Updated on 2024/10/01

Information

 

写真a

 
OKUMA TOSHIAKI
 
Organization
Kyushu University Hospital Department of Nephrology,Hypertension,and Strokology Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Tel
0926425256
Profile
研究 九州大学および関連施設と共同で行っている大規模ゲノムコホート研究、福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry; FDR)に従事している。 臨床 九州⼤学病院における糖尿病の診療を⾏っている.対象となる疾患は、1型糖尿病、2型糖尿病、遺伝⼦異常による糖尿病や薬剤による糖尿病、妊娠糖尿病、移植後糖尿病、インスリノーマ等の低⾎糖症など。特に⽣体腎移植や膵腎同時移植の周術期の⾎糖管理に関わることが多い。 教育 医学部学生に対する講義、ベッドサイド実習、クリニカルクラークシップでの指導を行っている。 大学院生に対して臨床疫学研究、論文作成について指導している。
External link

Degree

  • 医学博士

Research Interests・Research Keywords

  • Research theme:The Fukuoka Diabetes Registry: a multicenter prospective study designed to investigate the influence of the modern treatments on the prognoses of patients with diabetes mellitus

    Keyword:Diabetes Mellitus、Clinical epidemiology

    Research period: 2009.4 - 2025.5

Awards

  • 九州大学第二内科 尾前賞

    2023.11  

  • 牛乳乳製品健康科学 2021年度研究 最優秀賞

    2022.8  

  • 2021 AJKD Editors’ Choice Award

    2021.11  

  • 九州大学第二内科同門会賞奨励賞

    2019.11  

  • The John Chalmers Post-Doctoral Award 2018

    2018.12  

  • 日本高血圧学会 Hypertension Research Award 優秀賞

    2017.10  

  • 日本糖尿病学会九州支部賞

    2014.11  

  • 九州大学第二内科同門会賞奨励賞

    2013.11  

  • Kyushu Diabetes Research Conference 最優秀奨励賞

    2012.6  

  • 福岡県医学会総会 ポスター優秀賞

    2012.1  

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Papers

  • Sleep duration and its association with constipation in patients with diabetes: The fukuoka diabetes registry. International journal

    Toshiaki Ohkuma, Masanori Iwase, Takanari Kitazono

    PloS one   19 ( 5 )   e0302430   2024

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    AIMS: Shorter and longer sleep durations are associated with adverse health consequences. However, available evidence on the association of sleep duration with constipation is limited, especially in patients with diabetes, who are at a high risk of both conditions. This study aimed to examine the association between sleep duration and constipation in patients with type 2 diabetes. METHODS: A total of 4,826 patients with type 2 diabetes were classified into six groups according to sleep duration: <4.5, 4.5-5.4, 5.5-6.4, 6.5-7.4, 7.5-8.4, and ≥8.5 hours/day. The odds ratios for the presence of constipation, defined as a defecation frequency <3 times/week and/or laxative use, were calculated using a logistic regression model. RESULTS: Shorter and longer sleep durations were associated with a higher likelihood of constipation than an intermediate duration (6.5-7.4 hours/day). This U-shaped association persisted after adjusting for confounding factors, including lifestyle behavior, measures of obesity and glycemic control, and comorbidities. Broadly identical findings were observed when decreased defecation frequency and laxative use were individually assessed. CONCLUSIONS: This study shows a U-shaped association between sleep duration and constipation in patients with type 2 diabetes, and highlights the importance of assessing sleep duration in daily clinical practice.

    DOI: 10.1371/journal.pone.0302430

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  • ASL灌流像が診断に有用であった可逆性後頭葉白質脳症(PRES)合併2型糖尿病の1例

    牟田 大毅, 岩瀬 正典, 井手 均, 青谷 領一郎, 平田 詩乃, 高木 可南子, 酒匂 哲平, 由比 智裕, 宇都宮 英綱, 大隈 俊明, 北園 孝成

    糖尿病   66 ( 9 )   697 - 704   2023.9

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    症例は56歳の男性で頭痛,嘔吐,意識障害のため救急搬送された.血圧192/100mmHg,血糖233mg/dL,HbA1c 10.8&#37;,蛋白尿12.0g/gCr,血清アルブミン2.1g/dL,eGFR 41mL/min/1.73m2,右下1/4盲を認めた.頭部MRIのFLAIR,T2強調画像で両側側脳室周囲白質に慢性虚血性変化が認められたが,その他には異常信号域は認められなかった.arterial spin labeling(ASL)では左側頭葉から後頭葉にかけて過灌流状態であった.Posterior Reversible Encephalopathy Syndrome(PRES)と診断し,降圧治療とインスリン治療を施行した.経過中,無症候性の微小脳梗塞を発症したが,過灌流は改善し,右下1/4盲は改善した.ASLはPRESの診断に有用である.(著者抄録)

  • Incidence and risks of coronary heart disease and heart failure in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. International journal

    Masanori Iwase, Toshiaki Ohkuma, Hiroki Fujii, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Hitoshi Ide, Udai Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   201   110732 - 110732   2023.5

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    DOI: 10.1016/j.diabres.2023.110732

  • Sex differences in cardiovascular risk, lifestyle, and psychological factors in patients with type 2 diabetes: the Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Takanari Kitazono

    Biology of sex differences   14 ( 1 )   32 - 32   2023.5

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    DOI: 10.1186/s13293-023-00517-8

  • Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD).

    Mai Seki, Toshiaki Nakano, Shigeru Tanaka, Yuta Matsukuma, Kouta Funakoshi, Toshiaki Ohkuma, Takanari Kitazono

    Clinical and experimental nephrology   27 ( 4 )   358 - 364   2023.2

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    DOI: 10.1007/s10157-023-02322-4

  • Onset of type 1 diabetes during bone growth period is associated with increased prevalence of bone fracture: A post-hoc analysis of a cross-sectional study.

    2022.9

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    In this single-center, cross-sectional study, we demonstrated that the prevalence of fracture was significantly higher in patients who onset type 1 diabetes during 0-4 years, and 10-14 years compared with adult-onset type 1 diabetes. We are aware that this study contains a lot of limitations including non-prospective study design and a small number of participants. However, the results of this study, if followed by a larger cohort study, could provide important insights into the increased risk of fracture in patients with type 1 diabetes, and suggest the need for attention and perhaps early intervention for patients with type 1 diabetes who developed during these periods.

    DOI: 10.1111/jdi.13898

  • Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality: Results from a Randomized Controlled Trial of ACE Inhibitors. International journal

    Toshiaki Ohkuma, Katie Harris, Mark Cooper, Diederick E Grobbee, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Anushka Patel, Anthony Rodgers, Bryan Williams, Mark Woodward, John Chalmers

    Clinical journal of the American Society of Nephrology : CJASN   17 ( 8 )   1139 - 1149   2022.8

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    DOI: 10.2215/CJN.00180122

  • HLA-DRB1*04:04を有した高齢インスリン自己免疫症候群(平田病)の1例

    原 規子, 平田 詩乃, 高木 可南子, 於久 祐太郎, 牟田 大毅, 井手 均, 岩瀬 正典, 大隈 俊明, 北園 孝成

    糖尿病   65 ( 6 )   312 - 318   2022.6

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    我が国は超高齢化社会を迎え,低血糖を呈する非糖尿病の高齢者を診療する機会が増加している.今回,88歳男性で認知機能低下,不穏で救急搬送され,血糖38mg/dLの症例を経験した.高インスリン血症を認め(349μU/mL),インスリン抗体高値,Scatchard解析で低親和性高結合能のインスリン抗体を認めた.インスリン自己免疫症候群と関連するHLAを有さず,DRB1*04:04を認めた.インスリン自己免疫症候群を誘発することが知られているクロピドグレルを含む常用薬をすべて中止し,分割食,間食,さらに,ボグリボースを追加したが低血糖は改善しなかった.そのためプレドニゾロン30mg/日から開始したところ低血糖は消失し,血中インスリンやインスリン抗体も徐々に減少した.既知のHLA遺伝要因を有さない高齢者でインスリン自己免疫症候群を発症することがあり,臨床上注意が必要である.(著者抄録)

  • Usefulness of urinary tubule injury markers for predicting progression of renal dysfunction in patients with type 2 diabetes and albuminuria: The Fukuoka Diabetes Registry. International journal

    Hitoshi Ide, Masanori Iwase, Toshiaki Ohkuma, Hiroki Fujii, Yuji Komorita, Yutaro Oku, Taiki Higashi, Masahito Yoshinari, Udai Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   186   109840 - 109840   2022.3

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    DOI: 10.1016/j.diabres.2022.109840

  • Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry.

