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Shinjo Takanori Last modified date：2024.03.26

Assistant Professor / 歯周病学分野
Department of Dental Science
Faculty of Dental Science


Graduate School
Department of Dental Science
Graduate School of Dental Science


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Homepage
https://kyushu-u.elsevierpure.com/en/persons/takanori-shinjo
　Reseacher Profiling Tool　Kyushu University Pure
http://www.dent.kyushu-u.ac.jp/perio/
Phone
092-642-6358
Fax
092-642-6360
Academic Degree
Ph.D
Country of degree conferring institution (Overseas)
No
Field of Specialization
Dental Science(Periodontology)
ORCID(Open Researcher and Contributor ID)
0000-0002-8269-2826
Total Priod of education and research career in the foreign country
03years01months
Outline Activities
Outline of research
・Basic studies in the effect of periodontal disease on systemic disease and health.
・Basic studies in the pathogenic role of obesity/diabetes in periodontal disease.

Education
・Periodontal therapy
Research
Research Interests
  • The association of periodontitis in the development and progression of NASH and NAHS-related HCC
    keyword : periodontitis, NASH, HCC
    2022.04～2025.03.
  • The pathogenetic role of insulin resistance in Schwann cells on diabetes-related periodontitis
    keyword : diabetes-related periodontitis, Schwann cells, insulin resistance
    2024.03～2027.03.
  • The pathological role of adipose tissue neutrophils activated by periodontitis
    keyword : periodontitis, adipose tissue, neutrophil, obesity, diabetes
    2024.02～2026.01.
  • Investigation of the molecular basis of enhancement in wound healing from periodontitis using insulin action sensitizing agent
    keyword : insulin resistance, diabetes, periodontitis, wound healing
    2023.04～2025.03.
  • Investigation into the pathogenesis of diabetes-associated periodontitis by integrated omics analysis
    keyword : diabetes, periodontitis, metabolomics, proteomics, RNA-sequence
    2020.11～2024.03.
  • Development of a novel drug for prevention of periodontitis based on SPOCK-1 protein
    keyword : periodonititis, drug-induced gingival overgrowth, EMT, SPOCK-1
    2020.04～2023.03.
  • The investigation into potential mechanisms of the association between periodontal disease and diabetic kidney disease
    keyword : Periodontal disease, diabetic kidney disease, periodontal medicine
    2020.04～2023.03.
  • The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis
    keyword : inflammation, insulin resistance, obesity, diabetes, periodontitis
    2019.04～2022.03.
  • Investigation into the effect of periodontitis-induced Th17 immune respose on adipose tissue inflammation.
    keyword : chronic inflammation, periodontai disease, Th17 cell, adipose tissue
    2015.04～2016.04.
  • Investigation into molecule mechanism of anti-infllammatory effect of SK-0403 via DPP4 inhibition.
    keyword : anti-inflammatory effect, diabetes, macrophage, adipocyte
    2013.08～2015.03.
Current and Past Project
  • The aim of this study is to investigate into the pathogenesis of diabetes-associated periodontitis via multi-omics analysis and explore potential therapeutic targets for it.
Academic Activities
Books
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Papers
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1. Tatsuro Zeze, Takanori Shinjo, Kohei Sato, Yuki Nishimura, Mio Imagawa, Shuang Chen, Al-kafee Ahmed, Misaki Iwashita, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Kyoungmin Park, George L King, Fusanori Nishimura, Endothelial insulin resistance exacerbates experimental periodontitis, Journal of Dental Research, 2023.06.
2. Takanori Shinjo, Satoru Onizuka, Yumi Zaitsu, Atsushi Ishikado, Kyoungmin Park, Qian Li, Hisashi Yokomizo, Tatsuro Zeze, Kohei Sato, Ronald St-Louis, Jialin Fu, Wu I-Hsien, Koji Mizutani, Hatice Hasturk, Thomas E Van Dyke, Fusanori Nishimura, George L King, Dysregulation of CXCL1 expression and neutrophil recruitment in insulin resistance and diabetes-related periodontitis in male mice., Diabetes, 2023.04.
3. Rongzhi Li, Tomomi Sano, Akiko Mizokami, Takao Fukuda, ＠Takanori Shinjo, Misaki Iwashita, Akiko Yamashita, Terukazu Sanui, Yusuke Nakatsu, Yusuke Sotomaru, Tomoichiro Asano, Takashi Kanematsu, Fusanori Nishimura, miR-582-5p targets Skp1 and regulates NF-κB signaling-mediated inflammation., Archives of biochemistry and biophysics, 2022.12.
4. Yukari Watanabe, Takao Fukuda, Chikako Hayashi, Yuki Nakao, Masaaki Toyoda, Kentaro Kawakami, ＠Takanori Shinjo, Misaki Iwashita, Hiroaki Yamato, Karen Yotsumoto, Takaharu Taketomi, Takeshi Uchiumi, Terukazu Sanui, Fusanori Nishimura, Extracellular vesicles derived from GMSCs stimulated with TNF-α and IFN-α promote M2 macrophage polarization via enhanced CD73 and CD5L expression., Scientific reports, 2022.08.
5. Yuki Nishimura, Misaki Iwashita, Masato Hayashi, ＠Takanori Shinjo, Yukari Watanabe, Tatsuro Zeze, Akiko Yamashita, Takao Fukuda, Terukazu Sanui, Tomomi Sano, Tomoichiro Asano, Fusanori Nishimura, XAF1 overexpression exacerbates diabetes by promoting pancreatic β-cell apoptosis, Acta Diabetologica, 2022.07.
