15.7 ± 12.6 µg/day, closely aligned with the corresponding estimate derived from Excel Eiyou-kun. In summary, this study established a method using GC-MS to simultaneously measure vitamin D2 and D3 in meals, which may be suitable for analyzing food samples for their vitamin D content in large quantities.

    DOI： 10.1007/s11694-024-02734-0

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  • Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies. International journal

    Zhen Lu, Ioannis Verginadis, Motofumi Kumazoe, Gerardo M Castillo, Yao Yao, Rebecca E Guerra, Sandra Bicher, Menghao You, George McClung, Rong Qiu, Zebin Xiao, Zhen Miao, Subin S George, Daniel P Beiting, Takashi Nojiri, Yasutake Tanaka, Yoshinori Fujimura, Hiroaki Onda, Yui Hatakeyama, Akiko Nishimoto-Ashfield, Katrina Bykova, Wei Guo, Yi Fan, Nikolay M Buynov, J Alan Diehl, Ben Z Stanger, Hirofumi Tachibana, Terence P Gade, Ellen Puré, Constantinos Koumenis, Elijah M Bolotin, Serge Y Fuchs

    Science translational medicine   16 ( 761 )   eadn0904   2024.8   （ ISSN:1946-6234 eISSN:1946-6242 ）

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    Deficit of oxygen and nutrients in the tumor microenvironment (TME) triggers abnormal angiogenesis that produces dysfunctional and leaky blood vessels, which fail to adequately perfuse tumor tissues. Resulting hypoxia, exacerbation of metabolic disturbances, and generation of an immunosuppressive TME undermine the efficacy of anticancer therapies. Use of carefully scheduled angiogenesis inhibitors has been suggested to overcome these problems and normalize the TME. Here, we propose an alternative agonist-based normalization approach using a derivative of the C-type natriuretic peptide (dCNP). Multiple gene expression signatures in tumor tissues were affected in mice treated with dCNP. In several mouse orthotopic and subcutaneous solid tumor models including colon and pancreatic adenocarcinomas, this well-tolerated agent stimulated formation of highly functional tumor blood vessels to reduce hypoxia. Administration of dCNP also inhibited stromagenesis and remodeling of the extracellular matrix and decreased tumor interstitial fluid pressure. In addition, treatment with dCNP reinvigorated the antitumor immune responses. Administration of dCNP decelerated growth of primary mouse tumors and suppressed their metastases. Moreover, inclusion of dCNP into the chemo-, radio-, or immune-therapeutic regimens increased their efficacy against solid tumors in immunocompetent mice. These results demonstrate the proof of principle for using vasculature normalizing agonists to improve therapies against solid tumors and characterize dCNP as the first in class among such agents.

    DOI： 10.1126/scitranslmed.adn0904

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  • Smek2 is a multi-function regulator of three major nutritions

    Tanaka, Y; Kawano, M; Asahina, M; Imaizumi, K; Sato, M

    ANNALS OF NUTRITION AND METABOLISM   79   488 - 488   2023.8   （ ISSN:0250-6807 eISSN:1421-9697 ）

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  • Difference of sterol metabolism between mice and rats in response to a high-fat diet or diet supplemented with cholic acid

    Iwasaki, W; Yoshida, R; Hori, S; Tanaka, Y; Sato, M; Ishizuka, S

    ANNALS OF NUTRITION AND METABOLISM   79   691 - 691   2023.8   （ ISSN:0250-6807 eISSN:1421-9697 ）

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  • コール酸補給食によるラットのアルブミン尿症を伴う血圧上昇(A diet supplemented with cholic acid elevates blood pressure accompanied by albuminuria in rats)

    Shimoda Tomoko, Shimizu Hidehisa, Iwasaki Wakana, Liu Hongxia, Kamo Yoshie, Tada Koji, Hanai Taketo, Hori Shota, Joe Ga-Hyun, Tanaka Yasutake, Sato Masao, Miyazaki Hitoshi, Ishizuka Satoshi

    Bioscience, Biotechnology, and Biochemistry   87 ( 4 )   434 - 441   2023.4   （ ISSN:0916-8451 ）

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    Language：English   Publisher：(公社)日本農芸化学会  

    血圧に対するコール酸(CA)補給食の効果について検討した。WKAH/HkmSlcラット(3週齢)をAIN-93に基づく対照食またはCA補給食(0.5gCA/kg)で13週間飼育した。CA食は肝臓の脂質濃度と共に、収縮期と弛緩期の血圧を上昇させた。血液のナトリウム濃度には変化がなかった。CAで飼育したラットでは、尿のアルブミン濃度が上昇した。血圧と相関するATP-binding cassette subfamily B memberの肝臓での発現が上昇し、肝門のタウロコール酸濃度上昇と尿アルブミン濃度上昇が観察された。以上の結果から、12α-ヒドロキシル化胆汁酸は肝臓機能の変化を介して、血圧上昇とアルブミン尿症に関与すると考えられた。

  • A diet supplemented with cholic acid elevates blood pressure accompanied by albuminuria in rats Reviewed

    Tomoko Shimoda, Hidehisa Shimizu, Wakana Iwasaki, Hongxia Liu, Yoshie Kamo, Koji Tada, Taketo Hanai, Shota Hori, Ga-Hyun Joe, Yasutake Tanaka, Masao Sato, Hitoshi Miyazaki, Satoshi Ishizuka

    Bioscience, Biotechnology, and Biochemistry   87 ( 4 )   434 - 441   2023.1   （ ISSN:0916-8451 eISSN:1347-6947 ）

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    Language：Others   Publishing type：Research paper (scientific journal)   Publisher：Oxford University Press (OUP)  

    Abstract

    A diet supplemented with cholic acid (CA), the primary 12α-hydroxylated bile acid, can induce hepatic lipid accumulation in rats without obesity. This study examined the effects of a CA-supplemented diet on blood pressure (BP). After acclimation, WKAH/HkmSlc rats (3 week old) were divided into two groups and fed with a control AIN-93-based diet or a CA-supplemented diet (0.5 g CA/kg) for 13 weeks. The CA diet increased systolic and diastolic BP as well as hepatic lipid concentrations in the rats. No changes were found in the blood sodium concentration. Urinary albumin concentration increased in CA-fed rats. An increase was observed in the hepatic expression of ATP binding cassette subfamily B member 1B that correlated BPs and urinary albumin concentration accompanied by an increase in portal taurocholic acid concentration. These results suggest that 12α-hydroxylated bile acids are involved in increased BP and albuminuria via alteration of hepatic function.