    2022.2

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    AIMS/INTRODUCTION: The evidence regarding the effects of coffee consumption on incident chronic kidney disease is inconclusive, and no studies have investigated the relationship in patients with diabetes. We aimed to prospectively investigate the relationship between coffee consumption and the decline in estimated glomerular function rate (eGFR) in patients with type 2 diabetes. MATERIALS AND METHODS: A total of 3,805 patients (2,112 men, 1,693 women) with type 2 diabetes (mean age 64.2 years) and eGFR ≥60 mL/min/1.73 m2 were followed (completion of follow up, 97.6%; median 5.3 years). Coffee consumption was assessed at baseline. The end-point was a decline in eGFR to <60 mL/min/1.73 m2 during the follow-up period. RESULTS: During follow up, 840 participants experienced a decline in eGFR to <60 mL/min/1.73 m2 . Higher coffee consumption reduced the risk of decline in eGFR. Compared with no coffee consumption, the multivariate-adjusted hazard ratios (95% confidence intervals) were 0.77 (0.63-0.93) for less than one cup per day, 0.77 (0.62-0.95) for one cup per day and 0.75 (0.62-0.91) for two or more cups per day (P for trend 0.01). This trend was unaffected by further adjustment for baseline eGFR and albuminuria. The mean eGFR change per year was -2.16 mL/min/1.73 m2 with no coffee consumption, -1.89 mL/min/1.73 m2 with less than one cup per day, -1.80 mL/min/1.73 m2 with one cup per day and -1.78 mL/min/1.73 m2 with two or more cups per day (P for trend 0.03). CONCLUSIONS: Coffee consumption is significantly associated with a lower risk of decline in eGFR in patients with type 2 diabetes.

    DOI: 10.1111/jdi.13769

  • Safety and Efficacy of Sodium-glucose Cotransporter 2 Inhibitors in Kidney Transplant Recipients With Pretransplant Type 2 Diabetes Mellitus: A Retrospective, Single-center, Inverse Probability of Treatment Weighting Analysis of 85 Transplant Patients. International journal

    Yu Hisadome, Takanori Mei, Hiroshi Noguchi, Toshiaki Ohkuma, Yu Sato, Keizo Kaku, Yasuhiro Okabe, Masafumi Nakamura

    Transplantation direct   7 ( 11 )   e772   2021.11

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    DOI: 10.1097/TXD.0000000000001228

  • Polypharmacy and bone fracture risk in patients with type 2 diabetes: The Fukuoka Diabetes Registry. International journal

    Yuji Komorita, Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Wakako Sakamoto, Masahito Yoshinari, Udai Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   181   109097 - 109097   2021.11

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    DOI: 10.1016/j.diabres.2021.109097

  • Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry.

    Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Yuji Komorita, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Ayaka Oshiro, Udai Nakamura, Takanari Kitazono

    Clinical and experimental nephrology   25 ( 11 )   1247 - 1254   2021.11

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    DOI: 10.1007/s10157-021-02105-9

  • Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry.

    Masanori Iwase, Hitoshi Ide, Toshiaki Ohkuma, Hiroki Fujii, Yuji Komorita, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

    Clinical and experimental nephrology   26 ( 2 )   122 - 131   2021.9

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    DOI: 10.1007/s10157-021-02136-2

  • Changes in GFR and Albuminuria in Routine Clinical Practice and the Risk of Kidney Disease Progression. International journal

    Brendon L Neuen, Misghina Weldegiorgis, William G Herrington, Toshiaki Ohkuma, Margaret Smith, Mark Woodward

    American journal of kidney diseases : the official journal of the National Kidney Foundation   78 ( 3 )   350 - 360   2021.9

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    DOI: 10.1053/j.ajkd.2021.02.335

  • The comparative effects of intensive glucose lowering in diabetes patients aged below or above 65 years: Results from the ADVANCE trial. International journal

    23 ( 6 )   1292 - 1300   2021.6

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    AIMS: For relatively old patients with diabetes, current guidelines recommend adjustment of glycaemic goals based on patients' cognitive function, or coexisting chronic illnesses. However, the evidence which supports the efficacy and safety of intensive glucose lowering in older patients with diabetes is scarce. The objective of the present study was to compare the efficacy and safety of intensive glucose lowering in patients with type 2 diabetes stratified by age (<65 and ≥ 65 years), and examine whether the effects differ according to patients' characteristics in the older patient group. MATERIALS AND METHODS: The effects of intensive glucose lowering (to a target glycated haemoglobin [HbA1c] concentration of ≤48 mmol/mol [6.5%]) on major clinical outcomes were evaluated by Cox regression models according to subgroups defined by baseline age of <65 or ≥ 65 years in the ADVANCE trial (n = 11 140). RESULTS: Over a median follow-up of 5 years, intensive glucose lowering significantly decreased the risk of the composite of major macrovascular and microvascular events (hazard ratio 0.90, 95% confidence interval 0.82-0.98), with no heterogeneity in the effects across age subgroups (p for heterogeneity = 0.44). Relative effects on all-cause death, cardiovascular death, and components of major vascular events were also similar (P for heterogeneity ≥0.06), except for severe hypoglycaemia, which was of greater risk for patients aged <65 years. Absolute benefits and harms were broadly consistent across subgroups. Among patients aged ≥65 years, randomized treatment effects did not differ significantly across different levels of cognitive function or coexisting chronic illnesses. CONCLUSIONS: Our results suggest that an intensive glycaemic control strategy to reduce HbA1c to 48 mmol/mol (6.5%) provided broadly similar benefits and harms and may be recommended for older, as well as younger, patients.

    DOI: 10.1111/dom.14339

  • An adult patient with permanent neonatal diabetes successfully discontinued insulin therapy after initiating sitagliptin added to sulphonylurea. International journal

    Ayaka Oshiro, Toshiaki Ohkuma, Wakako Sakamoto, Yuji Komorita, Yutaro Oku, Yoichiro Hirakawa, Takanari Kitazono

    Diabetes, obesity & metabolism   23 ( 5 )   1213 - 1214   2021.5

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    DOI: 10.1111/dom.14318

  • Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. International journal

    Yuji Komorita, Masae Minami, Yasutaka Maeda, Rie Yoshioka, Toshiaki Ohkuma, Takanari Kitazono

    BMJ open diabetes research & care   9 ( 1 )   2021.4

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    DOI: 10.1136/bmjdrc-2020-002099

  • Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Yuji Komorita, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

    Journal of diabetes and its complications   35 ( 2 )   107751 - 107751   2021.2

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    DOI: 10.1016/j.jdiacomp.2020.107751

  • Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. International journal

    Masanori Iwase, Yuji Komorita, Toshiaki Ohkuma, Hiroki Fujii, Hitoshi Ide, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   172   108518 - 108518   2021.2

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    DOI: 10.1016/j.diabres.2020.108518

  • Relative and Absolute Risk Reductions in Cardiovascular and Kidney Outcomes With Canagliflozin Across KDIGO Risk Categories: Findings From the CANVAS Program. International journal

    Brendon L Neuen, Toshiaki Ohkuma, Bruce Neal, David R Matthews, Dick de Zeeuw, Kenneth W Mahaffey, Greg Fulcher, Jaime Blais, Qiang Li, Meg J Jardine, Vlado Perkovic, David C Wheeler

    American journal of kidney diseases : the official journal of the National Kidney Foundation   77 ( 1 )   23 - 34   2021.1

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    DOI: 10.1053/j.ajkd.2020.06.018

  • Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. International journal

    Hirofumi Tomiyama, Charalambos Vlachopoulos, Panagiotis Xaplanteris, Hiroki Nakano, Kazuki Shiina, Tomoko Ishizu, Takahide Kohro, Yukihito Higashi, Bonpei Takase, Toru Suzuki, Tsutomu Yamazaki, Tomoo Furumoto, Kazuomi Kario, Teruo Inoue, Shinji Koba, Yasuhiko Takemoto, Takuzo Hano, Masataka Sata, Yutaka Ishibashi, Koichi Node, Atsushi Tanaka, Koji Maemura, Yusuke Ohya, Taiji Furukawa, Hiroshi Ito, Toshiaki Ohkuma, Toshiharu Ninomiya, Taishiro Chikamori, Akira Yamashina, Shin-Ichiro Ueda

    Hypertension research : official journal of the Japanese Society of Hypertension   43 ( 11 )   1284 - 1292   2020.11

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    DOI: 10.1038/s41440-020-0472-7

  • Sex-specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: The ADVANCE-ON study. International journal

