Kyushu University [Keisuke Tomohara (Assistant Professor) Faculty of Arts and Science, Division for Experimental Natural Science]

Keisuke Tomohara

Last modified date：2023.08.09

Assistant Professor / Division for Experimental Natural Science
Faculty of Arts and Science

2 Academic Activities

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Homepage

Phone

092-802-5784

Academic Degree

Ph.D. (Kyoto University)

Field of Specialization

Medicinal chemistry

ORCID(Open Researcher and Contributor ID)

0000-0003-2305-5963

Research

Research Interests

Mechanistic characterization of enzyme inhibitors by solvent-perturbation assay
keyword : Perturbation
2013.04.
Chemical engineering of natural product extracts
keyword : Natural product extract, Unnatural natural product, natural product hybrid, chemical engineering
2013.04.

Academic Activities

Reports

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1.	友原　啓介, ヨウ化アリールの連続的オルトアミノ化—イプソホウ素化反応, ファルマシア, 2015.11.
2.	Keisuke Tomohara, Another aspect in use of DMSO in medicinal chemistry, Atlas of Science, 2016.10.

Papers

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1.	Keisuke Tomohara, Juthamart Maneene, Nao Ohashi, Takeru Nose, Rintaro Fujii, Min Jo Kim, Sijia Sun, Suresh Awale., Ugi Adducts as Novel Anti-Austerity Agents Against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach , Biological and Pharmaceutical Bulletin, in press, 2023.08.
2.	Keisuke Tomohara, Nao Ohashi, Tatsuya Uchida, Takeru Nose., Synthesis of natural product hybrids by the Ugi reaction in complex media containing plant extracts, Scientific Reports*, 12, 15568, 2022.09.
3.	Keisuke Tomohara, Nao Ohashi, Takeru Nose, Mechanistic Insights into a DMSO-Perturbing Inhibitory Assay of Hyaluronidase, Biochemistry, 59, 3879-3888, 2020.09.
4.	Keisuke Tomohara, Naoto Hasegawa, Isao Adachi, Yoshikazu Horino, Takeru Nose., Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay., Bioorg. Med. Chem. Lett., 30, 126815, 2020.01.
5.	Keisuke Tomohara, Isao Adachi, Yoshikazu Horino, Hitoshi Kesamaru, Hitoshi Abe, Keitaro Suyama, Takeru Nose., DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors., ACS Med. Chem. Lett., 10, 923-928, 2019.05.

Presentations

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1.	Keisuke Tomohara, Isao Adachi, Hitoshi Kesamaru, Takeru Nose, Mechanistic Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay, 10th International Peptide Symposium, 2018.12.
2.	Keisuke Tomohara, DMSO-perturbing assay for identifying promiscuous enzyme inhibitors, The Third International Symposium on Toyama-Asia-Africa Pharmaceutical Network (招待講演), 2018.09, Abstract: Nonspecific binding inhibitors of alpha-chymotrypsin, beta-lactamase, and hyaluronidase could be identified by the DMSO-perturbation assay..

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