    DOI： 10.1093/bbb/zbad004

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  • Mutation in Smek2 regulating hepatic glucose metabolism causes hypersarcosinemia and hyperhomocysteinemia in rats

    Yasutake Tanaka, Michio Kawano, Sawako Nakashima, Chisato Yamaguchi, Makoto Asahina, Mai Sakamoto, Bungo Shirouchi, Kousuke Tashiro, Katsumi Imaizumi, Masao Sato

    Scientific Reports   13 ( 1 )   3053   2022.12   （ ISSN:2045-2322 eISSN:2045-2322 ）

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    Suppressor of mek1 (Dictyostelium) homolog 2 (Smek2), was identified as one of the responsible genes for diet-induced hypercholesterolemia (DIHC) of exogenously hypercholesterolemic (ExHC) rats. A deletion mutation in Smek2 leads to DIHC via impaired glycolysis in the livers of ExHC rats. The intracellular role of Smek2 remains obscure. We used microarrays to investigate Smek2 functions with ExHC and ExHC.BN-Dihc2BN congenic rats that harbor a non-pathological Smek2 allele from Brown-Norway rats on an ExHC background. Microarray analysis revealed that Smek2 dysfunction leads to extremely low sarcosine dehydrogenase (Sardh) expression in the liver of ExHC rats. Sarcosine dehydrogenase demethylates sarcosine, a byproduct of homocysteine metabolism. The ExHC rats with dysfunctional Sardh developed hypersarcosinemia and homocysteinemia, a risk factor for atherosclerosis, with or without dietary cholesterol. The mRNA expression of Bhmt, a homocysteine metabolic enzyme and the hepatic content of betaine (trimethylglycine), a methyl donor for homocysteine methylation were low in ExHC rats. Results suggest that homocysteine metabolism rendered fragile by a shortage of betaine results in homocysteinemia, and that Smek2 dysfunction causes abnormalities in sarcosine and homocysteine metabolism.

    DOI： 10.1038/s41598-022-26115-z

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  • Author Correction: The ratio of 12α to non-12-hydroxylated bile acids reflects hepatic triacylglycerol accumulation in high-fat diet-fed C57BL/6J mice (Scientific Reports, (2022), 12, 1, (16707), 10.1038/s41598-022-20838-9)

    Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

    Scientific Reports   12 ( 1 )   22007   2022.12   （ eISSN:2045-2322 ）

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    The original version of this Article contained an error in Figure 1e, where the X-axis label Cyp27a1 was incorrectly stated as Cyp27b1. The original Figure 1 and accompanying legend appear below. Additionally, the Supplementary Information Table S2 published with this Article contained an error. Under the subheading ‘12α-hydroxylated BAs’, ‘Secondary BAs’, “5β-cholanic acid-3α,12α-diol-7-one (7-uxo-deoxycholic acid, 7oDCA)”. now reads: “5β-cholanic acid-3α,12α-diol-7-one (7-oxo-deoxycholic acid, 7oDCA)”. The original Article and accompanying Supplementary Information file have been corrected.

    DOI： 10.1038/s41598-022-26541-z

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  • The ratio of 12α to non-12-hydroxylated bile acids reflects hepatic triacylglycerol accumulation in high-fat diet-fed C57BL/6J mice. Reviewed International journal

    Wakana Iwasaki, Ryo Yoshida, Hongxia Liu, Shota Hori, Yuki Otsubo, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

    Scientific Reports   12 ( 1 )   16707 - 16707   2022.10   （ ISSN:2045-2322 eISSN:2045-2322 ）

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    In our previous study, enterohepatic 12α-hydroxylated (12α) bile acid (BA) levels were found to be correlated with hepatic triacylglycerol concentration in rats fed high-fat (HF) diet. Since BA composition is diverse depending on animal species, we evaluated whether such a relationship is applicable in mice in response to an HF diet. C57BL/6JJmsSLC (B6) male mice were fed HF diet for 13 weeks and analyzed for triacylglycerol, cholesterol, oxysterols, and other metabolites in the liver. The BA composition was determined in the liver, small intestinal contents, portal plasma, aortic plasma, and feces. Neutral sterols were also measured in the feces. The ratio of 12α BA/non-12 BA increased in the liver, portal plasma, small intestinal contents, and feces of HF-fed B6 mice. Moreover, a positive correlation was observed between the ratio of fecal 12α BAs/non-12 BAs and hepatic triacylglycerol concentration. The concentration of 7α-hydroxycholesterol was increased in the liver of HF-fed B6 mice, whereas no increase was observed in the hepatic expression of cytochrome P450 family 7 subfamily A member 1. The present study showed that the ratio of 12α BA/non-12 BA in feces is closely associated with hepatic triacylglycerol accumulation in B6 mice fed HF diet.

    DOI： 10.1038/s41598-022-20838-9

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  • Dietary lysophospholipids reduce lymphatic cholesterol transport compared with dietary phospholipids in thoracic lymph-duct cannulated rats Reviewed International journal

    #Ai Takeyama, Asami Teramoto, #Tianyu Wang, #Takuya Hayashi, Yasutake Tanaka, Masao Sato, Bungo Shirouchi

    Lipids   56 ( 6 )   579 - 590   2022.6

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  • Dietary lysophospholipids reduce lymphatic cholesterol transport compared with dietary phospholipids in thoracic lymph-duct cannulated rats Reviewed International journal

    Ai Takeyama, Asami Teramoto, Tianyu Wang, Takuya Hayashi, Yasutake Tanaka, Masao Sato, Bungo Shirouchi

    Lipids   56 ( 6 )   579 - 590   2022.6   （ ISSN:0024-4201 eISSN:1558-9307 ）

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    Dietary phospholipids have been traditionally known to affect micelle formation. Egg yolk-derived lysophospholipids (LysoPL) are commercially available. We investigated the effects of dietary LysoPL on lymphatic lipid transport. We also compared sn-1 LysoPL and sn-2 LysoPL, which have different fatty acyl esterification positions. Thoracic lymph duct-cannulated rats were fed a diet supplemented with egg yolk-derived sn-1 LysoPL, sn-2 LysoPL, or phospholipids (PL). The amount of lymphatic lipid transport was also evaluated. Time courses of transport were applied to the one-compartment model as one of the pharmacokinetic analyses. The solubility of cholesterol in bile acid micelles was measured. Compared to the PL diet, the sn-1 and sn-2 LysoPL diets significantly reduced the lymphatic transport of cholesterol. There were no differences in the lymphatic PL and TAG transport. There was no difference in cholesterol transport between the sn-1 LysoPL group and the sn-2 LysoPL group; however, the transport rate constant at a decrease in lymphatic cholesterol was lower in the sn-1 LysoPL group than in the sn-2 LysoPL group. Cholesterol solubility in bile acid micelles was significantly decreased in the sn-1 LysoPL and sn-2 LysoPL groups compared to that in the PL group. Dietary LysoPL affects the behavior of intestinal cholesterol and suppresses lymphatic cholesterol transport.

