Kyushu University Academic Staff Educational and Research Activities Database
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Hyoda Tomoko Last modified date:2019.06.20

Assistant Professor / Section of Medical Science and Technology
Department of Health Sciences
Faculty of Medical Sciences


Graduate School


Academic Degree
doctor
Field of Specialization
Blood
Outline Activities
I deliver a lecture on hematology, microbiology, immunology, international infectious and genetic testing for students of the laboratory technology sciences.
I investigate that search for new therapeutic agents for myelodysplastic syndrome, development of a novel anti-leukemic therapy targeting the circadian clock genes and establishment of evaluation method of airway inflammation state in breath condensate.
Research
Research Interests
  • Establishment of evaluation method of airway inflammation state in breath condensate
    keyword : breath condensae, eosinophil, basophil, inflammation
    2019.04.
  • Effects of new drugs on an MDS-derived cell line.
    keyword : myelodysplastic syndromes, apoptosis, cell cycle
    2012.04.
  • Development of a novel anti-leukemic therapy targeting the circadian clock genes

    keyword : circadian rhythm, leukemia
    2016.04.
  • Search for novel leukemia treatment by controlling mitochondria-related metabolic factors
    keyword : mitochondria, leukemia, p32, TFAM
    2016.11~2018.11.
Academic Activities
Papers
1. Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A. Kay, Kenichiro Itami, and Tsuyoshi Hirota, Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth., Science Advances, 10.1126, 5, 1, eaau9060, 2019.01, Compounds targeting the circadian clock have been identified as potential treatments for clock-related diseases, including cancer. Our cell-based phenotypic screen revealed uncharacterized clock-modulating compounds. Through affinity-based target deconvolution, we identified GO289, which strongly lengthened circadian period, as a potent and selective inhibitor of CK2. Phosphoproteomics identified multiple phosphorylation sites inhibited by GO289 on clock proteins, including PER2 S693. Furthermore, GO289 exhibited cell type-dependent inhibition of cancer cell growth that correlated with cellular clock function. The x-ray crystal structure of the CK2 alpha-GO289 complex revealed critical interactions between GO289 and CK2-specific residues and no direct interaction of GO289 with the hinge region that is highly conserved among kinases. The discovery of GO289 provides a direct link between the circadian clock and cancer regulation and reveals unique design principles underlying kinase selectivity..
Educational
Educational Activities
I deliver a lecture on hematology, microbiology, immunology, international infectious and genetic testing for students of the laboratory technology sciences.