| 1. |
Takuma Fukui, Keijiro Ishikawa, Satomi Shiose, Kumiko Kano, Kenichiro Mori, Shoji Notomi, Koh-Hei Sonoda, Spatial pattern of retinal pigment epithelium tear development and progression after anti-vascular endothelial growth factor therapy for neovascular age-related macular degeneration, Retin Cases Brief Rep, 2022.11. |
| 2. |
Shoji Notomi, Satomi Shiose, Yosuke Fukuda, Kenichiro Mori, Sawako Hashimoto, Kumiko Kano, Keijiro Ishikawa, Koh-Hei Sonoda, Characteristics of retinal pigment epithelium elevations preceding exudative age-related macular degeneration in Japanese, Ophthalmic Res, 2022.08. |
| 3. |
Notomi S, Shiose S, Kohno RI, Shimokawa S, Ishikawa K, Kano K, Mori K, Wada I, Fukuda Y, Nakatake S, Yamaguchi M, Sonoda KH, A case of bullous central serous chorioretinopathy treated with surgical removal of submacular fibrin and subsequent photodynamic therapy under silicone oil, Case Rep Ophthalmol 13:385-392, 2022/05/30, 2022.05. |
| 4. |
Funatsu J, Murakami Y, Shimokawa S, Nakatake S, Fujiwara K, Okita A, Fukushima Masatoshi, Shibata K, Yoshida N, Koyanagi Y, Akiyama M, Notomi S, Nakao S, Hisatomi T, Takeda A, Eleftherios I. Paschalis, Demetrios G. Vavvas, Ikeda Y, Sonoda KH, Circulating inflammatory monocytes oppose microglia and contribute to cone cell death in retinitis pigmentosa , PNAS Nexus 1(1):3, 2022/03/01, 2022.03. |
| 5. |
Takeda A, Hasegawa E, Yawata N, Notomi S, Ishikawa K, Murakami Y, Hisatomi T, Kimura K, Sonoda KH , Increased vitreous levels of B cell activation factor (BAFF) and soluble interleukin-6 receptor in patients with macular edema due to uveitis related to Behçet’s disease and sarcoidosis, Graefes Arch Clin Exp Ophthalmol. 2022/03/01, 2022.03. |
| 6. |
Wada I, Shiose S, Ishikawa K, Kano K, Notomi S, Mori K, Akiyama M, Nakao S, Sonoda KH, One-year efficacy of "rescue photodynamic therapy" for patients with typical age-related macular degeneration, polypoidal choroidal vasculopathy, and pachychoroid neovasculopathy refractory to anti-vascular endothelial growth factor therapy, Graefes Arch Clin Exp Ophthalmol. 260(6):2029-2036, 2022/01/01, 2022.01. |
| 7. |
Mori K, Ishikawa K, Fukuda Y, Rui ji, Wada I, Kubo Y, Akiyama M, Notomi Shoji, Murakami Y, Nakao S, Arakawa S, Shiose Satomi, Hisatomi T, Yoshida S, Ram Kannan, Sonoda KH, TNFRSF10A downregulation induces retinal pigment epithelium degeneration during the pathogenesis of age-related macular degeneration and central serous chorioretinopathy, Hum Mol Genet. 2022/02/01, 2022.01. |
| 8. |
Notomi S, Shiose S, Ishikawa K, Fukuda Y, Kano K, Mori K, Wada I, Kaizu Y, Matsumoto H, Akiyama M, Sonoda KH, Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients., PLoS One. 16(7):e0255213, 2021/07/27, 2021.07. |
| 9. |
Ishikawa K, Akiyama M, Mori K, Nakama T, Notomi S, Nakao S, Kohno RI, Takeda A, Sonoda KH, Drainage retinotomy confers risk of epiretinal membrane formation following vitrectomy for rhegmatogenous retinal detachment repair, Am J Ophthalmol. 234:20-27, 2021/07/30, 2021.07. |
| 10. |
Atsunobu Takeda, Eiichi Hasegawa, Shoji Notomi, Keijiro Ishikawa, Mitsuru Arima, Yusuke Murakami, Shintaro Nakao, Toshio Hisatomi, Koh-Hei Sonoda, Surgical Outcomes of Contrast Sensitivity and Visual Acuity in Uveitis-Associated Cataract., Clin Ophthalmol. 2021 Jun 24;15:2665-2673., 2021.06. |
| 11. |