    Toshiaki Ohkuma, Sanne A E Peters, Min Jun, Stephen Harrap, Mark Cooper, Pavel Hamet, Neil Poulter, John Chalmers, Mark Woodward

    Diabetes, obesity & metabolism   22 ( 10 )   1818 - 1826   2020.10

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    DOI: 10.1111/dom.14103

  • Home monitoring with technology-supported management in chronic heart failure: a randomised trial. International journal

    Kazem Rahimi, Milad Nazarzadeh, Ana-Catarina Pinho-Gomes, Mark Woodward, Gholamreza Salimi-Khorshidi, Toshiaki Ohkuma, Raymond Fitzpatrick, Lionel Tarassenko, Mike Denis, John Cleland

    Heart (British Cardiac Society)   106 ( 20 )   1573 - 1578   2020.10

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    DOI: 10.1136/heartjnl-2020-316773

  • Different eGFR Decline Thresholds and Renal Effects of Canagliflozin: Data from the CANVAS Program. International journal

    Megumi Oshima, Bruce Neal, Tadashi Toyama, Toshiaki Ohkuma, Qiang Li, Dick de Zeeuw, Hiddo J L Heerspink, Kenneth W Mahaffey, Gregory Fulcher, William Canovatchel, David R Matthews, Vlado Perkovic

    Journal of the American Society of Nephrology : JASN   31 ( 10 )   2446 - 2456   2020.10

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    DOI: 10.1681/ASN.2019121312

  • Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. International journal

    Yuji Komorita, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Masahito Yoshinari, Yutaro Oku, Taiki Higashi, Udai Nakamura, Takanari Kitazono

    BMJ open diabetes research & care   8 ( 1 )   2020.10

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    DOI: 10.1136/bmjdrc-2020-001252

  • Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry.

    11 ( 5 )   1258 - 1264   2020.9

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    AIMS/INTRODUCTION: The incidence of severe hypoglycemia and its risk factors including an insulin-sensitizing adipokine, adiponectin, were prospectively investigated in Japanese patients with type 1 or insulin-treated type 2 diabetes. MATERIALS AND METHODS: A total of 207 participants with type 1 diabetes (mean age 55 years) and 1,396 with insulin-treated type 2 diabetes (mean age 65 years) from the local diabetes registry were followed for 5 years (follow-up rate 99%). Severe hypoglycemia was defined as events requiring the assistance of others for recovery from hypoglycemia. RESULTS: The incidence of severe hypoglycemia was 9.2 per 100 person-years in those with type 1 diabetes, and 2.3 per 100 person-years in those with insulin-treated type 2 diabetes, respectively. For type 1 diabetes, the risk was significant in those with a history of severe hypoglycemia within the previous year, slow eating and higher serum adiponectin (the highest vs the lowest in quartile hazard ratio 2.36, 95% confidence interval 1.22-4.69). For insulin-treated type 2 diabetes, the risk included age ≥65 years, history of severe hypoglycemia within the previous year, alcohol consumption ≥60 g/day, larger insulin dose and higher serum adiponectin (the highest vs the lowest in quartile, hazard ratio 2.95, 95% confidence interval 1.22-4.69). For all participants, the incidence of severe hypoglycemia increased along with serum adiponectin (age- and sex-adjusted hazard ratio 1.65 per 1 standard deviation increase of log serum adiponectin, 95% confidence interval 1.45-1.87). CONCLUSIONS: The incidence of severe hypoglycemia was prospectively determined, and the association between severe hypoglycemia and higher serum adiponectin was observed in Japanese patients with type 1 and insulin-treated type 2 diabetes.

    DOI: 10.1111/jdi.13253

  • Effects of Intensive Glycemic Control on Clinical Outcomes Among Patients With Type 2 Diabetes With Different Levels of Cardiovascular Risk and Hemoglobin A1c in the ADVANCE Trial. International journal

    Jingyan Tian, Toshiaki Ohkuma, Mark Cooper, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Ji-Guang Wang, Sophia Zoungas, Mark Woodward, John Chalmers

    Diabetes care   43 ( 6 )   1293 - 1299   2020.6

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    DOI: 10.2337/dc19-1817

  • Clinical outcomes with canagliflozin according to baseline body mass index: results from post hoc analyses of the CANVAS Program. International journal

    Toshiaki Ohkuma, Luc Van Gaal, Wayne Shaw, Kenneth W Mahaffey, Dick de Zeeuw, David R Matthews, Vlado Perkovic, Bruce Neal

    Diabetes, obesity & metabolism   22 ( 4 )   530 - 539   2020.4

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    DOI: 10.1111/dom.13920

  • Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. International journal

    Obesity reviews : an official journal of the International Association for the Study of Obesity   21 ( 4 )   e12989   2020.4

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    DOI: 10.1111/obr.12989

  • Intensive glucose-lowering and the risk of vascular events and premature death in patients with decreased kidney function: The ADVANCE trial. International journal

    Toshiaki Ohkuma, Sophia Zoungas, Min Jun, Liu Lisheng, Giuseppe Mancia, Michel Marre, Anthony Rodgers, Bryan Williams, Mark Woodward, John Chalmers

    Diabetes, obesity & metabolism   22 ( 3 )   452 - 457   2020.3

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    DOI: 10.1111/dom.13878

  • Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry.

    11 ( 1 )   62 - 69   2020.1

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    AIMS/INTRODUCTION: Patients with type 2 diabetes mellitus have an increased hip fracture risk. We investigated the relationship between hip fracture and all-cause death in patients with type 2 diabetes in comparison with cardiovascular disease (CVD) or end-stage renal disease (ERSD). MATERIALS AND METHODS: In total, 4,923 Japanese participants with type 2 diabetes (mean age 65 years, 2,790 men, 2,133 women) were followed for a median of 5.3 years (follow-up rate 99.5%). We evaluated the associations between the presence of hip fracture (n = 110), upper limb fracture (n = 801), CVD (n = 1,344), ESRD (n = 104) and all-cause death by logistic regression analysis. RESULTS: A total of 309 participants died during follow up. Multivariate-adjusted odds ratios (ORs) for all-cause mortality were significantly higher in participants with hip fractures than those without hip fractures (OR 2.67, 95% confidence interval [CI] 1.54-4.41), whereas the ORs for upper limb fracture were not significant. The ORs for all-cause mortality were significantly higher in participants with CVD than those without CVD (OR 1.78, 95% CI, 1.39-2.70) and ESRD (OR 2.36, 95% CI 1.32-4.05). The ORs for all-cause mortality of hip fracture were not affected by further adjustment for CVD and ESRD (OR 2.74, 95% CI 1.58-4.54). The cause of death was infection (40.0%), malignant neoplasm (25.0%) and CVD (15.0%) among participants with hip fracture. CONCLUSIONS: Hip fractures were associated with an increased risk of death among Japanese patients with type 2 diabetes, independently of CVD and ESRD.

    DOI: 10.1111/jdi.13076

  • The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE. International journal

    Alexandra K Lee, Mark Woodward, Dan Wang, Toshiaki Ohkuma, Bethany Warren, A Richey Sharrett, Bryan Williams, Michel Marre, Pavel Hamet, Stephen Harrap, John W Mcevoy, John Chalmers, Elizabeth Selvin

    The Journal of clinical endocrinology and metabolism   105 ( 1 )   2020.1

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    DOI: 10.1210/clinem/dgz045

  • Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index β-Transformed Value as Risk Marker for Cardiovascular Disease. International journal

    8 ( 24 )   e013004   2019.12

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    Background The difference in the predictive ability of the brachial-ankle pulse wave velocity (baPWV) and its stiffness index β-transformed value (β-baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined. Methods and Results In study 1, a 7-year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β-baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3-year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. Conclusions Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects.

    DOI: 10.1161/JAHA.119.013004

  • Effect of Canagliflozin on Renal and Cardiovascular Outcomes across Different Levels of Albuminuria: Data from the CANVAS Program. International journal

    Brendon L Neuen, Toshiaki Ohkuma, Bruce Neal, David R Matthews, Dick de Zeeuw, Kenneth W Mahaffey, Greg Fulcher, Qiang Li, Meg Jardine, Richard Oh, Hiddo L Heerspink, Vlado Perkovic

    Journal of the American Society of Nephrology : JASN   30 ( 11 )   2229 - 2242   2019.11

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    DOI: 10.1681/ASN.2019010064

  • The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study. International journal

    Megumi Oshima, Min Jun, Toshiaki Ohkuma, Tadashi Toyama, Takashi Wada, Mark E Cooper, Samy Hadjadj, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Bryan Williams, John Chalmers, Mark Woodward, Vlado Perkovic

    Diabetologia   62 ( 11 )   1988 - 1997   2019.11

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    DOI: 10.1007/s00125-019-4948-4

  • Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. International journal

    Tadashi Toyama, Oliver van den Broek-Best, Toshiaki Ohkuma, David Handelsman, Louise M Waite, Markus J Seibel, Robert Cumming, Vasi Naganathan, Cathie Sherrington, Vasant Hirani, Amanda Y Wang

    The journals of gerontology. Series A, Biological sciences and medical sciences   74 ( 11 )   1812 - 1820   2019.10

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    DOI: 10.1093/gerona/glz100

  • Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry.

