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Hiroe KAKEHASHI Last modified date:2023.11.28

Assistant Professor / Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science
Department of Dental Science
Faculty of Dental Science

Graduate School
Other Organization
Administration Post

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Oral Maxillo Facial Surgery
Total Priod of education and research career in the foreign country
Research Interests
  • Elucidation of the pathogenesis of medication-related osteonecrosis of the jaw using dendritic cells as a new approach and development of novel treatment and prevention methods
    keyword : medication-related osteonecrosis of the jaw
  • Immune function analysis of ARONJ and development of preventive treatment method
    keyword : Anti-resorptive agents-related ONJ
  • Development of BRONJ an application of the regulatory T cells and immune function analysis of mouse models prevention treatment
    keyword : BRONJ regulatory T cells
  • A study on the role of proteolytic enzymes and dendritic cells in oral squamous cell carcinoma
    keyword : Cathepsin E, proteolytic enzyme, immunotherapy, oral squamous cell carcinoma, stem cell, dendritic cells, leukoplakia
  • Study on the role of dendritic cells in oral autoimmune diseases

    keyword : Oral Squamous Cell Carcinoma, dendritic cells, epithelial dysplasia, ΔNp63
Academic Activities
1. Saki Tamaki, Shinichiro Kuroshima, Hiroki Hayano, Kazunori Nakajima, Hiroe Kakehashi, Akira Ishisaki, Takashi Sawase, Dynamic polarization shifting from M1 to M2 macrophages in reduced osteonecrosis of the jaw-like lesions by cessation of anti-RANKL antibody in mice, Bone, 10.1016/j.bone.2020.115560., 141, 2020.07.
2. Hiroe KAKEHASHI, Takao Ando, Tokutaro Minamizato, Shinichiro Kuroshima, Yuya Nakatani, Atsushi Kawakami, Izumi Asahina, Administration of teriparatide improves the symptoms of advanced bisphosphonate-related osteonecrosis of the jaw: preliminary findings., Int J Oral Maxillofac Surg. 2015 Aug 21. pii: S0901-5027(15)01201-1. doi: 10.1016/j.ijom.2015.07.018. [Epub ahead of print], 2015.08, Teriparatide is a synthetic polypeptide hormone that contains the 1–34 amino
acid fragment of the recombinant human parathyroid hormone that stimulates bone
formation. Currently it is approved only for the treatment of osteoporosis. Here, we
report the outcomes of daily teriparatide injections for the treatment of bisphosphonaterelated
osteonecrosis of the jaw in ten patients. Two of ten cases dropped out due to
adverse events. Of the remaining eight cases, seven exhibited clinical improvement of
the jaw-related symptoms of osteonecrosis and the progression of the sequestration, while one case did not show any change in the symptoms. Administration of teriparatide in patients with osteonecrosis of the jaw promotes bone formation and subsequent sequestration over a short period of time. Our results suggest that adjunctive teriparatide therapy is a viable and effective option for treating osteonecrosis of the jaw..
3. Hiroe KAKEHASHI, Parotid gland myoepithelioma with remarkable cystic formation : A case report, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology , 25, 2, 183-188, 2012.05.
4. Hiroe KAKEHASHI, Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E., The Journal of Immunology , 179, 9, 5728-5737, 2007.11.
Membership in Academic Society
  • Japanese Society of Anti-aging Medicine
Educational Activities
Education of Students and Residents