Shunichi Adachi, Michiko Torio, Sayaka Okuzono, Yoshitomo Motomura, Yuko Ichimiya, Yuri Sonoda, Jyunya Nagata, Misato Okamoto, Shoji Notomi, Masafumi Sanefuji, Yasunari Sakai, Shouichi Ohga, Vitamin A deficiency-associated corneal perforation in a boy with autism spectrum disorder: A case report and literature review. , Nutrition. 2021;90:111275., 2021.04. |
| 12. |
Nikolaos E. Efstathiou, Giannis A. Moustafa, Daniel E. Maidana, Eleni K. Konstantinou, Shoji Notomi, Paulo R. T. Barbisan, Constantine D. Georgakopoulos, Joan W. Miller, Demetrios G. Vavvas, Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. , PLoS One. 2020;15(12): e0244307., 2020.12. |
| 13. |
永吉美月, 塩瀬聡美, 和田伊織, 狩野久美子, 石川桂二郎, 秋山雅人, 森賢一郎, 納富昭司, 中尾新太郎, 久冨智朗, 園田康平, ポリープ状脈絡膜血管症に対する光線力学的療法併用抗血管内皮増殖因子治療後短期における治療成績と再発予測因子, 臨床眼科, 2020.10. |
| 14. |
Jong-Jer Lee, Kenji Ishihara, Shoji Notomi, Nikolaos E Efstathiou, Takashi Ueta, Daniel Maidana, Xiaohong Chen, Yasuhiro Iesato, Alberto Caligiana, Demetrios G Vavvas, Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells., Biochem Biophys Res Commun. 2020;521(2):414-419. , 2020.01, Lysosome-associated membrane protein-2 (LAMP2), is a highly glycosylated lysosomal membrane protein involved in chaperone mediated autophagy. Mutations of LAMP2 cause the classic triad of myopathy, cardiomyopathy and encephalopathy of Danon disease (DD). Additionally, retinopathy has also been observed in young DD patients, leading to vision loss. Emerging evidence show LAMP2-deficiency to be involved in oxidative stress (ROS) but the mechanism remains obscure. In the present study, we found that tert-butyl hydroperoxide or antimycin A induced more cell death in LAMP2 knockdown (LAMP2-KD) than in control ARPE-19 cells. Mechanistically, LAMP2-KD reduced the concentration of cytosolic cysteine, resulting in low glutathione (GSH), inferior antioxidant capability and mitochondrial lipid peroxidation. ROS induced RPE cell death through ferroptosis. Inhibition of glutathione peroxidase 4 (GPx4) increased lethality in LAMP2-KD cells compared to controls. Cysteine and glutamine supplementation restored GSH and prevented ROS-induced cell death of LAMP2-KD RPE cells.. |
| 15. |
Shoji Notomi, Kenji Ishihara, Nikolaos E. Efstathiou, Jong-Jer Lee, Toshio Hisatomi, Takashi Tachibana, Eleni K. Konstantinou, Takashi Ueta, Yusuke Murakami, Daniel E. Maidana, Yasuhiro Ikeda, Shinji Kume, Hiroto Terasaki, Shozo Sonoda, Judith Blanz, Lucy Young, Taiji Sakamoto, Koh-Hei Sonoda, Paul Saftig, Tatsuro Ishibashi, Joan W. Miller, Guido Kroemer, and Demetrios G. Vavvas, Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina., Proc Natl Acad Sci U S A. 2019; 116(47):23724-23734., 2019.12, The early stages of age-related macular degeneration (AMD) are characterized by the accumulation of basal laminar deposits (BLamDs). The mechanism for BLamDs accumulating between the retinal pigment epithelium (RPE) and its basal lamina remains elusive. Here we examined the role in AMD of lysosome-associated membrane protein-2 (LAMP2), a glycoprotein that plays a critical role in lysosomal biogenesis and maturation of autophagosomes/phagosomes. LAMP2 was preferentially expressed by RPE cells, and its expression declined with age. Deletion of the Lamp2 gene in mice resulted in age-dependent autofluorescence abnormalities of the fundus, thickening of Bruch's membrane, and the formation of BLamDs, resembling histopathological changes occurring in AMD. Moreover, LAMP2-deficient mice developed molecular signatures similar to those found in human AMD-namely, the accumulation of APOE, APOA1, clusterin, and vitronectin-adjacent