Kyushu University Academic Staff Educational and Research Activities Database
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Kenichi Goto Last modified date:2023.02.05

Other Organization

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
internal medicine、cardiology, hypertension
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • Relationship of home blood pressure with target organ damage
    keyword : home blood pressure, target organ damage
  • Assessment of cardiovascular risks for prevention of cardiovascular diseases
    keyword : cardiovascular diseases, risk factors
  • Endothelial dysfunction in hypertension
    keyword : Hypertension, Endothelium, Endothelium-Derived Mediators, ion channel
Academic Activities
1. Kenichi Goto, Koji Fujii, Isao Abe., Effects of a converting enzyme inhibitor, an AT1 receptor antagonist and their combination on endothelial dysfunction in hypertension. In EDHF 2000 (Vanhoutte, P.M., ed.), Taylor&Francis, Ch46, 2001.01.
2. Koji Fujii, Kenichi Goto, Isao Abe, Inhibition of converting enzyme prevents the age-related decline in endothelium-dependent hyperpolarization. In EDHF 2000 (Vanhoutte, P.M., ed.), Taylor&Francis, Ch45, 2001.01.
1. Kenichi Goto and Takanari Kitazono, Chloride Ions, Vascular Function and Hypertension, Biomedicines 2022, 10(9), 2316;,, 2022.09.
2. Kenichi Goto and Takanari Kitazono, The transient receptor potential vanilloid 4 channel and cardiovascular disease risk factors., Frontiers in Physiology, 12:728979. doi: 10.3389/fphys.2021.728979, 2021.09.
3. Kenichi Goto and Takanari Kitazono, Endothelium-dependent hyperpolarization (EDH) in diet-induced obesity, Endocrine and Metabolic Science, 10.1016/j.endmts.2020.100062, 2020.11.
4. Kenichi Goto, Takanari Kitazono., Endothelium-Dependent Hyperpolarization (EDH) in Diabetes: Mechanistic Insights and Therapeutic Implications., Int J Mol Sci., 10.3390/ijms20153737, 2019 Jul 31;20(15). pii: E3737., 2019.07.
5. Kenichi Goto, Toshio Ohtsubo, Takanari Kitazono., Endothelium-dependent hyperpolarization (EDH) in hypertension: The role of endothelial ion channels., Int J Mol Sci., 10.3390/ijms19010315, 2018 Jan 21;19(1). pii: E315., 2018.01.
1. Takunori Seki, Kenichi Goto, Kanako Kiyohara, Yasuo Kansui, Noboru Murakami, Yoshie Haga, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono, Downregulation of endothelial transient receptor potential vanilloid type 4 channel and small-conductance of Ca2+-activated K+ channels underpins impaired endothelium-dependent hyperpolarization in hypertension, Hypertension, 69, 143-153, 2017.01.
2. Kenichi Goto, Yasuo Kansui, Hideyuki Oniki, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono, Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of dahl salt-sensitive hypertensive rats, HYPERTENSION RESEARCH, 10.1038/hr.2012.36, 35, 8, 849-854, 2012.08.
3. Anthie Ellis*, Kenichi Goto*, Daniel J. Chaston, Therese D. Brackenbury, Kate R. Meaney, J. R. Falck, Richard J. H. Wojcikiewicz, Caryl E. Hill, Enalapril treatment alters the contribution of epoxyeicosatrienoic acids but not gap junctions to endothelium-derived hyperpolarizing factor activity in mesenteric arteries of spontaneously hypertensive rats, Journal of Pharmacology and Experimental Therapeutics, 330, 413-422, 2009.08.
4. Kenichi Goto, Frank R Edwards, Caryl E Hill, Depolarization evoked by acetylcholine in mesenteric arteries of hypertensive rats attenuates endothelium-dependent hyperpolarizing factor, JOURNAL OF HYPERTENSION, 25, 2, 345-359, 2007.02.
5. Kenichi Goto, Nicole M Rummery, T. Hilton Grayson, Caryl E Hill, Attenuation of conducted vasodilatation in rat mesenteric arteries during hypertension: role of inwardly rectifying potassium channels, JOURNAL OF PHYSIOLOGY-LONDON, 561, 215-231, 2004.11.
6. Kenichi Goto, Koji Fujii, Yasuo Kansui, Mitsuo Iida, Changes in EDHF in hypertension and ageing: response to chronic treatment with rennin-angiotensin system inhibitors, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 31, 650-655, 2004.09.
7. Shaun L. Sandow*, Kenichi Goto*, Nicole M. Rummery, Caryl E. Hill, Developmental changes in myoendothelial gap junction mediated vasodilator activity in the rat saphenous artery, JOURNAL OF PHYSIOLOGY-LONDON, 10.1113/jphysiol.2003.058669, 556, 3, 875-886, 2004.05.
8. Kenichi Goto, Koji FUjii, Yasuo Kansui, Isao Abe, Mitsuo Iida, Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries, CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 29, 7, 595-602, 2002.07.
9. Kenichi Goto, Koji Fujii, Uran Onaka, Isao Abe, Masatoshi Fujishima, Renin-angiotensin system blockade improves endothelial dysfunction in hypertension, HYPERTENSION, 36, 4, 575-580, 2000.10.
10. Kenichi Goto, Koji Fujii, Uran Onaka, Isao Abe, Masatoshi Fujishima, Angiotensin-converting enzyme inhibitor prevents age-related endothelial dysfunction, HYPERTENSION, 36, 4, 581-587, 2000.10.
1. Kenichi Goto, Prevention and Management of Hypertension in Japan in the time of COVID-19, International Conference "Challenges in NCDs management to achieve the SDGs in the COVID-19 era and beyond", 2022.01.
2. Kenichi Goto, Endothelium-dependent hyperpolarization (EDH) and endothelial dysfunction in hypertension: The role of endothelial ion channels, Joint Meeting of The European Society for Clinical Hemorheology and Microcirculation, The International Society for Clinical Hemorheology, The International Society of Biorheology (ESCHM-IISCH-ISB 2021), 2021.07.
3. Kenichi Goto, New Insights into RVO 網膜静脈閉塞症の真相を探る
Hypertension and Guideline for the management of hypertension 2019 (JSH2019), 第73回日本臨床眼科学会, 2019.10.
Other Educational Activities
  • 2018.06.
  • 2016.06.