    Masanori Iwase, Hiroki Fujii, Yasuhiro Idewaki, Udai Nakamura, Toshiaki Ohkuma, Hitoshi Ide, Yuji Komorita, Tamaki Jodai-Kitamura, Masahito Yoshinari, Takanari Kitazono

    Diabetology international   10 ( 4 )   260 - 267   2019.10

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    DOI: 10.1007/s13340-019-00390-0

  • Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals. International journal

    Toshiaki Ohkuma, Yuji Komorita, Sanne A E Peters, Mark Woodward

    Diabetologia   62 ( 9 )   1550 - 1560   2019.9

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    DOI: 10.1007/s00125-019-4926-x

  • Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes. International journal

    Toshiaki Ohkuma, Min Jun, John Chalmers, Mark E Cooper, Pavel Hamet, Stephen Harrap, Sophia Zoungas, Vlado Perkovic, Mark Woodward

    Clinical journal of the American Society of Nephrology : CJASN   14 ( 6 )   862 - 872   2019.6

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    DOI: 10.2215/CJN.13391118

  • Effects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus. International journal

    Faisal Rahman, John W McEvoy, Toshiaki Ohkuma, Michel Marre, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Anthony Rodgers, Elizabeth Selvin, Bryan Williams, Paul Muntner, John Chalmers, Mark Woodward

    Hypertension (Dallas, Tex. : 1979)   73 ( 6 )   1291 - 1299   2019.6

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    DOI: 10.1161/HYPERTENSIONAHA.118.12414

  • Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis. International journal

    Tadashi Toyama, Brendon L Neuen, Min Jun, Toshiaki Ohkuma, Bruce Neal, Meg J Jardine, Hiddo L Heerspink, Muh Geot Wong, Toshiharu Ninomiya, Takashi Wada, Vlado Perkovic

    Diabetes, obesity & metabolism   21 ( 5 )   1237 - 1250   2019.5

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    DOI: 10.1111/dom.13648

  • Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention. International journal

    Hirofumi Tomiyama, Toshiaki Ohkuma, Toshiharu Ninomiya, Chisa Mastumoto, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina

    Hypertension (Dallas, Tex. : 1979)   73 ( 3 )   508 - 513   2019.3

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    DOI: 10.1161/HYPERTENSIONAHA.118.12110

  • Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus. International journal

    Toshiaki Ohkuma, Min Jun, Anthony Rodgers, Mark E Cooper, Paul Glasziou, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Michel Marre, Bruce Neal, Vlado Perkovic, Neil Poulter, Bryan Williams, Sophia Zoungas, John Chalmers, Mark Woodward

    Hypertension (Dallas, Tex. : 1979)   73 ( 1 )   84 - 91   2019.1

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    DOI: 10.1161/HYPERTENSIONAHA.118.12060

  • Is there evidence for sex differences in the association between diabetes and cancer? Reply to Dankner R, Boker LK, Freedman LS [letter]. International journal

    Toshiaki Ohkuma, Sanne A E Peters, Mark Woodward

    Diabetologia   62 ( 1 )   201 - 201   2019.1

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    DOI: 10.1007/s00125-018-4761-5

  • The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry. International journal

    Yuji Komorita, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Toshiaki Ohkuma, Tamaki Jodai-Kitamura, Akiko Sumi, Masahito Yoshinari, Udai Nakamura, Takanari Kitazono

    Diabetes research and clinical practice   146   202 - 210   2018.12

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    DOI: 10.1016/j.diabres.2018.10.021

  • Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function. International journal

    Brendon L Neuen, Toshiaki Ohkuma, Bruce Neal, David R Matthews, Dick de Zeeuw, Kenneth W Mahaffey, Greg Fulcher, Mehul Desai, Qiang Li, Hsiaowei Deng, Norm Rosenthal, Meg J Jardine, George Bakris, Vlado Perkovic

    Circulation   138 ( 15 )   1537 - 1550   2018.10

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    DOI: 10.1161/CIRCULATIONAHA.118.035901

  • Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events. International journal

    Toshiaki Ohkuma, Sanne A E Peters, Mark Woodward

    Diabetologia   61 ( 10 )   2140 - 2154   2018.10

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    DOI: 10.1007/s00125-018-4664-5

  • Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry.

    Akiko Sumi, Masanori Iwase, Udai Nakamura, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Takanari Kitazono

    Journal of diabetes investigation   9 ( 5 )   1216 - 1223   2018.9

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    DOI: 10.1111/jdi.12839

  • Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. International journal

    Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Victor Aboyans, Akira Yamashina

    Atherosclerosis   275   141 - 148   2018.8

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    DOI: 10.1016/j.atherosclerosis.2018.05.048

  • Use of the waist-to-height ratio to predict cardiovascular risk in patients with diabetes: Results from the ADVANCE-ON study. International journal

    Diabetes, obesity & metabolism   20 ( 8 )   1903 - 1910   2018.8

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    DOI: 10.1111/dom.13311

  • Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis. International journal

    Hirofumi Tomiyama, Toshiaki Ohkuma, Toshiharu Ninomiya, Chisa Mastumoto, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina

    Hypertension (Dallas, Tex. : 1979)   71 ( 6 )   1030 - 1038   2018.6

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    DOI: 10.1161/HYPERTENSIONAHA.118.10923

  • Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. International journal

    Yuji Komorita, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Akiko Sumi, Masahito Yoshinari, Udai Nakamura, Dongchon Kang, Takanari Kitazono

    Diabetes care   41 ( 5 )   1061 - 1067   2018.5

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    DOI: 10.2337/dc17-2004

  • Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. International journal

    Masanori Iwase, Hiroki Fujii, Udai Nakamura, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Akiko Sumi, Yuji Komorita, Masahito Yoshinari, Takanari Kitazono

    Diabetes research and clinical practice   137   183 - 189   2018.3

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    DOI: 10.1016/j.diabres.2018.01.020

  • Response to Comment on Ohkuma et al. Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial. Diabetes Care 2017;40:1203-1209. International journal

    Toshiaki Ohkuma, Mark Woodward, John Chalmers

    Diabetes care   41 ( 3 )   e39   2018.3

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    DOI: 10.2337/dci17-0060

  • Changes in Albuminuria and the Risk of Major Clinical Outcomes in Diabetes: Results From ADVANCE-ON. International journal

    Min Jun, Toshiaki Ohkuma, Sophia Zoungas, Stephen Colagiuri, Giuseppe Mancia, Michel Marre, David Matthews, Neil Poulter, Bryan Williams, Anthony Rodgers, Vlado Perkovic, John Chalmers, Mark Woodward

    Diabetes care   41 ( 1 )   163 - 170   2018.1

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    DOI: 10.2337/dc17-1467

  • The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. International journal

    Akiko Sumi, Udai Nakamura, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Yuji Komorita, Masahito Yoshinari, Yoichiro Hirakawa, Atsushi Hirano, Michiaki Kubo, Takanari Kitazono

    BMC medical genetics   18 ( 1 )   146 - 146   2017.12

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    DOI: 10.1186/s12881-017-0509-1

  • Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry. International journal

    Yuji Komorita, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai-Kitamura, Akiko Sumi, Masahito Yoshinari, Udai Nakamura, Dongchon Kang, Takanari Kitazono

    Diabetologia   60 ( 10 )   1922 - 1930   2017.10

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    DOI: 10.1007/s00125-017-4369-1

  • Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial. International journal

    Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers

    Diabetes care   40 ( 9 )   1203 - 1209   2017.9

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    DOI: 10.2337/dc17-0509

  • Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension.

    Toshiaki Ohkuma, Hirofumi Tomiyama, Toshiharu Ninomiya, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina

    Circulation journal : official journal of the Japanese Circulation Society   81 ( 10 )   1540 - 1542   2017.9

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    DOI: 10.1253/circj.CJ-17-0636

  • Joint impact of modifiable lifestyle behaviors on glycemic control and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry.

    Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Hitoshi Ide, Shinako Kaizu, Tamaki Jodai, Yohei Kikuchi, Yasuhiro Idewaki, Akiko Sumi, Udai Nakamura, Takanari Kitazono

    Diabetology international   8 ( 3 )   296 - 305   2017.8

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    DOI: 10.1007/s13340-017-0310-6

  • Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus: The ADVANCE-ON Study. International journal

    Toshiaki Ohkuma, Mark Woodward, Min Jun, Paul Muntner, Jun Hata, Stephen Colagiuri, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Peter Rothwell, John Chalmers

    Hypertension (Dallas, Tex. : 1979)   70 ( 2 )   461 - 468   2017.8

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    DOI: 10.1161/HYPERTENSIONAHA.117.09359

  • Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis. International journal

    Toshiaki Ohkuma, Toshiharu Ninomiya, Hirofumi Tomiyama, Kazuomi Kario, Satoshi Hoshide, Yoshikuni Kita, Toyoshi Inoguchi, Yasutaka Maeda, Katsuhiko Kohara, Yasuharu Tabara, Motoyuki Nakamura, Takayoshi Ohkubo, Hirotaka Watada, Masanori Munakata, Mitsuru Ohishi, Norihisa Ito, Michinari Nakamura, Tetsuo Shoji, Charalambos Vlachopoulos, Akira Yamashina

    Hypertension (Dallas, Tex. : 1979)   69 ( 6 )   1045 - 1052   2017.6

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    DOI: 10.1161/HYPERTENSIONAHA.117.09097

  • Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry.

    Hitoshi Ide, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Shinako Kaizu, Tamaki Jodai, Yohei Kikuchi, Yasuhiro Idewaki, Akiko Sumi, Udai Nakamura, Takanari Kitazono

    Clinical and experimental nephrology   21 ( 3 )   383 - 390   2017.6

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    DOI: 10.1007/s10157-016-1296-2

  • Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Udai Nakamura, Masanori Iwase, Hitoshi Ide, Hiroki Fujii, Tamaki Jodai, Shinako Kaizu, Yohei Kikuchi, Yasuhiro Idewaki, Akiko Sumi, Yoichiro Hirakawa, Takanari Kitazono

    Hypertension research : official journal of the Japanese Society of Hypertension   39 ( 10 )   744 - 751   2016.10

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    DOI: 10.1038/hr.2016.51

  • Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry. International journal

    Yasuhiro Idewaki, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Shinako Kaizu, Tamaki Jodai, Yohei Kikuchi, Atsushi Hirano, Udai Nakamura, Michiaki Kubo, Takanari Kitazono

    PloS one   10 ( 11 )   e0143288   2015.10

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    DOI: 10.1371/journal.pone.0143288

  • Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Masanori Iwase, Hiroki Fujii, Shinako Kaizu, Hitoshi Ide, Tamaki Jodai, Yohei Kikuchi, Yasuhiro Idewaki, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

    PloS one   10 ( 3 )   e0122023   2015.10

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    DOI: 10.1371/journal.pone.0122023

  • Association of severe hypoglycemia with depressive symptoms in patients with type 2 diabetes: the Fukuoka Diabetes Registry. International journal

    Yohei Kikuchi, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Shinako Kaizu, Hitoshi Ide, Tamaki Jodai, Yasuhiro Idewaki, Udai Nakamura, Takanari Kitazono

    BMJ open diabetes research & care   3 ( 1 )   e000063   2015.3

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    DOI: 10.1136/bmjdrc-2014-000063

  • Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. International journal

    Shinako Kaizu, Hiro Kishimoto, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Tamaki Jodai, Yohei Kikuchi, Yasuhiro Idewaki, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

    PloS one   9 ( 6 )   e98768   2014.9

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    DOI: 10.1371/journal.pone.0098768

  • U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Hiroki Fujii, Masanori Iwase, Shinako Ogata-Kaizu, Hitoshi Ide, Yohei Kikuchi, Yasuhiro Idewaki, Tamaki Jodai, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

    Metabolism: clinical and experimental   63 ( 4 )   484 - 91   2014.4

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    DOI: 10.1016/j.metabol.2013.12.001

  • Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. International journal

    Hiroki Fujii, Masanori Iwase, Toshiaki Ohkuma, Shinako Ogata-Kaizu, Hitoshi Ide, Yohei Kikuchi, Yasuhiro Idewaki, Tamaki Joudai, Yoichiro Hirakawa, Kazuhiro Uchida, Satoshi Sasaki, Udai Nakamura, Takanari Kitazono

    Nutrition journal   12   159 - 159   2013.12

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    DOI: 10.1186/1475-2891-12-159

  • Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes: the Fukuoka diabetes registry. International journal

    Toshiaki Ohkuma, Hiroki Fujii, Masanori Iwase, Shinako Ogata-Kaizu, Hitoshi Ide, Yohei Kikuchi, Yasuhiro Idewaki, Tamaki Jodai, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

    PloS one   8 ( 11 )   e78968   2013.8

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    DOI: 10.1371/journal.pone.0078968

  • Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters. International journal

    Shunsuke Yamada, Masanori Tokumoto, Toshiaki Ohkuma, Yasuo Kansui, Yoshinobu Wakisaka, Yuji Uchizono, Kazuhiko Tsuruya, Takanari Kitazono, Hiroaki Ooboshi

    Case reports in medicine   2013   498129 - 498129   2013.6

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    DOI: 10.1155/2013/498129

  • Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry. International journal

    Toshiaki Ohkuma, Hiroki Fujii, Masanori Iwase, Yohei Kikuchi, Shinako Ogata, Yasuhiro Idewaki, Hitoshi Ide, Yasufumi Doi, Yoichiro Hirakawa, Udai Nakamura, Takanari Kitazono

    Diabetes care   36 ( 3 )   611 - 7   2013.3

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    DOI: 10.2337/dc12-0904

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Presentations

  • Combination of changes in estimated GFR and albuminuria and the risk of major clinical outcomes in patients with type 2 diabetes: the ADVANCE-ON study International conference

    Toshiaki Ohkuma, Min Jun, John Chalmers, Sophia Zoungas, Vlado Perkovic, Mark Woodward

    Australasian Diabetes Congress 2018  2018.9 

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    Event date: 2022.4

    Language:Japanese  

    Country:Japan  

  • Sex-specific associations of conventional risk factors and duration of diabetes with myocardial infarction in type 2 diabetes: the ADVANCE-ON study International conference

    Toshiaki Ohkuma, Min Jun, John Chalmers, Mark Woodward

    Australasian Diabetes Congress 2019  2019.8 

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    Event date: 2019.8

    Language:Japanese  

    Country:Australia  

  • 2 型糖尿病患者におけるeGFR、アルブミン尿の変化が糖尿病合併症発症に及ぼす影響: ADVANCE-ON 研究

    大隈 俊明, Min Jun, John Chalmers, Sophia Zoungas, Vlado Perkovic, Mark Woodward

    日本臨床疫学会第2回年次学術大会  2018.9 

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    Event date: 2018.9

    Language:Japanese  

    Country:Japan  

  • Acute Increase in Creatinine after Starting ACE Inhibitor and Vascular Events and Premature Death in Patients with Type 2 Diabetes: the ADVANCE trial

    Toshiaki Ohkuma, Min Jun, Mark Woodward, John Chalmers, Vlado Perkovic, Anthony Rodgers

    American Diabetes Association 78th Scientific Sessions  2018.6 

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    Event date: 2018.6

    Language:English  

    Country:United States  

  • 2型糖尿病患者におけるACE阻害薬投与後早期のCr上昇と心血管病、腎症、総死亡との関連: ADVANCE試験

    大隈 俊明, Min Jun, Mark Woodward, John Chalmers, Vlado Perkovic, Anthony Rodgers

    第61 回日本糖尿病学会年次学術集会  2018.5 

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    Event date: 2018.5

    Language:Japanese  

    Country:Japan  

  • Cardiac stress and inflammatory markers as predictors of heart failure in patients with type 2 diabetes: the ADVANCE trial International conference

    Toshiaki Ohkuma , Min Jun , Sophia Zoungas , Paul Welsh , Naveed Sattar , Mark E. Cooper , Jonathan E. Shaw , John Chalmers , Mark Woodward

    2017 ADS/ADEA Annual Scientific Meeting  2017.8 

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    Event date: 2017.8

    Language:English  

    Country:Australia  

  • <シンポジウム: 本邦のリアルワールド研究からみる糖尿病患者の心・腎合併症> Fukuoka Diabetes Registry (FDR)

    大隈俊明, 岩瀬正典, 藤井裕樹, 北園孝成

    第57回 糖尿病学の進歩  2023.2 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 血清アディポネクチン高値は1型および2型糖尿病患者の重症低血糖のリスクである:福岡糖尿病患者 データベース研究(FDR)