to BLamDs. In contrast, collagen 4, laminin, and fibronectin, which are extracellular matrix proteins constituting RPE basal lamina and Bruch's membrane were reduced in Lamp2 knockout (KO) mice. Mechanistically, retarded phagocytic degradation of photoreceptor outer segments compromised lysosomal degradation and increased exocytosis in LAMP2-deficient RPE cells. The accumulation of BLamDs observed in LAMP2-deficient mice was eventually followed by loss of the RPE and photoreceptors. Finally, we observed loss of LAMP2 expression along with ultramicroscopic features of abnormal phagocytosis and exocytosis in eyes from AMD patients but not from control individuals. Taken together, these results indicate an important role for LAMP2 in RPE function in health and disease, suggesting that LAMP2 reduction may contribute to the formation of BLamDs in AMD.. |
| 16. |
Takashi Ueta, Kenji Ishihara, Shoji Notomi, Jong-Jer Lee, Daniel E Maidana, Nikolaos E Efstathiou, Yusuke Murakami, Eiichi Hasegawa, Kunihiro Azuma, Tetsuya Toyono, Eleftherios I Paschalis, Makoto Aihara, Joan W Miller, Demetrios G Vavvas, RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization., Proc Natl Acad Sci U S A. 2019; 116(47):23705-23713., 2019.12. |
| 17. |
Hisatomi T, Tachibana T, Notomi S, Nakatake S, Fujiwara K, Murakami Y, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T, Sonoda KH, Ishibashi T., INCOMPLETE REPAIR OF RETINAL STRUCTURE AFTER VITRECTOMY WITH INTERNAL LIMITING MEMBRANE PEELING., Retina. 2017 Aug;37(8):1523-1528. doi: 10.1097/IAE.0000000000001388.
PMID: 27828909, 2017.08. |
| 18. |
Tian B, Al-Moujahed A, Bouzika P, Hu Y, Notomi S, Tsoka P, Miller JW, Lin H, Vavvas DG.
, Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells.
, Sci Rep. 2017 May 24;7(1):2329. doi: 10.1038/s41598-017-02407-7.
PMID: 28539592 , 2017.05. |
| 19. |
Konstantinou EK, Notomi S, Kosmidou C, Brodowska K, Al-Moujahed A, Nicolaou F, Tsoka P, Gragoudas E, Miller JW, Young LH, Vavvas DG.
, Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity.
, Sci Rep. 2017 Apr 21;7:46581. doi: 10.1038/srep46581.
PMID: 28429726
, 2017.04. |
| 20. |
Klionsky DJ et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.
PMID: 26799652 , 2016.12. |
| 21. |
Nakatake S, Murakami Y, Ikeda Y, Morioka N, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Hisatomi T, Yoshida S, Ishibashi T, Nakabeppu Y, Sonoda KH.
, MUTYH promotes oxidative microglial activation and inherited retinal degeneration.
, JCI Insight. 2016 Sep 22;1(15):e87781. doi: 10.1172/jci.insight.87781.
PMID: 27699246 , 2016.09. |
| 22. |
Murakami Y, Ikeda Y, Akiyama M, Fujiwara K, Yoshida N, Nakatake S, Notomi S, Nabeshima T, Hisatomi T, Enaida H, Ishibashi T.
, Correlation between macular blood flow and central visual sensitivity in retinitis pigmentosa.
, Acta Ophthalmol. 2015 Dec;93(8):e644-8. doi: 10.1111/aos.12693. Epub 2015 Feb 17.
PMID: 25688697
, 2015.12. |
| 23. |
Yoshida N, Ikeda Y, Murakami Y, Nakatake S, Tachibana T, Notomi S, Hisatomi T, Ishibashi T.
, Vitreous cysts in patients with retinitis pigmentosa.
, Jpn J Ophthalmol. 2015 Nov;59(6):373-7. doi: 10.1007/s10384-015-0405-1. Epub 2015 Aug 29.
PMID: 26314744
, 2015.11. |
| 24. |
Murakami Y, Ikeda Y, Nakatake S, Tachibana T, Fujiwara K, Yoshida N, Notomi S, Nakao S, Hisatomi T, Miller JW, Vavvas DG, Sonoda KH, Ishibashi T.
, Necrotic enlargement of cone photoreceptor cells and the release of high-mobility group box-1 in retinitis pigmentosa.
