Kyushu University Academic Staff Educational and Research Activities Database
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Yuki Soma Last modified date:2021.10.25

Graduate School
Other Organization

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Academic Degree
Ph. D.
Country of degree conferring institution (Overseas)
Field of Specialization
Synthetic Biology, Metabolic Engineering, Metabolomics
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Research Interests
  • Development and application of quantitative metabolomic analysis methods
    keyword : metabolomics, metabolic engineering, mass spectrometry
  • Metabolic flux regulation by synthetic genetic circuit
    keyword : genetic circuit, metabolic flux regulation, quorum sensing, metabolomics
Academic Activities
1. Yuki Soma, Keigo Tsuruno, Masaru Wada, Atsushi Yokota, Taizo Hanai, Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch, METABOLIC ENGINEERING, 10.1016/j.ymben.2014.02.008, 23, 175-184, 2014.05.
2. Yuki Soma, Taizo Hanai, Self-induced metabolic state switching by a tunable cell density sensor for microbial isopropanol production, METABOLIC ENGINEERING, 10.1016/j.ymben.2015.04.005, 30, 7-15, 2015.07.
3. Yuki Soma, Yuri Fujiwara, Takuya Nakagawa, Keigo Tsuruno, Taizo Hanai, Reconstruction of a metabolic regulatory network in Escherichia coli for purposeful switching from cell growth mode to production mode in direct GABA fermentation from glucose, METABOLIC ENGINEERING, 10.1016/j.ymben.2017.08.002, 43, Pt A, 54-63, 2017.09, [URL], gamma-aminobutyric acid (GABA) is a drug and functional food additive and is used as a monomer for producing the biodegradable plastic, polyamide 4. Recently, direct GABA fermentation from glucose has been developed as an alternative to glutamate-based whole cell bioconversion. Although total productivity in fermentation is determined by the specific productivity and cell amount responsible for GABA production, the optimal metabolic state for GABA production conflicts with that for bacterial cell growth. Herein, we demonstrated metabolic state switching from the cell growth mode based on the metabolic pathways of the wild type strain to a GABA production mode based on a synthetic metabolic pathway in Escherichia coli through rewriting of the metabolic regulatory network and pathway engineering. The GABA production mode was achieved by multiple strategies such as conditional interruption of the TCA and glyoxylate cycles, engineering of GABA production pathway including a bypass for precursor metabolite supply, and upregulation of GABA transporter. As a result, we achieved 3-fold improvement in total GABA production titer and yield (4.8 g/L, 49.2% (mol/mol glucose)) in batch fermentation compared to the case without metabolic state switching (1.6 g/L, 16.4% (mol/mol glucose)). This study reports the highest GABA production performance among previous reports on GABA fermentation from glucose using engineered E. coli..
4. Hiroshi Honjo, Kenshiro Iwasaki, Yuki Soma, K. Tsuruno, Hiroyuki Hamada, T. Hanai, Synthetic microbial consortium with specific roles designated by genetic circuits for cooperative chemical production, Metabolic Engineering, 10.1016/j.ymben.2019.08.007, 55, 268-275, 2019.09.
5. Kosuke Hata, Yuki Soma, Toshiyuki Yamashita, Masatomo Takahashi, Kuniyo Sugitate, Takeshi Serino, Hiromi Miyagawa, Kenichi Suzuki, Kayoko Yamada, Takatomo Kawamukai, Teruhisa Shiota, Yoshihiro Izumi, Takeshi Bamba, Calibration-Curve-Locking Database for Semi-Quantitative Metabolomics by Gas Chromatography/Mass Spectrometry, Metabolites, 10.3390/metabo11040207, 11, 4, 207-207, 2021.03, [URL].
6. Yan-Yu Chen, Yuki Soma, Masahito Ishikawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Katsutoshi Hori, Metabolic alteration of Methylococcus capsulatus str. Bath during a microbial gas-phase reaction, Bioresource Technology, 10.1016/j.biortech.2021.125002, 330, 125002-125002, 2021.06, [URL].
7. Yuki Soma, Masatomo Takahashi, Yuri Fujiwara, Tamaki Shinohara, Yoshihiro Izumi, Taizo Hanai, Takeshi Bamba, Design of Synthetic Quorum Sensing Achieving Induction Timing-Independent Signal Stabilization for Dynamic Metabolic Engineering of E. coli, ACS Synthetic Biology, 10.1021/acssynbio.1c00008, 10, 6, 1384-1393, 2021.06, [URL].
1. , [URL].
2. Yuki Soma, Design of synthetic genetic circuit for dynamic metabolic engineering, 8thASIAN SYMPOSIUM ON INNOVATIVE BIO-PRODUCTION SINGAPORE (i-BioS), 2017.12, [URL].
3. Yuki Soma, Yuri Fujiwara, Taizo Hanai, Yoshihiro Izumi, Takeshi Bamba, Reprogramming of Collective Microbial Cell Behavior, The 27th Hot Spring Harbor International Symposium, 2017.10.
4. Yuki Soma, Metabolomics on designed metabolic dynamics by synthetic genetic circuits, The 26th Hot Spring Harbor International Symposium, 2016.11.
Membership in Academic Society
  • American Society for Mass Spectrometry
  • The Society of Biotechnology, Japan