    岩瀬正典,藤井裕樹,小森田佑二,大隈俊明,井手均,吉成匡人,村尾 愛,於久祐太郎,井手脇康裕, 佐々木伸浩,布井清秀,佐藤雄一, 五島大祐,井元博文, 野原栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,中村宇大,北園孝成

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • クレアチニン-/シスタチンC-推算糸球体濾過量比による糖尿病性腎臓病の進展予測:the Fukuoka Diabetes Registry

    井手均,岩瀬正典,藤井裕樹,大隈俊明,小森田祐二,吉成匡人,於久祐太郎,村尾愛,井手脇康裕,佐々木伸浩,布井清秀,佐藤雄一,五島大祐,井元博文,野原 栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,中村宇大,北園孝成

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 大腿骨骨折合併2型糖尿病患者の死亡リスクの検討:福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry)

    小森田祐二,岩瀬正典,藤井裕樹,大隈俊明,井手均,吉成匡人,村尾愛,於久祐太郎,井手脇康裕,佐々木伸浩,布井清秀,五島大祐,井元博文,野原栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,大星博明,中村宇大,北園孝成

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 2型糖尿病患者におけるBMIの変動性と死亡の関係:福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry)

    藤井裕樹,岩瀬正典,中村宇大,大隈俊明,井手均,小森田祐二,吉成匡人,村尾 愛,於久祐太郎,佐々木伸浩,佐藤雄一,布井清秀,五島大祐,井元博文,野原 栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,北園孝成

    第62回日本糖尿病学会年次学術集会  2019.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • DPP-4阻害薬服用中に発症した水疱性類天疱瘡の1例

    守谷聡一朗,大城彩香,冬野洋子,東大樹,於久祐太郎,吉成匡人,大隈俊明,中村宇大,北園孝成

    第326回日本内科学会九州地方会  2019.8 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 歌舞伎症候群に併発した1型糖尿病の一例

    大城彩香,東大樹,於久祐太郎,吉成匡人,平川洋一郎,大隈俊明,中村宇大, 北園孝成

    第57回日本糖尿病学会九州地方会  2019.10 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 抗PD-L1抗体デュルバルマブ投与後に発症した劇症1型糖尿病の1例

    東大樹,中尾晶子,大城彩香,於久祐太郎,吉成匡人,平川洋一郎,大隈俊明, 中村宇大,北園孝成

    第57回日本糖尿病学会九州地方会  2019.10 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 糖尿病性ケトアシドーシスに十二指腸炎を合併した2型糖尿病の一例

    坂本和可子, 大城彩香, 大隈俊明,於久祐太郎,吉成匡人、平川洋一郎,北園孝成

    第332回日本内科学会九州地方会  2021.1 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 2型糖尿病患者における骨折のリスク因子と予後に関する疫学研究: 福岡県糖尿病患者データベース研究 (Fukuoka Diabetes Registry)

    小森田祐二,岩瀬正典,大隈俊明, 藤井裕樹,中村宇大, 北園孝成

    第64回日本糖尿病学会年次学術集会  2021.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 2型糖尿病患者においてポリファーマシーは骨折リスク上昇と関連する:Fukuoka Diabetes Registry (FDR)

    小森田祐二,岩瀬正典,大隈俊明, 藤井裕樹,於久祐太郎,東大樹,大城彩香, 井手均,吉成匡人,佐々木伸浩,佐藤雄一,五島大祐,野原栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,中村宇大, 北園孝成

    第64回日本糖尿病学会年次学術集会  2021.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • タクロリムス内服により糖尿病性ケトアシドーシスを発症した一例

    坂本知子,高野瑛子, 大隈俊明, 坂本和可子, 東大樹, 大城彩香, 小森田祐二, 平川洋一郎, 北園孝成

    第334回日本内科学会九州地方会  2021.8 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 糖尿病教室後の患者への振り返りを行った看護師の実態調査

    前田英子,岩本夏美,豊福由香里,梅津人美,久冨清美,坂本和可子,大城彩香,大隈俊明.

    第59回日本糖尿病学会 九州地方会  2021.11 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • DPP4阻害薬の追加によりインスリン離脱が可能となった永続型新生児糖尿病の一例

    大城彩香,大隈俊明,坂本和可子,高野瑛子,坂本知子,東大樹,小森田祐二,平川洋一郎,北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • コーヒー摂取とCKD発症の関連:Fukuoka Diabetes Registry

    小森田祐二,大隈俊明,岩瀬正典,藤井裕樹,中村宇大,於久祐太郎,東大樹,大城彩香,坂本和可子,吉成匡人,北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 前立腺肥大症治療薬が糖尿病の発症・悪化に寄与したと考えられた一例

    坂本和可子, 大隈俊明, 東大樹、於久祐太郎、大城彩香、小森田祐二、平川洋一郎、北園孝成

    第336回日本内科学会九州地方会  2022.1 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 今、改めて見直す糖尿病の治療 ~食事・運動・薬物療法~

    大隈俊明

    第95回日本薬理学会年会  2022.3 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 糖尿病合併症の性差を規定する環境・遺伝要因の解明: 大規模ゲノムコホート研究

    大隈俊明, 岩瀬正典, 藤井裕樹, 小森田祐二, 中村宇大, 北園孝成

    第9回日本糖尿病協会年次学術集会  2022.7 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 生物学的製剤やCOVID-19ワクチン接種後に続発性アミロイドーシスによる亜急性甲状腺炎様症候群(STLS)を繰り返したクローン病の1例

    大村一華, 大隈俊明, 大城彩香, 岩武史朗, 川崎啓祐, 梅野淳嗣, 岡村建, 北園孝成

    第340回日本内科学会九州地方会  2022.8 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • ボノプラザンが低Ca, Mg血症の一因と考えられた1例

    大村一華, 大隈俊明, 於久祐太郎, 藤平美佳, 大城彩香, 東大樹, 坂本和可子, 高波百合那, 恒吉章治, 北園孝成

    第340回日本内科学会九州地方会  2023.1 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 前立腺肥大症の治療開始後に耐糖能が悪化した一例

    坂本和可子,於久祐太郎,大城彩香,東大樹,小森田祐二,平川洋一郎,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 2型糖尿病患者における乳製品摂取量とメタボリックシンドローム、慢性腎臓病の関連:Fukuoka Diabetes Registry(FDR)

    吉成匡人, 大隈俊明, 岩瀬正典,藤井裕樹,小森田祐二,東大樹, 大城彩香, 坂本和可子,佐々木伸浩,佐藤雄一,中村宇大, 五島大祐,野原栄,井手均, 南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,北園 孝成

    第66回 日本糖尿病学会年次学術集会  2023.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 2型糖尿病患者におけるACE阻害薬投与後の血清K上昇と生命予後や血管合併症との関連: ADVANCE試験

    大隈俊明, Katie Harris, Mark Woodward, John Chalmers

    第66回 日本糖尿病学会年次学術集会  2023.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • <シンポジウム: Big data, Real World研究が帰る糖尿病臨床> 福岡県糖尿病患者データベース研究 Fukuoka Diabetes Registry (FDR) Invited

    岩瀬正典, 中村宇大, 大隈俊明

    第66回 日本糖尿病学会年次学術集会  2023.5 

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    Event date: 2023.5

    Language:Japanese  

    Country:Japan  

  • 手術予定患者に対する糖尿病治療介入必要度トリアージの試み

    梶野美保,淀川千穂,坂本竜一,松田やよい,大隈俊明,佐藤直市,勝田仁,小川佳宏

    第60回日本糖尿病学会九州地方会  2022.10 

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    Event date: 2022.10 - 2023.5

    Language:Japanese  

    Country:Japan  

  • <シンポジウム: 予防に活かす 最新の大規模臨床研究の成果> 糖尿病診療におけるクリニカルクエスチョンと大規模臨床研究のエビデンス Invited

    大隈俊明, 岩瀬正典, 藤井裕樹, 北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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    Event date: 2022.10

    Language:Japanese  

    Country:Japan  

  • 糖尿病合併症および危険因子における性差の解明:福岡県糖尿病患者データベース研究:Fukuoka Diabetes Registry(FDR)

    大隈俊明,岩瀬正典,藤井裕樹,小森田祐二,中村宇大,北園孝成

    第65回日本糖尿病学会年次学術集会  2022.5 

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    Event date: 2022.5 - 2023.5

    Language:Japanese  

    Country:Japan  

  • 糖尿病患者において便秘は慢性腎臓病と関連する: Fukuoka Diabetes Registry (FDR)