    DOI： 10.1002/lipd.12319

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  • The effects of dietary linoleic acid on reducing serum cholesterol and atherosclerosis development are nullified by a high-cholesterol diet in male and female apolipoprotein E-deficient mice Reviewed International journal

    #Xingyu Yuan, #Rika Nagamine, Yasutake Tanaka, #Wei-Ting Tsai, #Zhe Jiang, #Ai Takeyama, Katsumi Imaizumi, Masao Sato

    British Journal of Nutrition   2022.5

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    DOI： https://doi.org/10.1017/S0007114522001325

  • Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats Reviewed International journal

    Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga-Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka

    Journal of Functional Foods   2022.4

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    DOI： https://doi.org/10.1016/j.jff.2022.104991

  • Dietary supplementation with okara and Bacillus coagulans lilac-01 improves hepatic lipid accumulation induced by cholic acids in rats Reviewed International journal

    Yeonmi Lee, Yasutake Tanaka, Wakana Iwasaki, Fumika Yokoyama, Ga-Hyun Joe, Misaki Tsuji, Takuma Nose, Koji Tada, Taketo Hanai, Shota Hori, Hidehisa Shimizu, Kimiko Minamida, Kazunori Miwa, Satoshi Ishizuka

    Journal of Functional Foods   90   104991 - 104991   2022.3   （ ISSN:1756-4646 eISSN:2214-9414 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Elsevier BV  

    A dietary symbiotic supplement of okara, a by-product of tofu manufacturing with Bacillus coagulans lilac-01 found to reduce secondary bile acid (BA) in a rat study and cholic acid (CA), a primary 12α-hydroxylated (12αOH) BA, induces lipid accumulation in rats. In this study, we investigated whether dietary supplementation of a synbiotic with okara and Bacillus coagulans lilac-01 improves CA-induced hepatic lipid accumulation. Male Wistar/ST rats (4 weeks old) were fed with or without CA-supplementation combined with the synbiotic for 2 weeks. The CA diet increased hepatic triglycerides and the synbiotic diet in combination with CA normalized liver triglyceride concentration accompanied by suppression of hepatic fatty acid synthase expression, enhancement of fecal triglyceride excretion, and increase in fecal non-12αOH BA excretion. Dietary supplementation with the okara synbiotic ameliorated hepatic lipid accumulation probably by reducing de novo lipogenesis and enhancing fecal triglyceride excretion.

    DOI： 10.1016/j.jff.2022.104991

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  • Dietary egg white protein hydrolysate improves orotic acid-induced fatty liver in rats by promoting hepatic phospholipid synthesis and microsomal triglyceride transfer protein expression Reviewed International journal

    #Zhe Jiang, #Yuki Kimura, Bungo Shirouchi, Yasutake Tanaka, #Wei-Ting Tsai, #Xingyu Yuan, Masao Sato

    The Journal of Nutritional Biochemistry   2021.12

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    DOI： 10.1016/j.jnutbio.2021.108820.

  • 12α-Hydroxylated bile acid enhances accumulation of adiponectin and immunoglobulin A in the rat ileum Reviewed International journal

    2021.11

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    DOI： 10.1038/s41598-021-92302-z

  • Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG. Reviewed International journal

    Motofumi Kumazoe, Yasutake Tanaka, #Ren Yoshitomi, #Yuki Marugame, Kwan-Woo Lee, Hiroaki Onda, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Hirofumi Tachibana

    Journal of natural medicines   2021.6

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    DOI： 10.1007/s11418-021-01538-6

  • Time-dependent increase of plasma cGMP concentration followed by oral EGCG administration in mice Reviewed International journal

    Yasutake Tanaka, Motofumi Kumazoe, Hiroaki Onda, Yoshinori Fujimura, Hirofumi Tachibana

    Food Bioscience   41   2021.6

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  • α-Globulin-rich rice cultivar, low glutelin content-1 (LGC-1), decreases serum cholesterol concentration in exogenously hypercholesterolemic rats. Reviewed International journal

    ＃Xingyu Yuan, #Yutaro Minobe, Yasutake Tanaka, #Yumi Fukuda, #Yumiko Furukawa, #Motonori Miyago, #Takuya Mizokami, #Wei-Ting Tsai, #Zhe Jiang, #Li-Tao Tong, Taiki Akasaka, Bungo Shirouchi, Yoshiko Toyosawa, Toshihiro Kumamaru, Masao Sato

    2021.5

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    DOI： 10.1002/jsfa.11312

  • Soyasaponin ameliorates obesity and reduces hepatic triacylglycerol accumulation by suppressing lipogenesis in high-fat diet-fed mice Invited Reviewed International journal

    #Wei-Ting Tsai, #Yuki Nakamura, Taiki Akasaka, Yoshinori Katakura, Yasutake Tanaka, Bungo Shirouchi, #Zhe Jiang, #Xingyu Yuan, Masao Sato

    JOURNAL OF FOOD SCIENCE   86 ( 5 )   2103 - 2117   2021.4

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    DOI： 10.1111/1750-3841.15696

  • 12α-Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats Reviewed International journal

    1865 ( 12 )   1865   2020.10

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    There is an increasing need to explore the mechanism of the progression of non-alcoholic fatty liver disease. Steroid metabolism is closely linked to hepatic steatosis and steroids are excreted as bile acids (BAs). Here, we demonstrated that feeding WKAH/HkmSlc inbred rats a diet supplemented with cholic acid (CA) at 0.5 g/kg for 13 weeks induced simple steatosis without obesity. Liver triglyceride and cholesterol levels were increased accompanied by mild elevation of aminotransferase activities. There were no signs of inflammation, insulin resistance, oxidative stress, or fibrosis. CA supplementation increased levels of CA and taurocholic acid (TCA) in enterohepatic circulation and deoxycholic acid (DCA) levels in cecum with an increased ratio of 12α-hydroxylated BAs to non-12α-hydroxylated BAs. Analyses of hepatic gene expression revealed no apparent feedback control of BA and cholesterol biosynthesis. CA feeding induced dysbiosis in cecal microbiota with enrichment of DCA producers, which underlines the increased cecal DCA levels. The mechanism of steatosis was increased expression of Srebp1 (positive regulator of liver lipogenesis) through activation of the liver X receptor by increased oxysterols in the CA-fed rats, especially 4β-hydroxycholesterol (4βOH) formed by upregulated expression of hepatic Cyp3a2, responsible for 4βOH formation. Multiple regression analyses identified portal TCA and cecal DCA as positive predictors for liver 4βOH levels. The possible mechanisms linking these predictors and upregulated expression of Cyp3a2 are discussed. Overall, our observations highlight the role of 12α-hydroxylated BAs in triggering liver lipogenesis and allow us to explore the mechanisms of hepatic steatosis onset, focusing on cholesterol and BA metabolism.

    DOI： 10.1016/j.bbalip.2020.158811.

  • A low coefficient of variation in hepatic triglyceride concentration in an inbred rat strain Reviewed International journal

    Tomoko Shimoda, Shota Hori, Kenta Maegawa, Akari Takeuchi, Yeonmi Lee, Ga-Hyun Joe, Yasutake Tanaka, Hidehisa Shimizu, Satoshi Ishizuka.

    Lipids in Health and Disease   19 ( 1 )   137   2020.6

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    DOI： 10.1186/s12944-020-01320

  • Low utilization of glucose in the liver causes diet-induced hypercholesterolemia in exogenously hypercholesterolemic rats Reviewed

    Yasutake Tanaka, Masahiro Ono, Motonori Miyago, Takahisa Suzuki, Yurika Miyazaki, Michio Kawano, Makoto Asahina, Bungo Shirouchi, Katsumi Imaizumi, Masao Sato

    PloS one   15 ( 3 )   2020.1

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    DOI： 10.1371/journal.pone.0229669

  • Ingestion of Difructose Anhydride III Partially Suppresses the Deconjugation and 7α-dehydroxylation of Bile Acids in Rats Fed With a Cholic Acid-Supplemented Diet Reviewed International journal

    83 ( 7 )   1329 - 1335   2019.3

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    DOI： 10.1080/09168451.2019.1597617.

