Kyushu University Academic Staff Educational and Research Activities Database
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Ogawa Yoshihiro Last modified date:2019.06.24

Professor / Department of Medical and Bioregulatory Science
Department of Clinical Medicine
Faculty of Medical Sciences

Graduate School
Undergraduate School
Other Organization
Administration Post

Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Internal Medicine, Endocrinology and Metabolism, Diabetes
Total Priod of education and research career in the foreign country
Research Interests
  • Molecular mechanisms of chronic inflammation and their clinical implications
    keyword : Chronic inflammation, tissue fibrosis, macrophages, epigenetic memory, DNA methylation, DOHaD
  • Epigenetic regulation of lifestyle-related diseases and its clinical implications
    keyword : Epigenetic memory, DNA methylation, DOHaD hypothesis
Current and Past Project
  • Tissue fibrosis, a common feature of chronic inflammatory diseases, may often result in the malfunction of a variety of organs and eventually organismal death. This study is designed to elucidate the molecular mechanism underlying tissue fibrosis, which occurs through the dysregulation of homeostatic mechanisms; local cell-cell interaction and systemic organ network. Accordingly, we wish to identify novel biomarkers and drug targets against non-alcoholic steatohepatitis (NASH), which may lay the groundwork for its preemptive medicine and innovative anti-fibrotic strategies.
Academic Activities
1. T. Goto, M. Itoh, T. Suganami, S. Kanai, I. Shirakawa, T. Sakai, M. Asakawa, T. Yoneyama, T. Kai, and Y. Ogawa., Clinicopathogenic and molecular characteristics of synchronous colorectal carcinoma with mismatch repair deficiency., Sci Rep. , 10.1038/s41598-018-26383-8., 8, 1, 8157, 2018.05.
2. K. Kawahori, K. Hashimoto, X. Yuan, K. Tsujimoto, N. Hanzawa, M. Hamaguchi, S. Kase, K. Fujita, K. Tagawa, H. Okazawa, Y. Nakajima, N. Shibusawa, M. Yamada, and Y. Ogawa. , Mild maternal hypothyroxinemia during pregnancy induces persistent DNA hypermethylation in the hippocampal brain-derived neurotrophic factor gene in mouse offspring. , Thyroid, 10.1089/thy.2017.0331., 28, 3, 395-406, 2018.03.
3. X. Yuan, K. Tsujimoto, K. Hashimoto, K. Kawahori, N. Hanzawa, M. Hamaguchi, T. Seki, M. Nawa, T. Ehara, Y. Kitamura, I. Hatada, M. Konishi, N. Itoh, Y. Nakagawa, H. Shimano, T. Takai-Igarashi, Y. Kamei, and Y. Ogawa., Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood., Nat. Commun., 10.1038/s41467-018-03038-w., 9, e636, 2018.02.
4. K. Hashimoto, E. Nishihara, M. Matsumoto, S. Matsumoto, Y. Nakajima, K. Tsujimoto, H. Yamakage, N. Asahara-Satoh, J. Noh, K. Ito, A. Miyauchi, M. Mori, M. Yamada, and Y. Ogawa., Sialic acid-binding immunoglobulin-like lectin1 as a novel predictive biomarker for relapse in Graves’ disease: a multicenter study., Thyroid, 10.1089/thy, 28, 1, 50-59, 2018.01.
5. K. Shiba, K. Tsuchiya, C. Komiya, Y. Miyachi, K. Mori, N. Shimazu, S. Yamaguchi, N. Ogasawara, M. Katoh, M. Itoh, T. Suganami, and Y. Ogawa., Canagliflozin, an SGLT2 inhibitor, attenuates the development of hepatocellular carcinoma in a mouse model of human NASH. , Sci. Rep. , 8, e2362, 2018.01.
1. 小川 佳宏, Lifestyle-related diseases viewed through metabolic organ network, 第41回日本分子生物学会年会, 2018.10.
2. Yoshihiro Ogawa, Role of DNA Methylation in Early Life and its Impact in Later Life, Keystone Symposia Drivers of Type2 Diabetes: From Genes to Environment, 2018.10.
3. Yoshihiro Ogawa, Obesity-induced lifestyle-related diseases: Let’s see both the wood and trees!, DMRC & study of drug research of KDA 2018 International Symposium, 2018.06.
Membership in Academic Society
  • The Japan Society of Hepatology
Other Educational Activities
  • 2016.09.