    大隈俊明, 岩瀬正典, 中村宇大, 藤井裕樹, 井手均, 小森田祐二, 吉成匡人, 於久祐太郎, 東大樹, 大城彩香, 佐々木伸浩, 佐藤雄一, 五島大祐, 野原栄, 南昌江, 和田美也, 横溝由史, 菊池正統, 野見山理久, 中村晋, 田代憲司, 吉成元孝, 市川晃治郎, 北園孝成

    第64回日本糖尿病学会年次学術集会  2021.5 

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    Event date: 2021.5

    Language:Japanese  

    Country:Japan  

  • 当院における膵臓移植登録と周術期の血糖管理

    大城彩香, 大隈俊明,坂本和可子,東大樹,於久祐太郎,小森田祐二、平川洋一郎,加来啓三,北園孝成

    第48回日本膵・膵島移植研究会  2021.3 

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    Event date: 2021.3

    Language:Japanese  

    Country:Japan  

  • 腎移植患者におけるSGLT2阻害薬の安全性と有効性の検討

    久留裕, 野口浩司, 佐藤優, 目井孝典, 加来啓三, 岡部安博, 大隈俊明, 中村雅史

    第54回日本臨床腎移植学会  2021.2 

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    Event date: 2021.2

    Language:Japanese  

    Country:Japan  

  • 喫煙習慣は2型糖尿病患者の血糖コントロールに関連する:Fukuoka Diabetes Registry (FDR12)

    大隈 俊明

    第57回日本糖尿病学会年次学術集会 

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    Language:Japanese  

    Country:Japan  

  • 生活習慣が2型糖尿病の病態や血管合併症に及ぼす影響: 福岡県糖尿病患者データベー ス研究 Invited

    大隈 俊明

    第52回日本糖尿病学会九州地方会 

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    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 脂肪萎縮性糖尿病の一例

    原 功哉, 堤 礼子, 野原 栄, 大隈 俊明, 北園 孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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    Language:Japanese  

    Country:Japan  

  • 当院外来における糖尿病神経障害に関する意識調査

    五島大祐, 坂本典彦, 中尾晶子, 松尾美奈, 大隈俊明, 北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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    Country:Japan  

  • 虚血性胃十二指腸炎から腹部アンギーナの診断に至った 2 型糖尿病の1例

    坂本典彦, 中尾晶子, 松尾美奈, 五島大祐, 大隈俊明, 北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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  • 頭部 CT・MRI で典型的な所見を示さなかった糖尿病性舞踏病疑いの1例

    舟越弘樹, 五島大祐, 坂本典彦, 中尾晶子, 大隈俊明, 北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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    Country:Japan  

  • 炭酸水素Na 大量投与により意識障害が増悪した糖尿病ケトアシドーシス(DKA)の一例

    高野瑛子,眞田智慧,海津梓奈子,井元博文,中村宇大,大隈俊明,北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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  • 胃切除後の膵外分泌機能低下に対する膵酵素補充により血糖管理が悪化した一例

    坂本和可子,大隈俊明,橋本千明,於久祐太郎,大城彩香,小森田祐二,平川洋一郎,北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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  • 1型糖尿病患者における骨折頻度,特徴,リスク因子の検討

    小森田祐二,南昌江,前田泰孝,吉岡利絵,大隈俊明,北園孝成

    第58回日本糖尿病学会九州地方会  2020.10 

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  • 2型糖尿病患者においてコーヒーや緑茶の摂取は死亡リスクの低下と関連する:福岡県糖尿病患者データベース研究

    小森田祐二,岩瀬正典,藤井裕樹,大隈俊明,井手均,吉成匡人,於久祐太郎,東大樹,北村環,佐々木伸浩,佐藤雄一,五島大祐,井元博文,野原栄,南昌江,和田美也,横溝由史,菊池正統,野見山理久,中村晋,田代憲司,吉成元孝,市川晃治郎,大星博明,中村宇大,北園孝成

    第63回日本糖尿病学会年次学術集会  2020.10 

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  • 診断に苦慮した化膿性門脈血栓症の1例

    落合由佳,坂本典彦,中尾晶子,松尾美奈,五島大祐,大隈俊明,北園孝成

    第333回日本内科学会九州地方会  2021.6 

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  • 視床下部性副腎機能低下を合併したと考えられるインスリン自己免疫症候群の 1 例

    小林和貴,原規子,中尾晶子,五島大祐,大隈俊明,北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 膵頭十二指腸切除後に気腫肝膿瘍を発症した 2 型糖尿病の 1 例

    中村捷太郎,中尾晶子,原規子,五島大祐,大隈俊明,北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 糖尿病合併COVID-19患者における重症化リスクの検討

    池内 千明、堤 礼子、野原 栄、肥山 和俊、大隈 俊明、北園 孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 当院における糖尿病合併COVID-19患者の酸素投与期間に関わる因子の検討

    野原 栄、池内 千明、堤 礼子、肥山 和俊、大隈 俊明、北園 孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 持続皮下インスリン注入療法における基礎分泌補充調整強化による効果

    井元博文、堀内俊輔、藤平美佳、於久真由美、川本徹、佐々木伸浩、大隈俊明、北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • HbA1c と血糖値に顕著な乖離を認めた肥満合併 2 型糖尿病患者の 1 例

    佐々木伸浩、堀内俊輔、藤平美佳、於久真由美、川本徹、井元博文、大隈俊明、北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 重度の起立性低血圧とインスリン分泌能低下のため筋肉量増加に難渋した 2 型糖尿病の 1 例

    藤平美佳、堀内俊輔、於久真由美、川本徹、井元博文、佐々木伸浩、大隈俊明、北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 当院での糖尿病合併高度肥満患者におけるスリーブ状胃切除術前後の体重変化について

    落合弘貴、佐々木伸浩、堀内俊輔、藤平美佳、於久真由美、川本徹、井元博文、 安井隆晴、永井英司、大隈俊明、北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 当院における COVID-19 の診療経験

    川本徹、堀内俊輔、藤平美佳、於久真由美、井元博文、佐々木伸浩、石丸敏之、吉成匡人、小森田祐二、大隈俊明、北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 2型糖尿病患者における肝線維化スコアリングシステムFIB-4 indexの検討

    坂本典彦,原功哉,眞田知慧,高野瑛子,大隈俊明,中村宇大,北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • HLA-DRB1*0404を有した超高齢インスリン自己免疫症候群(IAS)の1例

    原規子, 平田詩乃, 髙木可南子, 於久祐太郎, 井手均, 岩瀬正典, 五島大祐, 大隈俊明, 北園孝成

    第59回日本糖尿病学会 九州地方会  2021.11 

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  • 糖尿病教室を受講した患者の退院後のセルフケア能力および療養行動

    鳥越 夏美, 梅津 人美, 豊福 由香里, 前田 英子, 久冨 清美, 坂本 和可子, 大城 彩香, 大隈 俊明

    糖尿病  2022.4 

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  • 糖尿病合併症および危険因子における性差の解明 福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry:FDR)

    大隈 俊明, 岩瀬 正典, 藤井 裕樹, 小森田 祐二, 中村 宇大, 北園 孝成

    糖尿病  2022.4 

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  • 女性の生殖関連因子は糖尿病患者の死亡や心血管病リスクと関連する Fukuoka Diabetes Registry(FDR)

    大城 彩香, 大隈 俊明, 岩瀬 正典, 中村 宇大, 藤井 裕樹, 小森田 祐二, 吉成 匡人, 於久 祐太郎, 東 大樹, 坂本 和可子, 佐々木 伸浩, 佐藤 雄一, 五島 大祐, 野原 栄, 井手 均, 南 昌江, 和田 美也, 横溝 由史, 菊池 正統, 野見山 理久, 中村 晋, 田代 憲司, 吉成 元孝, 市川 晃治郎, 北園 孝成

    糖尿病  2022.5 

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  • SAP療法における基礎分泌補充調整強化の重要性

    井元 博文, 堀内 俊輔, 藤平 美佳, 於久 真由美, 川本 徹, 佐々木 伸浩, 大隈 俊明, 北園 孝成

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 2型糖尿病患者における脳血管障害の発症頻度と血糖コントロールや生活習慣との関連 福岡県糖尿病患者データベース研究(FDR)

    岩瀬 正典, 大隈 俊明, 小森田 祐二, 藤井 裕樹, 井手 均, 吉成 匡人, 於久 祐太郎, 東 大樹, 大城 彩香, 中村 宇大, 佐々木 伸浩, 布井 清秀, 佐藤 雄一, 五島 大祐, 野原 栄, 南 昌江, 和田 美也, 横溝 由史, 菊池 正統, 野見山 理久, 中村 晋, 田代 憲司, 吉成 元孝, 市川 晃治郎, 北園 孝成