  • Starch synthase IIIa and starch branching enzyme IIb-deficient mutant rice line ameliorates pancreatic insulin secretion in rats Screening and evaluating mutant rice lines with antidiabetic functionalities Reviewed

    Yasutake Tanaka, Kiyomi Takahashi, Jun Ichi Kato, Ai Sawazaki, Taiki Akasaka, Naoko Fujita, Toshihide Kumamaru, Yuhi Saito, Bungo Shirouchi, Masao Sato

    British Journal of Nutrition   119 ( 9 )   970 - 980   2018.1

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    DOI： 10.1017/S0007114518000314

  • The pathophysiological role of oxidized cholesterols in epicardial fat accumulation and cardiac dysfunction a study in swine fed a high caloric diet with an inhibitor of intestinal cholesterol absorption, ezetimibe Reviewed

    Michio Shimabukuro, Chinami Okawa, Hirotsugu Yamada, Shuhei Yanagi, Etsuko Uematsu, Noriko Sugasawa, Hirotsugu Kurobe, Yoichiro Hirata, Joo ri Kim-Kaneyama, Xiao Feng Lei, Shoichiro Takao, Yasutake Tanaka, Daiju Fukuda, Shusuke Yagi, Takeshi Soeki, Tetsuya Kitagawa, Hiroaki Masuzaki, Masao Sato, Masataka Sata

    Journal of Nutritional Biochemistry   35   66 - 73   2016.9

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    DOI： 10.1016/j.jnutbio.2016.05.010

  • Dietary egg yolk supplementation improves low-protein-diet-induced fatty liver in rats Reviewed

    Kazuo Erami, Yasutake Tanaka, Sayaka Kawamura, Motonori Miyago, Ai Sawazaki, Katsumi Imaizumi, Masao Sato

    Journal of Nutritional Science and Vitaminology   62 ( 4 )   240 - 248   2016.1

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    DOI： 10.3177/jnsv.62.240

  • Unavailability of liver triacylglycerol increases serum cholesterol concentration induced by dietary cholesterol in exogenously hypercholesterolemic (ExHC) rats Reviewed

    #Yasutake Tanaka, #Koji Nagao, #Hideaki Nakagiri, #Toshirou Nagaso, #Yasue Iwasa, #Haruhiko Mori, #Makoto Asahina, Katsumi Imaizumi, Masao Sato

    Lipids in Health and Disease   13 ( 1 )   2014.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1476-511X-13-19

  • SHRSP/Izm and WKY/NCrlCrlj rats having a missense mutation in Abcg5 deposited plant sterols in the body, but did not change their biliary secretion and lymphatic absorption-comparison with Jcl:Wistar and WKY/Izm rats Reviewed

    Masaki Kato, #Yusuke Ito, #Yasutake Tanaka, Masao Sato, Katsumi Imaizumi, Nao Inoue, Ikuo Ikeda

    Bioscience, Biotechnology and Biochemistry   76 ( 4 )   660 - 664   2012.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.110667

  • Effects of Kurozu concentrated liquid on adipocyte size in rats Reviewed

    #Li Tao Tong, Yoshinori Katakura, #Sayaka Kawamura, #Sanae Baba, #Yasutake Tanaka, Miyako Udono, Yoshie Kondo, Kumi Nakamura, Katsumi Imaizumi, Masao Sato

    Lipids in Health and Disease   9   2010.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/1476-511X-9-134

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Presentations

  • スクロースがコレステロール代謝に及ぼす影響

    #小松豪太、#蔡 瑋庭、田中愛健、佐藤匡央

    日本食物繊維学会第28回学術集会  2023.11 

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：愛媛大学   Country：Japan  

  • 血中チオールステータスが血管内皮細胞に与える影響

    #下條彩華、田中愛健、佐藤匡央

    2023年度（公社）日本栄養・食糧学会九州・沖縄支部大会および（一社）日本家政学会九州支部第67回大会合同大会  2023.10 

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：大分大学   Country：Japan  

  • 米糠脂質が血液脳関門内皮細胞に与える影響

    #松本晃希、#宮崎優里花、@樋口裕樹、@高橋 肇、田中愛健、佐藤匡央

    令和5年度日本食品科学工学会西日本支部大会  2023.10 

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    Event date： 2024.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：九州大学西新プラザ   Country：Japan  

  • スクロースがコレステロール代謝に及ぼす影響

    小松豪太, 蔡 瑋庭, 田中愛健, 佐藤匡央

    日本食物繊維学会第28回学術集会  2023.11 

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    Event date： 2024.5

    Language：Japanese  

    Venue：愛媛大学   Country：Japan  

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  • 血中チオールステータスが血管内皮細胞に与える影響

    下條彩華, 田中愛健, 佐藤匡央

    2023年度（公社）日本栄養・食糧学会九州・沖縄支部大会および（一社）日本家政学会九州支部第67回大会合同大会  2023.10 

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    Event date： 2024.5

    Language：Japanese  

    Venue：大分大学   Country：Japan  

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  • 米糠脂質が血液脳関門内皮細胞に与える影響

    松本晃希, 宮崎優里花, 樋口裕樹, 高橋 肇, 田中愛健, 佐藤匡央

    令和5年度日本食品科学工学会西日本支部大会  2023.10 

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    Event date： 2024.5

    Language：Japanese  

    Venue：九州大学西新プラザ   Country：Japan  

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  • 卵白タンパク加水分解物が腸内発酵に与える影響

    #臂亮介、#前田賢人、田中愛健、佐藤匡央

    第60回 化学関連支部合同九州大会  2023.7 

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    Event date： 2023.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北九州国際会議場   Country：Japan  

  • 卵白タンパク加水分解物が腸内発酵に与える影響

    臂亮介, 前田賢人, 田中愛健, 佐藤匡央

    第60回 化学関連支部合同九州大会  2023.7 

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    Event date： 2023.7

    Language：Japanese  

    Venue：北九州国際会議場   Country：Japan  

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  • 卵白タンパク加水分解物が食餌誘導性脂肪肝モデルラットに与える影響

    田中愛健、#前田賢人、#臂亮介、佐藤匡央

    第77回 日本栄養・食糧学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：札幌コンベンションセンター   Country：Japan  

  • 卵白タンパク加水分解物が食餌誘導性脂肪肝モデルラットに与える影響

    田中愛健, 前田賢人, 臂亮介, 佐藤匡央

    第77回 日本栄養・食糧学会大会  2023.5 

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    Event date： 2023.5

    Language：Japanese  

    Venue：札幌コンベンションセンター   Country：Japan  

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  • 新規代謝制御遺伝子Smek2の機能解析 Invited

