


Motofumi Kumazoe | Last modified date:2023.11.14 |

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Homepage
https://kyushu-u.elsevierpure.com/en/persons/motofumi-kumazoe
Reseacher Profiling Tool Kyushu University Pure
https://www.researchgate.net/profile/Motofumi-Kumazoe
Researchgate .
Phone
092-802-4747
Country of degree conferring institution (Overseas)
No
Field of Specialization
Bioscience Chemical Biology
ORCID(Open Researcher and Contributor ID)
0000-0002-3002-2994
Total Priod of education and research career in the foreign country
00years02months
Outline Activities
Most of my research focuses on the role of cGMP in the beneficial effects of phytochemicals.
Our group also identified several molecules including Tollip and demonstrated that those signaling pathway-induced by cGMP play crucial role in the resilience of the human body.
Our group also identified several molecules including Tollip and demonstrated that those signaling pathway-induced by cGMP play crucial role in the resilience of the human body.
Research
Research Interests
- My research focuses on the role of cGMP in the physiological effects of phytochemicals.
Our group previously identified several molecules including Tollip and demonstrated that those signaling pathways-induced by cGMP play crucial role in the resilience of the human body. To understand the physiological role of the cGMP in the beneficial effect of several compounds including phytochemicals, we use several disease mouse models including orthotopic tumor implantation model (Osteosarcoma, MPM, Pancreatic cancer, Lung cancer, breast cancer, etc) and other disease models (Obesity, SLE, IBD, ARDS, IgAN, NASH, PAH, Parkinson’s disease, Rheumatoid arthritis). Based on our findings, our recent clinical study found that GT-gH (our proposed polyphenols combination based by cGMP induction) suppressed weight gain and BMI increase in human subjects (UMIN000040109 Placebo-controlled, randomized, double-blind). My goal is to establish the novel strategy to prevent and treat the difficult diseases.
keyword : cGMP, Phytochemicals, Chemical biology, Immunology, Oncology
2021.12~2022.06.
- We have been investigated the signaling pathway of cGMP-elicited beneficial effects.
Reports
Papers
Presentations


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