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 2型糖尿病患者においてポリファーマシーは重症低血糖リスク上昇と関連する Fukuoka Diabetes Registry(FDR)

    小森田 祐二, 大隈 俊明, 岩瀬 正典, 中村 宇大, 藤井 裕樹, 吉成 匡人, 於久 祐太郎, 東 大樹, 大城 彩香, 坂本 和可子, 佐々木 伸浩, 佐藤 雄一, 五島 大祐, 野原 栄, 井手 均, 南 昌江, 和田 美也, 横溝 由史, 菊池 正純, 野見山 理久, 中村 晋, 田代 憲司, 吉成 元孝, 市川 晃治郎, 北園 孝成

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 2型糖尿病における2年間のルセオグリフロジン投与の肝機能に対する影響

    堀内 俊輔, 佐々木 伸浩, 井元 博文, 川本 徹, 於久 真由美, 藤平 美佳, 大隈 俊明, 北園 孝成

    第65回日本糖尿病学会年次学術集会  2022.5 

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  • 高齢糖尿病患者12例におけるフレイルチェックでの検討 Invited

    内薗祐二,武石千鶴子,本田美貴,濱砂麻美,中島康浩,田平泰徳,岩屋祐子,佐藤雄一,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • デュラグルチドが奏効した抗GAD抗体陽性の糖尿病の一例 Invited

    高野瑛子,川野聡子,眞田知慧,中村宇大,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • SGLT2阻害薬内服中に高度脱水を伴うケトアシドーシスを来した2型糖尿病の2例 Invited

    東木孝太,佐々木伸浩,原功哉,於久真由美,川本徹,井元博文,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • 当科における経口GLP-1受容体作動薬・セマグルチドの使用経験 Invited

    横溝舞子,濵小路美貴,納富威充,井手誠,内薗祐二,佐藤雄一,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • SGLT2阻害薬により著明な高血糖が顕在化せず発見が遅れた1型糖尿病ケトアシドーシス Invited

    土師晶子,知識裕喜,原規子,五島大祐,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • Posterior reversible encephalopathy syndrome(PRES)を合併した2型糖尿病の1例 Invited

    牟田大毅,井手均,於久祐太郎,髙木可南子,平田詩乃,青谷領一郎,岩瀬正典,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • 約束処方中のロキソプロフェンが誘因と疑われたインスリン自己免疫症候群の1例 Invited

    川野聡子,高野瑛子,眞田知慧,中村宇大,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • SAP療法における基礎分泌補充調整強化の重要性(第2報):MiniMed770Gによる影響 Invited

    井元博文,東木孝太,原功哉,於久真由美,川本徹,佐々木伸浩,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • 糖尿病性ケトアシドーシス(DKA)の契機が急性壊死性食道炎(ANE)であった一例 Invited

    徳田信二,佐藤雄一,内薗祐二,井手誠,納富威充,横溝舞子,濵小路美貴,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • 維持透析中に糖尿病ケトアシドーシスを発症し救命し得なかった一例 Invited

    西崎愛佳,井手誠,濵小路美貴,横溝舞子,納富威充,内薗祐二,佐藤雄一,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • アテゾリズマブによるirAEとして発症した急性発症1B型糖尿病の一例 Invited

    古賀淳也,知識裕喜,原規子,土師晶子,五島大祐,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • <シンポジウム: IoT/AI診療 すべての患者さんに最適な治療を> 共有意思決定のためのツールとしてCGMを活用する Invited

    野原栄, 坂本知子,堤礼子,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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  • <シンポジウム: ゼロ感染症 糖尿病患者を守る> 福岡における COVID19 の現状 Invited

    佐々木伸浩,大隈俊明,北園孝成

    第60回日本糖尿病学会九州地方会  2022.10 

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Committee Memberships

  • 福岡糖尿病療養指導士認定会   研修試験委員会 委員長   Domestic

    2024.3 - 2024.4   

  • Vice-chairman  

    2022.7 - 2024.6   

  • Councilor   Domestic

    2020.10 - Present   

  • 日本糖尿病協会   代議員  

    2020.4 - Present   

  • 福岡糖尿病療養指導士認定会   研修試験委員会 委員   Domestic

    2020.4 - Present   

  • 日本臨床疫学会   専門家制度委員会 委員   Domestic

    2020.4 - 2024.4   

  • Executive   Domestic

    2020.4 - 2022.5   

  • Councilor  

    2019.5 - 2027.5   

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Academic Activities

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:9

    Proceedings of domestic conference Number of peer-reviewed papers:15

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

    Proceedings of domestic conference Number of peer-reviewed papers:15

  • Screening of academic papers

    Role(s): Peer review

    2021

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

    Proceedings of domestic conference Number of peer-reviewed papers:15

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2019

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:7

    Proceedings of domestic conference Number of peer-reviewed papers:18

  • Screening of academic papers

    Role(s): Peer review

    2018

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:4

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:3

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Research Projects

  • 糖尿病合併症に対する環境・遺伝要因の性特異的影響の解明:大規模ゲノムコホート研究

    Grant number:24K14678  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 性差を考慮した糖尿病合併症の遺伝的、環境的因子の解明: 大規模ゲノムコホート研究

    Grant number:21K11700  2021 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模ゲノムコホートによる糖尿病合併症の性特異的遺伝・環境要因の同定

    Grant number:19K24229  2019 - 2020

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 大規模臨床試験に基づく糖尿病合併症の発症予測モデルの構築と血糖・血圧目標値の検討

    2016 - 2017

    日本学術振興会  海外特別研究員

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    Grant type:Joint research

  • 一般地域住民を含む糖尿病患者データベース構築による前向きゲノムコホート研究

    Grant number:23249037  2011 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Grant type:Scientific research funding

Class subject

  • 系統医学III (内分泌・代謝)

    2024.4 - 2024.9   First semester

  • 臨床医学II (内分泌・代謝・⽼化概論)

    2024.4 - 2024.9   First semester

  • 臨床医学II (内分泌・代謝・⽼化概論)

    2023.4 - 2023.9   First semester

  • 系統医学III (内分泌・代謝)

    2023.4 - 2023.9   First semester

  • 臨床医学II (内分泌・代謝・⽼化概論)

    2022.4 - 2022.9   First semester

  • 系統医学III (内分泌・代謝)

    2022.4 - 2022.9   First semester

  • 臨床医学II (内分泌・代謝・⽼化概論)

    2021.4 - 2021.9   First semester

  • 系統医学III (内分泌・代謝)

    2021.4 - 2021.9   First semester

  • 臨床医学II (内分泌・代謝・⽼化概論)

    2020.4 - 2020.9   First semester

  • 系統医学III (内分泌・代謝)

    2020.4 - 2020.9   First semester

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Outline of Social Contribution and International Cooperation activities

  • 市民を対象とした公開講座、糖尿病教室への参加

Social Activities

  • 今、改めて見直す糖尿病の治療

    第44回ふくおか市民糖尿病教室  2023.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 危険な合併症を発症する前に正しく知って、正しく管理を「糖尿病」

    朝日新聞  2023.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • この機会に正しく知ろう!糖尿病

    朝日新聞  2022.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • 今、改めて見直す糖尿病の治療~食事・運動・薬物療法~

    第95回日本薬理学会年会 市民公開講座  福岡市  2022.3

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 糖尿病の正しい理解普及のために~間違った認識と偏見をなくそう~

    朝日新聞  2021.11

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    Type:Newspaper, magazine

  • 筋肉量 コツコツ積み上げ 健康長寿

    朝日新聞  2020.11

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Newspaper, magazine

  • 令和時代の生活習慣改善法~改めて見直そう! 食事・運動・睡眠~

    第3回 九州大学病院 糖尿病市民公開講座  福岡市  2019.9

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Travel Abroad

  • 2016.7 - 2019.3

    Staying countory name 1:Australia   Staying institution name 1:The George Institute for Global Health

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Metabolism

Clinician qualification

  • Preceptor

    The Japan Diabetes Society(JDS)

  • Specialist

    The Japan Diabetes Society(JDS)

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

  • Certifying physician

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 2005

Notable Clinical Activities

  • 糖尿病・内分泌代謝疾患を中心に、腎疾患、高血圧・心疾患、脳血管疾患などの血管合併症の診療、腎移植や膵腎同時移植における血糖管理を行っている。 ⽇本糖尿病協会 代議員、福岡県糖尿病協会 副会長・常任理事として協会が⾏う糖尿病の社会啓発活動に参加している。