    田中愛健

    日本栄養・食糧学会北海道支部 冬シンポジウム 2022  2022.12 

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    Event date： 2022.12

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北海道大学   Country：Japan  

  • 新規代謝制御遺伝子Smek2の機能解析 Invited

    田中愛健

    日本栄養・食糧学会北海道支部 冬シンポジウム 2022  2022.12 

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    Event date： 2022.12

    Language：Japanese  

    Venue：北海道大学   Country：Japan  

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  • Difference of sterol metabolism between mice and rats in response to a high-fat diet or diet supplemented with cholic acid International conference

    Wakana Iwasaki, Ryo Yoshida, Shota Hori, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

    22nd-IUNS International Congress of Nutrition  2022.12 

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    Event date： 2022.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Smek2 is a multi-function regulator of three major nutritions International conference

    Yasutake Tanaka, #Michio Kawano, #Makoto Asahina, Katsumi Imaizumi, Masao Sato

    22nd-IUNS International Congress of Nutrition  2022.12 

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    Event date： 2022.12

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Difference of sterol metabolism between mice and rats in response to a high-fat diet or diet supplemented with cholic acid International conference

    Wakana Iwasaki, Ryo Yoshida, Shota Hori, Yasutake Tanaka, Masao Sato, Satoshi Ishizuka

    22nd-IUNS International Congress of Nutrition  2022.12 

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    Event date： 2022.12

    Language：English  

    Venue：東京・オンラインハイブリッド開催   Country：Japan  

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  • Smek2 is a multi-function regulator of three major nutritions International conference

    Yasutake Tanaka, Michio Kawano, Makoto Asahina, Katsumi Imaizumi, Masao Sato

    22nd-IUNS International Congress of Nutrition  2022.12 

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    Event date： 2022.12

    Language：English  

    Venue：東京・オンラインハイブリッド開催   Country：Japan  

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  • 金属粉による生理活性のある酸化コレステロール生成の制御

    #深見洋平、田中愛健、佐藤匡央

    （公社）日本食品科学工学会西日本支部および（公社）日本栄養・食糧学会九州・沖縄支部2022年度合同支部大会  2022.11 

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    Event date： 2022.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島大学   Country：Japan  

  • 金属粉による生理活性のある酸化コレステロール生成の制御

    深見洋平, 田中愛健, 佐藤匡央

    （公社）日本食品科学工学会西日本支部および（公社）日本栄養・食糧学会九州・沖縄支部2022年度合同支部大会  2022.11 

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    Event date： 2022.11

    Language：Japanese  

    Venue：鹿児島大学   Country：Japan  

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  • Effects of different carbohydrate source diets with cholesterol-containing on lipid metabolism in rats

    #Wei-ting Tsai, #Saki Inoue, Yasutake Tanaka, #Xingyu Yuan, #Zhe Jiang, #Koki Matsumoto, #Ai Takeyama, Bungo Shirouchi, Masao Sato

    2022.8 

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    Event date： 2022.8

    Language：English   Presentation type：Oral presentation (general)  

    Country：Japan  

  • Effects of different carbohydrate source diets with cholesterol-containing on lipid metabolism in rats

    Wei-ting Tsai, Saki Inoue, Yasutake Tanaka, Xingyu Yuan, Zhe Jiang, Koki Matsumoto, Ai Takeyama, Bungo Shirouchi, Masao Sato

    日本食品科学工学第69回大会  2022.8 

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    Event date： 2022.8

    Language：English  

    Venue：オンライン開催   Country：Japan  

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  • Smek2は三大栄養素代謝を制御しうる遺伝子である Invited

    田中愛健

    第382回細胞工学研究会第259回 遺伝子機能解析部門セミナー  2022.8 

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    Event date： 2022.8

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Country：Japan  

  • Smek2は三大栄養素代謝を制御しうる遺伝子である Invited

    田中愛健

    第382回細胞工学研究会第259回 遺伝子機能解析部門セミナー  2022.8 

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    Event date： 2022.8

    Language：Japanese  

    Country：Japan  

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  • 血中チオールステータスが血管内皮細胞に与える影響

    #下條彩華、#大坪友樹、#盛本舞、田中愛健、佐藤匡央

    第59回 化学関連支部合同九州大会  2022.7 

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州国際会議場   Country：Japan  

  • 米糠脂質のヒト大動脈内皮細胞に与える影響

    #松本晃希、#宮崎優里花、#蔡瑋庭、田中愛健、佐藤匡央

    第59回 化学関連支部合同九州大会  2022.7 

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    Event date： 2022.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北九州国際会議場   Country：Japan  

  • 米糠脂質のヒト大動脈内皮細胞に与える影響

    松本晃希, 宮崎優里花, 蔡瑋庭, 田中愛健, 佐藤匡央

    第59回 化学関連支部合同九州大会  2022.7 

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    Event date： 2022.7

    Language：Japanese  

    Venue：北九州国際会議場   Country：Japan  

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  • 血中チオールステータスが血管内皮細胞に与える影響

    下條彩華, 大坪友樹, 盛本舞, 田中愛健, 佐藤匡央

    第59回 化学関連支部合同九州大会  2022.7 

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    Event date： 2022.7

    Language：Japanese  

    Venue：北九州国際会議場   Country：Japan  

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  • 不死化ラット集合リンパ管内皮細胞株の樹立と酸化コレステロールの接着分子の発現に及ぼす影響の評価

    ＃盛本 舞、#麻生菜央、#武山 藍、鵜殿美弥子、田中愛健、照屋輝一郎、片倉喜範、佐藤匡央

    第76回 日本栄養・食糧学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：武庫川女子大学   Country：Japan  

  • 卵白タンパク質加水分解物はラットのオロチン酸誘導性脂肪肝を改善する

    #前田賢人、#姜 喆、#木村有希、城内文吾、田中愛健、佐藤匡央

    第76回 日本栄養・食糧学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：武庫川女子大学   Country：Japan  

  • 不死化ラット集合リンパ管内皮細胞株の樹立と酸化コレステロールの接着分子の発現に及ぼす影響の評価

    盛本 舞, 麻生菜央, 武山 藍, 鵜殿美弥子, 田中愛健, 照屋輝一郎, 片倉喜範, 佐藤匡央

    第76回 日本栄養・食糧学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese  

    Venue：武庫川女子大学   Country：Japan  

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  • 卵白タンパク質加水分解物はラットのオロチン酸誘導性脂肪肝を改善する

    前田賢人, 姜 喆, 木村有希, 城内文吾, 田中愛健, 佐藤匡央

    第76回 日本栄養・食糧学会大会  2022.6 

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    Event date： 2022.6

    Language：Japanese  

    Venue：武庫川女子大学   Country：Japan  

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  • 6-Ketocholestanolの腹腔内投与がラットの脂質・糖代謝に与える影響

    #大坪友樹、#武山藍、#中山恵理子、城内文吾、田中愛健、佐藤匡央

    令和3年度日本栄養・食糧学会九州・沖縄支部大会  2021.10 

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    Event date： 2021.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • コンブに含まれる植物ステロール組成の分析