6. Jialin Fu*, Takanori Shinjo*, Qian Li, Ronald St-Louis, Kyoungmin Park, Marc G Yu, Hisashi Yokomizo, Fabricio Simao, Qian Huang, I-Hsien Wu, George L King *: Co-first, Regeneration of glomerular metabolism and function by podocyte pyruvate kinase M2 in diabetic nephropathy, JCI Insight, 10.1172/jci.insight.155260, 7, 5, e155260, 2022.01.
7. Shinjo T, Ishikado A, Hasturk H, Pober DM, Paniagua SM, Shah H, Wu IH, Tinsley LJ, Matsumoto M, Keenan HA, Van Dyke TE, Genco RJ, King GL., Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration., J Periodontol., 10.1002/JPER.18-0735., 90, 6, 565-575, 2019.06.
8. Shinjo T, Zhang J, Nakatsu Y, Guo Y, Sakoda H, Yamamotoya T, Otani Y, Okubo H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Iwashita M, Nishimura F,Katagiri H, Takahashi S, Kurihara H, Ushida T, Asano T., Par14 protein associates with insulin receptor substrate 1(IRS-1), thereby enhancing insulin-induced IRS-1 phosphorylation and metabolic actions., Journal of Biological Chemistry, 10.1074/jbc.M113.485730, 288, 28, 20692-20701, 2013.07.
9. Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Fukushima T, Tsuchiya Y, Kamata H, Nishimura F, Asano T., DPP-4 inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation., American Journal of Physiolosy Endocrinology and Metabolism, 10.1152/ajpendo.00553.2014, 309, 3, E214-E223, 2015.05.
10. Shinjo T, Nakatsu Y, Iwashita M, Sano T, Sakoda H, Ishihara H, Kushiyama A, Fujishiro M, Nishimura F, Asano T., High-fat diet feeding significantly attenuates anagliptin-induced regeneration of islets of Langerhans in streptozotocin-induced diabetic mice., Diabetology and Metabic Syndrome, 10.1186/s13098-015-0047-y, 7, 50, 2015.06.
11. Shinjo T., Iwashita M., Yamashita A., Sano T., Matsugana H., Tsuruta M., Sanui T., Asano T., Nishimura F, IL-17A synergistically enhances TNFα-induced IL-6 and CCL20 production in 3T3-L1 adipocytes., Biochem and Biophys Res Commun, 10.1016/j.bbrc.2016.06.049., 477, 2, 241-246, 2016.08.
Presentations
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1. Takanori Shinjo, The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis., The 105th American Academy of Periodontology annual meeting, 2019.11.
2. Takanori Shinjo, The pathogenic role of insulin resistance in obesity/diabetes-related periodontitis, The 9th Japan-Thailand-Korea Joint Symposium, 2019.10.
3. Takanori Shinjo, Qian Li, Atsushi Ishikado, Park Kyoungmin, Ronald St-Louis, Hisashi Yokomizo, Fu Jialin, Marc Yu, Haiyan Wang, Hatice Hasturk, Thomas E Van Dyke, George L King, Insulin-regulation of CXCL1 expression is important for neutrophil recruitments, periodontitis, and poor wound healing in diabetes., 79th American Diabetes Association Scientific Sessions , 2019.06.
4. Shinjo T, Ishikado A, Hasturk H, Tinsley L, Pober D, Wu IH, Van Dyke TE, Genco R, King GL, Protection from periodontal disease among insulin-dependent type 1 diabetic patients with disease duration of 50 years or longer-The Joslin 50-Year Medalist Study. , 78th American Diabetes Association Scientific Sessions, 2018.06.
5. Shinjo T, Ishikado A, Park K, Li Q, St-Louis R, Yokomizo H, Alves V, Kantarci A, Van Dyke TE, King GL, Depletion of Insulin receptor beta in gingiva exacerbates alveolar bone loss in mice model of experimental periodontitis., 103rd American Academy of Periodontology annual meeting , 2017.09.
6. 新城 尊徳, DPP4 inhibitor anagliptin exerts anti-inflammatory effect on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. , Penn Periodontal Conference 2015, 2015.07.
7. 新城 尊徳, DPP-4 Inhibitor Anagliptin exerts Anti-inflammatory Effects on Macrophages, Adipocytes, and Mouse Liver by suppressing LPS-induced NF-κB Activation., 第74回アメリカ糖尿病学会, 2014.06.
8. Takanori Shinjo, Ronald St-Louis, Jialin Fu, Park Kyoungmin, Qian Li, Hisashi Yokomizo, Marc Yu, Haiyan Wang, Aimo Kannt, Thorsten Sadowski and George L. King, Pyruvate kinase M2 overexpression in podocytes ameliorates nephropathy in diabetic mice., 79th American Diabetes Association Scientific Sessions, 2019.06.
Membership in Academic Society
  • THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY
  • JAPANESE SOCIETY OF PERIODONTOLOGY
  • Japan Society of Diabetic Complications
  • Japan Society of Conservative Dentistry
  • Japan Society of Periodontology
Awards
  • Kyushu University Dental Science Best Research Award (Field weighed citation impact division) 2023 FY
  • Par14 protein associates with insulin receptor substrate 1 (IRS-1), thereby enhancing inslulin-induced IRS-1 phosphorylation and metabolic actions.
Educational
Educational Activities
・Assistant for clinical preliminary training (for 5th-degree dental students)
・CBT, OSCE
・Assistant for clinical training (for 5th and 6th-degree dental students)
・Assistant for basic clinical training of periodontology (for 4th-degree dental students)


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