Kyushu University Academic Staff Educational and Research Activities Database
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Mitsuru Arima Last modified date:2020.06.25

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Doctor of Medicine
Country of degree conferring institution (Overseas)
Field of Specialization
Pediatric ophthalmology
Total Priod of education and research career in the foreign country
Research Interests
  • Development of eye drop therapy for retinopathy of prematurity
    keyword : retinopathy of prematurity
  • Development of portable fundus camera
    keyword : fundus camera
  • Development of novel treatment for diabetic macular edema
    keyword : diabetic macular edema
  • Comparison of ocular findings between Loeys-Dietz syndrome and Marfan syndrome
    keyword : Loeys-Dietz syndrome, Marfan syndrome
Academic Activities
1. Mitsuru Arima,Masato Akiyama,Kohta Fujiwara,Yujiro Mori,Hirosuke Inoue,Eiko Seki,Takahito Nakama,Shoko Tsukamoto,Masayuki Ochiai,Shouichi Ohga,Koh-Hei Sonoda, Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1 retinopathy of prematurity, PLoS One, 15, 3, e0230678, 2020.03.
2. Mitsuru Arima,Shintaro Nakao,Muneo Yamaguchi,Hao Feng,Yuya Fujii,Kensuke Shibata,Iori Wada,Yoshihiro Kaizu,Hamid Ahmadieh,Alan W Stitt,Tatsuro Ishibashi,Koh-Hei Sonoda, Claudin-5 Redistribution Induced by Inflammation Leads to Anti-VEGF Resistant Diabetic Macular Edema, Diabetes, 69, 5, 981-989, 2020.05.
3. Arima M, Tsukamoto S, Fujiwara K, Murayama M, Fujikawa K, Sonoda KH., Late-onset Circulatory Collapse and Continuous Positive Airway Pressure are Useful Predictors of Treatment-requiring Retinopathy of Prematurity: A 9-year Retrospective Analysis., Sci Rep., 2017.06, Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the efficiency of significant predictors compared with existing predictive models, ROPScore and CHOP model. Multivariable logistic regression analyses supported the following factors were useful for predicting TR-ROP from all infants and infants with any ROP: GA (odds ratio [OR], 0.47 and 0.48), history of late-onset circulatory collapse (LCC) (OR, 2.76 and 2.44) and use of continuous positive airway pressure (CPAP) at 35 weeks of postmenstrual age (OR, 3.78 and 4.50). The comparison of areas under receiver operating characteristic curves indicated the combination of LCC, CPAP and ROPScore was better than ROPScore to predict TR-ROP from all infants and infants with any ROP (P = 0.007 and 0.02) and the combination of LCC, CPAP and CHOP model was also better than CHOP model to predict TR-ROP from all infants and infants with any ROP (P = 0.01 and 0.02). Our results suggested infants with a history of LCC and a long CPAP support have a high incidence of TR-ROP..
4. Yamaguchi M, Nakao S, Arima M, Wada I, Kaizu Y, Hao F, Yoshida S, Sonoda KH., Rho-Kinase/ROCK as a Potential Drug Target for Vitreoretinal Diseases., J Ophthalmol., 2017.05.
5. Arima M, Cui D, Kimura T, Sonoda KH, Ishibashi T, Matsuda S, Ikeda E., Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy., Sci Rep., 2016.12.
6. Yamaguchi M, Nakao S, Arita R, Kaizu Y, Arima M, Zhou Y, Kita T, Yoshida S, Kimura K, Isobe T, Kaneko Y, Sonoda KH, Ishibashi T., Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia., Invest Ophthalmol Vis Sci., 2016.04.
7. Cui D, Arima M, Takubo K, Kimura T, Horiuchi K, Minagawa T, Matsuda S, Ikeda E., ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function., Sci Rep., 2015.08.
8. Arima M, Yoshida S, Nakama T, Ishikawa K, Nakao S, Yoshimura T, Asato R, Sassa Y, Kita T, Enaida H, Oshima Y, Matsuda A, Kudo A, Ishibashi T., Involvement of periostin in regression of hyaloidvascular system during ocular development., Invest Ophthalmol Vis Sci., 2012.09.
9. Nakao S, Arima M, Ishikawa K, Kohno R, Kawahara S, Miyazaki M, Yoshida S, Enaida H, Hafezi-Moghadam A, Kono T, Ishibashi T., Intravitreal anti-VEGF therapy blocks inflammatory cell infiltration and re-entry into the circulation in retinal angiogenesis., Invest Ophthalmol Vis Sci., 2012.06.
1. Rumi Akiyama, Shoko Tsukamoto, Mitsuru Arima, Miwa Murayama, Koh-Hei Sonoda, Ophthalmic findings of a male infant with Pierson syndrome, The 10th Joint Meeting of Korea-China-Japan Ophthalmologists, 2017.11.
2. Mitsuru Arima, Shoko Tsukamoto, Kohta Fujiwara, Kanako Yamana, Miwa Murayama, Koh-Hei Sonoda, LCC and CPAP are useful predictors of the development of TR-ROP, Annual Meeting of the Japanese Association of Pediatric Ophthalmology, 2018.03.
3. Mitsuru Arima, Shintaro Nakao, Feng Hao, Muneo Yamaguchi, Kensuke Shibata, Yoshihiro Kaizu, Iori Wada, Shigeo Yoshida, Koh-Hei Sonoda, Impact of a ROCK inhibitor ripasudil on distribution of claudin-5 in vascular endothelial cells in diabetic retinopathy, The Association for Research in Vision and Ophthalmology, 2018.05.
Membership in Academic Society
  • The Japanese Society of Ophthalmic Diabetology