    #服部来実、#武山藍、@田中愛健、@佐藤匡央

    日本食品科学工学会 第68回大会  2021.8 

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    Event date： 2021.8

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • 魚油の事前乳化はn-3系多価不飽和脂肪酸の吸収速度を高める

    ＃武山藍、#中山恵理子、加藤綾華、柳本賢一、@田中愛健、@佐藤匡央、@城内文吾

    第75回日本栄養・食糧学会大会  2021.7 

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    Event date： 2021.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • 外因性高コレステロール血症ラットの三大栄養素代謝 Invited

    田中愛健

    第75回日本栄養・食糧学会大会  2021.7 

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    Event date： 2021.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン開催   Country：Japan  

  • ラットにおける酸化コレステロール分子の血中リポタンパク分布

    #麻生菜央、#青木円花、@城内文吾、@田中愛健、@佐藤匡央

    令和2年日本栄養・食糧学会九州・沖縄支部大会  2020.11 

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    Event date： 2020.6 - 2022.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：オンライン開催   Country：Japan  

  • ラットにおける酸化コレステロール分子の血中リポタンパク分布

    麻生菜央, 青木円花, 城内文吾, 田中愛健, 佐藤匡央

    令和2年日本栄養・食糧学会九州・沖縄支部大会  2020.11 

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    Event date： 2020.6 - 2022.6

    Language：Japanese  

    Venue：オンライン開催   Country：Japan  

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  • 腸内細菌代謝産物スカトールを介した高食肉摂取によるトリアシルグリセロール代謝改善メカニズムに関する解析

    湯浅佳奈, 蔵田航一, 戸松良介, 田中愛健, 能勢琢馬, 河原秀明, 渡辺優太, 石塚敏, 清水英寿

    第41回 日本分子生物学会年会  2018.11 

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    Event date： 2018.11

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：神奈川   Country：Other  

  • 外因性高コレステロール血症ラットにおける糖代謝

    小野雅博, 宮後元徳, 鈴木隆久, 田中愛健, 城内文吾, 佐藤匡央

    平成30年度日本栄養・食糧学会九州・沖縄支部大会  2018.10 

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    Event date： 2018.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：宮崎   Country：Other  

  • ラットにおける米糠脂質抽出物投与による脳内ステロール状態の変化

    宮﨑優里花, 小野雅博, 澤﨑 愛, 宮後元徳, 田中愛健, 城内文吾, 佐藤匡央

    第55回化学関連支部合同九州大会  2018.6 

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    Event date： 2018.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • Effects of dietary trimethylglycine on cholesterol metabolism International conference

    Mizokami T, Tanaka Y, Shirouchi B, Ishizuka S, Nagura T, Fukushima M, and Sato M

    AFELiSA (International Symposium on Agriculture, Food, Environmental and Life Science in Asia) 2017  2017.11 

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    Event date： 2017.11

    Language：English   Presentation type：Oral presentation (general)  

    Country：Other  

  • 外因性高コレステロール血症（ExHC）ラットにおける糖代謝

    小野雅博, 宮後元徳, 鈴木隆久, 田中愛健, 城内文吾, 佐藤匡央

    第54回化学関連支部合同九州大会  2017.7 

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    Event date： 2017.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 認知症モデルとしての外因性高コレステロール血症ラット

    宮後元徳, 小野雅博, 鈴木隆久, 田中愛健, 城内文吾, 佐藤匡央

    第71回日本栄養・食糧学会大会  2017.5 

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    Event date： 2017.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：沖縄   Country：Other  

  • ベタイン摂取がラットの脂質代謝に及ぼす影響

    溝上拓哉, 林拓也, 田中愛健, 城内文吾, 石塚敏, 名倉泰三, 福島道広, 佐藤匡央

    日本農芸化学会2017年度大会  2017.3 

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    Event date： 2017.3

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：京都   Country：Other  

  • 胆汁酸誘導性脂肪肝の発症における糖代謝の関与

    田中愛健, 花井健人, 堀将太, 加茂佳恵, 多田幸司, 溝上拓哉, 渡辺真通, 清水英寿, 城内文吾, 佐藤匡央, 吹谷智, 横田篤, 原博, 石塚敏

    第46回日本栄養・食糧学会北海道支部会  2016.10 

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    Event date： 2016.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道   Country：Other  

  • 外因性高コレステロール血症ラットの脳内コレステロール代謝

    宮後元徳, 鈴木隆久, 田中愛健, 城内文吾, 佐藤匡央

    第53回化学関連支部合同九州大会  2016.7 

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    Event date： 2016.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 食後血糖上昇抑制米のインスリン分泌能亢進の作用機序に関する研究

    澤﨑愛, 加藤順一, 髙橋清美, 田中愛健, 藤田直子, 城内文吾, 佐藤匡央

    第53回化学関連支部合同九州大会  2016.7 

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    Event date： 2016.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 炭水化物の分子種の差がラットの食後血糖の推移に与える影響

    田中愛健, 髙橋清美, 加藤順一, 澤﨑愛, 赤坂泰輝, 藤田直子, 齋藤雄飛, 城内文吾, 佐藤匡央

    日本農芸化学会2016年度大会  2016.3 

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    Event date： 2016.3

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：北海道   Country：Other  

  • ラットにおける米α—グロブリンの抗肥満作用

    福田優美, 宮後元徳, 鈴木隆久, 田中愛健, 城内文吾, 佐藤匡央

    日本農芸化学会2015年度中四国・西日本支部合同大会  2015.9 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：愛媛   Country：Other  

  • 炊飯時に高保水性かつ高RS含量を有する変異米の探索とラットに対する血糖上昇抑制効果

    赤坂泰輝, 齋藤雄飛, 髙橋清美, 加藤順一, 田中愛健, 城内文吾, 藤田直子, 熊丸敏博, 佐藤匡央

    第64回応用糖質科学シンポジウム  2015.9 

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    Event date： 2015.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：奈良   Country：Other  

  • 高デンプン食を摂食させたラットにおける米グロブリンの脂質代謝に及ぼす影響

    福田優美, 美濃部裕太郎, 田中愛健, 髙橋清美, 加藤順一, 城内文吾, 佐藤匡央

    平成26年度日本栄養・食糧学会九州・沖縄支部大会  2014.10 

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    Event date： 2014.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Other  

  • ラットを用いた血糖上昇抑制作用をもつ米品種の探索

    髙橋清美, 加藤順一, 赤坂泰輝, 藤田直子, 齊藤雄飛, 田中愛健, 城内文吾, 佐藤匡央

    平成26年度日本栄養・食糧学会九州・沖縄支部大会  2014.10 

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    Event date： 2014.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：熊本   Country：Other  

  • 食事誘導性高コレステロール血症（ExHC）ラットの肝臓における糖質代謝

    鈴木隆久, 田中愛健, 石田尽, 佐藤匡央

    第51回化学関連支部合同九州大会  2014.6 

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    Event date： 2014.6

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 食事誘導性高コレステロール血症（ExHC）ラットにおける糖質代謝

