Kyushu University Academic Staff Educational and Research Activities Database
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Yuta Shirogane Last modified date:2020.07.17

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Department of Virology, Faculty of Medicine, Kyushu University .
Academic Degree
M.D.-Ph.D. (Kyushu University, school of medicine)
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
A virus infects the living cells of other organisms and reproduces itself. We study interactions between different viruses in the same host cell. Co-infection of different viruses in the same cell result in not a simple sum of each phenotype, but sometimes 'cooperative or 'interfering' interactions.
Our goal is to elucidate universal mechanisms of virus replication by investigating a variety of interactions between different viruses. In addition, we are trying to develop new virological methods applicable to all virus species to study their interactions.

In addition, we are now investigating how measles virus evolves in human brains and causes subacute sclerosing panencephalitis (SSPE). We have found an unique mechanism acquired by mutant measles viruses in the human brains where the viruses have mutant hyperfusogenic fusion proteins which allow weak cis and trans interactions of the viral attachment protein with receptors to cause membrane fusion (Shirogane, et al., 2020, Journal of Virology).
Research Interests
  • Mumps virus is the causative agent of acute parotitis. However, it is not clear why the virus favors glandular tissues including salivary glands. We have found that several LAMP family molecules, which are expressed in these tissues, support cleavage of the mumps virus fusion protein. Thus, these molecules could be key to understand why mumps virus causes acute parotitis.Now we are investigating the mechanism in detail.
    keyword : mumps virus, acute parotitis, LAMP family, membrane fusion
  • Measles virus (MV) is the causative agent of measles, which rarely infects human brain and causes lethal subacute sclerosing panencephalitis (SSPE).
    Actually, MV does not infect human brain which does not have its host receptors. However, MV evolves and gains the ability to grow in human brain. We continue to study how it occurs.
    We also study how different species of viruses interact with each other, which may promisingly lead us to understanding common mechanisms of virus replication.
    We hope that our basic sciences will contribute to improvement of public welfare.
    keyword : measles virus, subacute sclerosing panencephalitis, mumps virus, evolution, interaction
Academic Activities
Membership in Academic Society
  • Japanese society of virology