, Cell Death Discov. 2015 Nov 30;1:15058. doi: 10.1038/cddiscovery.2015.58. eCollection 2015.
PMID: 27551484
, 2015.11. |
| 25. |
Matsumoto H, Murakami Y, Kataoka K, Notomi S, Mantopoulos D, Trichonas G, Miller JW, Gregory MS, Ksander BR, Marshak-Rothstein A, Vavvas DG., Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium.
, Cell Death Dis. 2015 Nov 19;6(11):e1986. doi: 10.1038/cddis.2015.334., 2015.11. |
| 26. |
Ikeda Y, Yoshida N, Murakami Y, Nakatake S, Notomi S, Hisatomi T, Enaida H, Ishibashi T.
, Long-term Surgical Outcomes of Epiretinal Membrane in Patients with Retinitis Pigmentosa.
, Sci Rep. 2015 Aug 13;5:13078. doi: 10.1038/srep13078.
PMID: 26268934
, 2015.08. |
| 27. |
Murakami Y, Yoshida N, Ikeda Y, Nakatake S, Fujiwara K, Notomi S, Nabeshima T, Nakao S, Hisatomi T, Enaida H, Ishibashi T.
, Relationship between aqueous flare and visual function in retinitis pigmentosa.
, Am J Ophthalmol. 2015 May;159(5):958-63.e1. doi: 10.1016/j.ajo.2015.02.001. Epub 2015 Feb 10.
PMID: 25677184
, 2015.05. |
| 28. |
Yoshida N, Ikeda Y, Murakami Y, Nakatake S, Fujiwara K, Notomi S, Hisatomi T, Ishibashi T.
, Factors affecting visual acuity after cataract surgery in patients with retinitis pigmentosa.
, Ophthalmology. 2015 May;122(5):903-8. doi: 10.1016/j.ophtha.2014.12.003. Epub 2015 Jan 17.
PMID: 25601536, 2015.05. |
| 29. |
Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG.
, Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death.
, Cell Death Dis. 2015 Apr 23;6(4):e1731. doi: 10.1038/cddis.2015.73.
PMID: 25906154
, 2015.04. |
| 30. |
Hirayama Y, Ikeda-Matsuo Y, Notomi S, Enaida H, Kinouchi H, Koizumi S., Astrocyte-mediated ischemic tolerance., J Neurosci. 2015 Mar 4;35(9):3794-805. doi: 10.1523/JNEUROSCI.4218-14.2015.
PMID: 25740510, 2015.03. |
| 31. |
Hisatomi T, Notomi S, Tachibana T, Oishi S, Asato R, Yamashita T, Murakami Y, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T.
, Brilliant Blue G double staining enhances successful internal limiting membrane peeling with minimal adverse effect by low cellular permeability into live cells.
, Retina. 2015 Feb;35(2):310-8. doi: 10.1097/IAE.0000000000000289.
PMID: 25105316, 2015.02. |
| 32. |
Hisatomi T, Notomi S, Tachibana T, Sassa Y, Ikeda Y, Nakamura T, Ueno A, Enaida H, Murata T, Sakamoto T, Ishibashi T.
, Ultrastructural changes of the vitreoretinal interface during long-term follow-up after removal of the internal limiting membrane.
, Am J Ophthalmol. 2014 Sep;158(3):550-6.e1. doi: 10.1016/j.ajo.2014.05.022. Epub 2014 May 27.
PMID: 24878309, 2014.09. |
| 33. |
Ando R, Noda K, Tomaru U, Kamoshita M, Ozawa Y, Notomi S, Hisatomi T, Noda M, Kanda A, Ishibashi T, Kasahara M, Ishida S.
, Decreased proteasomal activity causes photoreceptor degeneration in mice.
, Invest Ophthalmol Vis Sci. 2014 Jul 3;55(7):4682-90. doi: 10.1167/iovs.13-13272.
PMID: 24994871
, 2014.07. |
| 34. |
Akiyama M, Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T., Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa., Acta Ophthalmol. 2014 May;92(3):e229-34. doi: 10.1111/aos.12293.
PMID: 24868583, 2014.05. |
| 35. |
Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K, Morizane Y, Kayama M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor KM, Miller JW, Vavvas DG.
, Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration.
, Cell Death Differ. 2014 Feb;21(2):270-7. doi: 10.1038/cdd.2013.109. Epub 2013 Aug 16.
