Kyushu University Academic Staff Educational and Research Activities Database
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Yoshihiro Izumi Last modified date:2019.12.24



Graduate School
Other Organization


Homepage
http://www.bioreg.kyushu-u.ac.jp/labo/metabolomics/
HP: Division of Metabolomics, Medical Institute of Bioregulation, Kyushu University
.
Academic Degree
Ph.D in Engineering
Country of degree conferring institution (Overseas)
No
Field of Specialization
Metabolomics, Analytical chemistry, Mass spectrometry, Chromatography
ORCID(Open Researcher and Contributor ID)
0000-0003-4608-4652
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
With the recent breakthrough in metabolomics technologies, application of metabolomics has been increasing in the medical field. Identification and semiquantitation of the compounds in the metabolome is defined as metabolic profiling, and it is applied to define metabolic changes related to genetic differences, environmental influences and disease or drug perturbations. Medical metabolomics are two major purposes for its use; the first is to acquire knowledge on the mechanisms of drug action or the disease itself, and another is biomarker detection and disease diagnosis. Our group has developed a novel high-sensitivity and absolute quantitative metabolomics methodology based on gas chromatography, liquid chromatography, and supercritical fluid chromatography coupled to mass spectrometry. Advances in metabolic profiling offer comprehensive coverage of a metabolome as well as provide valuable insight towards understanding the different biochemical profiles of a biosystem.
Research
Research Interests
  • Development of basic technologies for single-cell metabolomics
    keyword : Single-cell metabolomics
    2016.10.
  • Next-generation metabolomics: Technological development and medical application
    keyword : Metabolomics, Metabolome analysis, Widely-targeted Quantitaive metabolomics, Non-target metabolomics
    2015.04.
Academic Activities
Presentations
1. Yoshihiro Izumi, Eiichiro Fukusaki, Takeshi Bamba, Supercritical fluid chromatography fast-scanning triple-quadrupole mass spectrometry: An alternative to LC/MS/MS for highly-sensitive and high-throughput analysis of multiresidue pesticides

, SHIMADZU GLOBAL INNOVATION SUMMIT 2017, 2017.07, Recently, a generally applicable screening method for multiresidue pesticide analysis, which is simple, quick, accurate, and has a reliable performance, is becoming increasingly important for food safety and international trade. Herein, we established a high-throughput screening methodology that enables the detection of multiresidue pesticides using supercritical fluid chromatography coupled to a fast-scanning triple-quadrupole mass spectrometry (SFC/MS/MS). A total of 509 chemicals covering a wide polarity range (logPow from ‒4.6 to 8.1) and a wide molecular range (from 99.0 to 1052.0) were analyzed simultaneously through a combination of fast-speed multiple reaction monitoring (MRM) with positive/negative polarity switching and highly efficient separation by SFC. The developed analytical system is a potentially useful tool for practical multiresidue pesticide screening with high-sensitivity and -throughput..
2. Takato Uchikata, Hidetoshi Terada, Yasuhiro Funada, Yoshihiro Izumi, Takeshi Bamba, Automatically extraction and analysis using on-line supercritical fluid extraction (SFE) / supercritical fluid chromatography (SFC) system, SFC 2015, 9th International Conference on Packed-Column SFC, 2015.07.
Membership in Academic Society
  • The Society for Chromatographic Sciences
  • The Mass Spectrometry Society of Japan
  • The Society for Biotechnology, Japan
  • Japan Society for Bioscience, Biotechnology, and Agrochemistry
  • Japan Society for SFC
Awards
  • Supercritical fluid chromatography/triple-quadrupole mass spectrometry-based method for highly sensitive and high-throughput analysis of multiresidue pesticides
Educational
Educational Activities
Division of Metabolomics, Graduate School of Systems Life Sciences, Kyushu University