Takahiro Maeda | Last modified date:2023.11.22 |
Professor /
Division of Precision Medicine
Research Center for Precision Medicine
Faculty of Medical Sciences
Research Center for Precision Medicine
Faculty of Medical Sciences
Graduate School
Homepage
https://kyushu-u.elsevierpure.com/en/persons/takahiro-maeda
Reseacher Profiling Tool Kyushu University Pure
https://precision.kyushu-u.ac.jp/en/
Academic Degree
MD., Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Hematology/Oncology
ORCID(Open Researcher and Contributor ID)
orcid.org/0000-0003-4530-6460
Total Priod of education and research career in the foreign country
15years01months
Research
Research Interests
Membership in Academic Society
- Goals of our research projects are to:
1. Identify novel targets for acute leukemia therapy.
2. Determine molecular mechanisms underlying fetal global repression in adult erythroid cells.
3. Determine the role of the transcription factor LRF/ZBTB7A in hematopoietic cellular differentiation.
keyword : Acute leukemia, Sickle cell disease, Differentiation of hematopoietic lineage cells
2016.10.
- Hemoglobinopathies, such as sickle cell disease (SCD) and thalassemia, are among the greatest public health concerns in the world. Although new therapeutic modalities, such as gene therapy, are currently being tested, there is a pressing need for pharmacologic approaches to treat general patient populations. Our long-term goal is to develop a compound(s) that induces fetal-type globin (HbF) production by targeting the transcriptional complex regulating globin switching. The objective of this application is to determine molecular mechanisms underlying the LRF-NuRD-mediated γ-globin silencing and identify a mean(s) to target them. Our central hypothesis is that the LRF-containing NuRD complex is a potential target for HbF reactivation therapy. The rationale for the proposed research is that understanding the LRF/NuRD-mediated globin regulation will provide greater understanding of the transcriptional complex regulating γ-globin repression and facilitate development of novel therapeutic strategies for HbF induction therapy.
- Goal of this study is to identify novel targets for leukemia therapy using a genome-wide CRISPR/Cas9 screen.
Presentations
- American Society of Hematology
- Japanese Society of Hematology
- Society of Hematologic Oncology
- Japan Society for Hematopoietic Cell Transplantation
- Japanese Cancer Association
- Japanese Society of Internal Medicine
- Japan Society of Transfusion Medicine and Cell Therapy
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