PMID: 23954861 , 2014.02. |
| 36. |
Murakami Y, Notomi S, Hisatomi T, Nakazawa T, Ishibashi T, Miller JW, Vavvas DG.
, Photoreceptor cell death and rescue in retinal detachment and degenerations.
, Prog Retin Eye Res. 2013 Nov;37:114-40. doi: 10.1016/j.preteyeres.2013.08.001. Epub 2013 Aug 28.
PMID: 23994436 , 2013.11. |
| 37. |
Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T.
, Therapeutic effect of prolonged treatment with topical dorzolamide for cystoid macular oedema in patients with retinitis pigmentosa.
, Br J Ophthalmol. 2013 Sep;97(9):1187-91. doi: 10.1136/bjophthalmol-2012-303005. Epub 2013 Jun 19.
PMID: 23782868, 2013.09. |
| 38. |
Notomi S, Hisatomi T, Murakami Y, Terasaki H, Sonoda S, Asato R, Takeda A, Ikeda Y, Enaida H, Sakamoto T, Ishibashi T.
, Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage., PLoS One. 2013;8(1):e53338. doi: 10.1371/journal.pone.0053338. Epub 2013 Jan 8.
, 2013.01. |
| 39. |
Yoshida N, Ikeda Y, Notomi S, Ishikawa K, Murakami Y, Hisatomi T, Enaida H, Ishibashi T., Laboratory evidence of sustained chronic inflammatory reaction in retinitis pigmentosa., Ophthalmology. 2013 Jan;120(1):e5-12. doi: 10.1016/j.ophtha.2012.07.008. Epub 2012 Sep 15.
PMID: 22986110, 2013.01. |
| 40. |
Yoshida N, Ikeda Y, Notomi S, Ishikawa K, Murakami Y, Hisatomi T, Enaida H, Ishibashi T.
, Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa., Ophthalmology. 2013 Jan;120(1):100-5. doi: 10.1016/j.ophtha.2012.07.006. Epub 2012 Sep 15.
PMID: 22986109, 2013.01. |
| 41. |
Murakami Y, Ikeda Y, Yoshida N, Notomi S, Hisatomi T, Oka S, De Luca G, Yonemitsu Y, Bignami M, Nakabeppu Y, Ishibashi T., MutT homolog-1 attenuates oxidative DNA damage and delays photoreceptor cell death in inherited retinal degeneration.
, Am J Pathol. 2012 Oct;181(4):1378-86. doi: 10.1016/j.ajpath.2012.06.026. Epub 2012 Jul 27.
PMID: 22841817 , 2012.10. |
| 42. |
Ikeda Y, Hisatomi T, Yoshida N, Notomi S, Murakami Y, Enaida H, Ishibashi T.
, The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa.
, Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):809-14. doi: 10.1007/s00417-011-1904-5. Epub 2012 Jan 4.
PMID: 22215259, 2012.06. |
| 43. |
Hisatomi T, Nakao S, Murakami Y, Noda K, Nakazawa T, Notomi S, Connolly E, She H, Almulki L, Ito Y, Vavvas DG, Ishibashi T, Miller JW., The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization.
, Am J Pathol. 2012 Jul;181(1):53-61. doi: 10.1016/j.ajpath.2012.03.022. Epub 2012 May 19., 2012.06. |
| 44. |
Nakao T, Tsujikawa M, Notomi S, Ikeda Y, Nishida K.
, The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa.
, PLoS One. 2012;7(4):e32472. doi: 10.1371/journal.pone.0032472. Epub 2012 Apr 2., 2012.04. |
| 45. |
Notomi S, Hisatomi T, Kanemaru T, Takeda A, Ikeda Y, Enaida H, Kroemer G, Ishibashi T., Critical involvement of extracellular ATP acting on P2RX7 purinergic receptors in photoreceptor cell death., Am J Pathol. 2011;179:2798-809., 2011.12. |
| 46. |
Jo YJ, Sonoda KH, Oshima Y, Takeda A, Kohno R, Yamada J, Hamuro J, Yang Y, Notomi S, Hisatomi T, Ishibashi T.
, Establishment of a new animal model of focal subretinal fibrosis that resembles disciform lesion in advanced age-related macular degeneration.
, Invest Ophthalmol Vis Sci. 2011 Aug 1;52(9):6089-95. doi: 10.1167/iovs.10-5189.
PMID: 21051730, 2011.08. |
