Kyushu University Academic Staff Educational and Research Activities Database
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Kazuki Takeishi Last modified date:2020.08.13

Assistant Professor / Surgery and Science
Kyushu University Hospital

Graduate School
Undergraduate School

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Doctor of Medical Science
Country of degree conferring institution (Overseas)
Field of Specialization
digestive surgery, hepato-biliary- pancreatic surgery, Liver transplantation
Total Priod of education and research career in the foreign country
Outline Activities
I am working as a hepatobiliary pancreatic surgeon and a liver transplantation surgeon. I also research a progression of liver cancer. In addition, I research liver regeneration using iPS cells.
Research Interests
  • Regenerative medicine of Liver
    keyword : iPS
  • Biological Significance of the signal in Hepatocellular Carcinoma Progression
    keyword : Hepatocellular carcinoma
Academic Activities
1. Takeishi K, Yoshizumi T, Itoh S, Yugawa K, Yoshiya S, Toshima T, Harada N, Ikegami T, Nishie A, Mori M., Surgical Indications for Hepatocellular Carcinoma with Non-hypervascular Hypointense Nodules Detected by Gd-EOB-DTPA-Enhanced MRI, Ann Surg Oncol, 10.1245/s10434-020-08419-4., 27, 9, 3344-3353, 2020.09.
2. Florentino RM, Fraunhoffer NA, Morita K, Takeishi K, Ostrowska A, Achreja A, Animasahun O, Haep N, Arazov S, Agarwal N, Collin de l'Hortet A, Guzman-Lepe J, Tafaleng EN, Mukherjee A, Troy K, Banerjee S, Paranjpe S, Michalopoulos GK, Bell A, Nagrath D, Hainer SJ, Fox IJ, Soto-Gutierrez A., Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans, Hepatol Commun, 10.1002/hep4.1505. , 4, 6, 859-875, 2020.08.
3. Takeishi K, Collin de l'Hortet A, Wang Y, Handa K, Guzman-Lepe J, Matsubara K, Morita K, Jang S, Haep N, Florentino RM, Yuan F, Fukumitsu K, Tobita K, Sun W, Franks J, Delgado ER, Shapiro EM, Fraunhoffer NA, Duncan AW, Yagi H, Mashimo T, Fox IJ, Soto-Gutierrez A., Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells, Cell Rep, 10.1016/j.celrep., 31, 9, 107711-107711, 2020.06, The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has not been previously described. By improving methods for liver decellularization, recellularization, and differentiation of different liver cellular lineages of human iPSCs in an organ-like environment, we generated functional engineered human mini livers and performed transplantation in a rat model. Whereas previous studies recellularized liver scaffolds largely with rodent hepatocytes, we repopulated not only the parenchyma with human iPSC-hepatocytes but also the vascular system with human iPS-endothelial cells, and the bile duct network with human iPSC-biliary epithelial cells. The regenerated human iPSC-derived mini liver containing multiple cell types was tested in vivo and remained functional for 4 days after auxiliary liver transplantation in immunocompromised, engineered (IL2rg-/-) rats..
4. Takeishi K, Maeda T, Shirabe K, Tsujita E, Yamashita YI, Harimoto N, Itoh S, Ikegami T, Yoshizumi T, Maehara Y, Clinicopathologic Features and Outcomes of Non-B Non-C Hepatocellular Carcinoma after Hepatectomy., Ann Surg Oncol, 22, Suppl, 1116-1124, 2015.05.
5. Takeishi K, Taketomi A, Shirabe K, Toshima T, Motomura T, Ikegami T, Yoshizumi T, Sakane F, Maehara Y, Diacylglycerol kinase alpha enhances hepatocellular carcinoma progression by activation of Ras-Raf-MEK-ERK pathway., J Hepatol, 57, 1, 77-83, 2012.05.
6. 武石 一樹, Small Upper Midline Incision for Living Donor Hemi-Liver Graft Procurement in Adults, JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 10.1016/j.jamcollsurg.2014.04.021, 219, 3, E39-E43, 2014.09.
7. Takeishi K , Shirabe K, Yoshida Y, Tsutsui Y, Kurihara T, Kimura K, Itoh S, Harimoto N, Yamashita YI, Ikegami T, Yoshizumi T, Nishie A, Maehara Y, Correlation between portal vein anatomy and bile duct variation in 407 living liver donors., Am J Transplant. , 15, 155-160, 2014.12, 肝移植ドナーの門脈、胆管の走行を500例近く検討した。.
1. Kazuki Takeishi, Tomoharu Yoshizumi, Shohei Yoshiya, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Alexandra Collin de l‘Hortet, Alejandro Soto-Gutierrez, Masaki Mori , Assembly and function of an engineered liver graft generated solely from human induced pluripotent stem cells-Towards Autologous Liver Transplantation.
, American College of Surgeons Clinical congress 2019, 2019.10.
Other Educational Activities
  • 2020.08.
  • 2014.12.