    鈴木隆久, 田中愛健, 石田尽, 佐藤匡央

    第68回日本栄養・食糧学会大会  2014.5 

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    Event date： 2014.5 - 2014.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：北海道   Country：Other  

  • Screening of rice (Oryza sativa L.) grains with antidiabetic functionalities International conference

    Tanaka Y, Takahashi K, Kato J, Akasaka T, Fujita N, Saito Y, Shirouchi B, Sato M

    12th Asian Congress of Nutrition  2014.5 

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    Event date： 2014.5

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Other  

  • INCREASE OF SERUM CHOLESTEROL LEVEL INDUCED BY DIETARY CHOLSTEROL INVOLVES SECRETION OF TRIACYLGLYCEROL FROM LIVER IN ExHC RATS. International conference

    Tanaka Y, Nagao K, Nakagiri H, Nagaso T, Iwasa Y, Mori H, Asahina M, Imaizumi K, Sato M

    IUNS 20th International Congress of Nutrition  2013.9 

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    Event date： 2013.9

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Other  

  • 食事性高コレステロール血症モデルラットにおけるホモシステイン代謝

    田中愛健, 河野通生, 山口千仁, 朝比奈誠, 佐藤匡央

    日本油化学会第52回年会  2013.9 

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    Event date： 2013.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：宮城   Country：Other  

  • 米α-グロブリンの血清コレステロール濃度に及ぼす影響

    福田優美, 美濃部裕太郎, 田中愛健, 熊丸敏博, 佐藤匡央

    第50回化学関連支部合同九州大会  2013.7 

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    Event date： 2013.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • ラットにおける高α-グロブリン米の血清コレステロール濃度低下作用

    美濃部裕太郎, 福田優美, 田中愛健, 熊丸敏博, 佐藤匡央

    第67回日本栄養・食糧学会大会  2013.5 

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    Event date： 2013.5

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：愛知   Country：Other  

  • 食事誘導性高コレステロール血症の責任遺伝子Smek2の機能解析

    山口千仁, 河野通生, 石田尽, 壽山智也, 田中愛健, 城内文吾, 佐藤匡央

    平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会  2012.9 

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    Event date： 2012.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島   Country：Other  

  • 食事性高コレステロール血症ラットにおけるインスリン感受性の低下

    田中愛健, 石田尽, 壽山智也, 山口千仁, 城内文吾, 今泉勝己, 佐藤匡央

    平成24年度日本農芸化学会西日本支部および日本栄養・食糧学会九州・沖縄支部合同大会  2012.9 

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    Event date： 2012.9

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：鹿児島   Country：Other  

  • 食事誘導性高コレステロール血症モデルラットにおけるトリアシルグリセロール代謝

    田中愛健, 永尾晃治, 佐藤匡央, 今泉勝己

    第54回日本脂質生化学会  2012.6 

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    Event date： 2012.6

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：福岡   Country：Other  

  • 連鎖解析による食事性高コレステロール血症の性差原因遺伝子の同定

    田中愛健

    平成23年度 革新的研究開発リーダー養成事業高度化のためのワークショップ  2012.2 

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    Event date： 2012.2

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • Analysis of female-specific gene for responsiveness to dietary cholesterol in rats. International conference

    Tanaka Y, Kawano M, Nakashima S, Sakamoto M, Asahina M, Imaizumi K, Sato M

    The XVIIIth International Workshop on Genetic Systems in the Rat  2011.12 

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    Event date： 2011.12

    Language：English   Presentation type：Symposium, workshop panel (public)  

    Country：Other  

  • 病態モデル動物における白色脂肪組織重量を規定する遺伝子の同定

    壽山智也, 田中愛健, 河野通生, 朝比奈誠, 城内文吾, 佐藤匡央

    第48回化学関連支部合同九州大会  2011.7 

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    Event date： 2011.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 連鎖解析による食事性高コレステロール血症原因遺伝子の探索

    田中愛健, 坂本 麻衣, 河野 通生, 中島 早和子, 朝比奈 誠, 佐藤 匡央, 今泉 勝己

    日本農芸化学会関西･中四国・西日本支部、日本栄養･食糧学会九州沖縄支部、日本食品科学工学会西日本支部 合同沖縄大会  2009.10 

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    Event date： 2009.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：沖縄   Country：Other  

  • 病態モデル動物を用いた食事性高コレステロール血症原因遺伝子の探索

    田中愛健, 坂本 麻衣, 河野 通生, 中島 早和子, 朝比奈 誠, 佐藤 匡央, 今泉 勝己

    夏期コレステロール研究会  2009.7 

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    Event date： 2009.7

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：栃木   Country：Other  

  • 病態モデル動物を用いた食事性高コレステロール血症原因遺伝子の探索

    田中愛健, 中島 早和子, 坂本 麻衣, 佐藤 匡央, 今泉 勝己

    第46回化学関連支部合同大会  2009.7 

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    Event date： 2009.7

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：福岡   Country：Other  

  • 卵白タンパク質加水分解物はラットのオロチン酸誘導性脂肪肝を改善する

    前田 賢人, 姜 テツ, 木村 有希, 城内 文吾, 田中 愛健, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2022.5  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • 卵白タンパク加水分解物摂取が食餌誘導性脂肪肝モデルラットに与える影響

    田中 愛健, 前田 賢人, 臂 亮輔, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2023.3  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • 動物実験の新しい展開　外因性高コレステロール血症(ExHC)ラットの特徴的な病態と新しい展開について

    田中 愛健

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • 不死化ラット集合リンパ管内皮細胞株の樹立と酸化コレステロールの接着分子の発現に及ぼす影響の評価

    盛本 舞, 麻生 菜央, 武山 藍, 鵜殿 美弥子, 田中 愛健, 照屋 輝一郎, 片倉 喜範, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2022.5  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • ラットにおけるビタミンD欠乏性骨粗鬆症に対する食事植物ステロールの影響

    和 文昭, 田中 愛健, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • マウスおよびラットにおいて12α水酸化胆汁酸の存在比は肝脂質蓄積と相関する

    岩崎 若菜, 吉田 凌, 堀 将太, 田中 愛健, 佐藤 匡央, 石塚 敏

    日本栄養・食糧学会大会講演要旨集  2022.5  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • チーズ中のステロールとその生理作用の探索

    張 博鯤, 平井 諒, 空閑 朱音, 上野 宏, 田中 愛健, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • 6-Ketocholestanolはβ酸化活性の上昇を介してラット骨格筋の脂肪酸代謝を亢進する

    伊藤 綺更, 大坪 友樹, 大川 知奈美, 古賀 舞子, 今泉 勝己, 田中 愛健, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

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    Language：Japanese  

  • 24-methylene-cholesterolはヒト培養表皮角化細胞(HaCaT)中のコラーゲンを増加させる

    平井 諒, 張 博鯤, 服部 来実, 田中 愛健, 佐藤 匡央

    日本栄養・食糧学会大会講演要旨集  2024.4  (公社)日本栄養・食糧学会

    　More details

    Language：Japanese  

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Industrial property rights

Patent   Number of applications: 3   Number of registrations: 3
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • Japan Society of Nutrition and Food Science

