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Motofumi Kumazoe Last modified date:2023.11.14

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Country of degree conferring institution (Overseas)
Field of Specialization
Bioscience Chemical Biology
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
Most of my research focuses on the role of cGMP in the beneficial effects of phytochemicals.
Our group also identified several molecules including Tollip and demonstrated that those signaling pathway-induced by cGMP play crucial role in the resilience of the human body.
Research Interests
  • My research focuses on the role of cGMP in the physiological effects of phytochemicals.
    Our group previously identified several molecules including Tollip and demonstrated that those signaling pathways-induced by cGMP play crucial role in the resilience of the human body. To understand the physiological role of the cGMP in the beneficial effect of several compounds including phytochemicals, we use several disease mouse models including orthotopic tumor implantation model (Osteosarcoma, MPM, Pancreatic cancer, Lung cancer, breast cancer, etc) and other disease models (Obesity, SLE, IBD, ARDS, IgAN, NASH, PAH, Parkinson’s disease, Rheumatoid arthritis). Based on our findings, our recent clinical study found that GT-gH (our proposed polyphenols combination based by cGMP induction) suppressed weight gain and BMI increase in human subjects (UMIN000040109 Placebo-controlled, randomized, double-blind). My goal is to establish the novel strategy to prevent and treat the difficult diseases.
    keyword : cGMP, Phytochemicals, Chemical biology, Immunology, Oncology
Current and Past Project
  • We have been investigated the signaling pathway of cGMP-elicited beneficial effects.
Academic Activities
1. Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana, 67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG, Current Pharmacology Reports,, 2020.01.
1. Motofumi Kumazoe, Yoshinori Fujimura, Ren Yoshitomi, Yu Shimada, Hirofumi Tachibana., Fustin, a Flavanonol, Synergically Potentiates the Anticancer Effect of Green Tea Catechin Epigallocatechin-3-O-Gallate with Activation of the eNOS/cGMP Axis., Journal of agricultural and food chemistry, 10.1021/acs.jafc.1c07567, 70, 11, 3458-3466, 2022.03.
2. Motofumi Kumazoe, Kanako Takamatsu, Fuyumi Horie, Ren Yoshitomi, Hiroki Hamagami, Hiroshi Tanaka, Yoshinori Fujimura, Hirofumi Tachibana., Methylated (-)-epigallocatechin 3-O-gallate potentiates the effect of split vaccine accompanied with upregulation of Toll-like receptor 5., Scientific reports, 10.1038/s41598-021-02346-4, 11, 1, 23101-23101, 2021.11.
3. Motofumi Kumazoe, Yasutake Tanaka, Ren Yoshitomi, Yuki Marugame, Kwan-Woo Lee, Hiroaki Onda, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Hirofumi Tachibana., Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG., Journal of natural medicines, 10.1007/s11418-021-01538-6, 75, 4, 1037-1042, 2021.09.
4. Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana., Cancer cell selective probe by mimicking EGCG., Biochemical and biophysical research communications, 10.1016/j.bbrc.2020.03.021, 525, 4, 974-981, 2020.05.
5. Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa, Hirofumi Tachibana., Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression., JOURNAL OF IMMUNOLOGY, 10.4049/jimmunol.1601822, 199, 9, 3261-3269, 2017.11.
6. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Mai Kadomatsu, Takashi Nojiri, Hiroaki Onda, Jaehoon Bae, Yuhui Huang, Kanako Takamatsu, Shuya Yamashita, Kenji Kangawa, Hirofumi Tachibana., The FOXO3/PGC-1 beta signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma., JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.M116.772111, 292, 26, 10813-10823, 2017.06.
7. M. Kumazoe, M. Takai, J. Bae, S. Hiroi, Y. Huang, K. Takamatsu, Y. Won, M. Yamashita, S. Hidaka, S. Yamashita, S. Yamada, M. Murata, S. Tsukamoto, H. Tachibana., FOXO3 is essential for CD44 expression in pancreatic cancer cells., ONCOGENE, 10.1038/onc.2016.426, 36, 19, 2643-2654, 2017.05.
8. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Jaehoon Bae, Yuhui Huang, Kanako Takamatsu, Shuya Yamashita, Shuhei Yamada, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana., PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma., SCIENTIFIC REPORTS, 10.1038/s41598-017-02162-9, 7, 1, 1917, 2017.05.
9. Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Kanako Takamatsu, Yuhui Huang, Jaehoon Bae, Shuya Yamashita, Motoki Murata, Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana., Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216., JOURNAL OF BIOLOGICAL CHEMISTRY, 10.1074/jbc.M116.755959, 292, 10, 4077-4088, 2017.03.
10. Motofumi Kumazoe, Yoshinori Fujimura, Shiori Hidaka, Yoonhee Kim, Kanako Murayama, Mika Takai, Yuhui Huang, Shuya Yamashita, Motoki Murata, Daisuke Miura, Hiroyuki Wariishi, Mari Maeda-Yamamoto, Hirofumi Tachibana., Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells., SCIENTIFIC REPORTS, 10.1038/srep09474, 5, 2015.03.
11. Motofumi Kumazoe, Shuntaro Tsukamoto, Connie Lesnick, Neil E. Kay, Koji Yamada, Tait D. Shanafelt, Hirofumi Tachibana, Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells., BRITISH JOURNAL OF HAEMATOLOGY, 168, 4, 610-613, 2015.02.
12. Motofumi Kumazoe, Yoonhee Kim, Jaehoon Bae, Mika Takai, Motoki Murata, Yumi Suemasu, Kaori Sugihara, Shuya Yamashita, Shuntaro Tsukamoto, Yuhui Huang, Kanami Nakahara, Koji Yamada, Hirofumi Tachibana, Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis., FEBS LETTERS, 10.1016/j.febslet.2013.07.041, 587, 18, 3052-3057, 2013.09.
13. Motofumi Kumazoe, Kaori Sugihara, Shuntaro Tsukamoto, Yuhui Huang, Yukari Tsurudome, Takashi Suzuki, Yumi Suemasu, Naoki Ueda, Shuya Yamashita, Yoonhee Kim, Koji Yamada, Hirofumi Tachibana, 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis., JOURNAL OF CLINICAL INVESTIGATION, 10.1172/JCI64768, 123, 2, 787-799, 2013.02.
1. Kumazoe M, Yoshinori F, Tachibana H., cGMP mediates beneficial effect of EGCG., International Conference on Food Factors, 2019.11.
2. Kumazoe M, Tachibana H., 67-kDa laminin receptor and cGMP induced cancer-selective apoptosis., The 6th International Meeting on cGMP, 2013.06.
3. Kumazoe M, Tachibana H., EGCG induces cancer-specific cell death via the sensing receptor-mediated cGMP production., International Conference on Tea., 2013.12.