  • Japan Society for Bioscience, Biotechnology, and Agrochemistry

  • The Japanese society for food science and technology

  • Japan Society of Nutrition and Food Science

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  • The Japanese society for food science and technology

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  • Japan Society for Bioscience, Biotechnology, and Agrochemistry

    　 More details

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Committee Memberships

  • Steering committee member   Domestic

    2023.5 - 2024.6   

  • Steering committee member   Domestic

    2023.5 - 2024.6   

  • 日本栄養・食糧学会   第78回日本栄養・食糧学会大会実行委員会　プログラム編成担当   Domestic

    2023.5 - 2024.6   

  • 日本栄養・食糧学会   第78回日本栄養・食糧学会大会実行委員会　会計担当   Domestic

    2023.5 - 2024.6   

  • 日本栄養・食糧学会   運営委員  

    2023.5 - 2024.6   

    　 More details

  • 日本栄養・食糧学会   運営委員  

    2023.5 - 2024.6   

    　 More details

  • Organizer   Domestic

    2020.5 - 2026.5   

  • Organizer   Domestic

    2020.5 - 2026.5   

  • 日本栄養・食糧学会   日本栄養・食糧学会　九州・沖縄支部　会計幹事   Domestic

    2020.5 - 2026.5   

  • 日本栄養・食糧学会   日本栄養・食糧学会　九州・沖縄支部　庶務幹事   Domestic

    2020.5 - 2026.5   

  • 日本栄養・食糧学会   幹事  

    2020.5 - 2024.5   

    　 More details

  • 日本栄養・食糧学会 九州・沖縄支部   庶務幹事・会計幹事  

    2020.5 - 2022.5   

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Academic Activities

  • Screening of academic papers

    Role(s)： Peer review

    2023

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2022

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：5

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2021

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

  • Screening of academic papers

    Role(s)： Peer review

    2020

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

    Number of peer-reviewed articles in Japanese journals：0

    Proceedings of International Conference Number of peer-reviewed papers：0

    Proceedings of domestic conference Number of peer-reviewed papers：0

Research Projects

  • 卵白タンパク加水分解物による腸内発酵促進の作用機序解明とその利用

    2024

    2024年度旗影会研究助成

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    Authorship：Principal investigator  Grant type：Contract research

  • 腸内細菌代謝産物に焦点を当てた高食肉摂取による健康増進と病態発症の分岐点の解明

    Grant number：23K21620  2021.4 - 2025.3

    科学研究費助成事業  基盤研究(B)

    清水 英寿, 石塚 敏, 橋口 亜由未, 吹谷 智, 吉清 恵介, 田中 愛健

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    Grant type：Scientific research funding

    近年、高食肉摂取において、健康増進に寄与する一方、疾患発症・進展にも関与するという相反する効果が疫学的な調査から実証されている。しかし、この要因に関する詳細は、未だ不明である。当研究グループでは現在までに、腸内で産生される摂取タンパク質由来の腸内細菌代謝産物インドール系化合物の種類と量の違いが、各種組織の機能障害を導く一方、それら障害に対して予防・改善効果を導く事を示唆する結果を得
    ている。よって本研究では、「各種インドール系化合物が臓器機能に与える影響とその作用メカニズムの解明」、および「腸内におけるインドール系化合物の代謝促進に寄与する因子の同定」を試みる。

    CiNii Research

  • 三大栄養素の代謝を制御する遺伝子Smek2の機能解析

    Grant number：21K14806  2021 - 2023

    日本学術振興会  科学研究費助成事業  若手研究

    田中 愛健

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    Authorship：Principal investigator  Grant type：Scientific research funding

    本研究は代表者らが食事誘導性高コレステロール血症の原因遺伝子として同定した、遺伝子Smek2の機能性の解明に取り組むものである。Smek2の機能をより厳密に解析するため、ゲノム編集技術を利用してSmek2ノックアウトラットを確立する。また、Smek2の機能異常によって食事誘導性高コレステロール血症以外の病態の発生が予測されるため、その側面を評価し、新規モデル動物としての可能性も探索する。

    CiNii Research

  • 卵白タンパク加水分解物による肝臓脂肪分泌促進の作用機序解明とその利用法の確立

    2021

    2021年度旗影会研究助成

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    Authorship：Principal investigator  Grant type：Contract research

Class subject

  • 基礎科学実習

    2024.12 - 2025.2   Winter quarter

  • 栄養化学実験

    2024.4 - 2024.9   First semester

  • 食品機能学特論

    2024.4 - 2024.6   Spring quarter

  • 生物統計学

    2024.4 - 2024.6   Spring quarter

  • 物理化学実験

    2023.10 - 2024.3   Second semester

  • 栄養化学実験

    2023.4 - 2023.9   First semester

  • 食品機能学特論

    2023.4 - 2023.6   Spring quarter

  • 生物統計学

    2023.4 - 2023.6   Spring quarter

  • 物理化学実験（食糧化学工学分野）

    2022.10 - 2023.3   Second semester

  • 物理化学実験

    2022.10 - 2023.3   Second semester

  • 栄養生理学

    2022.10 - 2022.12   Fall quarter

  • 栄養化学実験

    2022.4 - 2022.9   First semester

  • 食品機能学特論

    2022.4 - 2022.6   Spring quarter

  • 食品機能学特論

    2022.4 - 2022.6   Spring quarter

  • 物理化学実験（食糧化学工学分野）

    2021.10 - 2022.3   Second semester

  • 栄養化学実験

    2021.4 - 2021.9   First semester

  • 食品機能学特論

    2021.4 - 2021.6   Spring quarter

  • 栄養化学実験

    2020.4 - 2020.9   First semester

  • 基礎科学実習

    2024.12 - 2025.2   Winter quarter

  • 栄養化学実験

    2024.4 - 2024.9   First semester

  • 生物統計学

    2024.4 - 2024.6   Spring quarter

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FD Participation

  • 2022.3   Role：Participation   Title：農学研究院FD：国費特別プログラム「未来の農を描くビジョンデザイン実践プログラム」実施に向けて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2022.3   Role：Participation   Title：全学FD:メンタルヘルス講演会

    Organizer：University-wide

  • 2022.3   Role：Participation   Title：農学研究院FD：リポジトリ登録を対象とした大学改革推進経費の新指標案について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.11   Role：Participation   Title：農学研究院FD「人を対象とする生命科学・医学系研究に関する倫理指針」について

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.7   Role：Participation   Title：農学研究院FD「科研費を獲りにいこう！　科研費獲得の技術と工夫」

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2021.3   Role：Participation   Title：大学院学際教育の質向上に関するFD：2018-2019年度NEEP成果をふまえて

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.12   Role：Participation   Title：大学の研究評価の現状と農学研究院の「部局独自の評価基準」案における業績分析

    Organizer：[Undergraduate school/graduate school/graduate faculty]

  • 2020.9   Role：Participation   Title：科研費を獲りにいこう！　勝ち抜く気合と技術

    Organizer：[Undergraduate school/graduate school/graduate faculty]

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